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41. 发明申请

WO2002097096A3 NUCLEOTIDE SEQUENCES WHICH CODE FOR THE METD GENE 审中-公开
公开(公告)号：WO2002097096A3
公开(公告)日：2002-12-05
申请号：PCT/EP2002/005152
申请日：2002-05-10
申请人： DEGUSSA AG
发明人： REY, Daniel , RÜCKERT, Christian , KALINOWSKI, Jörn , PÜHLER, Alfred , BATHE, Brigitte , HUTHMACHER, Klaus , PFEFFERLE, Walter
IPC分类号： C12N15/31
摘要： The invention relates to nucleotide sequences from coryneform bacteria which code for the metD gene and to a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the metD gene is present in attenuated form, as well as to the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.

42. 发明申请

WO2005090590A1 VERFAHREN ZUR HERSTELLUNG VON L-AMINOSÄUREN AUS D-AMINOSÄUREN 审中-公开
标题翻译：工艺生产L-氨基酸从D-氨基酸
公开(公告)号：WO2005090590A1
公开(公告)日：2005-09-29
申请号：PCT/EP2005/000768
申请日：2005-01-27
申请人： DEGUSSA AG
发明人： HUMMEL, Werner , GEUEKE, Birgit , OSSWALD, Steffen , WECKBECKER, Christoph , HUTHMACHER, Klaus
IPC分类号： C12P13/04
CPC分类号： C12P13/04 , C12N9/0016 , C12N9/0024 , C12N9/0065 , C12P13/06 , C12P13/12
摘要： Die Erfindung betrifft rekombinante Mikroorganismen, die eine gegenüber dem Startorganismus erhöhte Konzentration oder Aktivität einer D-Aminosäureoxidase, einer Aminosäuredehydrogenase, eines das Cosubstrat NADH regenerierenden Enzyms und gegebenenfalls einer Katalase aufweisen und ein Verfahren zur Herstellung von L-Aminosäuren aus D-Aminosäuren unter Verwendung dieser Mikroorganismen.
摘要翻译：本发明涉及一种具有相对于D-氨基酸氧化酶，氨基酸脱氢酶，共底物的起始生物体浓度增加或活性，NADH再生酶和具有任选的过氧化氢酶和用于从使用这些D-氨基酸生产L-氨基酸的方法的重组微生物微生物。

43. 发明申请

WO2003062184A1 PROCESS FOR THE PREPARATION OF 3,5,5-TRIMETHYL-CYCLOHEX-2-ENE-1,4-DIONE 审中-公开
标题翻译：制备3,5,5-三甲基环己酮-2-环己酮-1,4-二酮的方法
公开(公告)号：WO2003062184A1
公开(公告)日：2003-07-31
申请号：PCT/EP2002/000621
申请日：2002-01-23
申请人： DEGUSSA AG
发明人： MAASSEN, Ralf , HÄFNER, Volker , KRILL, Steffen , BILZ, Jürgen , MARKOWZ, Georg , HUTHMACHER, Klaus
IPC分类号： C07C49/603
CPC分类号： C07C45/34 , C07C2601/16 , C07C49/603
摘要： The present invention relates to an improved process for the preparation of 3,5,5-trimethylcyclohex-2-ene-1,4-dione by oxidation of 3,5,5-trimethylcyclohex-3-en-1-one in the presence of an oxidizing agent and a catalyst system comprising a transition metal complex catalyst, an auxiliary base, possibly water, and a catalytically active co-additive, characterized in that carboxylic acid amides are employed as the solvent.
摘要翻译：本发明涉及通过在存在下氧化3,5,5-三甲基环己-3-烯-1-酮的方法制备3,5,5-三甲基环己-2-烯-1,4-二酮的改进方法的氧化剂和包含过渡金属配合物催化剂，辅助碱，可能的水和催化活性助剂的催化剂体系，其特征在于使用羧酸酰胺作为溶剂。

44. 发明申请

WO2002088064A1 PROCESS FOR THE PREPARATION OF UNSATURATED KETONES 审中-公开
标题翻译：制备不饱和酮的方法
公开(公告)号：WO2002088064A1
公开(公告)日：2002-11-07
申请号：PCT/EP2002/002243
申请日：2002-03-01
申请人： DEGUSSA AG
发明人： SHI, Nongyuan , DRAPAL, Bernd , KRILL, Steffen , JULINO, Markus , HUTHMACHER, Klaus
IPC分类号： C07C45/51
CPC分类号： C07C45/513 , C07C45/62 , C07C49/203 , C07C49/04
摘要： Process for the preparation of ß,Υ,Δ-unsaturated ketones and/or α,ß,Υ,Δ-unsaturated ketones by the reaction of an unsaturated alcohol with an enol ether or mixture of enol ethers, with formation of ketals as a by-product, at temperatures of from 50°C to 200°C, in the presence of an acid catalyst, whereby one or all of the reagents is/are heated to the reaction temperature of from 50°C to 200°C before the acid catalyst is added.
摘要翻译：通过不饱和醇与烯醇醚或烯醇醚的混合物的反应制备ss，UPSILON，Δ-不饱和酮和/或α，ss，UPSILON，Δ-不饱和酮的方法， - 产物，在50℃至200℃的温度下，在酸催化剂的存在下，在酸之前将一种或全部试剂加热至50℃至200℃的反应温度加入催化剂。

45. 发明申请

WO2002059329A1 NEUE FÜR DAS CITE-GEN KODIERENDE NUKLEOTIDSEQUENZEN 审中-公开
标题翻译：新换的CITE基因编码核苷酸
公开(公告)号：WO2002059329A1
公开(公告)日：2002-08-01
申请号：PCT/EP2001/000797
申请日：2001-01-25
申请人： DEGUSSA AG
发明人： FARWICK, Mike , HUTHMACHER, Klaus , MARX, Achim , BATHE, Brigitte , PFEFFERLE, Walter
IPC分类号： C12N15/60
CPC分类号： C12P13/08 , C12N9/88 , C12P13/04
摘要： Die Erfindung betrifft ein isoliertes Polynukleotid enthaltend eine Polynukleotidsequenz, ausgewählt aus der Gruppe a) Polynukleotid, das mindestens zu 70 % identisch ist mit einem Polynukleotid, das für ein Polypeptid kodiert, das die Aminosäuresequenz von SEQ ID No. 2 enthält, b) Polynukleotid, das für ein Polypeptid kodiert, das eine Aminosäuresequenz enthält, die zu mindestens 70 % identisch ist mit der Aminosäuresequenz von SEQ ID No. 2, c) Polynukleotid, das komplementär ist zu den Polynukleotiden von a) oder b), und d) Polynukleotid, enthaltend mindestens 15 aufeinanderfolgende Nukleotide der Polynukleotidsequenz von a), b) oder c), und ein Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung von coryneformen Bakterien, in denen zumindest das citE-Gen abgeschwächt vorliegt, und die Verwendung von Polynukleotiden, die die erfindungsgemäßen Sequenzen enthalten, als Hybridisierungssonden.
摘要翻译：本发明涉及包含选自A）多核苷酸，其是至少70％相同的编码具有SEQ ID号的氨基酸序列的多肽的多核苷酸的多核苷酸序列的分离多核苷酸含有2，b）中的多核苷酸，其编码包含氨基酸序列，其是相同的与SEQ ID No.1的氨基酸序列至少70％的多肽 2，C）多核苷酸，其是一个多核苷酸）或互补b）中，和d）含有的多核苷酸序列的至少15个连续核苷酸的多核苷酸），b）或c）中，以及用于L-的发酵制备方法使用棒状细菌，其中至少所述CITE基因氨基酸是本减弱，以及使用其含有本发明的序列作为杂交探针的多核苷酸。

46. 发明申请

WO2002074944A1 PROCESS FOR THE PREPARATION OF L-AMINO ACIDS BY USING CORYNEFORM BACTERIA 审中-公开
标题翻译：通过使用CORYNEFORM BACTERIA制备L-氨基酸的方法
公开(公告)号：WO2002074944A1
公开(公告)日：2002-09-26
申请号：PCT/EP2002/002830
申请日：2002-03-14
申请人： DEGUSSA AG
发明人： FARWICK, Mike , BATHE, Brigitte , BREHME, Jennifer , HUTHMACHER, Klaus
IPC分类号： C12N9/12
CPC分类号： C12N9/1205 , C12P13/04 , C12P13/08
摘要： The invention relates to a process for the preparation of L-amino acids, wherein the following steps are implemented: a) fermentation of the coryneform bacteria producing the desired L-amino acid, in which at least the gene coding for 6-phosphofructokinase and/or the gene coding for 1-phosphofructokinase are/is attenuated, b) enrichment of the desired L-amino acid in the medium or in the cells of the bacteria, and c) isolation of the L-amino acid, and optionally bacteria are employed in which, in addition, further genes of the biosynthetic pathway of the desired L-amino acid are enhanced, or bacteria are employed in which the metabolic pathways that diminish the formation of the desired L-amino acid are at least partly switched off.
摘要翻译：本发明涉及一种制备L-氨基酸的方法，其中实施以下步骤：a）产生所需L-氨基酸的棒状细菌的发酵，其中至少编码6-磷酸果糖激酶和/ 或编码1-磷酸果糖激酶的基因被减毒，b）富集培养基或细菌中的所需L-氨基酸，和c）分离L-氨基酸，并且任选地使用细菌此外，另外还提供了所需L-氨基酸的生物合成途径的其它基因，或者使用其中至少部分地切断了减少所需L-氨基酸形成的代谢途径的细菌。

47. 发明申请

WO2002088065A1 PROCESS FOR THE PREPARATION OF KETONES 审中-公开
标题翻译：制备酮的方法
公开(公告)号：WO2002088065A1
公开(公告)日：2002-11-07
申请号：PCT/EP2002/002244
申请日：2002-03-01
申请人： DEGUSSA AG
发明人： SHI, Nongyuan , KRILL, Steffen , HUTHMACHER, Klaus , DRAPAL, Bernd
IPC分类号： C07C45/62
CPC分类号： C07C45/62 , C07C45/513 , C07C49/203 , C07C49/04
摘要： The invention relates to a process for the preparation of ketones corresponding to the general Formula I in which β,γ,δ-allenic, di-unsaturated ketones and/or β,γ,δ-conjugated, di-unsaturated ketones, which are obtained from propargyl alcohols with enol ethers, may be converted in direct manner by hydrogenation to saturated ketones corresponding to the general Formula I without purification by distillation.
摘要翻译：本发明涉及一种制备相应于通式Ⅰ的酮的方法，其中获得了β，γ，δ-泛酸，二不饱和酮和/或β，γ，δ-共轭二不饱和酮，来自具有烯醇醚的炔丙醇可以直接通过氢化转化成对应于通式I的饱和酮而不通过蒸馏纯化。

48. 发明申请

WO2002034775A3 NUCLEOTIDE SEQUENCES ENCODING THE HEMD AND HEMB GENES 审中-公开
公开(公告)号：WO2002034775A3
公开(公告)日：2002-05-02
申请号：PCT/EP2001/011705
申请日：2001-10-10
申请人： DEGUSSA AG
发明人： FARWICK, Mike , HUTHMACHER, Klaus , PFEFFERLE, Walter , SCHISCHKA, Natalie , MARX, Achim
IPC分类号： C07K14/34
摘要： The invention relates to an isolated polynucleotide containing a polynucleotide sequence, selected from the group a) polynucleotide that is at least 70 % identical with a polynucleotide encoding a polypeptide that contains the amino acid sequence of SEQ ID No. 2, b) polynucleotide that is at least 70 % identical with a polynucleotide encoding a polypeptide that contains the amino acid sequence of SEQ ID No. 3, c) polynucleotide encoding a polypeptide that contains an amino acid sequence that is at least 70 % identical with the amino acid sequence of SEQ ID No. 2, d) polynucleotide encoding a polypeptide that contains an amino acid sequence that is at least 70 % identical with the amino acid sequence of SEQ ID No. 3, e) polynucleotide that is complementary to the polynucleotides of a), b), c) and d), and f) polynucleotide containing at least 15 consecutive nucleotides of the polynucleotide sequence of a), b), c), d) and e), and a method for the fermentative production of L-amino acids using coryneform bacteria, in which at least the hemD-gene and/or the hemB-gene is/are amplified, and the use, as Hybridization probes, of polynucleotides that contain the sequences according to the invention.

49. 发明公开

EP1670754A2 PROCESS FOR THE MANUFACTURE OF METHYLMERCAPTAN 审中-公开
标题翻译：用于生产甲硫醇
公开(公告)号：EP1670754A2
公开(公告)日：2006-06-21
申请号：EP04765676.4
申请日：2004-09-29
申请人： Degussa AG
发明人： YANG, Yiquan , WANG, Qi , LIN, Renchun , ZHANG, Hongbin , YUAN, Youzhu , FANG, Weiping , ZHENG, Quanxing , DAI, Shenjun , YAN, Xingguo , CHEN, Aiping , BARTH, Jan-Olaf , WECKBECKER, Christoph , HUTHMACHER, Klaus , REDLINGSHÖFER, Hubert , ACKERMANN, Sabine
IPC分类号： C07C319/04 , B01J23/28 , C07C321/04
CPC分类号： B01J37/0203 , B01J23/28 , B01J23/8872 , B01J37/0201 , C07C319/02 , Y02P20/582 , C07C321/04
摘要： The present invention refers to a continuous process for the manufacture of methyl mercaptan using Mo-O-K-based catalysts. It is further described that the total selectivity of methylmercaptan can be increased by at least 1% by lowering the total gas hourly space velocity. The invention further refers to a process for the preparation of a solid, preformed catalyst system.

50. 发明公开

EP1390504A2 NUCLEOTIDE SEQUENCES WHICH CODE FOR THE METD GENE 有权
标题翻译： METD编码核苷酸
公开(公告)号：EP1390504A2
公开(公告)日：2004-02-25
申请号：EP02740582.8
申请日：2002-05-10
申请人： Degussa AG
发明人： REY, Daniel , RÜCKERT, Christian , KALINOWSKI, Jörn , PÜHLER, Alfred , BATHE, Brigitte , HUTHMACHER, Klaus , PFEFFERLE, Walter
IPC分类号： C12N15/31 , C07K14/34 , C12P13/12 , C12R1/15 , C12Q1/68 , A23K1/16
CPC分类号： C07K14/34 , A23K10/12 , A23K20/142 , A23K40/10 , C12P13/12
摘要： The invention relates to nucleotide sequences from coryneform bacteria which code for the metD gene and to a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the metD gene is present in attenuated form, as well as to the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.

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