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41. 发明授权

US08492407B2 Quaternary ammonium compounds useful as muscarinic receptor antagonists 有权
公开(公告)号：US08492407B2
公开(公告)日：2013-07-23
申请号：US13473792
申请日：2012-05-17
申请人： Craig Husfeld , YuHua Ji , Rick Lee , Li Li , YongQi Mu , Cameron Smith , Johnny Uy
发明人： Craig Husfeld , YuHua Ji , Rick Lee , Li Li , YongQi Mu , Cameron Smith , Johnny Uy
IPC分类号： A61K31/445 , C07D409/06
CPC分类号： C07D409/14 , C07D205/04 , C07D211/26 , C07D211/58 , C07D401/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12
摘要： The invention provides compounds of the formula: in salt or zwitterionic form or a pharmaceutically acceptable salt thereof, wherein R1-6, a, Z and Q are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.

42. 发明申请

US20130162094A1 SYNCHRONOUS ROTARY ELECTRIC MACHINE HAVING HYBRID- EXCITATION ROTOR 有权
标题翻译：具有混合动力转子的同步旋转电机
公开(公告)号：US20130162094A1
公开(公告)日：2013-06-27
申请号：US13810616
申请日：2011-06-07
申请人： Jean-Claude Matt , Jean-Claude Mipo , Li Li , Albert Foggia
发明人： Jean-Claude Matt , Jean-Claude Mipo , Li Li , Albert Foggia
IPC分类号： H02K21/04
CPC分类号： H02K21/04 , H02K1/27 , H02K1/2766 , H02K21/042 , H02K2213/03
摘要： A machine (1) having a rotor (11) including permanent magnets (PM) and field coils (EC). The magnets are housed in first axial recesses (E1) distributed within a circumferential portion of the magnetic body, thus defining circumferential polar sections. The coils are housed in second axial recesses (E2) distributed within an intermediate portion of the magnetic body. The circumferential polar section includes a third recess (E3), and a portion of the magnetic body forming a bridge having a height of around 0.7 mm to around 2 mm is retained between an apex of the recess and an outer pole face.
摘要翻译：一种具有包括永磁体（PM）和励磁线圈（EC）的转子（11）的机器（1）。磁体容纳在分布在磁体的圆周部分内的第一轴向凹槽（E1）中，从而限定周向的极性部分。线圈容纳在分布在磁体的中间部分内的第二轴向凹部（E2）中。周向极性部分包括第三凹部（E3），并且形成具有大约0.7mm至大约2mm的高度的桥的磁体的一部分保持在凹部的顶点和外极面之间。

43. 发明申请

US20130089008A1 Method Of Accessing A Wireless Network And A Wireless Device 有权
标题翻译：无线网络和无线设备的接入方法
公开(公告)号：US20130089008A1
公开(公告)日：2013-04-11
申请号：US13270564
申请日：2011-10-11
申请人： Li Li , Thomas Marzetta
发明人： Li Li , Thomas Marzetta
IPC分类号： H04W4/00
CPC分类号： H01Q1/246 , H04W76/00 , H04W84/08 , H04W88/08
摘要： In one embodiment, this method includes sending, from a terminal, a random access request; and receiving, at the terminal, system information from a base station via a unicast transmission in response to the random access request. The system information includes an identifier, uplink bandwidth information and downlink bandwidth information. The identifier identifies the base station, the uplink bandwidth information indicates a bandwidth to use for uplink transmission, and the downlink bandwidth information indicates a bandwidth used for downlink transmission.
摘要翻译：在一个实施例中，该方法包括从终端发送随机接入请求; 以及响应于随机接入请求，在终端从基站经由单播传输接收系统信息。系统信息包括标识符，上行带宽信息和下行带宽信息。标识符识别基站，上行带宽信息表示用于上行链路传输的带宽，下行带宽信息表示用于下行链路传输的带宽。

44. 发明授权

US08406132B2 Estimating cardinality distributions in network traffic 有权
标题翻译：估计网络流量中的基数分布
公开(公告)号：US08406132B2
公开(公告)日：2013-03-26
申请号：US12129883
申请日：2008-05-30
申请人： Jin Cao , Aiyou Chen , Li Li
发明人： Jin Cao , Aiyou Chen , Li Li
IPC分类号： H04J3/14 , H04L12/28 , H04L12/66
CPC分类号： H04L43/00
摘要： In one embodiment, a method of monitoring a network. The method includes: receiving, from each host of a set of two or more hosts of the network, a corresponding vector of M components constructed based on data packets received at the host during a time period, M being an integer greater than 1; and, based on the constructed vectors, using an expectation-maximization algorithm to estimate a cardinality distribution for the hosts in the set, wherein constructing a vector includes updating a component of the vector of the corresponding host in response to the corresponding host receiving a data packet, the updating including selecting the component for updating by hashing one or more fields of the data packet received by the corresponding host.
摘要翻译：在一个实施例中，一种监视网络的方法。该方法包括：从网络的一组两个或多个主机的每个主机接收在一段时间内基于在主机处接收的数据分组构成的M个分量的相应向量，M是大于1的整数; 并且基于构造的向量，使用期望最大化算法来估计集合中的主机的基数分布，其中构建向量包括响应于相应主机接收到数据来更新对应主机的向量的分量分组，所述更新包括通过对由相应主机接收的数据分组的一个或多个字段进行哈希来选择用于更新的分量。

45. 发明申请

US20130072140A1 METHOD OF IMPROVING TRANSMISSION GAIN AT A NETWORK ELEMENT HAVING A PLURALITY OF ANTENNAS 有权
标题翻译：在具有多个天线的网络元件上改善传输增益的方法
公开(公告)号：US20130072140A1
公开(公告)日：2013-03-21
申请号：US13236082
申请日：2011-09-19
申请人： Li Li , Thomas Marzetta , Hong Yang
发明人： Li Li , Thomas Marzetta , Hong Yang
IPC分类号： H01Q11/12
CPC分类号： H04B7/0617 , H01Q1/246 , H01Q3/26 , H04W52/04
摘要： In one embodiment, the method includes reducing a beam width of transmission to increase an open-loop beamforming gain, reducing a channel bandwidth of the transmission to increase a channel bandwidth gain, and increasing a sequence length of the transmission to increase a sequence length gain. In this embodiment, a gain improvement is based on the product of the open loop beamforming gain, the channel bandwidth gain and the sequence length gain.
摘要翻译：在一个实施例中，该方法包括减小传输的波束宽度以增加开环波束成形增益，减少传输的信道带宽以增加信道带宽增益，以及增加传输的序列长度以增加序列长度增益。在该实施例中，增益改善基于开环波束形成增益，信道带宽增益和序列长度增益的乘积。

46. 发明申请

US20130015557A1 SEMICONDUCTOR PACKAGE INCLUDING AN EXTERNAL CIRCUIT ELEMENT 审中-公开
标题翻译：包含外部电路元件的半导体封装
公开(公告)号：US20130015557A1
公开(公告)日：2013-01-17
申请号：US13181899
申请日：2011-07-13
申请人： Zhiping Yang , Jie Xue , Jovica Savic , Li Li
发明人： Zhiping Yang , Jie Xue , Jovica Savic , Li Li
IPC分类号： H01L29/02 , H01L21/02
CPC分类号： H01L23/49822 , H01L23/50 , H01L24/05 , H01L24/13 , H01L24/16 , H01L25/0657 , H01L2224/03462 , H01L2224/03464 , H01L2224/0401 , H01L2224/05009 , H01L2224/0557 , H01L2224/05624 , H01L2224/05647 , H01L2224/131 , H01L2224/16225 , H01L2224/16227 , H01L2924/00014 , H01L2924/10253 , H01L2924/10272 , H01L2924/10329 , H01L2924/12042 , H01L2924/1205 , H01L2924/1206 , H01L2924/1207 , H01L2924/1304 , H01L2924/14 , H01L2924/1433 , H01L2924/1434 , H01L2924/15311 , H01L2924/19011 , H01L2924/19041 , H01L2924/19042 , H01L2924/19043 , H05K1/0243 , H01L2924/014 , H01L2224/05552 , H01L2924/00
摘要： Circuit elements such as DC blocking capacitors used in communication such as a serial communication link between two or more electrical components are disposed in pre-existing openings in a support structure that supports at least one of the two electrical components. The openings may be plated and used for signal transmission from the one electrical component to a printed circuit board (PCB) supporting the substrate. The DC blocking capacitors may be oriented substantially vertically, and a non-conducting material may be disposed in each opening in the substrate such that the non-conducting material at least partially surrounds and fixes the orientation of the DC blocking capacitor disposed in the opening.
摘要翻译：在诸如两个或更多个电气部件之间的串行通信链路的通信中使用的诸如隔直流电容器之类的电路元件被布置在支撑结构中的预先存在的开口中，该支撑结构支撑两个电气部件中的至少一个。开口可以被电镀并用于从一个电气部件到支撑衬底的印刷电路板（PCB）的信号传输。隔直电容器可以基本垂直地定向，并且非导电材料可以设置在基板中的每个开口中，使得非导电材料至少部分地围绕并固定设置在开口中的隔直流电容器的取向。

47. 发明授权

US08355770B2 Conductive silicone material for human skin electrode 有权
标题翻译：用于人体皮肤电极的导电硅胶材料
公开(公告)号：US08355770B2
公开(公告)日：2013-01-15
申请号：US12729206
申请日：2010-03-22
申请人： Raymond Chan , Mun Hoong Leong , Li Li
发明人： Raymond Chan , Mun Hoong Leong , Li Li
IPC分类号： A61B5/0408 , H01B1/04
CPC分类号： C08L83/04 , A61B5/0408 , C08G77/20 , C08K3/04 , Y10T29/49117
摘要： A conductive silicone material for human skin electrode is disclosed. In one embodiment, the conductive silicone material comprises a mixture of silicone and carbon powder such that the mixture has a resistivity of 0.08 to 0.12 Ω·m and a Shore A hardness of 50 to 60. In an exemplary embodiment, the mixture comprises 60 to 80 weight percent silicone and 20 to 40 weight percent carbon powder. A sensor for detecting human biological signal using a conductive silicone electrode is also disclosed.
摘要翻译：公开了一种用于人体皮肤电极的导电硅材料。在一个实施方案中，导电硅树脂材料包括硅酮和碳粉末的混合物，使得该混合物的电阻率为0.08至0.12，OHgr.m，肖氏A硬度为50至60.在示例性实施方案中，混合物包含60 至80重量％的硅酮和20至40重量％的碳粉末。还公开了一种用于使用导电硅氧烷电极检测人类生物信号的传感器。

48. 发明申请

US20130012705A1 DICYCLOAZAALKANE DERIVATIVES, PREPARATION PROCESSES AND MEDICAL USES THEREOF 有权
标题翻译： DICYCLOAZAALKANE衍生物，其制备方法及其医疗用途
公开(公告)号：US20130012705A1
公开(公告)日：2013-01-10
申请号：US13619138
申请日：2012-09-14
申请人： Peng Cho Tang , Zhigang Lin , Hejun Lü , Fuqiang Zhao , Li Li , Fanglong Yang , Jianghong Fu , Lin Wang , Guangyuan Shen , Dongliang Guan
发明人： Peng Cho Tang , Zhigang Lin , Hejun Lü , Fuqiang Zhao , Li Li , Fanglong Yang , Jianghong Fu , Lin Wang , Guangyuan Shen , Dongliang Guan
IPC分类号： C07D209/52 , C07D413/06 , C07D403/06 , C07D401/06
CPC分类号： C07D209/52 , C07D403/12
摘要： Disclosed are new dicycloazaalkane derivates represented by general formula (I), preparation processes and pharmaceutical compositions containing them, and the uses for treatment especially for dipeptidyl peptidase inhibitor (DPP-IV), in which each substitute group of general formula (I) is as defined in specification.
摘要翻译：公开了由通式（I）表示的新的二环唑烷衍生物，其制备方法和含有它们的药物组合物，以及特别用于二肽基肽酶抑制剂（DPP-IV）的用途，其中通式（I）的每个取代基为在规范中定义。

49. 发明授权

US08338424B2 Guanidine-containing compounds useful as muscarinic receptor antagonists 有权
公开(公告)号：US08338424B2
公开(公告)日：2012-12-25
申请号：US13468200
申请日：2012-05-10
申请人： YuHua Ji , Craig Husfeld , YongQi Mu , Rick Lee , Li Li
发明人： YuHua Ji , Craig Husfeld , YongQi Mu , Rick Lee , Li Li
IPC分类号： A61K31/496
CPC分类号： C07D333/24 , C07D209/14 , C07D213/38 , C07D231/12 , C07D277/28 , C07D295/13 , C07D307/52 , C07D307/81 , C07D317/58 , C07D333/20 , C07D333/58
摘要： The invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein R1-3, R5-7, a, X, Y, Y′, Y″, and Z are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.

50. 发明授权

US08277809B2 CXCL13 antagonists and their use for the treatment of inflammatory diseases 有权
标题翻译： CXCL13拮抗剂及其用于治疗炎性疾病的用途
公开(公告)号：US08277809B2
公开(公告)日：2012-10-02
申请号：US11738019
申请日：2007-04-20
申请人： Peter Bugelski , Anuk Das , Donald E. Griswold , Bailin Liang , Li Li , Robert T. Sarisky , Xiaozhou Shang
发明人： Peter Bugelski , Anuk Das , Donald E. Griswold , Bailin Liang , Li Li , Robert T. Sarisky , Xiaozhou Shang
IPC分类号： A61K39/395
CPC分类号： C07K16/241 , A61K2039/507 , C07K16/24 , C07K2317/76
摘要： Methods of treating disorders related to CXCL13 activity utilize CXCL13 antagonists and, optionally, TNFα antagonists, such as antibodies, including specified portions or variants, polypeptides, polynucleotides, siRNA, shRNA, ribozymes, and DNAzymes. Disorders related to CXCL13 activity include inflammatory disorders, such as pulmonary disorders, for example, asthma, emphysema, and COPD, and systemic lupus erythematosus.
摘要翻译：治疗与CXCL13活性相关的疾病的方法利用CXCL13拮抗剂和任选的TNFα拮抗剂，例如包括特定部分或变体，多肽，多核苷酸，siRNA，shRNA，核酶和DNA酶的抗体。与CXCL13活性相关的疾病包括炎症性疾病，例如肺部疾病，例如哮喘，肺气肿和COPD，以及系统性红斑狼疮。

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