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41. 发明授权

US5064766A Method for differentiating the source of occult gastrointestinal bleeding 失效
标题翻译：用于区分隐匿性胃肠道出血的来源的方法
公开(公告)号：US5064766A
公开(公告)日：1991-11-12
申请号：US423181
申请日：1989-10-18
申请人： Stephen C. Wardlaw , Robert A. Levine
发明人： Stephen C. Wardlaw , Robert A. Levine
IPC分类号： G01N33/72
CPC分类号： G01N33/726 , G01N33/725 , Y10S435/805 , Y10T436/25125 , Y10T436/255
摘要： The specification discloses a fecal occult blood test device capable of determining whether the blood found during the test originated in the upper or lower gastrointestinal track. A fecal sample is applied to a test medium charged to be differentially attractive to blood components originating in the upper and lower gastrointestinal track respectively. A solvent is applied to the test specimen to cause differential migration of the blood components and an indicator is then applied to indicate the presence of the blood components, if any.
摘要翻译：本说明书公开了一种能够确定测试期间发现的血液是否起源于上胃肠道或下胃肠道的粪便潜血检测装置。将粪便样品应用于分别对源自上胃肠道和下胃肠道的血液成分具有差异吸引力的测试介质。将溶剂施加到测试样品上以引起血液成分的差异迁移，然后施加指示剂以指示血液成分的存在（如果有的话）。

42. 发明授权

US4953975A Correction of material layer volume measurements 失效
标题翻译：材料层体积测量的校正
公开(公告)号：US4953975A
公开(公告)日：1990-09-04
申请号：US303125
申请日：1989-01-30
申请人： Robert A. Levine , Stephen C. Wardlaw
发明人： Robert A. Levine , Stephen C. Wardlaw
IPC分类号： B01L3/14
CPC分类号： B01L3/50215
摘要： Centrifuged material layer volume measurements are made in a transparent capillary tube containing an elongated float which expands the layers being measured. The extent of layer expansion will vary depending on the tube bore diameter and the float diameter. The tube bore diameter and float diameter for each tube/float pair are measured, and an indication of the difference between the two is marked on the tube. When the volume determinations are made, the measured difference between the tube bore diameter and the float diameter is taken into account before calculating actual layer volume malues.
摘要翻译：离心材料层体积测量是在含有细长浮子的透明毛细管中进行的，该细长的浮子膨胀所测量的层。层膨胀的程度将根据管孔直径和浮子直径而变化。测量每个管/浮子对的管孔直径和浮子直径，并在管上标出两者之间的差异指示。当进行体积确定时，在计算实际层体积误差之前，考虑管孔直径和浮子直径之间的测量差。

43. 发明授权

US4823624A Material layer volume determination with correction band 失效
标题翻译：材料层体积确定与校正带
公开(公告)号：US4823624A
公开(公告)日：1989-04-25
申请号：US248632
申请日：1988-09-26
申请人： Rodolfo R. Rodriguez , Matthew W. Lesniesky , Charles F. Galanaugh , Robert A. Levine , Stephen C. Wardlaw , Theodore Juraschek
发明人： Rodolfo R. Rodriguez , Matthew W. Lesniesky , Charles F. Galanaugh , Robert A. Levine , Stephen C. Wardlaw , Theodore Juraschek
IPC分类号： B01L3/14 , G01N15/05 , A61B5/14
CPC分类号： B01L3/50215 , G01N15/05
摘要： A centrifuge tube is used to hold a mixture of several constituents, and also contains a generally cylindrical float. The float settles, after centrifugation, into the zone occupied by the constituent whose volume is to be measured. The constituent layer will settle, after centrifugation, into the annular space between the tube bore and the outside of the float, and will be expanded axially due to the restricted volume of the annular space. The degree of expansion is dependent upon the respective sizes of the float O.D. and the tube bore ID, both of which must be closely controlled for accurate results. A known volume of a control material is placed in the tube to settle into the annular space during centrifugation in an area thereof outside of the constituent layer zone. The length of the band of the control material is measured after centrifugation and is compared to a known length which will result if the annular space is of the proper target volume. A correction factor is thus obtained and applied to all of the other constituent layers which were measured. The band thus forms a varying reference which reflects the actual volume of the annulus.
摘要翻译：离心管用于容纳几种成分的混合物，并且还包含一般为圆柱形的浮子。离心后，浮子沉降到被测量体积所占据的区域内。构成层在离心后将沉淀到管孔和浮体外部之间的环形空间中，并且由于环形空间的体积受限制而将轴向膨胀。膨胀程度取决于浮子O.D的各自尺寸。和管孔ID，两者都必须严格控制以获得准确的结果。将已知体积的对照材料放置在管中，以便在构成层区域外的区域中离心期间沉降到环形空间中。在离心后测量对照材料带的长度，并将其与已知的长度进行比较，如果环形空间具有适当的目标体积，则该长度将产生。因此获得校正因子并将其应用于所测量的所有其它构成层。因此，带形成变化的参考，其反映环的实际体积。

44. 发明授权

US4181609A Blood constituents testing method 失效
标题翻译：血液成分检测方法
公开(公告)号：US4181609A
公开(公告)日：1980-01-01
申请号：US959462
申请日：1978-11-13
申请人： Stephen C. Wardlaw , James V. Massey, III , Robert A. Levine
发明人： Stephen C. Wardlaw , James V. Massey, III , Robert A. Levine
IPC分类号： A61B5/145 , G01N33/49 , B01D17/00
CPC分类号： G01N33/491 , A61B5/150022 , A61B5/150343
摘要： A method whereby separation of red cells from white cells in a centrifuged blood sample is improved. An effective amount of potassium oxalate is added to the blood sample to increase the density of the red cells. The blood sample is then warmed to minimize the increase in density of the white cells which otherwise occurs in certain cases.
摘要翻译：提高离心血液样品中红细胞与白细胞分离的方法。将有效量的草酸钾加入到血液样品中以增加红细胞的密度。然后将血液样品加热以最小化在某些情况下发生的白细胞的密度增加。

45. 发明授权

US4159896A Enhancement of separation of cell layers in centrifuged blood sample 失效
标题翻译：增强离心血样中细胞层的分离
公开(公告)号：US4159896A
公开(公告)日：1979-07-03
申请号：US910807
申请日：1978-05-30
申请人： Robert A. Levine , Stephen C. Wardlaw
发明人： Robert A. Levine , Stephen C. Wardlaw
IPC分类号： B01L3/14 , G01N33/49 , A61B5/14 , G01N33/16
CPC分类号： B01L3/5021 , G01N33/491 , Y10T436/107497 , Y10T436/25375
摘要： An improvement in the degree of separation of constituent cell layers in a centrifuged sample of human blood is achieved by decreasing the natural water content of the red blood cells to increase their density or specific gravity. Thus the red cell layer packs more tightly and separates more completely from the next lighter cell layer adjacent thereto, i.e., the granulocyte layer.
摘要翻译：通过降低红细胞的天然水含量以提高其血液的密度或比重，可以提高离心的人血液样品中组分细胞层的分离程度。因此，红细胞层更紧密地包装并且与其相邻的下一个更轻的细胞层（即，粒细胞层）更完全分离。

46. 发明授权

US4137755A Material layer volume determination 失效
标题翻译：材料层体积确定
公开(公告)号：US4137755A
公开(公告)日：1979-02-06
申请号：US862543
申请日：1977-12-20
申请人： Stephen C. Wardlaw , Robert A. Levine , James V. Massey, III
发明人： Stephen C. Wardlaw , Robert A. Levine , James V. Massey, III
IPC分类号： B01L3/14 , G01N11/00
CPC分类号： B01L3/50215
摘要： A technique for generally determining the volume of a layer of a constituent material in a centrifugally separated mixture of material. A centrifuge tube is used to hold the material mixture and an appropriately shaped body is disposed in the tube in the zone occupied by the constituent material whose volume is to be measured. The body reduces the available volume within the tube which may be occupied by the constituent material, and thus expands the axial extent of the constituent material to make visual measurement of the constituent material more accurate.
摘要翻译：用于通常确定离心分离的材料混合物中的构成材料层的体积的技术。使用离心管来保持材料混合物，并且在由待测量的构成材料占据的区域中的管中设置适当的成形体。本体减少了可能被构成材料占据的管内的可用体积，从而扩大了构成材料的轴向范围，使组成材料的视觉测量更准确。

47. 发明授权

US08994930B2 Method and apparatus for analyzing individual cells or particulates using fluorescent quenching and/or bleaching 有权
标题翻译：使用荧光猝灭和/或漂白分析单个细胞或微粒的方法和装置
公开(公告)号：US08994930B2
公开(公告)日：2015-03-31
申请号：US13959294
申请日：2013-08-05
申请人： Robert A. Levine , Stephen C. Wardlaw , Niten V. Lalpuria , Darryn W. Unfricht
发明人： Robert A. Levine , Stephen C. Wardlaw , Niten V. Lalpuria , Darryn W. Unfricht
IPC分类号： G01N33/48 , G01N33/50 , G01N15/14 , G01N21/64 , G01N15/00
CPC分类号： G01N33/49 , G01N15/1463 , G01N15/1475 , G01N21/6428 , G01N21/6456 , G01N33/48 , G01N33/5091 , G01N2015/008 , G01N2015/1477 , G01N2021/6432 , G01N2021/6439 , G01N2201/062
摘要： A method for analyzing a blood sample is provided that includes the steps of: providing a blood sample having one or more of each first and second constituents; admixing a colorant with the sample, which colorant is operative to cause the first constituents and second constituents to fluoresce and absorb light; illuminating at least a portion of the sample; e) imaging a portion of the sample; determining a fluorescence value for each the first constituents and second constituents; determining an optical density value for each of the first constituents and second constituents; and identifying the first constituents and the second constituents using the determined fluorescence and optical density values.
摘要翻译：提供了一种用于分析血液样本的方法，其包括以下步骤：提供具有每个第一和第二成分中的一个或多个的血液样品; 将着色剂与样品混合，该着色剂可操作以使第一组分和第二组分发光和吸收光; 照亮样品的至少一部分; e）对样品的一部分进行成像; 确定每个第一组分和第二组分的荧光值; 确定每个第一组分和第二组分的光密度值; 以及使用所确定的荧光和光密度值来识别第一成分和第二成分。

48. 发明授权

US08569076B2 Method for serologic agglutination and other immunoassays performed in a thin film fluid sample 有权
标题翻译：在薄膜液体样品中进行血清学凝集和其他免疫测定的方法
公开(公告)号：US08569076B2
公开(公告)日：2013-10-29
申请号：US12417353
申请日：2009-04-02
申请人： Stephen C. Wardlaw , Robert A. Levine
发明人： Stephen C. Wardlaw , Robert A. Levine
IPC分类号： G01N33/543
CPC分类号： G01N33/48 , G01N21/6428 , G01N33/5304 , G01N33/54373 , G01N33/54386
摘要： A method and system for performing a serological agglutination assay in a liquid sample. The system provides a simple method for creating an in-situ sample/reagent admixture within a sample analysis chamber without the use of any precision fluid-handling components.
摘要翻译：用于在液体样品中进行血清学凝集测定的方法和系统。该系统提供了在样品分析室内创建原位样品/试剂外加剂的简单方法，而不使用任何精密的流体处理组件。

49. 发明授权

US08319954B2 Virtual separation of bound and free label in a ligand assay for performing immunoassays of biological fluids, including whole blood 有权
标题翻译：用于进行生物液体包括全血的免疫测定的配体测定中的结合和游离标记的虚拟分离
公开(公告)号：US08319954B2
公开(公告)日：2012-11-27
申请号：US13204416
申请日：2011-08-05
申请人： Stephen C. Wardlaw , Robert A. Levine
发明人： Stephen C. Wardlaw , Robert A. Levine
IPC分类号： G01N33/48
CPC分类号： G01N33/48 , G01N21/6428 , G01N33/5304 , G01N33/54373 , G01N33/54386
摘要： Detection and characterization of immunologically detected substances are performed electronically on human and animal biological fluids such as whole blood, serum, plasma, urine, milk, pleural and peritoneal fluids, and semen, which fluids are contained in a thin chamber forming a quiescent fluid sample, which chamber has at least two parallel planar walls, at least one of which is transparent.
摘要翻译：免疫检测物质的检测和表征以人和动物生物流体如全血，血清，血浆，尿，牛奶，胸膜和腹膜液以及精液电子方式进行，这些流体包含在形成静态流体样品的薄室中该室具有至少两个平行的平面壁，其中至少一个是透明的。

50. 发明申请

US20120282635A1 SELF-CALIBRATING GRADIENT DILUTION IN A CONSTITUTENT ASSAY AND GRADIENT DILUTION APPARATUS PERFORMED IN A THIN FILM SAMPLE 有权
标题翻译：组合式测定中的自校准梯级稀释和薄膜样品中的梯度稀释仪
公开(公告)号：US20120282635A1
公开(公告)日：2012-11-08
申请号：US13550131
申请日：2012-07-16
申请人： Stephen C. Wardlaw , Robert A. Levine
发明人： Stephen C. Wardlaw , Robert A. Levine
IPC分类号： G01N21/77
CPC分类号： G01N33/48 , G01N21/6428 , G01N33/5304 , G01N33/54373 , G01N33/54386
摘要： A method and apparatus for measuring antibody titers in a thin film sample in an automated system which does not require multiple dilutions. The system provides a simple method for creating an in-situ dilution within a sample analysis chamber without the use of any precision fluid-handling components, and further, to use the same principles to provide a wide range of sample dilutions within the chamber so as to obviate the need for additional dilution steps when dealing with samples possibly containing wide ranges of analyte concentrations.
摘要翻译：一种在不需要多次稀释的自动化系统中测量薄膜样品中抗体滴度的方法和装置。该系统提供了一种用于在样品分析室内创建原位稀释而不使用任何精密流体处理组件的简单方法，此外，使用相同的原理在腔室内提供范围广泛的样品稀释度，以便以避免在处理可能含有大范围分析物浓度的样品时需要额外的稀释步骤。

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