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41. 发明授权

US06673776B1 Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human 失效
标题翻译：外源多核苷酸序列在脊椎动物，哺乳动物，鱼类，鸟类或人类中的表达
公开(公告)号：US06673776B1
公开(公告)日：2004-01-06
申请号：US08481932
申请日：1995-06-07
申请人： Philip L. Felgner , Jon Asher Wolff , Gary H. Rhodes , Robert Wallace Malone , Dennis A. Carson
发明人： Philip L. Felgner , Jon Asher Wolff , Gary H. Rhodes , Robert Wallace Malone , Dennis A. Carson
IPC分类号： A01N4304
CPC分类号： C07K14/005 , A61K9/1272 , A61K48/00 , C07K14/61 , C12N9/0069 , C12N9/1033 , C12N9/1247 , C12N9/78 , C12N15/87 , C12N2740/16122 , C12Y113/12007
摘要： A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.
摘要翻译：一种用于将分离的多核苷酸递送至脊椎动物细胞内部的方法，包括将分离的多核苷酸间插入脊椎动物的组织中，其中所述多核苷酸被组织的细胞吸收并对其施用治疗效果脊椎动物。该方法可用于将治疗性多肽递送至脊椎动物的细胞，以在多核苷酸的体内翻译中提供免疫应答，递送反义多核苷酸，将受体递送至脊椎动物的细胞，或提供短暂基因治疗。

42. 发明授权

US06214804B1 Induction of a protective immune response in a mammal by injecting a DNA sequence 失效
标题翻译：通过注射DNA序列诱导哺乳动物的保护性免疫应答
公开(公告)号：US06214804B1
公开(公告)日：2001-04-10
申请号：US08481919
申请日：1995-06-07
申请人： Philip L. Felgner , Jon Asher Wolff , Gary H. Rhodes , Robert Wallace Malone , Dennis A. Carson
发明人： Philip L. Felgner , Jon Asher Wolff , Gary H. Rhodes , Robert Wallace Malone , Dennis A. Carson
IPC分类号： A61K4800
CPC分类号： A61K9/1272 , A61K48/00 , C07K14/005 , C07K14/61 , C12N9/0069 , C12N9/1033 , C12N9/1247 , C12N9/78 , C12N15/87 , C12N2740/16122 , C12Y113/12007
摘要： A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and exerts a therapeutic effect on the vertebrate. The method can be used to deliver a therapeutic polypeptide to the cells of the vertebrate, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the vertebrate, or to provide transitory gene therapy.
摘要翻译：一种用于将分离的多核苷酸递送至脊椎动物细胞内部的方法，包括将分离的多核苷酸间插入脊椎动物的组织中，其中所述多核苷酸被组织的细胞吸收并对其施用治疗效果脊椎动物。该方法可用于将治疗性多肽递送至脊椎动物的细胞，以在多核苷酸的体内翻译中提供免疫应答，递送反义多核苷酸，将受体递送至脊椎动物的细胞，或提供短暂基因治疗。

43. 发明授权

US06210917B1 Method for suppressing multiple drug resistance in cancer cells 失效
标题翻译：抑制癌细胞多重耐药性的方法
公开(公告)号：US06210917B1
公开(公告)日：2001-04-03
申请号：US08956657
申请日：1997-10-23
申请人： Dennis A. Carson , Carlos J. Carrera
发明人： Dennis A. Carson , Carlos J. Carrera
IPC分类号： C12Q134
CPC分类号： C07K16/40 , C12N9/1077 , C12Q1/25 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/5005 , G01N33/573
摘要： Methods for treating and preventing the onset and maintainance of multiple drug resistance (MDR) in animals undergoing chemotherapy for cancer are provided. According to the methods, target cells are depleted of adenosine 5′-monophosphate (AMP) and adenosine 5′-triphosphate (ATP) such that the cells are unable to support P-glycoprotein activity. According to one method, a population of target cells is obtained from a host and assayed for loss of methylthioadenosine phosphorylase (MTAse) activity. MTAse catabolizes methylthioadenosine to adenine for endogenous salvage incorporation into the intracellular AMP pool. MTAse deficient cells are treated with a purine synthesis inhibitor, such as L-alanosine, which starves the cells of adenine and suppresses P-glycoprotein activity. MTAse competent cells are also treated for MDR with purine synthesis inhibitors. In conjunction with treatment according to the invention, MTAse competent and deficient cells are also treated for malignancy with other anti-cancer drugs. A method for protecting non-malignant cells from adenine starvation during treatment of malignant cells according to the invention is provided.
摘要翻译：提供了治疗和预防接受化疗癌症的动物多发耐药（MDR）发病和维持的方法。根据该方法，靶细胞耗尽腺苷5'-单磷酸（AMP）和腺苷5'-三磷酸（ATP），使得细胞不能支持P-糖蛋白活性。根据一种方法，从宿主获得靶细胞群并测定甲硫基腺苷磷酸化酶（MTAse）活性的损失。 MTAs将甲基硫代腺苷分解为腺嘌呤，用于内源性补救并入细胞内AMP库。 MTAse缺陷细胞用嘌呤合成抑制剂如L-肌氨酸处理，其使腺嘌呤的细胞饥饿并抑制P-糖蛋白活性。 MTAse感受态细胞也用嘌呤合成抑制剂治疗MDR。结合根据本发明的治疗，MTAs感受态细胞和缺陷细胞也用其它抗癌药治疗恶性肿瘤。提供了根据本发明的在恶性细胞治疗期间保护非恶性细胞免于腺嘌呤饥饿的方法。

44. 发明授权

US5843943A Compounds for inhibition of ceramide-mediated signal transduction 失效
标题翻译：用于抑制神经酰胺介导的信号转导的化合物
公开(公告)号：US5843943A
公开(公告)日：1998-12-01
申请号：US482551
申请日：1995-06-07
申请人： Dennis A. Carson , Howard B. Cottam , D. Bruce Wasson
发明人： Dennis A. Carson , Howard B. Cottam , D. Bruce Wasson
IPC分类号： A61K31/47 , A61K31/472 , A61K31/505 , A61K31/519 , A61K31/52 , A61K31/522 , A61P17/00 , A61P29/00 , A61P43/00 , C07D217/24 , C07D239/96 , C07D473/04 , C07D473/06 , C07D473/10 , C07D475/02 , C07D487/04 , C07D513/04 , A61K31/495
CPC分类号： C07D513/04 , C07D217/24 , C07D239/96 , C07D473/06 , C07D473/10 , C07D475/02
摘要： Novel, heterocyclic compounds having at least one ring nitrogen, disclosed side chains and, in some embodiments, an oxygen ortho to the ring nitrogen inhibit inflammatory responses associated with TNF-.alpha. and fibroblast proliferation in vivo and in vitro. The compounds of the invention neither appreciably inhibit the activity of cAMP phosphodiesterase nor the hydrolysis of phosphatidic acid, and are neither cytotoxic nor cytostatic. Preferred compounds of the invention are esters. Methods for the use of the novel compounds to inhibit ceramide-mediated intracellular responses to stimuli in vivo (particularly TNF-.alpha.) are also described. The methods are expected to be of use in reducing inflammatory responses (for example, after angioplasty), in limiting fibrosis (for example, of the liver in cirrhosis), in inhibiting cell senescence, cell apoptosis and UV induced cutaneous immune suppression.
摘要翻译：新颖的，具有至少一个环氮的杂环化合物，所公开的侧链，并且在一些实施方案中，环氮原子上的氧在体内和体外抑制与TNF-α和成纤维细胞增殖相关的炎症反应。本发明的化合物既不明显地抑制cAMP磷酸二酯酶的活性也不抑制磷脂酸的水解，既不是细胞毒性的也不是细胞抑制的。本发明优选的化合物是酯。还描述了使用新化合物抑制神经酰胺介导的体内刺激的细胞内反应的方法（特别是TNF-α）。预期这些方法可用于减少炎症反应（例如血管成形术后），限制纤维化（例如肝硬化），抑制细胞衰老，细胞凋亡和UV诱导的皮肤免疫抑制。

45. 发明授权

US5571510A Method for selective methionine starvation of malignant cells in mammals 失效
标题翻译：哺乳动物恶性细胞选择性甲硫氨酸饥饿的方法
公开(公告)号：US5571510A
公开(公告)日：1996-11-05
申请号：US176413
申请日：1993-12-29
申请人： Tsutomu Nobori , Dennis A. Carson
发明人： Tsutomu Nobori , Dennis A. Carson
IPC分类号： C12N15/09 , A61K38/00 , A61K38/46 , A61K38/51 , A61K47/48 , A61P35/00 , C07H21/04 , C12N9/88 , C12N15/00 , C12N15/60 , C12Q1/48 , C12Q1/527 , C12Q1/68 , C12R1/19 , C12R1/40 , G01N33/573
CPC分类号： A61K47/48215 , A61K38/51 , C12N9/88 , C12Q1/527
摘要： An improved method for chemotherapy of mammalian malignant cells which have an absolute requirement for methionine but lack methylthioadenosine phosphorylase (MTAse). The method comprises detection of MTAse negative cells in a mammal, administration of methionine .gamma.-lyase in sufficient amounts to reduce the volume of MTAse negative cells in the mammal, and co-administration of methylthioadenosine in amounts sufficient to ensure the continued availability of methionine to the mammal's non-malignant cells. Means for detection of MTAse negative cells are provided. Means for production and use of recombinant chemotherapeutic agents are also provided.
摘要翻译：一种改进的哺乳动物恶性细胞化疗方法，对蛋氨酸具有绝对要求但缺乏甲硫基腺苷磷酸化酶（MTAse）。该方法包括检测哺乳动物中MTAs阴性细胞，以足够量的量施用甲硫氨酸γ-裂解酶以减少哺乳动物中MTAs阴性细胞的体积，并以足以确保甲硫氨酸持续可用性的量共同给予甲硫基腺苷哺乳动物的非恶性细胞。提供了检测MTA阴性细胞的方法。还提供了生产和使用重组化学治疗剂的方法。

46. 发明授权

US5068177A Anti-idiotype antibodies induced by synthetic polypeptides 失效
标题翻译：由合成多肽诱导的抗独特型抗体
公开(公告)号：US5068177A
公开(公告)日：1991-11-26
申请号：US762698
申请日：1985-08-05
申请人： Dennis A. Carson , Sherman Fong , Pojen P. Chen
发明人： Dennis A. Carson , Sherman Fong , Pojen P. Chen
IPC分类号： A61K39/00 , C07K16/18 , C07K16/42 , G01N33/68
CPC分类号： C07K16/18 , C07K16/4208 , G01N33/6878 , A61K39/00 , Y10S424/81 , Y10S435/81 , Y10S435/965 , Y10S436/808 , Y10S530/868
摘要： Chemically synthesized polypeptides containing about 6 to 40 amino acid residues and having amino acid residue sequences that substantially correspond to the primary amino acid residue sequences of particular variable or hypervariable regions of immunoglobulins, when administered alone or as polymers or as conjugates bound to carriers, induce the production of anti-idiotype antibodies of predetermined specificities.
摘要翻译：含有约6至40个氨基酸残基并具有基本上对应于免疫球蛋白特定可变区或高变区的初级氨基酸残基序列的氨基酸残基序列的化学合成多肽，当单独施用或作为聚合物或与载体结合的缀合物时，诱导生产具有预定特异性的抗独特型抗体。

47. 发明授权

US08846697B2 Purine analogs 有权
标题翻译：嘌呤类似物
公开(公告)号：US08846697B2
公开(公告)日：2014-09-30
申请号：US12302738
申请日：2007-04-23
申请人： Dennis A. Carson , Howard B. Cottam , Guangyi Jin , Christina C. N. Wu , Suzanne Grimshaw
发明人： Dennis A. Carson , Howard B. Cottam , Guangyi Jin , Christina C. N. Wu , Kenji Takabayashi
IPC分类号： A61K31/52 , C07D473/18
CPC分类号： A61K47/48046 , C07D473/18
摘要： The present invention provides purine analog compounds, as well as compositions and methods of using them, for example, to prevent or treat various diseases and disorders in human and non-human animals. For example, the invention provides for a compound having formula II:
摘要翻译：本发明提供嘌呤类似物，以及使用它们的组合物和方法，例如预防或治疗人和非人动物中的各种疾病和病症。例如，本发明提供了具有式II的化合物：

48. 发明申请

US20130202629A1 USES OF PHOSPHOLIPID CONJUGATES OF SYNTHETIC TLR7 AGONISTS 审中-公开
标题翻译：使用合成TLR7激动剂的磷脂结合
公开(公告)号：US20130202629A1
公开(公告)日：2013-08-08
申请号：US13695385
申请日：2011-04-29
申请人： Dennis A. Carson , Howard B. Cottam , Tomoko Hayashi , Michael Chan , Christina C.N. Wu
发明人： Dennis A. Carson , Howard B. Cottam , Tomoko Hayashi , Michael Chan , Christina C.N. Wu
IPC分类号： A61K39/39 , C07F9/6561
CPC分类号： A61K39/39 , A61K31/52 , A61K31/66 , A61K39/07 , A61K47/544 , A61K2039/543 , A61K2039/55511 , A61K2039/55555 , C07F9/65616 , Y02A50/414
摘要： The invention provides uses for phospholipid conjugates of TLR agonists, for instance in vaccines, and to prevent, inhibit or treat a variety of disorders including inflammation, cancer and pathogen, e.g., microbe, infection.
摘要翻译：本发明提供了用于例如疫苗中TLR激动剂的磷脂缀合物的用途，并且用于预防，抑制或治疗各种疾病，包括炎症，癌症和病原体，例如微生物感染。

49. 发明授权

US08357374B2 Conjugates of synthetic TLR agonists and uses therefor 有权
公开(公告)号：US08357374B2
公开(公告)日：2013-01-22
申请号：US12027960
申请日：2008-02-07
申请人： Dennis A. Carson , Wolfgang Wrasidlo , Christina C. N. Wu
发明人： Dennis A. Carson , Wolfgang Wrasidlo , Christina C. N. Wu
IPC分类号： A61K39/385 , A61K45/00 , A61K47/00 , A61K9/127 , A61K31/522 , A01N43/90 , C07D473/00
CPC分类号： A61K47/48815 , A61K31/52 , A61K39/07 , A61K39/085 , A61K39/39 , A61K47/6911 , A61K2039/55511 , A61K2039/55555 , C07D487/04 , C07F9/65616 , A61K2300/00
摘要： The invention provides TLR agonists and conjugates thereof useful in vaccines and to prevent, inhibit or treat a variety of disorders including pathogen infection and asthma.

50. 发明授权

US07816352B2 Apoptosis inhibitors 有权
标题翻译：凋亡抑制剂
公开(公告)号：US07816352B2
公开(公告)日：2010-10-19
申请号：US11885463
申请日：2006-03-10
申请人： Dennis A. Carson , Howard B. Cottam , Sylvie Barchéchath , Mary Patricia Corr
发明人： Dennis A. Carson , Howard B. Cottam , Sylvie Barchéchath , Mary Patricia Corr
IPC分类号： A61K31/535 , A61K31/47 , A61K31/497 , C07D213/56 , C07D217/00 , C07D215/38
CPC分类号： C07D513/04 , C07D213/20 , C07D215/227
摘要： The present invention provides compounds that act as selective agents to protect against unintentional cell death or tissue damage and can relieve side effects of cancer treatment such as, for example, oral mucositis, hair loss, diarrhea due to damage to the gastrointestinal epithelium, and myelosuppression. In addition, these compounds can be used to prevent premature cell death when the cell death is caused by signals from damaged cells, for example, signals generated as the result of a traumatic incident or an ischemic episode.
摘要翻译：本发明提供了用作选择剂以防止无意的细胞死亡或组织损伤并可以减轻癌症治疗的副作用的化合物，例如口腔粘膜炎，脱发，胃肠上皮损伤引起的腹泻和骨髓抑制。此外，当细胞死亡是由受损细胞的信号引起的，例如作为创伤事件或缺血发作的结果产生的信号，这些化合物可用于防止过早的细胞死亡。

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