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41. 发明申请

US20100308167A1 ARTICULATING PASSENGER SEAT 有权
标题翻译：描述乘客座椅
公开(公告)号：US20100308167A1
公开(公告)日：2010-12-09
申请号：US12745039
申请日：2009-06-12
申请人： Nathaniel Hawkins , Dennis Hedrick , Jeremy Green
发明人： Nathaniel Hawkins , Dennis Hedrick , Jeremy Green
IPC分类号： B64D11/06
CPC分类号： B64D11/064 , B60N2/181 , B60N2/2209 , B64D11/06
摘要： A passenger seat, having a seat back, and a seat bottom, including a seat pan, supported by a frame mounted on laterally spaced-apart legs for being mounted to the deck of the aircraft by track fittings. A seat back frame assembly and a seat bottom assembly are joined for articulating movement such that when the seat back is reclined, the seat pan is shifted forward and the forward end of the seat pan and thus the seat bottom is raised in order to maintain an appropriate passenger seating angle.
摘要翻译：具有座椅靠背的乘客座椅和座椅底部包括座椅底盘，该座椅底座由安装在横向间隔开的腿部的框架支撑，以通过轨道配件安装到飞机的甲板上。座椅靠背框架组件和座椅底部组件被连接以用于铰接运动，使得当座椅靠背倾斜时，座椅板向前移动，并且座椅底盘的前端并因此升高座椅底部以便保持适当的乘客座角。

42. 发明申请

US20100184980A1 Process for Preparing 5-Fluoro-1H-Pyrazolo [3,4-b] Pyridin-3-amine and Derivatives Thereof 失效
标题翻译：制备5-氟-1H-吡唑并[3,4-b]吡啶-3-胺及其衍生物的方法
公开(公告)号：US20100184980A1
公开(公告)日：2010-07-22
申请号：US12695292
申请日：2010-01-28
申请人： Juan-Miguel Jimenez , Philip Collier , Andrew Miller , Jeremy Green , Huai Gao , Sylvain Loïc Jean-Luc Hamon , Albert Cornelis Dros
发明人： Juan-Miguel Jimenez , Philip Collier , Andrew Miller , Jeremy Green , Huai Gao , Sylvain Loïc Jean-Luc Hamon , Albert Cornelis Dros
IPC分类号： C07D401/14 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to a process for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine in high yield and purity. The present invention also relates to processes for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives. These processes are useful for preparing biologically active compounds, particularly certain GSK-3 inhibitors, or derivatives thereof.
摘要翻译：本发明涉及以高产率和纯度合成5-氟-1H-吡唑并[3,4-b]吡啶-3-胺的方法。本发明还涉及5-氟-1H-吡唑并[3,4-b]吡啶-3-胺衍生物的合成方法。这些方法可用于制备生物活性化合物，特别是某些GSK-3抑制剂或其衍生物。

43. 发明授权

US07452873B2 Inhibitors of GSK-3 and uses thereof 失效
标题翻译： GSK-3抑制剂及其用途
公开(公告)号：US07452873B2
公开(公告)日：2008-11-18
申请号：US11145356
申请日：2005-06-03
申请人： Jeremy Green , Michael J. Arnost , Albert Pierce
发明人： Jeremy Green , Michael J. Arnost , Albert Pierce
IPC分类号： C07D231/20 , C07D401/04 , C07D401/12 , A61K31/4152 , A61K31/4155 , A61K31/655
CPC分类号： C07D401/12 , C07D231/20 , C07D231/46 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to compounds of formula I that are useful as GSK-3 inhibitors. The invention also relates to methods of using compounds of formula I or pharmaceutical compositions comprising compounds of formula I to inhibit GSK-3 activity. The invention further provides methods of utilizing these compounds and pharmaceutical compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. The invention also relates to methods for inhibiting Aurora-2 activity and for treating or preventing Aurora-2-mediated diseases using compounds of formula I or pharmaceutical compositions comprising compounds of formula I. The invention also relates to methods for inhibiting cyclin-dependent kinase-2 activity and for treating or preventing inhibiting cyclin-dependent kinase-2-mediated diseases using compounds of formula I or pharmaceutical compositions comprising compounds of formula I.
摘要翻译：本发明涉及可用作GSK-3抑制剂的式I化合物。本发明还涉及使用式I化合物或包含式I化合物的药物组合物抑制GSK-3活性的方法。本发明还提供了利用这些化合物和药物组合物治疗和预防各种疾病如糖尿病和阿尔茨海默病的方法。本发明还涉及使用式I化合物或包含式I化合物的药物组合物抑制Aurora-2活性和治疗或预防Aurora-2介导的疾病的方法。本发明还涉及抑制细胞周期蛋白依赖性激酶 - 2活性，以及使用式I化合物或包含式I化合物的药物组合物治疗或预防抑制细胞周期蛋白依赖性激酶-2介导的疾病。

44. 发明授权

US07390808B2 Inhibitors of GSK-3 and crystal structures of GSK-3β protein and protein complexes 失效
公开(公告)号：US07390808B2
公开(公告)日：2008-06-24
申请号：US10135255
申请日：2002-04-29
申请人： Jeremy Green , Michael J. Arnost
发明人： Jeremy Green , Michael J. Arnost
IPC分类号： C07D487/04 , A61K31/5025
CPC分类号： C07D487/04 , C07K2299/00 , C12N9/1205 , G06F19/16
摘要： The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. In addition, the invention relates to molecules or molecular complexes which comprise binding pockets of GSK-3β or its homologues. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to GSK-3β protein or homologues thereof. The invention also relates to crystallizable compositions and crystals comprising GSK-3β protein or GSK-3β protein complexes.

45. 发明申请

US20060122185A1 Bicyclic inhibitors of Rho kinase 审中-公开
标题翻译： Rho激酶的双环抑制剂
公开(公告)号：US20060122185A1
公开(公告)日：2006-06-08
申请号：US11285516
申请日：2005-11-22
申请人： Jeremy Green , Jingrong Cao , Upul Bandarage , Huai Gao , Cornelia Forster
发明人： Jeremy Green , Jingrong Cao , Upul Bandarage , Huai Gao , Cornelia Forster
IPC分类号： A61K31/519 , A61K31/503 , A61K31/498 , A61K31/4745 , C07D471/02 , C07D487/02
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of ROCK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译：本发明涉及可用作蛋白激酶抑制剂，特别是ROCK的化合物。本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。

46. 发明申请

US20050182061A1 Phthalimide compounds useful as protein kinase inhibitors 审中-公开
标题翻译：可用作蛋白激酶抑制剂的邻苯二甲酰亚胺化合物
公开(公告)号：US20050182061A1
公开(公告)日：2005-08-18
申请号：US10958167
申请日：2004-10-04
申请人： Jeremy Green , Craig Marhefka
发明人： Jeremy Green , Craig Marhefka
IPC分类号： A61K31/4035 , A61K31/4745 , A61K31/498 , C07D209/46 , C07D209/48 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D471/02 , C07D487/02
CPC分类号： C04B35/632 , C07D209/46 , C07D209/48 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04
摘要： The present invention provides compounds as inhibitors of protein kinase, particularly inhibitors of AKT, PDK1, p70S6K, or ROCK kinase, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides processes for preparing the compounds of the invention, pharmaceutical compositions comprising the compounds, and methods of utilizing those compounds and compositions in the treatment of various disorders.
摘要翻译：本发明提供了作为蛋白激酶抑制剂的化合物，特别是AKT，PDK1，p70S6K或ROCK激酶的抑制剂，涉及增殖性和神经变性疾病的哺乳动物蛋白激酶。本发明还提供了制备本发明化合物的方法，包含该化合物的药物组合物，以及利用这些化合物和组合物治疗各种疾病的方法。

47. 发明授权

US06825190B2 Protein kinase inhibitors and uses thereof 失效
标题翻译：蛋白激酶抑制剂及其用途
公开(公告)号：US06825190B2
公开(公告)日：2004-11-30
申请号：US10172888
申请日：2002-06-14
申请人： Young-Choon Moon , Jeremy Green , Robert Davies , Deborah Choquette , Albert Pierce , Mark Ledeboer
发明人： Young-Choon Moon , Jeremy Green , Robert Davies , Deborah Choquette , Albert Pierce , Mark Ledeboer
IPC分类号： C07D41304
CPC分类号： C07D413/04 , C07D413/14
摘要： Described herein are benzisoxazole compounds of formula I: or a pharmaceutically acceptable derivative or prodrug thereof, wherein A-B is N—O or O—N; Ar is an optionally substituted C5-10 aryl group; R1 is hydrogen or an optionally substituted group selected from C1-10 aliphatic, C5-10 aryl, C6-12 aralkyl, C3-10 heterocyclyl, or C4-12 heterocyclylalkyl; and T, n, R2 and R3 are as described in the specification. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK-3 and JAK mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.
摘要翻译：本文描述的是式I的苯并异恶唑化合物：或其药学上可接受的衍生物或前药，其中A-B是N-O或O-N; Ar是任选取代的C 5-10芳基; R 1是氢或任选取代的基团，其选自C 1-10脂族基，C 5-10芳基，C 6-12芳烷基，C 3-10杂环基或C 4-12杂环基烷基; 和T，n，R 2和R 3如说明书中所述。这些化合物是蛋白激酶的抑制剂，特别是GSK-3和JAK哺乳动物蛋白激酶的抑制剂。本发明还提供包含本发明化合物的药学上可接受的组合物和利用这些化合物和组合物治疗各种蛋白激酶介导的病症的方法。

48. 发明授权

US06699865B2 Pyrazole compositions useful as inhibitors of ERK 失效
标题翻译：吡唑组合物可用作ERK的抑制剂
公开(公告)号：US06699865B2
公开(公告)日：2004-03-02
申请号：US10335793
申请日：2003-01-02
申请人： Michael Hale , Xiaoling Xie , Jeremy Green , Jingrong Cao , Christopher Baker , Francois Maltais , James Janetka , Guy Bemis , Michael Mullican , Judith Straub , Qing Tang
发明人： Michael Hale , Xiaoling Xie , Jeremy Green , Jingrong Cao , Christopher Baker , Francois Maltais , James Janetka , Guy Bemis , Michael Mullican , Judith Straub , Qing Tang
IPC分类号： A61K314155
CPC分类号： C07D401/14 , C07D231/38 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04
摘要： Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
摘要翻译：本文描述了可用作具有下式的蛋白激酶抑制剂的化合物：其中R 1-4，Q和T在说明书中描述。该化合物可用于治疗由蛋白激酶抑制剂，特别是癌症，炎症性疾病，再狭窄和心血管疾病等疾病减轻的哺乳动物的疾病状态。

49. 发明公开

US20240191953A1 HEAT EXCHANGER TUBE WITH HIGH HEAT TRANSFER AND LOW PRESSURE DROP 审中-公开
公开(公告)号：US20240191953A1
公开(公告)日：2024-06-13
申请号：US18510145
申请日：2023-11-15
申请人： Carl Nett , Jeremy Green , Mohammadreza Salimpour
发明人： Carl Nett , Jeremy Green , Mohammadreza Salimpour
IPC分类号： F28F1/40
CPC分类号： F28F1/40
摘要： A heat exchanger tube with outside diameter less than or equal to ten (10) inches and inside diameter greater than or equal to one-tenth (0.1) inches, comprising an inlet and an outlet; the heat exchanger tube enclosing and at least partly in contact with flow of a first fluid with the tube inner surface, separated from a second fluid at least partially in contact with the heat exchanger tube outer surface; one or a plurality of ridges disposed on the inner surface of the heat exchanger tube wall; a ridge having a height measured from the inner heat exchanger wall surface of less than or equal to one (1.0) millimeter.

50. 发明申请

US20180325898A1 DNA-PK INHIBITORS 审中-公开
公开(公告)号：US20180325898A1
公开(公告)日：2018-11-15
申请号：US16042206
申请日：2018-07-23
申请人： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
发明人： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC分类号： A61K31/506 , A61K9/48 , C07D417/10 , A61K41/00 , C07D521/00 , C07D495/04 , C07D491/056 , C07D491/048 , C07D471/04 , C07D417/14 , C07D417/04 , C07D413/10 , C07D413/04 , C07D409/14 , C07D409/04 , C07D239/42 , C07D403/10 , C07D403/04 , C07D401/04 , C07D413/14 , C07D405/14 , C07D401/14 , A61K47/55 , A61K31/53 , A61K47/54 , A61K31/5377 , A61K9/20
CPC分类号： C07D401/14 , A61K9/20 , A61K9/48 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K41/0038 , A61K47/545 , A61K47/55 , C07D239/42 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

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