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41. 发明申请

WO2014037506A1 SYSTEM FOR DISPENSING A SAMPLE INTO A BUFFER LIQUID 审中-公开
标题翻译：将样品分配到缓冲液中的系统
公开(公告)号：WO2014037506A1
公开(公告)日：2014-03-13
申请号：PCT/EP2013/068474
申请日：2013-09-06
申请人： F. HOFFMANN-LA ROCHE AG
发明人： BERNDT, Peter , FATTINGER, Christof , STEINER, Roger
IPC分类号： G01N35/10 , B01L3/00
CPC分类号： B01L3/52 , B01L3/0262 , B01L3/0293 , B01L3/502715 , B01L2200/027 , B01L2200/0673 , B01L2300/069 , B01L2300/0838 , B01L2300/0877 , B01L2300/14 , B01L2400/024 , B01L2400/0406 , B01L2400/0487 , G01N35/1095 , Y10T436/25625
摘要： A system for dispensing a sample (5) into a buffer liquid comprises a pressure chamber (1) having pressure supply means for generating an overpressure within the pressure chamber. An inlet capillary (2) is provided for supplying a buffer liquid (9) to an outlet end (6) arranged in the pressure chamber. Also, an outlet capillary (3) is provided for discharging buffer liquid and/or sample from the pressure chamber. The outlet capillary (3) has an inlet end (7) arranged in the pressure chamber (1) facing the outlet end (6) of the inlet capillary (2) to form a capillary gap (8). A dispenser (4) having a dispensing end (10) is arranged in the pressure chamber (1) at the capillary gap (8) to allow the sample (5) at the dispensing end (10) to be dispensed from the dispensing end (10) into the buffer liquid entering the inlet end (7) of the outlet capillary (3). The pressure chamber (1) comprises a pressure-tight sample port (13) adapted to allow the dispenser (4) with the dispensing end (10) to be moved into and out of the pressure chamber (1), wherein the pressure chamber (1) comprises a pressure-tight sample port adapted to allow the dispenser (4) with the dispensing end (10) to be moved into and out of the pressure chamber ( 1 ).
摘要翻译：用于将样品（5）分配到缓冲液体中的系统包括具有用于在压力室内产生超压的压力供应装置的压力室（1）。提供入口毛细管（2），用于将缓冲液（9）供应到布置在压力室中的出口端（6）。而且，出口毛细管（3）用于从压力室排放缓冲液体和/或样品。出口毛细管（3）具有布置在压力室（1）中的入口毛细管（2）的出口端（6）的入口端（7），以形成毛细管间隙（8）。具有分配端（10）的分配器（4）在毛细管间隙（8）处设置在压力室（1）中，以允许在分配端（10）处的样品（5）从分配端 10）进入进入出口毛细管（3）的入口端（7）的缓冲液中。压力室（1）包括适于允许具有分配端（10）的分配器（4）进入和离开压力室（1）的压力密封样品端口（13），其中压力室 1）包括适于允许具有分配端（10）的分配器（4）进入和离开压力室（1）的耐压样品端口。

42. 发明申请

WO2013182537A1 AUTOIMMUNE ANTIBODIES 审中-公开
标题翻译：自动免疫抗体
公开(公告)号：WO2013182537A1
公开(公告)日：2013-12-12
申请号：PCT/EP2013/061430
申请日：2013-06-04
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： BERNDT, Peter , KLUGHAMMER, Barbara
IPC分类号： A61K39/395 , G01N33/574
CPC分类号： G01N33/6854 , C07K16/2863 , G01N33/564 , G01N33/57423 , G01N2333/71
摘要： The invention generally relates to biomarkers associated with NSCLC, and methods and compositions for the detection and diagnosis of non-small cell lung cancer in a human subject.
摘要翻译：本发明一般涉及与NSCLC相关的生物标志物，以及用于在人类受试者中检测和诊断非小细胞肺癌的方法和组合物。

43. 发明授权

EP1579220B1 USE OF NICOTINAMIDE N-METHYLTRANSFERASE AS A MARKER FOR COLORECTAL CANCER 有权
标题翻译：烟酰胺N-甲基对结肠直肠癌的诊断中的应用，
公开(公告)号：EP1579220B1
公开(公告)日：2007-08-15
申请号：EP03813582.8
申请日：2003-12-19
申请人： Roche Diagnostics GmbH , F. HOFFMANN-LA ROCHE AG
发明人： BERNDT, Peter , HAGMANN, Marie-Luise , LANGEN, Hanno , PALME, Stefan , ROESSLER, Markus , ROLLINGER, Wolfgang , TACKE, Michael , ZOLG, Werner , KARL, Johann , KOTT, Theresa
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , C12Q1/48
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of the protein nicotinamide N-methyltransferase (NNMT) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring NNMT in said sample. Measurement of NNMT can, e.g., be used in the early detection or diagnosis of colorectal cancer.

44. 发明公开

EP1676136A1 USE OF PROTEIN UBC13 AS A MARKER FOR BREAST CANCER 审中-公开
标题翻译：使用本protiens UBC13作为标记物时为乳腺癌
公开(公告)号：EP1676136A1
公开(公告)日：2006-07-05
申请号：EP04790499.0
申请日：2004-10-15
申请人： Roche Diagnostics GmbH , F. HOFFMANN-LA ROCHE AG
发明人： PESTLIN, Gabriele , ANDRES, Herbert , BERNDT, Peter , HAGMANN, Marie-Luise , KARL, Johann , LANGEN, Hanno , ZOLG, Werner
IPC分类号： G01N33/574
CPC分类号： G01N33/57415
摘要： The present invention relates to the diagnosis of breast cancer. It discloses the use of ubiquitin-conjugating enzyme E2N (UBC13) in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring UBC13 in said sample. Measurement of UBC13 can, e.g., be used in the early detection or diagnosis of breast cancer.

45. 发明公开

EP1654541A1 USE OF PROTEIN PSA3 AS A MARKER FOR COLORECTAL CANCER 审中-公开
标题翻译：使用作为标记大肠肿瘤PSA3
公开(公告)号：EP1654541A1
公开(公告)日：2006-05-10
申请号：EP04763897.8
申请日：2004-08-06
申请人： Roche Diagnostics GmbH , F. HOFFMANN-LA ROCHE AG
发明人： TACKE, Michael , BERNDT, Peter , HAGMANN, Marie-Luise , KARL, Johann , LANGEN, Hanno , PALME, Stefan , ROESSLER, Markus , ROLLINGER, Wolfgang , ZOLG, Werner
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N2333/95
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein proteasome subunit alpha 3 (PSA3) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring PSA3 in said sample. Measurement of PSA3 can, e.g., be used in the early detection or diagnosis of colorectal cancer.

46. 发明授权

EP1676135B1 USE OF PROTEIN ASC AS A MARKER FOR BREAST CANCER 有权
标题翻译：中蛋白质ASC作为标志物用于乳腺癌USE
公开(公告)号：EP1676135B1
公开(公告)日：2011-11-16
申请号：EP04790451.1
申请日：2004-10-15
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： PESTLIN, Gabriele , ANDRES, Herbert , BERNDT, Peter , HAGMANN, Marie-Luise , KARL, Johann , LANGEN, Hanno , ZOLG, Werner
IPC分类号： G01N33/574
CPC分类号： G01N33/57415
摘要： The present invention relates to the diagnosis of breast cancer. It discloses the use of protein ASC in the diagnosis of breast cancer. It relates to a method for diagnosis of breast cancer from a liquid sample, derived from an individual by measuring ASC in said sample. Measurement of ASC can, e.g., be used in the early detection or diagnosis of breast cancer.

47. 发明公开

EP1654539A1 USE OF PROTEIN SAHH AS A MARKER FOR COLORECTAL CANCER 审中-公开
标题翻译： USE THE SAHH蛋白作为标记物时大肠癌
公开(公告)号：EP1654539A1
公开(公告)日：2006-05-10
申请号：EP04763805.1
申请日：2004-08-05
申请人： Roche Diagnostics GmbH , F. HOFFMANN-LA ROCHE AG
发明人： TACKE, Michael , BERNDT, Peter , HAGMANN, Marie-Luise , KARL, Johann , LANGEN, Hanno , PALME, Stefan , ROESSLER, Markus , ROLLINGER, Wolfgang , ZOLG, Werner
IPC分类号： G01N33/574
CPC分类号： G01N33/57419
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein SAHH (S-adenosylhomocysteine hydrolase) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a stool sample, derived from an individual by measuring SAHH in said sample. Measurement of SAHH can, e.g. be used in the early detection or diagnosis of colorectal cancer.

48. 发明公开

EP1654538A1 USE OF PROTEIN PROTEASOME ACTIVATOR SUBUNIT 3 (PSE3) AS A MARKER FOR COLORECTAL CANCER 有权
标题翻译：使用本蛋白蛋白酶体亚基ACTIVATOR 3 AS MARKER大肠癌
公开(公告)号：EP1654538A1
公开(公告)日：2006-05-10
申请号：EP04741385.1
申请日：2004-08-06
申请人： Roche Diagnostics GmbH , F. HOFFMANN-LA ROCHE AG
发明人： TACKE, Michael , BERNDT, Peter , HAGMANN, Marie-Luise , KARL, Johann , LANGEN, Hanno , PALME, Stefan , ROESSLER, Markus , ROLLINGER, Wolfgang , ZOLG, Werner
IPC分类号： G01N33/574
CPC分类号： G01N33/57419
摘要： The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein PSE3 (proteasome activator subunit 3) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring PSE3 in said sample. Measurement of PSE3 can, e.g., be used in the early detection or diagnosis of colorectal cancer.

49. 发明授权

EP1654538B1 USE OF PROTEIN PROTEASOME ACTIVATOR SUBUNIT 3 (PSE3) AS A MARKER FOR COLORECTAL CANCER 有权
标题翻译：使用本蛋白蛋白酶体亚基ACTIVATOR 3 AS MARKER大肠癌
公开(公告)号：EP1654538B1
公开(公告)日：2008-10-08
申请号：EP04741385.1
申请日：2004-08-06
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： TACKE, Michael , BERNDT, Peter , HAGMANN, Marie-Luise , KARL, Johann , LANGEN, Hanno , PALME, Stefan , ROESSLER, Markus , ROLLINGER, Wolfgang , ZOLG, Werner
IPC分类号： G01N33/574
CPC分类号： G01N33/57419

50. 发明授权

EP1676134B1 USE OF PROTEIN SPEE AS A MARKER FOR BREAST CANCER 有权
标题翻译：蛋白SPEE作为标志物用于乳腺癌USE
公开(公告)号：EP1676134B1
公开(公告)日：2008-04-23
申请号：EP04790449.5
申请日：2004-10-15
申请人： Roche Diagnostics GmbH , F. Hoffmann-La Roche AG
发明人： PESTLIN, Gabriele , BERNDT, Peter , HAGMANN, Marie-Luise , KARL, Johann , LANGEN, Hanno , WILD, Norbert , ZOLG, Werner
IPC分类号： G01N33/574
CPC分类号： G01N33/57415 , G01N2333/91171

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