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41. 发明专利

JP2008271978A Composition and method for therapy and diagnosis of prostate cancer 审中-公开
标题翻译：用于治疗和诊断前列腺癌的组合物和方法
公开(公告)号：JP2008271978A
公开(公告)日：2008-11-13
申请号：JP2008126447
申请日：2008-05-13
申请人： Corixa Corp , コリクサコーポレイション
发明人： XU JIANGCHUN , DILLON DAVIN C , MITCHAM JENNIFER L , HARLOCKER SUSAN L , JIANG YUQIU , HENDERSON ROBERT A , KALOS MICHAEL D , FANGER GARY R , RETTER MARC W , STOLK JOHN A , DAY CRAIG H , VEDVICK THOMAS S , CARTER DARRICK , LI SAMUEL X , WANG AIJUN , SKEIKY YASIR A W , HEPLER WILLIAM T , HURAL JOHN , MCNEILL PATRICIA D , HOUGHTON RAYMOND L , VINALS Y DE BASSOLS CARLOTA , FOY TERESA M , WATABE YOSHIHIRO , DENG TA
IPC分类号： C12N15/09 , A61K35/12 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P13/08 , A61P35/00 , A61P37/04 , C07K7/06 , C07K7/08 , C07K16/18 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/07 , C12N5/0783 , C12N5/09 , C12N5/10 , C12Q1/02 , C12Q1/68 , G01N33/53 , G01N33/574
摘要： PROBLEM TO BE SOLVED: To provide a composition and method for the therapy and diagnosis of cancer, particularly prostate cancer. SOLUTION: The composition comprises one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供用于治疗和诊断癌症，特别是前列腺癌的组合物和方法。组合物包含一种或多种前列腺特异性多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及表达此类多肽的细胞特异性的T细胞。版权所有（C）2009，JPO＆INPIT

42. 发明专利

JP2008249727A Compound for immunodiagnosis of prostate cancer and method for its use 审中-公开
标题翻译：前列腺癌免疫缺陷病的化合物及其使用方法
公开(公告)号：JP2008249727A
公开(公告)日：2008-10-16
申请号：JP2008172191
申请日：2008-07-01
申请人： Corixa Corp , コリクサコーポレイション
发明人： XU JIANGCHUN , DILLON DAVIN C
IPC分类号： G01N33/574 , C07K16/30 , C12N15/09 , C12P21/08 , C12Q1/68 , G01N33/577
CPC分类号： G01N33/57434 , C12Q1/6886 , C12Q2600/158
摘要： PROBLEM TO BE SOLVED: To provide compounds and methods for diagnosing prostate cancer. SOLUTION: This is the method for detecting prostate cancer in a patient, which comprises a process (a) for bringing a biological sample obtained from the patient into contact with a bonding factor combinable with polypeptide, where polypeptide contains immunogenic part of prostate protein or its engineered body, while protein contains nucleotide sequence shown in sequencing numbers 2-3, 5-107, 109-111, 115-171, 173-175, 177 and 179-224, complementary body of the nucleotide sequence, and amino acid sequence coded by DNA molecule provided with sequencing selected from sequencing groups which consist of the engineered body on nucleotide sequence; and a process (b) for detecting protein or polypeptide combined with bonding factor from the sample to detect prostate cancer in the patient. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供用于诊断前列腺癌的化合物和方法。解决方案：这是用于检测患者中前列腺癌的方法，其包括使得从患者获得的生物样品与可与多肽组合的结合因子接触的方法（a），其中多肽含有前列腺的免疫原性部分蛋白质或其工程化体，而蛋白质含有序列号2-3,5-107,109-111,115-171,173-175,177和179-224中所示的核苷酸序列，核苷酸序列的互补体和氨基由DNA分子编码的酸序列，其具有选自由核苷酸序列上的工程化体组成的测序组的测序; 以及用于检测与来自样品的结合因子结合的蛋白质或多肽以检测患者中的前列腺癌的方法（b）。版权所有（C）2009，JPO＆INPIT

44. 发明公开

EP1349485A4 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF OVARIAN CANCER 审中-公开
标题翻译：组合物和方法为卵巢癌的治疗和诊断
公开(公告)号：EP1349485A4
公开(公告)日：2005-11-09
申请号：EP01987192
申请日：2001-11-13
申请人： CORIXA CORP
发明人： XU JIANGCHUN , STOLK JOHN A , ALGATE PAUL A , FLING STEVEN P , MOLESH DAVID ALAN
IPC分类号： G01N33/53 , A61K31/7088 , A61K35/14 , A61K38/00 , A61K39/00 , A61K39/395 , A61K48/00 , A61P35/00 , A61P37/04 , C07K14/47 , C07K16/18 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/566 , A61B1/00
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47 , Y10S436/813 , Y10T436/143333

45. 发明公开

EP1578380A4 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF PROSTATE CANCER 审中-公开
标题翻译：组合物和方法治疗和诊断前列腺癌
公开(公告)号：EP1578380A4
公开(公告)日：2007-12-26
申请号：EP03812782
申请日：2003-11-12
申请人： CORIXA CORP
发明人： XU JIANGCHUN , STOLK JOHN A , KALOS MICHAEL D
IPC分类号： A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , A61P37/04 , C07K14/11 , C07K14/47 , C07K14/705 , C07K16/30 , C12N1/21 , C12N5/08 , C12N9/64 , C12N15/12 , C12N15/57 , C12P21/04 , A61K6/00
CPC分类号： C07K14/005 , A01K2227/105 , A01K2267/0331 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2035/124 , A61K2039/505 , A61K2039/5156 , A61K2039/53 , A61K2039/55566 , C07K14/47 , C07K14/4748 , C07K14/705 , C07K16/3069 , C07K2317/565 , C07K2317/73 , C07K2319/00 , C12N9/6424 , C12N2760/16222 , G01N33/57434
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

46. 发明申请

WO2004052276A3 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF PROSTATE CANCER 审中-公开
标题翻译：前列腺癌的治疗和诊断的组合物和方法
公开(公告)号：WO2004052276A3
公开(公告)日：2006-06-22
申请号：PCT/US0335961
申请日：2003-11-12
申请人： CORIXA CORP
发明人： XU JIANGCHUN , STOLK JOHN A , KALOS MICHAEL D
IPC分类号： C12Q1/68 , A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , A61P37/04 , C07K14/11 , C07K14/47 , C07K14/705 , C07K16/30 , C12N1/21 , C12N5/08 , C12N9/64 , C12N15/12 , C12N15/57 , C12P21/04
CPC分类号： C07K14/005 , A01K2227/105 , A01K2267/0331 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2035/124 , A61K2039/505 , A61K2039/5156 , A61K2039/53 , A61K2039/55566 , C07K14/47 , C07K14/4748 , C07K14/705 , C07K16/3069 , C07K2317/565 , C07K2317/73 , C07K2319/00 , C12N9/6424 , C12N2760/16222 , G01N33/57434
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
摘要翻译：公开了用于治疗和诊断癌症，特别是前列腺癌的组合物和方法。说明性组合物包含一种或多种前列腺特异性多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。所公开的组合物可用于例如疾病，特别是前列腺癌的诊断，预防和/或治疗。

47. 发明申请

WO0239885A3 COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF OVARIAN CANCER 审中-公开
标题翻译： OVARIAN癌症治疗和诊断的组成和方法
公开(公告)号：WO0239885A3
公开(公告)日：2003-07-31
申请号：PCT/US0145395
申请日：2001-11-13
申请人： CORIXA CORP
发明人： XU JIANGCHUN , STOLK JOHN A , ALGATE PAUL A , FLING STEVEN P , MOLESH DAVID ALAN
IPC分类号： G01N33/53 , A61K31/7088 , A61K35/14 , A61K38/00 , A61K39/00 , A61K39/395 , A61K48/00 , A61P35/00 , A61P37/04 , C07K14/47 , C07K16/18 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N33/566 , C07K14/465 , C07H21/00
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47 , Y10S436/813 , Y10T436/143333
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.
摘要翻译：公开了用于治疗和诊断癌症，特别是卵巢癌的组合物和方法。说明性组合物包含一个或多个卵巢肿瘤多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。所公开的组合物可用于例如疾病，特别是卵巢癌的诊断，预防和/或治疗。

48. 发明申请

WO0004149A2 COMPOSITIONS AND METHODS FOR THERAPY AND DIAGNOSIS OF PROSTATE CANCER 审中-公开
标题翻译：前列腺癌的治疗和诊断的组合物和方法
公开(公告)号：WO0004149A2
公开(公告)日：2000-01-27
申请号：PCT/US9915838
申请日：1999-07-14
申请人： CORIXA CORP
发明人： DILLON DAVIN CLIFFORD , HARLOCKER SUSAN LOUISE , YUQIU JIANG , XU JIANGCHUN , MITCHAM JENNIFER LYNN
IPC分类号： G01N33/574 , A61K38/00 , A61K39/00 , A61K39/395 , A61P35/00 , C07K14/47 , C07K16/30 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/68 , C12N5/02 , C12N15/62
CPC分类号： C07K14/4748 , A61K39/00 , A61K2039/5156 , C07K2319/00
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate tumor protein, or mRNA encoding such a protein, in a sample are also provided.
摘要翻译：公开了用于治疗和诊断癌症的组合物和方法，例如前列腺癌。组合物可以包含一种或多种前列腺肿瘤蛋白，其免疫原性部分或编码这些部分的多核苷酸。或者，治疗组合物可包含表达前列腺肿瘤蛋白的抗原呈递细胞或对表达此类蛋白的细胞特异的T细胞。例如，这种组合物可以用于预防和治疗诸如前列腺癌的疾病。还提供了基于检测样品中前列腺肿瘤蛋白质或编码这种蛋白质的mRNA的诊断方法。

49. 发明申请

WO9837093A3 COMPOUNDS FOR IMMUNOTHERAPY OF PROSTATE CANCER AND METHODS FOR THEIR USE 审中-公开
标题翻译：前列腺癌免疫治疗化合物及其使用方法
公开(公告)号：WO9837093A3
公开(公告)日：1998-12-17
申请号：PCT/US9803492
申请日：1998-02-25
申请人： CORIXA CORP
发明人： XU JIANGCHUN , DILLON DAVIN C
IPC分类号： A61K38/00 , A61K39/00 , C07K14/705 , C07K14/00
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K2319/00 , C12N9/90
摘要： Compounds and methods for treating prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.
摘要翻译：提供了用于治疗前列腺癌的化合物和方法。本发明的化合物包括含有至少一部分前列腺肿瘤蛋白质的多肽。还提供了用于包含此类多肽的前列腺癌免疫治疗的疫苗和药物组合物，或者编码这些多肽的DNA分子，以及用于制备本发明多肽的DNA分子。

50. 发明申请

WO9933869A3 COMPOUNDS FOR IMMUNOTHERAPY AND DIAGNOSIS OF BREAST CANCER AND METHODS FOR THEIR USE 审中-公开
标题翻译：免疫治疗和乳腺癌诊断的化合物及其使用方法
公开(公告)号：WO9933869A3
公开(公告)日：1999-12-23
申请号：PCT/US9827416
申请日：1998-12-22
申请人： CORIXA CORP
发明人： REED STEVEN G , XU JIANGCHUN
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/39 , A61K39/395 , A61P35/00 , C07K14/47 , C07K14/82 , C07K16/18 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08 , C12Q1/68 , G01N33/577 , C12N15/12 , A61K31/71 , A61K48/00 , C07K16/30 , C12N5/08 , G01N33/574
CPC分类号： C07K14/82 , A61K38/00 , A61K39/00
摘要： Compounds and methods for the treatment and diagnosis of breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of a breast tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of breast cancer comprising such polypeptides, or polynucleotide molecules encoding such polypeptides, are also provided, together with polynucleotide molecules for preparing the inventive polypeptides.
摘要翻译：提供了用于治疗和诊断乳腺癌的化合物和方法。本发明化合物包括含有至少一部分乳腺肿瘤蛋白质的多肽。还提供包含这些多肽的乳腺癌的免疫治疗用疫苗和药物组合物，或编码这些多肽的多核苷酸分子，以及用于制备本发明多肽的多核苷酸分子。

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