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41. 发明授权

US07186401B2 Dry powder for inhalation 有权
标题翻译：用于吸入的干粉
公开(公告)号：US07186401B2
公开(公告)日：2007-03-06
申请号：US10628965
申请日：2003-07-28
申请人： Manfred Keller , Rudi Müller-Walz
发明人： Manfred Keller , Rudi Müller-Walz
IPC分类号： A61K9/12 , A61K9/14 , A61M11/00
CPC分类号： A61K9/0075 , A61K47/12
摘要： The aim of the invention is to improve the moisture resistance of dry powder formulations for inhalation which contain a pharmaceutically ineffective carrier of not-inhalable particle size and a finely divided pharmaceutically active compound of inhalable particle size and to also improve the storage stability of said formulations. To this end, magnesium stearate is used in said formulations. One of the features of the inventive dry powder is that a high fine particle dosage or fine particle fraction can be maintained also under relatively extreme temperature and humidity conditions.
摘要翻译：本发明的目的是提高含有不可吸入粒度的药学上无效载体的吸入粉末制剂和可吸入粒径的细碎药物活性化合物的吸湿干粉配方的耐湿性，并且还提高所述制剂的储存稳定性。为此，在所述制剂中使用硬脂酸镁。本发明干粉的特征之一是在相对极端的温度和湿度条件下也可以保持高的细颗粒剂量或细颗粒分数。

42. 发明授权

US07131441B1 Inhaler for multiple dosed administration of a pharmacological dry powder 有权
标题翻译：多剂量给药药物干粉的吸入器
公开(公告)号：US07131441B1
公开(公告)日：2006-11-07
申请号：US09570107
申请日：2000-05-12
申请人： Manfred Keller , Thomas Eggimann
发明人： Manfred Keller , Thomas Eggimann
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61M15/0026 , A61M15/0045 , A61M15/0068 , A61M15/007 , A61M15/0076 , A61M15/0086 , A61M2202/064 , A61M2205/825 , G06M1/083 , G06M1/22
摘要： An inhaler for multiple dosed administration of a pharmacological dry powder has a housing with a mouthpiece fitted thereon and a removable protective cap that covers the mouthpiece prior to removal. The mouthpiece may be fitted with or without lip grooves, which aid a user in the positioning and manipulation of the inhaler. The inhaler includes a dosing slide, a carriage, a dosing cavity and a valve shield, all of which are arranged within the housing. Removal of the protective cap initiates dosing, which consists of a dose of a pharmacological dry powder being received in the dosing cavity and then transported to the mouthpiece by means of the dosing slide. Only upon application of a defined minimum intensity of inhalation is the shutter moved by the suctioned valve shield, resulting in the release of the dose for inhalation.
摘要翻译：用于多剂量给药药理学干粉的吸入器具有安装在其上的接口的外壳和在移除之前覆盖接口管的可移除的保护帽。吸嘴可以安装有或没有唇槽，这有助于使用者定位和操纵吸入器。吸入器包括定量滑块，滑架，计量腔和阀屏蔽件，所有这些都布置在壳体内。保护帽的移除开始给药，其由在剂量腔中接收的一定剂量的药物干燥粉末组成，然后通过定量给药载体输送到吸口。只有在施加了限定的最小吸入强度后，通过抽吸的阀屏才能移动活门，导致吸入剂量的释放。

43. 发明申请

US20060057073A1 Wet granulation process 审中-公开
标题翻译：湿法造粒工艺
公开(公告)号：US20060057073A1
公开(公告)日：2006-03-16
申请号：US10517910
申请日：2003-10-28
申请人： Frank-Christophe Lintz , Manfred Keller
发明人： Frank-Christophe Lintz , Manfred Keller
IPC分类号： A61L9/04 , A61K9/20
CPC分类号： A61K31/427 , A61K9/1611 , A61K9/1617 , A61K31/472
摘要： The invention is in the field of pharmaceutical dosage forms, and more particularly in the field of pharmaceutical granules and processes for making granules. The invention provides a process for preparing pharmaceutical granules which contain an active ingredient in the form of a salt, said process comprising the steps of (a) providing a powder containing the active ingredient as a free base or acid, and (b) agglomerating the powder by adding a granulation liquid to form granules; wherein step (b) is conducted in the presence of a neutralization agent capable of neutralizing the active ingredient, and for a sufficient amount of time to allow the active ingredient to become at least partially converted into a salt. The invention also provides pharmaceutical granules obtainable by said process and pharmaceutical compositions comprising said granules. The invention further provides the use of pharmaceutical granules for the pulmonary delivery of an active ingredient.
摘要翻译：本发明在药物剂型领域，更特别是在药物颗粒领域和制造颗粒的方法中。本发明提供一种制备含有盐形式活性成分的药物颗粒的方法，所述方法包括以下步骤：（a）提供含有作为游离碱或酸的活性成分的粉末，和（b）将粉末通过加入造粒液形成颗粒; 其中步骤（b）在能够中和活性成分的中和剂的存在下进行，并且足够的时间使活性成分至少部分地转化成盐。本发明还提供可通过所述方法获得的药物颗粒和包含所述颗粒的药物组合物。本发明进一步提供药物颗粒用于肺部递送活性成分的用途。

44. 发明申请

US20060056772A1 Spectral broadband and a high efficiency light source 审中-公开
标题翻译：光谱宽带和高效光源
公开(公告)号：US20060056772A1
公开(公告)日：2006-03-16
申请号：US10529571
申请日：2003-07-30
申请人： Manfred Keller
发明人： Manfred Keller
IPC分类号： G02B6/36
CPC分类号： G02B6/4249 , G02B6/4206
摘要： A spectrally broadband light source of high optical power for fiber optic applications. A number of LEDs are arranged as a monolithic array of adjacent surface-emitting, bright, on a wafer or chip. A microoptics array is arranged upstream of the monolithic LED linear array on the emission side for focusing the light beams emanating from the LEDs. Collecting optics in particular a spherical lens, is provided for optimizing the optical power to be launched into a fiber.
摘要翻译：用于光纤应用的高光功率的光谱宽带光源。许多LED被布置为在晶片或芯片上相邻表面发射，明亮的单片阵列。微发光阵列布置在发射侧的单片LED线阵列的上游，用于聚焦从LED发出的光束。集光学特别是球面透镜被提供用于优化要发射到光纤中的光功率。

45. 发明授权

US06585958B1 Medicinal aerosol formulations 有权
标题翻译：药用气雾剂
公开(公告)号：US06585958B1
公开(公告)日：2003-07-01
申请号：US09744379
申请日：2001-04-13
申请人： Manfred Keller , Kurt Herzog , Rudi Müller-Walz , Holger Kraus
发明人： Manfred Keller , Kurt Herzog , Rudi Müller-Walz , Holger Kraus
IPC分类号： A61K912
CPC分类号： A61K9/008 , A61K9/124
摘要： A pressure-liquefied propellant mixture for aerosols, comprising dinitrogen monoxide and a hydrofluoroalkane having 1 to 3 carbon atoms, in particular 1,1,1,2-tetrafluoroethane and/or 1,1,1,2,3,3,3-heptafluoropropane, makes possible an improvement in the wetting properties of pharmaceutically active compounds, whereby the formulation problems existing with hydrofluoroalkanes can be overcome with respect to suspension and solution aerosols and thus improved medicinal aerosol formulations can be obtained. With the aid of dinitrogen monoxide, it is also possible to influence the pressure and thus the particle size distribution specifically and, by displacement of oxygen from the hydrofluoroalkanes, to improve the storage stability of oxidation-sensitive active compounds. If desired, the propellant mixture can additionally contain carbon dioxide.
摘要翻译：一种用于气溶胶的压力液化推进剂混合物，其包含一氧化二氮和具有1至3个碳原子的氢氟烷烃，特别是1,1,1,2-四氟乙烷和/或1,1,1,2,3,3,3- 七氟丙烷可以改善药物活性化合物的润湿性能，由此可以克服悬浮液和溶液气溶胶存在的氢氟烷存在的配方问题，从而可以获得改进的药物气溶胶制剂。借助于一氧化二氮，还可以特别影响压力，从而影响粒度分布，并且通过从氢氟烷烃中排出氧来提高氧化敏感活性化合物的储存稳定性。如果需要，推进剂混合物可另外含有二氧化碳。

46. 发明授权

US06182655B2 Inhaler for multiple dosed administration of a pharmacological dry powder 失效
标题翻译：多剂量给药药物干粉的吸入器
公开(公告)号：US06182655B2
公开(公告)日：2001-02-06
申请号：US09077387
申请日：1998-05-28
申请人： Manfred Keller , Thomas Eggimann
发明人： Manfred Keller , Thomas Eggimann
IPC分类号： A61M1500
CPC分类号： A61M15/0086 , A61M11/002 , A61M15/0025 , A61M15/0045 , A61M15/0065 , A61M15/0068 , A61M15/0076 , A61M15/008 , A61M15/0091 , A61M2016/0039 , A61M2202/064 , A61M2205/215 , A61M2205/825 , G06M1/163
摘要： An inhaler for multiple dosed administration of a pharmacological dry powder consists externally of a housing (100,150) and of a protective cap (950) which can be removed from a special mouthpiece (900) fitted on the housing. Arranged on the inside there are a slide rail (200), a dosing slide (300), a shutter (400), a carriage (500), a funnel arrangement (600), a counter device (700), a valve shield (800) and a valve guide (850). Removal of the protective cap (950) initiates the dosing, with a dose received in the dosing cavity (302) being transported to the mouth-piece (900) by means of the dosing slide (300). Only upon application of a defined minimum intensity of inhalation is the shutter (400) moved by the suctioned valve shield (800), as a result of which the dose is released for inhalation. Completed with an electronic module and a controllable nozzle, all inhalation-relevant data can be recorded and the flow conditions regulated.
摘要翻译：用于多剂量给药药物干粉的吸入器由外壳（100,150）和保护盖（950）外部组成，其可以从装配在外壳上的特殊接口（900）移除。在内侧设置有滑轨（200），配料滑块（300），快门（400），滑架（500），漏斗装置（600），计数器装置（700），阀屏蔽 800）和阀引导件（850）。保护帽（950）的去除启动剂量，在剂量腔（302）中接收的剂量通过定量给药载玻片（300）输送到口件（900）。只有当施加了限定的最小吸入强度时，由抽吸阀屏蔽（800）移动的快门（400），结果释放剂量用于吸入。完成了电子模块和可控喷嘴，可以记录所有吸入相关数据，并调节流量条件。

47. 发明授权

US4795612A Apparatus for the detection of filterable gas contaminants 失效
标题翻译：用于检测可过滤气体污染物的装置
公开(公告)号：US4795612A
公开(公告)日：1989-01-03
申请号：US75209
申请日：1987-07-17
申请人： Manfred Keller
发明人： Manfred Keller
IPC分类号： G01N1/02 , G01N1/22 , G01N1/24 , G01T7/04 , G01N35/02 , G01T1/167
CPC分类号： G01N1/2214 , G01T7/04 , G01N1/24 , G01N2001/2223
摘要： For the determination of filterable pollutants in gases there is a filter sc, which is located on a horizontal, compact rotary plate, which is moved over a suction head, whose suction lips interact with corresponding holes or borings in the rotary plate. The suction head is pushed upon from underneath by action of a universal-joint spring bearing against the plane-parallel rotary plate. Preferably, the rotary plate is rotated each time in steps at determined cycle times, specifically according to a program, by a determined number of collection spaces with "phase-shifted" multiple rotations of the plate, until the filter surface is completely used up. Instead of a filter disc, absorber material can also be used for radioactivity monitoring with a forward motion cycle of 1 to 2 days. Three detectors are provided, with the first detector being typically disposed above a first space, the second detector disposed above a space three spaces from the first space, and the third detector disposed above a space eleven spaces from the first space, for example, if the rotary plate is always moved forward by 2 spaces after the accumulation of the specimen in the first space.
摘要翻译：为了确定气体中的可过滤污染物，有一个过滤盘，位于水平紧凑的旋转板上，该过滤盘在抽吸头上移动，吸嘴与旋转板中相应的孔或钻孔相互作用。通过万向接头弹簧轴承抵靠平面平行旋转板的作用，将吸头从下面推开。优选地，旋转板每次以确定的循环时间（具体地根据程序）以确定数量的板的“相移”多次旋转的收集空间旋转，直到过滤表面完全消耗。代替滤盘，吸收材料也可以用于1到2天的前向运动循环的放射性监测。提供三个检测器，其中第一检测器通常设置在第一空间上方，第二检测器设置在与第一空间三个空间的空间上方，第三检测器设置在距离第一空间十一个空间的空间上方，例如，如果在第一空间中的样本积聚之后，旋转板总是向前移动2个空间。

48. 发明授权

US4630330A Fastening clip rotatable in a housing bore 失效
标题翻译：紧固夹可在外壳孔中旋转
公开(公告)号：US4630330A
公开(公告)日：1986-12-23
申请号：US777590
申请日：1985-09-19
申请人： Manfred Keller , Rudi Kolle , Winfried Schreiber , Klaus Claar
发明人： Manfred Keller , Rudi Kolle , Winfried Schreiber , Klaus Claar
IPC分类号： F16B19/10 , F16B2/20 , F16B5/06 , F16B9/02 , F16B19/00 , B23P11/02
CPC分类号： F16B5/0685 , F16B9/023 , Y10T16/05 , Y10T16/39
摘要： A fastening clip configured for rotation in a housing bore, the clip fashioned to house a beveled terminal region of a linkage of circular cross-section. So that the clip rotates spontaneously into a correct installation position during assembly of the linkage, a plurality of clip orifices are provided and the walls of an associated introductory channel are beveled so that an introductory bevel extends from every point on the edge of the clip to intersect a clip orifice.
摘要翻译：紧固夹构造成用于在壳体孔中旋转，所述夹子被形成为容纳圆形横截面的连杆的倾斜端部区域。因此，在组合联动装置期间，夹子自动地旋转到正确的安装位置，提供了多个夹子孔口，并且相关的导入通道的壁被倒角，使得介入斜面从夹子的边缘上的每个点延伸到与夹子相交。

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