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41. 发明申请

US20120207789A1 TOPICAL CORNEAL ANALGESIA USING NEUROTENSIN RECEPTOR AGONISTS AND SYNERGISTIC NEUROTENSIN COMBINATIONS WITHOUT DELAYING WOUND HEALING 审中-公开
标题翻译：使用神经舒缓素受体激动剂和神经性神经递质组合使用，不延迟伤口愈合的局限性神经痛
公开(公告)号：US20120207789A1
公开(公告)日：2012-08-16
申请号：US13197638
申请日：2011-08-03
申请人： Denise Barbut , Gavril W. Pasternak , Elliott Richelson
发明人： Denise Barbut , Gavril W. Pasternak , Elliott Richelson
IPC分类号： A61K38/08 , A61P25/04 , A61P27/02 , A61K47/00 , A61P37/06 , A61P31/12 , A61P23/02 , A61K38/03 , A61P27/04
CPC分类号： A61K38/08 , A61K9/0048 , A61K9/06 , A61K9/7084 , A61K31/485 , A61K38/10 , A61K45/06 , A61K2300/00
摘要： Ocular analgesics for topical administration are described. The topical ocular analgesic includes a neo-tryptophan-containing neurotensin analog. The topical ocular analgesic may alternatively include a buffered salt solution, a local anesthetic solution, a tissue penetrating agent, and/or an opiate. The neo-tryptophan-containing neurotensin analog may be present in a dose of about 0.0005 to about 1.2 mg.
摘要翻译：描述用于局部给药的眼镇痛剂。局部眼镇痛药包括含有新色氨酸的神经降压素类似物。局部眼部止痛剂可以替代地包括缓冲盐溶液，局部麻醉剂溶液，组织穿透剂和/或阿片剂。含有新色氨酸的神经降压素类似物可以约0.0005至约1.2mg的剂量存在。

42. 发明授权

US07671025B2 Neurotensin receptor agonists and opioid receptor agonists 失效
标题翻译：神经降压素受体激动剂和阿片受体激动剂
公开(公告)号：US07671025B2
公开(公告)日：2010-03-02
申请号：US11709991
申请日：2007-02-23
申请人： Denise Barbut , Elliott Richelson
发明人： Denise Barbut , Elliott Richelson
IPC分类号： A61K38/08
CPC分类号： A61K38/10 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： This document provides methods and materials for treating pain. For example, this document provides methods that involve administering a neurotensin receptor (NTR) agonist and an opioid receptor agonist to a mammal (e.g., a human). Compositions containing an NTR agonist in combination with an opioid receptor agonist also are provided.
摘要翻译：本文件提供了治疗疼痛的方法和材料。例如，本文件提供了涉及向哺乳动物（例如人）施用神经降压素受体（NTR）激动剂和阿片受体激动剂的方法。还提供了含有与阿片受体激动剂组合的NTR激动剂的组合物。

43. 发明申请

US20080249188A1 METHODS AND DEVICES FOR NON-INVASIVE CEREBRAL AND SYSTEMIC COOLING 有权
标题翻译：非侵入性胚胎和系统冷却的方法和装置
公开(公告)号：US20080249188A1
公开(公告)日：2008-10-09
申请号：US12101933
申请日：2008-04-11
申请人： Denise Barbut , Allan Rozenberg , John K. Hoffman
发明人： Denise Barbut , Allan Rozenberg , John K. Hoffman
IPC分类号： A61K31/02 , A61P43/00
CPC分类号： A61F7/12 , A61F7/123 , A61F2007/0065 , A61K31/02 , A61M11/02 , A61M11/06 , A61M15/08 , A61M15/085 , A61M16/04 , A61M16/0409 , A61M16/0438 , A61M16/0443 , A61M16/0459 , A61M16/0461 , A61M16/0479 , A61M16/0486 , A61M16/06 , A61M16/107 , A61M16/209 , A61M19/00 , A61M25/003 , A61M25/0032 , A61M25/0068 , A61M25/007 , A61M25/1011 , A61M31/00 , A61M2016/0027 , A61M2025/0034 , A61M2025/0036 , A61M2025/0073 , A61M2202/0275 , A61M2205/3606
摘要： A method for cerebral and systemic cooling by providing a nebulized liquid having a boiling point of 38-300° C. The nebulized liquid is delivered as a mist or a spray via the nasal and/or oral cavities of a patient. The mist causes cooling by direct heat transfer through the nasopharynx and hematogenous cooling through the carotids and the Circle of Willis. Compositions and medical devices for cerebral and systemic cooling are also provided. Cooling assemblies, and methods of use, are also provided that include flexible balloon assemblies that are inserted to various locations in a patient's body. The flexible balloons are then infused with a liquid having a temperature between about −20° C. and about 37° C. The flexible balloon assemblies can be inserted into the nasal cavity, oral cavity, throat, stomach, and other locations to effect cerebral cooling.
摘要翻译：通过提供沸点为38-300℃的雾化液体来进行脑和全身冷却的方法。雾化的液体以雾或喷雾的形式通过患者的鼻腔和/或口腔腔输送。雾气通过颈部直接热传导通过鼻咽和血液冷却通过颈动脉和威利斯圈引起冷却。还提供了用于脑和全身冷却的组合物和医疗装置。还提供了冷却组件和使用方法，其包括插入患者体内各个位置的柔性气囊组件。然后将柔性气囊注入温度在约-20℃和约37℃之间的液体。柔性气囊组件可以插入鼻腔，口腔，咽喉，胃和其他位置以实现脑冷却。

44. 发明申请

US20080215002A1 METHODS AND DEVICES FOR NON-INVASIVE CEREBRAL AND SYSTEMIC COOLING 有权
标题翻译：非侵入性胚胎和系统冷却的方法和装置
公开(公告)号：US20080215002A1
公开(公告)日：2008-09-04
申请号：US12038720
申请日：2008-02-27
申请人： Allan Rozenberg , Denise Barbut , John K. Hoffman
发明人： Allan Rozenberg , Denise Barbut , John K. Hoffman
IPC分类号： A61F7/12 , A61M29/00 , A61B17/00 , A61M31/00
CPC分类号： A61F7/123 , A61F2007/0056
摘要： A method for cerebral and systemic cooling by circulating a cold liquid through a nasal catheter looped through the patient's nasal cavities and around the nasal septum. The nasal catheter is inserted into the patient's first nostril, advanced through the nasal cavity, around the nasal septum and out of the patient's second nostril. A cold fluid having a temperature between about −20° C. and about 37° C. is flowed though a lumen in the nasal catheter to cool the nasal cavity. The nasal catheter may have one or more flexible balloons mounted on the catheter such that when the catheter is looped around the nasal septum, the balloon(s) are positioned in a portion of the patient's first and second nasal cavities. When a cold liquid is circulated through the catheter lumen, the flexible balloons expand to a contact the inner walls of the nasal cavities and provide direct cooling of the nasal cavities.
摘要翻译：通过将冷液循环穿过患者鼻腔和鼻中隔周围的鼻导管进行脑和全身冷却的方法。将鼻导管插入患者的第一鼻孔，通过鼻腔，鼻中隔周围并从病人的第二鼻孔排出。温度在约-20℃和约37℃之间的冷流体通过鼻导管中的内腔流动以冷却鼻腔。鼻导管可以具有安装在导管上的一个或多个柔性气囊，使得当导管环绕鼻中隔环时，气囊被定位在患者的第一和第二鼻腔的一部分中。当冷液体通过导管腔循环时，柔性气囊膨胀成与鼻腔的内壁接触并提供对鼻腔的直接冷却。

45. 发明申请

US20080004613A1 Methods and devices for treatment of migraines 审中-公开
标题翻译：用于治疗偏头痛的方法和装置
公开(公告)号：US20080004613A1
公开(公告)日：2008-01-03
申请号：US11881105
申请日：2007-07-24
申请人： Denise Barbut , Allan Rozenberg
发明人： Denise Barbut , Allan Rozenberg
IPC分类号： A61B18/18 , A61K31/02 , A61K31/40 , A61M31/00 , A61P43/00
CPC分类号： A61F7/12 , A61F7/123 , A61F2007/0065 , A61K31/02 , A61M11/02 , A61M11/06 , A61M15/08 , A61M15/085 , A61M16/04 , A61M16/0409 , A61M16/0438 , A61M16/0443 , A61M16/0459 , A61M16/0461 , A61M16/0479 , A61M16/0486 , A61M16/06 , A61M16/107 , A61M16/209 , A61M19/00 , A61M25/003 , A61M25/0032 , A61M25/0068 , A61M25/007 , A61M25/1011 , A61M31/00 , A61M2016/0027 , A61M2025/0034 , A61M2025/0036 , A61M2025/0073 , A61M2202/0275 , A61M2205/3606
摘要： Methods for treating a migraine by cooling a patient's nasopharyngeal cavity are described. In one method, a cooling assembly is inserted into a nasal cavity through a patient's nostril. The cooling assembly includes a flexible balloon defining a chamber and a first elongate tubular member having a lumen in fluid communication with the chamber. A liquid having a temperature between about −20° C. and about 37° C. is infused through the lumen of the first elongate tubular member into the chamber, wherein the flexible balloon expands to place it in contact with the nasal cavity. In another method, an elongate member having a plurality of ports is inserted into the nasal cavity. A perfluorocarbon spray and a gas are then delivered onto a surface of the nasal cavity through the plurality of ports.
摘要翻译：描述了通过冷却患者的鼻咽腔来治疗偏头痛的方法。在一种方法中，通过病人的鼻孔将冷却组件插入鼻腔。冷却组件包括限定腔室的柔性气囊和具有与腔室流体连通的内腔的第一细长管状构件。将温度在约-20℃和约37℃之间的液体通过第一细长管状构件的内腔输入到腔室中，其中柔性气囊膨胀以使其与鼻腔接触。在另一种方法中，具有多个端口的细长构件被插入到鼻腔中。然后通过多个端口将全氟化碳喷雾和气体输送到鼻腔的表面上。

46. 发明申请

US20070123813A1 Methods and devices for non-invasive cerebral and systemic cooling 有权
标题翻译：非侵入性脑系统冷却的方法和装置
公开(公告)号：US20070123813A1
公开(公告)日：2007-05-31
申请号：US11603846
申请日：2006-11-22
申请人： Denise Barbut , Allan Rozenberg
发明人： Denise Barbut , Allan Rozenberg
IPC分类号： A61N1/30
CPC分类号： A61F7/12 , A61F7/123 , A61F2007/0065 , A61K31/02 , A61M11/02 , A61M11/06 , A61M15/08 , A61M15/085 , A61M16/04 , A61M16/0409 , A61M16/0438 , A61M16/0443 , A61M16/0459 , A61M16/0461 , A61M16/0479 , A61M16/0486 , A61M16/06 , A61M16/107 , A61M16/209 , A61M19/00 , A61M25/003 , A61M25/0032 , A61M25/0068 , A61M25/007 , A61M25/1011 , A61M31/00 , A61M2016/0027 , A61M2025/0034 , A61M2025/0036 , A61M2025/0073 , A61M2202/0275 , A61M2205/3606
摘要： A method for cerebral and systemic cooling by providing a nebulized liquid having a boiling point of 38-300° C. The nebulized liquid is delivered as a mist or a spray via the nasal and/or oral cavities of a patient. The mist causes cooling by direct heat transfer through the nasopharynx and hematogenous cooling through the carotids and the Circle of Willis. Compositions and medical devices for cerebral and systemic cooling are also provided. Cooling assemblies, and methods of use, are also provided that include flexible balloon assemblies that are inserted to various locations in a patient's body. The flexible balloons are then infused with a liquid having a temperature between about −20° C. and about 37° C. The flexible balloon assemblies can be inserted into the nasal cavity, oral cavity, throat, stomach, and other locations to effect cerebral cooling.
摘要翻译：通过提供沸点为38-300℃的雾化液体来进行脑和全身冷却的方法。雾化的液体以雾或喷雾的形式通过患者的鼻腔和/或口腔腔输送。雾气通过颈部直接热传导通过鼻咽和血液冷却通过颈动脉和威利斯圈引起冷却。还提供了用于脑和全身冷却的组合物和医疗装置。还提供了冷却组件和使用方法，其包括插入患者体内各个位置的柔性气囊组件。然后将柔性气囊注入温度在约-20℃和约37℃之间的液体。柔性气囊组件可以插入鼻腔，口腔，咽喉，胃和其他位置以影响脑冷却。

47. 发明申请

US20060276552A1 Methods and devices for non-invasive cerebral and systemic cooling 有权
公开(公告)号：US20060276552A1
公开(公告)日：2006-12-07
申请号：US11432285
申请日：2006-05-10
申请人： Denise Barbut , Allan Rozenberg , John Hoffman
发明人： Denise Barbut , Allan Rozenberg , John Hoffman
IPC分类号： A61K31/02 , A61N1/39
CPC分类号： A61F7/12 , A61F7/123 , A61F2007/0065 , A61K31/02 , A61M11/02 , A61M11/06 , A61M15/08 , A61M15/085 , A61M16/04 , A61M16/0409 , A61M16/0438 , A61M16/0443 , A61M16/0459 , A61M16/0461 , A61M16/0479 , A61M16/0486 , A61M16/06 , A61M16/107 , A61M16/209 , A61M19/00 , A61M25/003 , A61M25/0032 , A61M25/0068 , A61M25/007 , A61M25/1011 , A61M31/00 , A61M2016/0027 , A61M2025/0034 , A61M2025/0036 , A61M2025/0073 , A61M2202/0275 , A61M2205/3606
摘要： A method for cerebral and systemic cooling by providing a nebulized liquid having a boiling point of 38-300° C. The nebulized liquid is delivered as a mist or a spray via the nasal and/or oral cavities of a patient. The mist causes cooling by direct heat transfer through the nasopharynx and hematogenous cooling through the carotids and the Circle of Willis. Compositions and medical devices for cerebral and systemic cooling are also provided. Cooling assemblies, and methods of use, are also provided that include flexible balloon assemblies that are inserted to various locations in a patient's body. The flexible balloons are then infused with a liquid having a temperature between about −20° C. and about 37° C. The flexible balloon assemblies can be inserted into the nasal cavity, oral cavity, throat, stomach, and other locations to effect cerebral cooling.

48. 发明授权

US06878140B2 Methods for flow augmentation in patients with occlusive cerebrovascular disease 失效
标题翻译：闭塞性脑血管病患者流量增加的方法
公开(公告)号：US06878140B2
公开(公告)日：2005-04-12
申请号：US10431051
申请日：2003-05-06
申请人： Denise Barbut
发明人： Denise Barbut
IPC分类号： A61B17/22 , A61F2/958 , A61M1/36 , A61M31/00 , A61B17/00 , A61B19/00 , A61M37/00
CPC分类号： A61M25/1011 , A61B17/3207 , A61M1/3613 , A61M1/3621 , A61M1/369
摘要： The invention provides a method for augmenting circulation in a patient having carotid stenosis. An elongate tubular member is provided having a lumen communicating with a port at a distal end. The tubular member is inserted into a peripheral artery and the distal port is advanced into a first carotid artery substantially free of a lesion where the patient possesses a second carotid artery substantially occluded by a lesion. Blood is perfused into the first carotid artery through the tubular member. Contralateral flow is augmented to improve perfusion to an ischemic region distal to the carotid stenosis. Angioplasty and stenting can be used to open the lesion in the second carotid artery.
摘要翻译：本发明提供了一种在患有颈动脉狭窄的患者中增加循环的方法。提供有细长管状构件，其具有与远端端口连通的内腔。管状构件插入到外周动脉中，并且远端进入基本上没有病变的第一颈动脉，其中患者具有基本上被病变收缩的第二颈动脉。血液通过管状部件灌注到第一颈动脉中。增加对侧流量以改善对颈动脉狭窄远端缺血区域的灌注。血管成形术和支架置入可用于打开第二颈动脉中的病变。

49. 发明授权

US06558356B2 Medical device for flow augmentation in patients with occlusive cerebrovascular disease and methods of use 有权
公开(公告)号：US06558356B2
公开(公告)日：2003-05-06
申请号：US09559307
申请日：2000-04-25
申请人： Denise Barbut
发明人： Denise Barbut
IPC分类号： A61M500
CPC分类号： A61M25/1011 , A61B17/3207 , A61M1/3613 , A61M1/3621 , A61M1/369
摘要： The invention provides a medical device having first and second elongate tubular members. Each member comprises a manometer at a distal end and a lumen communicating with a port at the distal end. An expandable occlusive member is optionally mounted on either or both tubular members proximal to the distal port. A proximal end of each tubular member is adapted for attachment to an oxygenator and/or a pump for aspirating blood from an artery or a symptomatic carotid artery through the first tubular member and perfusing the blood into the contralateral carotid artery through the second tubular member, thereby providing a means of augmenting the collateral vasculature and maintaining perfusion distal to the offending lesion. The flow rate of blood can be controlled by inflating or deflating the balloon occluder. The device may employ a neuroprotective agent, hypothermic perfusion, and an atherectomy device or an extracorporeal pumping mechanism to remove a vascular occlusion and reestablish cerebral perfusion. Methods of using the devices in treating patients with acute stroke or occlusive cerebrovascular disease are also disclosed.

50. 发明授权

US09358150B2 Methods and devices for non-invasive cerebral and systemic cooling alternating liquid mist/gas for induction and gas for maintenance 有权
标题翻译：用于非侵入式脑和系统冷却交替液雾/气体进行感应和气体维护的方法和装置
公开(公告)号：US09358150B2
公开(公告)日：2016-06-07
申请号：US13423561
申请日：2012-03-19
申请人： Allan Rozenberg , Denise Barbut , John K Hoffman , Thomas H Shaffer
发明人： Allan Rozenberg , Denise Barbut , John K Hoffman , Thomas H Shaffer
IPC分类号： A61F7/12 , A61F7/00 , A61M15/08 , A61M25/00 , A61K31/02 , A61M16/04 , A61M25/10 , A61M31/00
CPC分类号： A61F7/12 , A61F7/0085 , A61F7/123 , A61F2007/0006 , A61F2007/0065 , A61K9/007 , A61K31/02 , A61K47/06 , A61M15/08 , A61M16/04 , A61M16/0409 , A61M16/0438 , A61M16/0445 , A61M16/0479 , A61M16/0486 , A61M25/003 , A61M25/0032 , A61M25/0068 , A61M25/007 , A61M25/1011 , A61M31/00 , A61M2025/0034 , A61M2025/0036 , A61M2025/0073 , A61M2205/7545
摘要： Methods for cerebral and systemic cooling via a patient's nasopharyngeal cavity are described. In one method, a cooling assembly is inserted into a nasal cavity through a patient's nostril. A substantially dry gas is delivered through a lumen of the catheter onto the surface of the patient's nasal cavity. Evaporative heat loss cools the patient's nasal cavity. If additional cooling is needed, a liquid coolant is delivered through a separated lumen of the catheter. The liquid coolant is nebulized at a plurality of delivery ports on the distal end of the catheter and is delivered onto the surface of the patient's nasal cavity in combination with the dry gas. The dry gas enhances evaporation of the nebulized coolant and additional cooling is provided from the evaporative heat loss of the liquid coolant.
摘要翻译：描述了通过患者鼻咽腔进行脑和全身冷却的方法。在一种方法中，通过病人的鼻孔将冷却组件插入鼻腔。将基本上干燥的气体通过导管的内腔输送到患者鼻腔的表面上。蒸发热损失冷却患者的鼻腔。如果需要额外的冷却，液体冷却剂通过导管的分离的内腔被输送。液体冷却剂在导管远端上的多个输送口处被喷雾，并且与干燥气体一起被输送到病人鼻腔的表面上。干燥气体增强雾化冷却剂的蒸发，并且由液体冷却剂的蒸发热损失提供另外的冷却。

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