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41. 发明授权

US08580516B2 Methods and compositions for direct detection of DNA damage 有权
标题翻译：直接检测DNA损伤的方法和组成
公开(公告)号：US08580516B2
公开(公告)日：2013-11-12
申请号：US12555668
申请日：2009-09-08
申请人： David A. Schwartz , Stephen J. Kron
发明人： David A. Schwartz , Stephen J. Kron
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/582 , G01N33/5308 , G01N2800/40 , Y10T436/143333
摘要： The present invention is a method for detecting the extent of DNA damage in a subject suspected of having DNA damage wherein the damage results in the formation of aldehyde moieties in DNA comprising, obtaining a DNA sample from the subject, combining the DNA sample with a fluorescent, chromogenic, pro-fluorescent or pro-chromogenic hydrazine compound to from a fluorescent DNA, detecting the presence of the fluorescent DNA by monitoring the fluorescent emission and quantitating the fluorescent emission thereby determining the extent of DNA damage in the subject.
摘要翻译：本发明是一种检测疑似患有DNA损伤的受试者的DNA损伤程度的方法，其中所述损伤导致在DNA中形成醛部分，其包括：从受试者获得DNA样品，将DNA样品与荧光，显色性，前荧光或原色显色肼化合物，通过监测荧光发射和定量荧光发射来检测荧光DNA的存在，从而确定受试者中DNA损伤的程度。

42. 发明申请

US20130184184A1 Methods and/or Use of Oligonucleotide Conjugates Having Varied Degrees of Labeling for Assays and Detections 审中-公开
标题翻译：具有不同标记度的寡核苷酸缀合物的方法和/或用途，用于测定和检测
公开(公告)号：US20130184184A1
公开(公告)日：2013-07-18
申请号：US13302819
申请日：2011-11-22
申请人： David A. Schwartz , Jimmy Williams , Xinfang Zhao , Chunfang Zhao , William B. Busa , Stephen J. Kron , Amy Catherine Flor
发明人： David A. Schwartz , Jimmy Williams , Xinfang Zhao , Chunfang Zhao , William B. Busa , Stephen J. Kron , Amy Catherine Flor
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6804 , C07H21/00 , C12Q1/6834 , C12Q2565/113
摘要： The present disclosure is directed to methods and/or uses of oligonucleotide conjugates having varied degrees of labeling for assays and detections and related systems and/or kits. Certain methods are directed to a method for detecting one or more biological targets of a sample in a detection assay, comprising: providing a molecular probe, comprising a binding moiety and an oligonucleotide sequence, to a sample comprising one or more biological targets; binding the one or more biological targets with the binding moiety; providing a detectable component to the sample, wherein the detectable component comprises a signal generating moiety conjugated to an oligonucleotide sequence complementary to the oligonucleotide sequence of the molecular probe; hydridizing the oligonucleotide sequence of the target-bound molecular probe to the detectable component; and detecting a signal generated from the hydridized detectable component. Various other embodiments, applications etc. are disclosed herein.
摘要翻译：本公开涉及具有不同程度的标记用于测定和检测以及相关系统和/或试剂盒的寡核苷酸缀合物的方法和/或用途。某些方法涉及用于在检测测定中检测样品的一种或多种生物学靶标的方法，其包括：向包含一种或多种生物靶标的样品提供包含结合部分和寡核苷酸序列的分子探针; 将一种或多种生物靶与结合部分结合; 向所述样品提供可检测组分，其中所述可检测组分包含与与所述分子探针的寡核苷酸序列互补的寡核苷酸序列缀合的信号产生部分; 将靶结合分子探针的寡核苷酸序列杂交到可检测组分; 以及检测由所述可混合的可检测组分产生的信号。本文公开了各种其它实施例，应用等。

43. 发明授权

US08161857B2 Blind and shade cutting center for cutting two different window covering products 有权
公开(公告)号：US08161857B2
公开(公告)日：2012-04-24
申请号：US10462897
申请日：2003-06-13
申请人： David Roberts , Thomas A. Caputo , Richard D. Coulcher, Jr. , David A. Schwartz
发明人： David Roberts , Thomas A. Caputo , Richard D. Coulcher, Jr. , David A. Schwartz
IPC分类号： B26D7/02
CPC分类号： B23D45/003 , B23D23/00 , B23D35/008 , E06B9/266 , Y10T29/39 , Y10T83/04 , Y10T83/0453 , Y10T83/05 , Y10T83/0586 , Y10T83/141 , Y10T83/162 , Y10T83/207 , Y10T83/222 , Y10T83/404 , Y10T83/408 , Y10T83/412 , Y10T83/654 , Y10T83/6608 , Y10T83/6656 , Y10T83/7487 , Y10T83/7493 , Y10T83/7593 , Y10T83/76 , Y10T83/7607 , Y10T83/7647 , Y10T83/7693 , Y10T83/819 , Y10T83/853 , Y10T83/857 , Y10T83/858 , Y10T83/929 , Y10T83/95
摘要： A sizing center for and a method of sizing different styles of window coverings includes at least two sizing mechanisms disposed on a sizing center in which each sizing mechanism is adapted to size a different style of window covering. Each window covering includes a color marking. At least two measuring scales are disposed on the sizing center, each measuring scale being associated with a sizing mechanism and having a different color, and each color associated with a sizing center being associated with a color marking of a window covering.

44. 发明申请

US20100107839A1 BLIND AND SHADE CUTTING CENTER FOR CUTTING TWO DIFFERENT WINDOW COVERING PRODUCTS 有权
标题翻译：用于切割两个不同窗户覆盖产品的黑色和黑色切割中心
公开(公告)号：US20100107839A1
公开(公告)日：2010-05-06
申请号：US12685843
申请日：2010-01-12
申请人： David Roberts , Thomas A. Caputo , Richard D. Coulcher, JR. , David A. Schwartz
发明人： David Roberts , Thomas A. Caputo , Richard D. Coulcher, JR. , David A. Schwartz
IPC分类号： B26D7/02 , B26D3/00
CPC分类号： B23D45/003 , B23D23/00 , B23D35/008 , E06B9/266 , Y10T29/39 , Y10T83/04 , Y10T83/0453 , Y10T83/05 , Y10T83/0586 , Y10T83/141 , Y10T83/162 , Y10T83/207 , Y10T83/222 , Y10T83/404 , Y10T83/408 , Y10T83/412 , Y10T83/654 , Y10T83/6608 , Y10T83/6656 , Y10T83/7487 , Y10T83/7493 , Y10T83/7593 , Y10T83/76 , Y10T83/7607 , Y10T83/7647 , Y10T83/7693 , Y10T83/819 , Y10T83/853 , Y10T83/857 , Y10T83/858 , Y10T83/929 , Y10T83/95
摘要： A sizing center for and a method of sizing different styles of window coverings includes at least two sizing mechanisms disposed on a sizing center in which each sizing mechanism is adapted to size a different style of window covering. Each window covering includes a color marking. At least two measuring scales are disposed on the sizing center, each measuring scale being associated with a sizing mechanism and having a different color, and each color associated with a sizing center being associated with a color marking of a window covering.
摘要翻译：尺寸调整中心和调整不同款式的窗帘的尺寸的方法包括设置在尺寸调整中心上的至少两个筛分机构，其中每个施胶机构适于调整不同风格的窗帘。每个窗帘都包括一个颜色标记。至少两个测量刻度设置在尺寸调节中心上，每个测量刻度尺与尺寸调节机构相关联，并且具有不同的颜色，并且与尺寸中心相关联的每种颜色与窗口覆盖物的颜色标记相关联。

45. 发明授权

US07681480B2 Blind and shade cutting center for cutting two different window covering products 有权
标题翻译：遮阳帘切割中心可切割两种不同的窗帘产品
公开(公告)号：US07681480B2
公开(公告)日：2010-03-23
申请号：US11873317
申请日：2007-10-16
申请人： David C. Roberts , Thomas A. Caputo , Richard Coulcher , David A. Schwartz
发明人： David C. Roberts , Thomas A. Caputo , Richard Coulcher , David A. Schwartz
IPC分类号： B26D7/01
CPC分类号： B23D45/003 , B23D23/00 , B23D35/008 , E06B9/266 , Y10T29/39 , Y10T83/04 , Y10T83/0453 , Y10T83/05 , Y10T83/0586 , Y10T83/141 , Y10T83/162 , Y10T83/207 , Y10T83/222 , Y10T83/404 , Y10T83/408 , Y10T83/412 , Y10T83/654 , Y10T83/6608 , Y10T83/6656 , Y10T83/7487 , Y10T83/7493 , Y10T83/7593 , Y10T83/76 , Y10T83/7607 , Y10T83/7647 , Y10T83/7693 , Y10T83/819 , Y10T83/853 , Y10T83/857 , Y10T83/858 , Y10T83/929 , Y10T83/95
摘要： A sizing center for sizing different styles of window coverings includes at least two sizing mechanisms disposed on the sizing center in which each sizing mechanism is adapted to size a different style of window covering. The sizing center includes a squaring block for orienting a window covering on the sizing center. The squaring block includes a first side and a second side. A cutout for receiving a plurality of slats of a window covering is located in a top surface of the squaring block, the cutout extends from the first side of the squaring block to the second side of the squaring block.
摘要翻译：用于调整不同风格的窗帘的尺寸调整中心包括设置在尺寸调节中心上的至少两个定尺寸机构，其中每个尺寸调整机构适于调整不同风格的窗帘。尺寸调整中心包括用于定向尺寸中心上的窗口的平方块。平方块包括第一侧和第二侧。用于接收窗帘的多个板条的切口位于平方块的顶表面中，切口从平整块的第一侧延伸到正方形块的第二侧。

46. 发明授权

US07462689B2 Hydrazine-based and carbonyl-based bifunctional crosslinking reagents 有权
标题翻译：基于肼和羰基的双功能交联试剂
公开(公告)号：US07462689B2
公开(公告)日：2008-12-09
申请号：US10720843
申请日：2003-11-24
申请人： David A. Schwartz
发明人： David A. Schwartz
IPC分类号： C07C281/06 , C07K1/113 , C07K17/00
CPC分类号： C07D207/452 , A61K47/61 , A61K47/62 , A61K47/643 , A61K47/645 , A61K47/6801 , C07D207/46 , C07D213/82 , C07D401/12 , C07F7/1804 , C07K1/1077 , C08G65/329 , C08G65/336 , C08L2203/02 , C12N9/96 , Y10S530/81
摘要： Reagents and methods are provided for crosslinking and immobilizing biomolecules, drugs and synthetic polymers. The reagents possess (i) a thiol or amino reactive group; and (ii) a hydrazino or oxyamino moiety. Conjugates and immobilized biomolecules are also provided.
摘要翻译：提供了用于交联和固定生物分子，药物和合成聚合物的试剂和方法。试剂含有（i）硫醇或氨基反应性基团; 和（ii）肼基或氧基氨基部分。还提供了缀合物和固定的生物分子。

47. 发明申请

US20080109118A1 Lane marker detection and fitting 有权
标题翻译：车道标记检测和装配
公开(公告)号：US20080109118A1
公开(公告)日：2008-05-08
申请号：US11592824
申请日：2006-11-03
申请人： David A. Schwartz , Jan K. Schiffmann , Lisa R. Hamilton
发明人： David A. Schwartz , Jan K. Schiffmann , Lisa R. Hamilton
IPC分类号： G06F17/00
CPC分类号： G06K9/4609 , G06K9/00798
摘要： A method of lane marker detection and lane fitting is provided for lane tracking. A lane marker is modeled and split into left and right steps. A filter response is calculated from a cumulative row sum, and normalized for filter pixel size, lane marker brightness and road brightness. A lane marker response is peak detected for positive and negative peaks and checked for having a magnitude above a threshold and being a local peak in a five point neighborhood. A Hough transform is extended to multiple planes to use lane marker features to determine a best line. Lane marker features include a mean and variance of lane marker brightness, lane marker width, lane marker parallelism to a host vehicle direction of travel, and consistence with a predicted lane marker characteristic. A closest lane marker line to a host vehicle is identified, and refitted to account for any curvature.
摘要翻译：提供车道跟踪检测方法和车道配合。车道标记被建模并分为左右步骤。从累积行和计算滤波器响应，并对滤波器像素大小，车道标记亮度和道路亮度进行归一化。车道标记响应是正峰值和负峰值的峰值，并且检查幅度高于阈值，并且是五点邻域中的局部峰值。霍夫变换扩展到多个平面以使用车道标记功能来确定最佳线。车道标记特征包括道路标记亮度的平均值和方差，车道标记宽度，与主车辆行驶方向的车道标记平行度，以及预测车道标记特征的一致性。识别到主车辆的最近的车道标记线，并且重新设计以考虑任何曲率。

48. 发明授权

US07173125B2 Triphosphate oligonucleotide modification reagents and uses thereof 有权
标题翻译：三磷酸寡核苷酸修饰试剂及其用途
公开(公告)号：US07173125B2
公开(公告)日：2007-02-06
申请号：US10720840
申请日：2003-11-24
申请人： David A. Schwartz , Richard I. Hogrefe
发明人： David A. Schwartz , Richard I. Hogrefe
IPC分类号： C07H19/04 , C07H19/20 , A61K31/70 , A01N83/04
CPC分类号： C07H21/04 , C07H19/00 , C07H19/04 , C07H21/00
摘要： Hydrazino, oxyamino and carbonyl-based monomers and methods for incorporation into oligonucleotides during enzymatic synthesis are provided. Modified oligonucleotides are provided that incorporate the monomers provided herein. Immobilized oligonucleotides and oligonucleotide conjugates that contain covalent hydrazone or oxime linkages are provided. Methods for preparation of surface bound oligonucleotides are provided. Methods for the preparation of oligonucleotide conjugates are also provided.
摘要翻译：提供了肼基，氧基氨基和羰基单体以及在酶合成期间掺入寡核苷酸的方法。提供了引入本文提供的单体的修饰的寡核苷酸。提供含有共价腙或肟键的固定寡核苷酸和寡核苷酸缀合物。提供了制备表面结合寡核苷酸的方法。还提供了制备寡核苷酸缀合物的方法。

49. 发明授权

US07069833B2 Moveable blind and shade cutting center 有权
公开(公告)号：US07069833B2
公开(公告)日：2006-07-04
申请号：US10463711
申请日：2003-06-16
申请人： David Roberts , Thomes A. Caputo , Richard D. Coulcher, Jr. , David A. Schwartz
发明人： David Roberts , Thomes A. Caputo , Richard D. Coulcher, Jr. , David A. Schwartz
IPC分类号： B26D7/20
CPC分类号： B23D45/003 , B23D23/00 , B23D35/008 , E06B9/266 , Y10T29/39 , Y10T83/04 , Y10T83/0453 , Y10T83/05 , Y10T83/0586 , Y10T83/141 , Y10T83/162 , Y10T83/207 , Y10T83/222 , Y10T83/404 , Y10T83/408 , Y10T83/412 , Y10T83/654 , Y10T83/6608 , Y10T83/6656 , Y10T83/7487 , Y10T83/7493 , Y10T83/7593 , Y10T83/76 , Y10T83/7607 , Y10T83/7647 , Y10T83/7693 , Y10T83/819 , Y10T83/853 , Y10T83/857 , Y10T83/858 , Y10T83/929 , Y10T83/95
摘要： An apparatus for and a method of sizing a window covering in a sizing mechanism in a retail outlet includes a slide secured to a bay of a retail outlet. A housing configured to support a sizing mechanism for sizing a window covering is slidably coupled to the slide and is movable from a retracted position located substantially within the bay to a extended position in which at least a portion of the housing extends out of the bay. A sizing mechanism for sizing a window covering is disposed on the housing.

50. 发明授权

US07007576B2 Method of positioning a window covering in a sizing mechanism 有权
标题翻译：将窗户覆盖物定位在定型机构中的方法
公开(公告)号：US07007576B2
公开(公告)日：2006-03-07
申请号：US10463713
申请日：2003-06-16
申请人： David C. Roberts , Thomas A. Caputo , Richard D. Coulcher, Jr. , David A. Schwartz
发明人： David C. Roberts , Thomas A. Caputo , Richard D. Coulcher, Jr. , David A. Schwartz
IPC分类号： B26D7/01 , B26D45/04 , B23D45/04
CPC分类号： B23D45/003 , B23D23/00 , B23D35/008 , E06B9/266 , Y10T29/39 , Y10T83/04 , Y10T83/0453 , Y10T83/05 , Y10T83/0586 , Y10T83/141 , Y10T83/162 , Y10T83/207 , Y10T83/222 , Y10T83/404 , Y10T83/408 , Y10T83/412 , Y10T83/654 , Y10T83/6608 , Y10T83/6656 , Y10T83/7487 , Y10T83/7493 , Y10T83/7593 , Y10T83/76 , Y10T83/7607 , Y10T83/7647 , Y10T83/7693 , Y10T83/819 , Y10T83/853 , Y10T83/857 , Y10T83/858 , Y10T83/929 , Y10T83/95
摘要： A method of and apparatus for positioning a stock window covering in a sizing mechanism for sizing the window covering in a retail outlet includes obtaining a width specification for a finished window covering, which includes a bottom rail, a window covering material and a head rail, the method comprising. The stock window covering is disposed in a sizing mechanism adjacent a scale. The scale is calibrated from a cutting plane of the sizing mechanism, and has indicia that are twice the actual distance from the cutting plane. The center of the stock window covering is located on an indicia in the scale having a value equal to the width specification.
摘要翻译：一种用于将储存窗口覆盖物定位在尺寸调节机构中的方法和装置，用于使零售口中的窗户覆盖尺寸，包括获得包括底部导轨，窗户覆盖材料和头部导轨的成品窗户覆盖物的宽度规格，该方法包括。储存窗口覆盖物设置在与刻度尺相邻的施胶机构中。刻度尺从校准机构的切割平面校准，并具有距切割平面实际距离的两倍的标记。储存窗口覆盖物的中心位于具有等于宽度规格的值的刻度上的标记上。

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