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    • 43. 发明申请
    • METHOD AND APPARATUS FOR REGENERATING ACTIVATED COKE USED FOR TREATING WASTEWATER OR SEWAGE
    • 用于再生活化焦炭用于处理废水或污水的方法和装置
    • US20100311568A1
    • 2010-12-09
    • US12809557
    • 2008-12-16
    • Dawei Zhang
    • Dawei Zhang
    • B01J20/34B01J19/00
    • B01J20/20B01J20/3416B01J20/3466B01J20/3483C01B32/366C02F1/283C02F2303/16Y02C10/08
    • A method for regenerating activated coke used for treating wastewater or sewage is provided. The method includes loading the activated coke to an environment under 150 to 250° C., heating the activated coke to a temperature of 700 to 850° C. for about 40 to 90 minutes; and providing a steam to the activated coke with a rate of 0.1 to 0.5 m3/(ton of activated coke). When the activated coke is being heated at the temperature, it generates a gas mixture including a steam portion and at least a paraffine gas. The gas mixture flows along a reverse direction relative to a flow of cooling water, so that the steam portion is converted into a part of the cooling water for recycling. The paraffine gas is used as a fuel. An apparatus for regenerating the activated coke used for treating wastewater or sewage is also provided.
    • 提供了一种再生用于处理废水或污水的活性焦炭的方法。 该方法包括将活化的焦炭装载到150至250℃的环境中,将活化的焦炭加热至700至850℃的温度约40至90分钟; 并以0.1至0.5m 3 /(tt活性焦炭)的速率向活化焦炭提供蒸汽。 当活化焦炭在该温度下被加热时,其产生包括蒸汽部分和至少一种石蜡气体的气体混合物。 气体混合物相对于冷却水的流动沿相反方向流动,使得蒸汽部分被转化成冷却水的一部分以便再循环。 石蜡气被用作燃料。 还提供了用于再生用于处理废水或污水的活性焦炭的装置。
    • 44. 发明授权
    • Substituted quinolines and their uses in treatment of inflammatory and related conditions
    • 取代喹啉及其用于治疗炎症和相关病症的用途
    • US07705018B2
    • 2010-04-27
    • US12079322
    • 2008-03-24
    • Yi ChenTimothy D. CushingXiaolin HaoXiao HeAndreas ReicheltRobert M. RzasaJennifer SeganishYoungsook ShinDawei Zhang
    • Yi ChenTimothy D. CushingXiaolin HaoXiao HeAndreas ReicheltRobert M. RzasaJennifer SeganishYoungsook ShinDawei Zhang
    • A61K31/47
    • C07D401/12C07D401/14
    • Substituted bicyclic heteroaryls having the general formula and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
    • 具有通式的取代的双环杂芳基和含有它们的组合物,用于治疗一般炎症,关节炎,风湿性疾病,骨关节炎,炎性肠病,炎症性眼病,炎性或不稳定性膀胱病,牛皮癣,皮肤炎症成分炎症,慢性炎症 包括但不限于自身免疫疾病如系统性红斑狼疮(SLE),重症肌无力,类风湿性关节炎,急性播散性脑脊髓炎,特发性血小板减少性紫癜,多发性硬化症,Sjoegren综合征和自身免疫性溶血性贫血,包括所有形式的超敏反应的过敏性疾病, 本发明还使得能够治疗依赖于p110δ活性或与p110δ活性相关的癌症的方法,包括但不限于白血病,例如急性骨髓性白血病(AML)骨髓增生异常综合征(MDS)骨髓增殖性疾病(MPD) )慢性骨髓性白血病(CML)T细胞急性淋巴细胞白血病(T-ALL)B细胞急性淋巴细胞性白血病(B-ALL)非霍奇金淋巴瘤(NHL)B细胞淋巴瘤和实体瘤如乳腺癌。
    • 45. 发明申请
    • Substituted heterocyclic compounds and methods of use
    • 取代的杂环化合物及其使用方法
    • US20090149468A1
    • 2009-06-11
    • US12322671
    • 2009-02-04
    • Guo-Qiang CaoJian J. ChenCelia DominguezAnthony ReedKelvin K.C. ShamMaya C. ThamanDawei ZhangBradley J. Herberich
    • Guo-Qiang CaoJian J. ChenCelia DominguezAnthony ReedKelvin K.C. ShamMaya C. ThamanDawei ZhangBradley J. Herberich
    • A61K31/497C07D401/14A61K31/496
    • C07D487/06C07D213/56C07D239/95C07D401/04C07D401/14C07D417/14
    • The present invention relates to therapeutic diazobicyclo pyridines and their use in the treatment of arthritis, rheumatoid arthritis, psoriatic arthritis or osteoarthritis, organ transplant, acute transplant or heterograft and homograft rejection, ischemic and reperfusion injury, transplantation tolerance induction, multiple sclerosis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, lupus, graft vs. host diseases, T-cell mediated hypersensitivity diseases, contact hypersensitivity, delayed-type hypersensitivity, gluten-sensitive enteropathy, Type 1 diabetes, psoriasis, contact dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Graves' Disease, Addison's disease, autoimmune polyglandular disease, autoimmune alopecia, pernicious anemia, vitiligo, autoimmune hypopituatarism, Guillain-Barre syndrome, autoimmune diseases, glomerulonephritis, serum sickness, uticaria, respiratory allergies, asthma, hayfever, allergic rhinitis, skin allergies, scleracielma, mycosis fungoides, acute inflammatory responses, acute respiratory distress syndrome, dermatomyositis, alopecia areata, chronic actinic dermatitis, eczema, Behcet's disease, Pustulosis palmoplanteris, Pyoderma gangrenum, Sezary's syndrome, atopic dermatitis, systemic schlerosis, morphea, Type II diabetes and cancers where PKC theta or other PKC-family kinases are activated, overexpressed or facilitate tumor growth or survival of tumor cells, T cell leukemia, thymoma, T and B cell lymphoma, colon carcinoma, breast carcinoma and lung carcinoma or provides resistance to chemotherapeutic drugs.
    • 本发明涉及治疗性重氮二环吡啶及其在治疗关节炎,类风湿性关节炎,银屑病关节炎或骨关节炎,器官移植,急性移植或异种移植和同种异体移植排斥,缺血和再灌注损伤,移植耐受诱导,多发性硬化,炎性肠中的用途 疾病,溃疡性结肠炎,克罗恩病,狼疮,移植物抗宿主病,T细胞介导的超敏反应疾病,接触性超敏反应,延迟型超敏反应,麸质敏感性肠病,1型糖尿病,牛皮癣,接触性皮炎,桥本氏甲状腺炎,干燥综合征 ,自身免疫性甲状腺功能亢进症,格雷夫斯病,艾迪生病,自身免疫性多腺病,自身免疫性脱发,恶性贫血,白癜风,自身免疫性低分化症,吉兰巴利综合征,自身免疫性疾病,肾小球肾炎,血清病,荨麻疹,呼吸道过敏,哮喘,过敏性鼻炎,过敏性鼻炎 ,皮肤过敏 s,scleracielma,蕈样真菌病,急性炎症反应,急性呼吸窘迫综合征,皮肌炎,斑秃,慢性光化性皮炎,湿疹,白塞病,脓疱疮,疱疹性坏疽,Sezary综合征,特应性皮炎,全身性硬化症,morphea,II型糖尿病 和PKCθ或其他PKC家族激酶被激活,过度表达或促进肿瘤细胞,T细胞白血病,胸腺瘤,T细胞和B细胞淋巴瘤,结肠癌,乳腺癌和肺癌的肿瘤生长或存活的癌症,或提供对化学治疗的抗性 药物
    • 50. 发明授权
    • Substituted heterocyclic compounds and methods of use
    • 取代的杂环化合物及其使用方法
    • US07026326B2
    • 2006-04-11
    • US10438553
    • 2003-05-13
    • Guo-Qiang CaoCelia DominguezMartin H. GoldbergFang-Tsao HongKelvin K. C. ShamSeifu TadesseNuria A. TamayoKurt E. WeilerDawei ZhangHongyu Liao
    • Guo-Qiang CaoCelia DominguezMartin H. GoldbergFang-Tsao HongKelvin K. C. ShamSeifu TadesseNuria A. TamayoKurt E. WeilerDawei ZhangHongyu Liao
    • A61K31/505
    • C07D401/04
    • The present invention relates to compounds having the general formula or a pharmaceutically acceptable salt thereof, wherein R1 is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 atoms selected from N, O and S, wherein the ring may be fused with a benzo group, and is substituted by 0, 1 or 2 oxo groups, and wherein R1 is additionally substituted; and R2 is a substituted C1-6alkyl. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.
    • 本发明涉及具有通式的化合物或其药学上可接受的盐,其中R 1是饱和或不饱和的5-,6-或7-元环,其含有0,1,2或 3个选自N,O和S的原子,其中环可以与苯并稠合,并被0,1或2个氧代基取代,并且其中R 1是另外被取代的; R 2是取代的C 1-6烷基。 还包括预防或治疗炎症,类风湿性关节炎,斑节病,骨质疏松症,多发性骨髓瘤,葡萄膜炎,急性或慢性骨髓性白血病,胰腺β细胞破坏,骨关节炎,类风湿性脊椎炎,痛风性关节炎,炎性肠病,成人呼吸 窘迫综合征(ARDS),牛皮癣,克罗恩病,过敏性鼻炎,溃疡性结肠炎,过敏反应,接触性皮炎,哮喘,肌肉退化,恶病质,赖特综合征,I型糖尿病,II型糖尿病,骨吸收疾病,移植物抗宿主反应, 阿尔茨海默病,中风,心肌梗死,缺血再灌注损伤,动脉粥样硬化,脑外伤,多发性硬化,脑疟疾,败血症,败血性休克,中毒性休克综合征,发热,HIV-1,HIV-2,HIV-3,巨细胞病毒引起的肌痛 (CMV),流感,腺病毒,哺乳动物中的疱疹病毒或带状疱疹感染,包括给予有效量的化合物d 以上所述。