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41. 发明授权

US09637542B2 CX3CR1-targeting imaging agents and their use in the diagnosis and treatment of disease 有权
公开(公告)号：US09637542B2
公开(公告)日：2017-05-02
申请号：US14463689
申请日：2014-08-20
申请人： Alisa K. Waterman , Nick Mark Devoogdt , Tony Lahoutte , Matthias Schneider , Sanjaya Singh , Cedric Jozef Néotère Ververken
发明人： Alisa K. Waterman , Nick Mark Devoogdt , Tony Lahoutte , Matthias Schneider , Sanjaya Singh , Cedric Jozef Néotère Ververken
IPC分类号： A61K51/10 , C07K16/28 , A61K49/00 , A61K49/04 , A61K49/22 , G01N33/569
CPC分类号： C07K16/28 , A61K49/0058 , A61K49/04 , A61K49/221 , A61K51/10 , A61K51/1021 , A61K51/1093 , A61K2039/505 , A61P9/10 , C07K16/2866 , C07K2317/22 , C07K2317/569 , C07K2317/94 , G01N33/56966 , G01N33/6872 , G01N2333/7158
摘要： The present invention relates to CX3CR1-targeting imaging agents and their use in treatment and diagnosis of diseases. Single domain CX3CR1-targeting polypeptides linked to detection labels and their use in in vivo imaging of atherosclerotic plaques are described. The CX3CR1-targeting imaging agents are useful in the treatment and diagnosis of CX3CR1-mediated diseases including atherosclerosis.

42. 发明授权

US08672181B2 Dispenser for administering strip-shaped substances 有权
标题翻译：用于管理带状物质的分配器
公开(公告)号：US08672181B2
公开(公告)日：2014-03-18
申请号：US13202232
申请日：2010-03-23
申请人： Matthias Schneider
发明人： Matthias Schneider
IPC分类号： B65D83/08
CPC分类号： B65D83/0829 , B65D83/087
摘要： A dispenser for administering strip-shaped substances, includes a housing having a chamber to store a stack of the strip-shaped substances and forming a removal opening for the strip-shaped substances that can be opened and closed again with a lid, said lid being joined to the housing, and being joined to a transport bar that can be moved together with the lid in order to transport the strip-shaped substances. The objective of designing and refining a dispenser of the above-mentioned type in such a manner as to allow a contamination-free and reliable transport of one single strip-shaped substance from the inside of the housing merely by moving the lid is characterized in that the transport bar is elastically pre-tensioned and mounted in the housing in such a way that it is at a distance from the stack when the removal opening is closed.
摘要翻译：一种用于管理带状物质的分配器，包括一个壳体，该壳体具有一个存储条形物质的堆叠的腔室，并且形成用于带状物质的去除开口，该开口可以用盖子再次打开和关闭，所述盖子连接到壳体，并且连接到可以与盖一起移动的运输条，以便运输带状物质。设计和精炼上述类型的分配器的目的是使得仅通过移动盖就允许一个单一带状物质从壳体内部无污染地且可靠地运输的特征在于：传送杆弹性预张紧并安装在壳体中，使得当拆卸开口关闭时，传送杆离堆叠一定距离。

43. 发明申请

US20130303395A1 MARKER SEQUENCES FOR SYSTEMIC LUPUS ERYTHEMATOSUS AND THE USE THEREOF 审中-公开
标题翻译：系统性红斑狼疮的标记序列及其用途
公开(公告)号：US20130303395A1
公开(公告)日：2013-11-14
申请号：US13879149
申请日：2011-10-12
申请人： Angelika Lueking , Axel Kowald , Stefan Müllner , Christian Scheer , Matthias Schneider
发明人： Angelika Lueking , Axel Kowald , Stefan Müllner , Christian Scheer , Matthias Schneider
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , C12Q1/6834 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158
摘要： The invention relates to novel marker sequences for systemic lupus erythematosus and to the use thereof in diagnosis as well as to a method for screening potential active ingredients for systemic lupus erythematosus diseases using said marker sequences. The invention further relates to a diagnostic device containing such marker sequences for systemic lupus erythematosus, especially to a protein biochip and the use thereof.
摘要翻译：本发明涉及用于系统性红斑狼疮的新型标志物序列及其在诊断中的应用以及使用所述标记序列筛选系统性红斑狼疮疾病潜在活性成分的方法。本发明还涉及包含用于系统性红斑狼疮，特别是蛋白质生物芯片的标记序列的诊断装置及其用途。

44. 发明授权

US08390144B2 Overheating protection of an electric control device 有权
标题翻译：电气控制装置的过热保护
公开(公告)号：US08390144B2
公开(公告)日：2013-03-05
申请号：US12561052
申请日：2009-09-16
申请人： Christian Lammers , Matthias Schneider , Steffen Reinhardt , Reinhard Rieger
发明人： Christian Lammers , Matthias Schneider , Steffen Reinhardt , Reinhard Rieger
IPC分类号： B60L1/00
CPC分类号： H02H5/04 , H02H3/066
摘要： A method for operating an electric control device for at least one power unit of a motor vehicle, an operating temperature range being assigned to the control device, and the control device being automatically switched off if its temperature exceeds the operating temperature range. A switch-on of the automatically switched-off control device may be implemented only if its temperature is within the operating temperature range. Furthermore, a corresponding electric control device.
摘要翻译：一种用于操作机动车辆的至少一个动力单元的电气控制装置的方法，操作温度范围被分配给所述控制装置，并且所述控制装置在其温度超过所述工作温度范围时被自动关闭。只有当其温度在工作温度范围内时，才能实现自动关闭控制装置的接通。另外，相应的电控装置。

45. 发明申请

US20100089473A1 Method for checking the operability of an actuator 审中-公开
标题翻译：用于检查致动器的可操作性的方法
公开(公告)号：US20100089473A1
公开(公告)日：2010-04-15
申请号：US12597931
申请日：2008-04-25
申请人： Nicolas Grein , Matthias Schneider
发明人： Nicolas Grein , Matthias Schneider
IPC分类号： F16K37/00 , G05B19/19 , G05B23/02 , G05D3/12
CPC分类号： F16K37/0083 , Y10T137/8225
摘要： A method of checking the operability of an actuator is provided. The actuator includes a control valve adjustable via an actuating drive by an actuating element, a position sensor detecting the actual position of the actuating element, and an electropneumatic position controller creating a pneumatic controlled variable depending on an actual position and a target position. The target position is provided to the actuating drive via an activated magnetic valve. The actuating element is moved over a section of an adjustment path for an execution of a partial-stroke test of the actuating element, the adjustment movement being detected. The magnetic valve is deactivated for a short time such that the actuating element is moved over only a section of the adjustment path. To facilitate the monitoring of the operability of the actuator, the partial-stroke test and the test of the magnetic valve are performed in a single test sequence.
摘要翻译：提供了一种检查致动器的可操作性的方法。致动器包括通过致动元件的致动驱动器调节的控制阀，检测致动元件的实际位置的位置传感器以及根据实际位置和目标位置产生气动控制变量的电动气动位置控制器。目标位置通过激活的电磁阀提供给致动驱动器。致动元件在调节路径的一部分上移动，以执行致动元件的部分行程测试，检测调节运动。电磁阀在短时间内被停用，使得致动元件仅在调节路径的一部分上移动。为了便于对致动器的可操作性的监视，单次测试顺序执行部分行程测试和电磁阀的测试。

46. 发明申请

US20100056585A1 N-(2-Aminophenyl)-4-[N-(Pyridine-3-yl)-Methoxycarbonyl-Aminomethyl]-Benzamide (MS-275) Polymorph B 有权
标题翻译： N-（2-氨基苯基）-4- [N-（吡啶-3-基） - 甲氧基羰基 - 氨基甲基] - 苯甲酰胺（MS-275）多晶型B
公开(公告)号：US20100056585A1
公开(公告)日：2010-03-04
申请号：US12549458
申请日：2009-08-28
申请人： Matthias Schneider , Michael Gottfried , Jens Geisler , Gabriele Winter
发明人： Matthias Schneider , Michael Gottfried , Jens Geisler , Gabriele Winter
IPC分类号： A61K31/4406 , C07D213/46 , A61P35/00 , A61P37/00 , A61P17/00
CPC分类号： A61K31/4406 , C07D213/30 , Y02A50/411
摘要： The crystalline Polymorph B of N-(2-aminophenyl)-4-[N-(pyridine-3-yl)methoxy-carbonyaminomethyl]benzamide (MS-275) of formula Iis described, as well as the process for the production of said compound, and its use as a medicament for the treatment of selected diseases.
摘要翻译：描述了式I的N-（2-氨基苯基）-4- [N-（吡啶-3-基）甲氧基 - 碳氨基甲基]苯甲酰胺（MS-275）的结晶多晶型B，以及制备所述化合物及其作为用于治疗所选疾病的药物的用途。

47. 发明申请

US20060116396A1 5-Substituted quinoline and isoquinoline derivatives, a process for their production and their use as anti-inflammatory agents 失效
标题翻译： 5-取代的喹啉和异喹啉衍生物，其制备方法及其作为抗炎剂的用途
公开(公告)号：US20060116396A1
公开(公告)日：2006-06-01
申请号：US11272009
申请日：2005-11-14
申请人： Stefan Jaroch , Hartmut Rehwinkel , Heike Schaecke , Norbert Schmees , Werner Skuballa , Jan Huebner , Orlin Petrov , Matthias Schneider , Christian Dinter
发明人： Stefan Jaroch , Hartmut Rehwinkel , Heike Schaecke , Norbert Schmees , Werner Skuballa , Jan Huebner , Orlin Petrov , Matthias Schneider , Christian Dinter
IPC分类号： A61K31/4709 , C07D405/02
CPC分类号： C07D405/12
摘要： Compounds of general formula (IIa) or (IIb) and their use as pharmaceutical agents.
摘要翻译：通式（IIa）或（IIb）的化合物及其作为药剂的用途。

48. 发明申请

US20050126877A1 Method and system for cooling the clutch system of a transmission 审中-公开
标题翻译：用于冷却变速器离合器系统的方法和系统
公开(公告)号：US20050126877A1
公开(公告)日：2005-06-16
申请号：US10486042
申请日：2002-08-01
申请人： Matthias Schneider , Gerd Ahnert , Dietmar Lang , Burkhard Pollack
发明人： Matthias Schneider , Gerd Ahnert , Dietmar Lang , Burkhard Pollack
IPC分类号： B23P21/00 , B60K13/04 , B60K17/00 , B60K17/02 , B60K17/08 , B60W10/00 , B60W10/02 , B60W10/04 , B60W10/10 , B62D65/10 , F02D29/00 , F02D35/00 , F16D13/22 , F16D13/58 , F16D13/60 , F16D13/64 , F16D13/72 , F16D48/02 , F16D48/06 , F16H3/00 , F16H3/089 , F16H3/091 , F16H3/093 , F16H3/12 , F16H61/04 , F16H61/66 , F16H61/68 , F16H61/684 , F16H63/00 , F16H63/16 , F16H63/40
CPC分类号： F16D13/64 , B60K13/04 , B60K17/02 , F16D13/58 , F16D13/72 , F16D2300/12 , Y10T29/49815 , Y10T29/49822 , Y10T29/49826 , Y10T29/4984 , Y10T29/49904 , Y10T477/677 , Y10T477/688
摘要： A method and apparatus for reducing the thermal load on a motor vehicle clutch system. The clutch includes at least a pressure plate, a clutch disk, and a flywheel, by way of which a torque is transmitted. The friction forces that exist on the respective friction surfaces of the clutch disk are unevenly distributed. The clutch is cooled by a flow of cooling air that is led through the clutch bell that encloses the clutch and that defines a housing. The cooling air is conducted from the existing ventilation air inlets of the vehicle, and a jet pump arranged in the exhaust system is disclosed for withdrawing the cooling air from the clutch housing.
摘要翻译：一种用于减少机动车辆离合器系统上的热负荷的方法和装置。离合器至少包括压板，离合器盘和飞轮，通过它们传递转矩。存在于离合器盘的各摩擦面上的摩擦力不均匀分布。离合器被冷却空气流冷却，冷却空气被引导通过封闭离合器并且限定壳体的离合器钟。冷却空气从车辆的现有通风空气入口传导，并且布置在排气系统中的喷射泵被公开用于从离合器壳体中抽出冷却空气。

49. 发明授权

US09412044B2 Method of compensation of respiratory motion in cardiac imaging 有权
标题翻译：心脏成像中呼吸运动补偿方法
公开(公告)号：US09412044B2
公开(公告)日：2016-08-09
申请号：US12767908
申请日：2010-04-27
申请人： Matthias Schneider , Hari Sundar , Rui Liao , Chenyang Xu
发明人： Matthias Schneider , Hari Sundar , Rui Liao , Chenyang Xu
IPC分类号： G06K9/00 , G06K9/62 , G06T7/00 , G06T7/20
CPC分类号： G06K9/6247 , G06K2209/05 , G06T7/277 , G06T7/35 , G06T2207/10081 , G06T2207/10121 , G06T2207/20081 , G06T2207/30048
摘要： A method (10) for respiratory motion compensation by applying principle component analysis (PCA) on cardiac imaging samples obtained using 2D/3D registration of a pre-operative 3D segmentation of the coronary arteries.
摘要翻译：一种用于呼吸运动补偿的方法（10），其通过对冠状动脉的术前3D分割的2D / 3D登记获得的心脏成像样本应用主成分分析（PCA）。

50. 发明申请

US20110297695A1 DISPENSER FOR ADMINISTERING PLATE-SHAPED SUBSTANCES 有权
标题翻译：用于管理板形物质的分配器
公开(公告)号：US20110297695A1
公开(公告)日：2011-12-08
申请号：US13202232
申请日：2010-03-23
申请人： Matthias Schneider
发明人： Matthias Schneider
IPC分类号： B65D83/08
CPC分类号： B65D83/0829 , B65D83/087
摘要： A dispenser for administering strip-shaped substances (1), comprising a housing (2, 2′), said housing (2, 2′) having a chamber (3, 3′) to store a stack (4) of the strip-shaped substances (1), said housing (2, 2′) forming a removal opening (5, 5′) for the strip-shaped substances (1) that can be opened and closed again with a lid (6, 6′), said lid (6, 6′) being joined to the housing (2, 2′), and said lid (6, 6′) being joined to a transport bar (7, 7′) that can be moved together with the lid (6, 6′) in order to transport the strip-shaped substances (1), in view of the objective of designing and refining a dispenser of the above-mentioned type in such a manner as to allow a contamination-free and reliable transport of one single strip-shaped substance from the inside of the housing merely by moving the lid, is characterized in that the transport bar (7, 7′) is elastically pre-tensioned and mounted in the housing (2, 2′) in such a way that it is at a distance from the stack (4) when the removal opening (5, 5′) is closed.
摘要翻译：一种用于施用带状物质（1）的分配器，包括壳体（2,2'），所述壳体（2,2'）具有容纳所述带状物质的堆叠（4）的腔室（3,3'），所述壳体（2,2'）形成用于带状物质（1）的移除开口（5,5'），所述移除开口可以用盖子（6,6'）再次打开和关闭，所述盖子（6,6'）连接到所述壳体（2,2'），并且所述盖子（6,6'）连接到可与盖子一起移动的传送杆（7,7'）为了运输带状物质（1），考虑到设计和精制上述类型的分配器的目的，使得无污染和可靠地运输其特征在于，传送杆（7,7'）弹性地预张紧并安装在壳体（2,2'）中，其中，那就是它距离的距离当拆卸开口（5,5'）关闭时，堆（4）。

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