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41. 发明授权

US10354540B2 Method for generating a dedicated format file for a panorama mode teaching system 有权
公开(公告)号：US10354540B2
公开(公告)日：2019-07-16
申请号：US14771370
申请日：2014-02-20
申请人： Jian Yan
发明人： Jian Yan
IPC分类号： G09B5/10 , G09B5/06 , H04L29/06 , G09B5/00 , G09B19/00
摘要： The invention relates to a method for generating a dedicated format file for a panorama mode teaching system. By using the method of the invention, the size of the generated format file is small and recording and interaction process is convenient. The method is suitable for digitalized teaching and remote teaching. A traditional remote teaching process is lack of interactions and depends on a high quality network. By using the method of the invention, the above problems are solved. A reliable technology support is provided for teaching resource equalization.

42. 发明申请

US20160022802A1 Novel Vaccines Against Multiple Subtypes Of Dengue Virus 审中-公开
标题翻译：针对登革热病毒多重亚型的新型疫苗
公开(公告)号：US20160022802A1
公开(公告)日：2016-01-28
申请号：US14775069
申请日：2014-03-14
申请人： David WEINER , Jian YAN , Niranjan SARDESAI , INOVIO PHARMACEUTICALS, INC.
发明人： David B. Weiner , Jian Yan , Niranjan Sardesai
IPC分类号： A61K39/12 , A61N1/32 , A61N1/04 , C07K14/005 , C12N7/00
CPC分类号： A61K39/12 , A61K31/7088 , A61K2039/53 , A61K2039/54 , A61K2039/55527 , A61K2039/55538 , A61K2039/575 , A61N1/0412 , A61N1/0476 , A61N1/327 , C07K14/005 , C12N7/00 , C12N2770/24122 , C12N2770/24134 , C12N2770/24141 , Y02A50/386 , Y02A50/394
摘要： An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide, such as a consensus dengue prME that elicits an immune response in a mammal against more than one subtype of dengue virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of dengue virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a consensus dengue antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal that is cross reactive against all 4 dengue subtypes.
摘要翻译：本发明的一个方面涉及能够表达多肽的核酸构建体，例如在哺乳动物中针对多于一种登革热病毒亚型引起免疫应答的共有登革热prME及其使用方法。此外，存在能够在哺乳动物中产生针对多种登革热病毒亚型的免疫应答的DNA质粒疫苗，其包含DNA质粒和药学上可接受的赋形剂及其使用方法。 DNA质粒能够在哺乳动物细胞中以有效引发对所有4种登革热亚型交叉反应的哺乳动物的免疫应答的量表达共有登革热抗原。

43. 发明申请

US20130099327A1 CMOS DEVICES AND METHOD FOR MANUFACTURING THE SAME 审中-公开
标题翻译： CMOS器件及其制造方法
公开(公告)号：US20130099327A1
公开(公告)日：2013-04-25
申请号：US13807309
申请日：2011-11-30
申请人： Hsiaochia Wu , Li Guo , Guangtao Han , Jian Yan
发明人： Hsiaochia Wu , Li Guo , Guangtao Han , Jian Yan
IPC分类号： H01L21/265 , H01L29/78
CPC分类号： H01L21/265 , H01L21/823814 , H01L29/1083 , H01L29/7833
摘要： A complementary metal-oxide semiconductor (CMOS) device is disclosed. The CMOS device includes a substrate, a well region formed in the substrate, and a gate formed on the substrate. The CMOS device also includes a first region and a second region formed in the well region and arranged at two sides of the gate. Further, the CMOS device includes a first light-doped drain (LDD) region and a second LDD region formed in the well region and extending the first region and the second region, respectively, towards the gate. The CMOS device also includes a first doped layer formed in the first LDD region, and a conduction type of an ion doped in the first doped layer is opposite to a conduction type of an ion doped in the first LDD region.
摘要翻译：公开了一种互补金属氧化物半导体（CMOS）器件。 CMOS器件包括衬底，形成在衬底中的阱区和形成在衬底上的栅极。 CMOS器件还包括形成在阱区中并布置在栅极两侧的第一区和第二区。此外，CMOS器件包括形成在阱区中的第一掺光漏极（LDD）区域和第二LDD区域，并分别朝向栅极延伸第一区域和第二区域。 CMOS器件还包括形成在第一LDD区域中的第一掺杂层，并且掺杂在第一掺杂层中的导电类型与在第一LDD区域中掺杂的离子的导电类型相反。

44. 发明授权

US11925685B2 DNA antibody constructs encoding anti-ZIKV envelope antibodies 有权
公开(公告)号：US11925685B2
公开(公告)日：2024-03-12
申请号：US16334441
申请日：2017-09-19
申请人： David Weiner , Karuppiah Muthumani , Jian Yan
发明人： David Weiner , Karuppiah Muthumani , Jian Yan
IPC分类号： A61K39/12 , A61K31/7088 , A61K39/42 , A61P31/14 , C07K14/18 , C07K16/10 , C12N7/00 , A61K39/00
CPC分类号： A61K39/42 , A61K31/7088 , A61K39/12 , A61P31/14 , C07K14/18 , C07K16/10 , C07K16/1081 , C12N7/00 , A61K2039/505 , A61K2039/53 , C07K2317/56 , C12N2770/24134 , C12N2770/24171 , Y02A50/30 , A61K39/12 , A61K2300/00 , A61K39/42 , A61K2300/00
摘要： Disclosed herein is a composition comprising a recombinant nucleic acid sequence that encodes an antibody to a Zika viral antigen, and functional fragments thereof. The invention also relates to a composition comprising the combination of a first composition that elicits an immune response in a mammal against zika virus and a second composition comprising a recombinant nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof. In some instances, the nucleic acid molecule comprises a nucleotide sequence encoding an anti-ZIKV-Envelope (anti-ZIKV E) Protein antibody.

45. 发明授权

US10223930B2 Action data generation device and client and system for information transmission 有权
公开(公告)号：US10223930B2
公开(公告)日：2019-03-05
申请号：US15186136
申请日：2016-06-17
申请人： Jian Yan
发明人： Jian Yan
IPC分类号： G09B5/10 , G09B5/14 , G09B5/06
摘要： The invention relates to an action data generation device, and a client and a system for information transmission, wherein the action data generation device comprises an action input unit and an action data generation unit, the action input unit is for receiving action information on an interface and sending the action information to the action data generation unit, and the action data generation unit is for receiving the action information input by the action input unit and generating action data including a path part and a data part according to the action information. The technical solution provided by the present invention realizes effective extraction of data from the interface and improves the data transmission efficiency.

46. 发明申请

US20160175427A1 Influenza Nucleic Acid Molecules And Vaccines Made Therefrom 审中-公开
标题翻译：流感核酸分子和疫苗
公开(公告)号：US20160175427A1
公开(公告)日：2016-06-23
申请号：US14910136
申请日：2014-08-04
申请人： David WEINER , Jian YAN , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , INOVIO PHARMACEUTICALS, INC.
发明人： David B. Weiner , Jian Yan
IPC分类号： A61K39/145 , C12N7/00 , C07K14/005
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2760/16122 , C12N2760/16134
摘要： Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA Influenza A of serotype H7N9 alone and in combination with HA hemagglutinin and/or influenza B hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more influenza A serotypes and/or influenza B serotypes, or combinations thereof, using the vaccines that are provided.
摘要翻译：本文提供了编码单独的血清型H7N9的HA流感A与HA血凝素和/或乙型流感血凝素以及表达序列的遗传构建体/载体和疫苗的新型共有氨基酸序列的核酸序列。本文还提供了使用提供的疫苗产生针对一种或多种甲型流感血清型和/或流感乙型血清型或其组合的免疫应答的方法。

47. 发明申请

US20130022384A1 MECHANISM FOR DEPLOYING A STICK OF COSMETIC PRODUCT, ASSOCIATED DEVICE AND PROCESS 有权
标题翻译：用于制作化妆品，相关装置和过程的机构
公开(公告)号：US20130022384A1
公开(公告)日：2013-01-24
申请号：US13520711
申请日：2010-01-12
申请人： Jian Yan
发明人： Jian Yan
IPC分类号： A45D40/06 , B23P11/00
CPC分类号： A45D40/06 , Y10T29/49826
摘要： The mechanism comprises an inner hollow sleeve (60) and an outer sleeve (62) rotatably mounted around the inner sleeve (60). The outer sleeve (62) delimits an helical track (105), the inner sleeve (60) delimiting an axial track (72) intersecting the helical track (105). The mechanism comprises a cup (64) for holding the stick (12). The cup (64) is able to be actuated from an initial configuration, in which its axial movement between a retracted inner position and a deployed outer position is prevented when the inner sleeve (60) is rotated relative to the outer sleeve (62), and a use configuration, in which relative rotation between the inner sleeve (60) and the outer sleeve (62) induces an axial movement of the cup (64) between its inner retracted position and its outer deployed position.
摘要翻译：该机构包括内部中空套筒（60）和可围绕内部套筒（60）可旋转地安装的外部套筒（62）。外套筒（62）限定螺旋轨道（105），内套筒（60）限定与螺旋轨道（105）相交的轴向轨道（72）。该机构包括用于保持棒（12）的杯（64）。当内套筒（60）相对于外套筒（62）旋转时，杯（64）能够从初始构型致动，其中当缩回的内部位置和展开的外部位置之间的轴向运动被阻止时，以及内套筒（60）和外套筒（62）之间的相对旋转引起杯子（64）在其内缩回位置和其外部展开位置之间的轴向移动的使用构造。

48. 发明申请

US20160240094A1 DEDICATED FORMAT FILE GENERATION METHOD FOR PANORAMA MODE TEACHING SYSTEM 审中-公开
标题翻译：全景模式教学系统专用格式文件生成方法
公开(公告)号：US20160240094A1
公开(公告)日：2016-08-18
申请号：US14771370
申请日：2014-02-20
申请人： Jian YAN
发明人： Jian Yan
IPC分类号： G09B5/10 , H04L29/06 , G09B5/06
CPC分类号： G09B5/10 , G09B5/00 , G09B5/065 , G09B19/00 , H04L65/60
摘要： The invention relates to a method for generating a dedicated format file for a panorama mode teaching system. By using the method of the invention, the size of the generated format file is small and recording and interaction process is convenient. The method is suitable for digitalized teaching and remote teaching. A traditional remote teaching process is lack of interactions and depends on a high quality network. By using the method of the invention, the above problems are solved. A reliable technology support is provided for teaching resource equalization.
摘要翻译：本发明涉及一种用于生成全景模式教学系统的专用格式文件的方法。通过使用本发明的方法，生成的格式文件的大小很小，记录和交互处理方便。该方法适用于数字化教学和远程教学。传统的远程教学过程缺乏互动，依赖于高质量的网络。通过使用本发明的方法，解决了上述问题。为教学资源均衡提供可靠的技术支持。

49. 发明申请

US20160030536A1 Cancer Vaccines And Methods Of Treatment Using The Same 审中-公开
标题翻译：癌症疫苗及其治疗方法
公开(公告)号：US20160030536A1
公开(公告)日：2016-02-04
申请号：US14775047
申请日：2014-03-14
申请人： David WEINER , Karuppiah MUTHUMANI , Jewell WALTERS , Jian YAN
发明人： David Weiner , Jian Yan , Karuppiah Muthumani , Jewell Walters
IPC分类号： A61K39/00 , C12N9/02 , A61K39/395
CPC分类号： A61K39/0011 , A61K39/3955 , A61K2039/505 , A61K2039/53 , A61K2039/54 , A61K2039/55522 , A61K2039/55527 , A61K2039/575 , C12N9/0071 , C12N2710/20034 , C12N2730/10111 , C12N2770/24234 , C12Y114/18001
摘要： Disclosed herein are compositions and methods for treating cancer and in particular vaccines that treat and provide protection against tumor growth.
摘要翻译：本文公开了治疗癌症的组合物和方法，特别是治疗和提供针对肿瘤生长的保护的疫苗。

50. 发明授权

US09113693B2 Mechanism for deploying a stick of cosmetic product, associated device and process 有权
标题翻译：用于部署化妆品产品，相关设备和工艺的机构
公开(公告)号：US09113693B2
公开(公告)日：2015-08-25
申请号：US13520711
申请日：2010-01-12
申请人： Jian Yan
发明人： Jian Yan
IPC分类号： B43K21/08 , A45D40/06
CPC分类号： A45D40/06 , Y10T29/49826
摘要： The mechanism comprises an inner hollow sleeve (60) and an outer sleeve (62) rotatably mounted around the inner sleeve (60). The outer sleeve (62) delimits an helical track (105), the inner sleeve (60) delimiting an axial track (72) intersecting the helical track (105). The mechanism comprises a cup (64) for holding the stick (12). The cup (64) is able to be actuated from an initial configuration, in which its axial movement between a retracted inner position and a deployed outer position is prevented when the inner sleeve (60) is rotated relative to the outer sleeve (62), and a use configuration, in which relative rotation between the inner sleeve (60) and the outer sleeve (62) induces an axial movement of the cup (64) between its inner retracted position and its outer deployed position.
摘要翻译：该机构包括内部中空套筒（60）和可围绕内部套筒（60）可旋转地安装的外部套筒（62）。外套筒（62）限定螺旋轨道（105），内套筒（60）限定与螺旋轨道（105）相交的轴向轨道（72）。该机构包括用于保持棒（12）的杯（64）。当内套筒（60）相对于外套筒（62）旋转时，杯（64）能够从初始构型致动，其中当缩回的内部位置和展开的外部位置之间的轴向运动被阻止时，以及内套筒（60）和外套筒（62）之间的相对旋转引起杯子（64）在其内缩回位置和其外部展开位置之间的轴向移动的使用构造。

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