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41. 发明授权

US06947787B2 System and methods for imaging within a body lumen 有权
标题翻译：用于在体腔内成像的系统和方法
公开(公告)号：US06947787B2
公开(公告)日：2005-09-20
申请号：US10029740
申请日：2001-12-21
申请人： William E. Webler
发明人： William E. Webler
IPC分类号： A61B1/04 , A61B8/12 , A61B6/00
CPC分类号： A61B1/042 , A61B5/0066 , A61B5/0084 , A61B5/7232 , A61B8/12
摘要： Systems, methods and apparatus for acquiring an image from within a body lumen are provided. Systems embodying features of the invention include an intracorporeal imaging component for acquiring imaging information, an image information recording component, and an image information playback component. Methods for acquiring image information from within a body lumen include steps of acquiring imaging information, storing image information, and playing back imaging information. Imaging information may be played back as acquired, or non-sequentially, or composite images may be formed by combining, filtering, enhancing, or subtracting images and the composite images displayed. Devices embodying features of the invention include optical imaging components such as an optical IGW, an optical imaging recording component, and an optical image playback component. The systems, methods and devices are suitable for use with angiopoplasty, stent delivery, and other intracorporeal clinical procedures.
摘要翻译：提供了用于从体腔内获取图像的系统，方法和装置。体现本发明特征的系统包括用于获取成像信息的体内成像组件，图像信息记录组件和图像信息重放组件。从体腔内获取图像信息的方法包括获取成像信息，存储图像信息和再现成像信息的步骤。成像信息可以被获取或非顺序地回放，或者可以通过组合，过滤，增强或减少图像和所显示的合成图像来形成合成图像。体现本发明特征的装置包括诸如光学IGW，光学成像记录组件和光学图像重放组件的光学成像组件。系统，方法和装置适用于血管成形术，支架输送和其他体内临床手术。

42. 发明授权

US06855124B1 Flexible polymer needle catheter 有权
标题翻译：柔性聚合物针导管
公开(公告)号：US06855124B1
公开(公告)日：2005-02-15
申请号：US10263640
申请日：2002-10-02
申请人： Fernando Gonzalez , William E. Webler
发明人： Fernando Gonzalez , William E. Webler
IPC分类号： A61B17/00 , A61B17/22 , A61B17/34 , A61M29/00
CPC分类号： A61B17/3478 , A61B2017/00247 , A61B2017/22077 , A61B2018/00392 , A61M2025/0086 , A61M2025/0089
摘要： A catheter device having an elongated tubular member with a proximal end and a distal end, and a needle disposed near the distal end. In one embodiment, the needle has a rigid, penetrating tip coupled to a flexible portion by an overlapping joint. The flexible portion enables the needle to bend to a penetrating angle relative to the distal end of the elongated tubular member and penetrate a body tissue without kinking.
摘要翻译：导管装置，其具有带近端和远端的细长管状构件，以及设置在远端附近的针。在一个实施例中，针具有通过重叠接头联接到柔性部分的刚性的穿透尖端。柔性部分使得针能够相对于细长管状构件的远端弯曲成穿透角度并穿透身体组织而没有扭结。

43. 发明授权

US5759153A Automated longitudinal position translator for ultrasonic imaging probes, and methods of using same 失效
公开(公告)号：US5759153A
公开(公告)日：1998-06-02
申请号：US747773
申请日：1996-11-13
申请人： William E. Webler , Mark S. Buhr
发明人： William E. Webler , Mark S. Buhr
IPC分类号： A61B8/12 , G01S7/521 , G01S15/89 , A61B8/00
CPC分类号： A61B8/12 , A61B8/4209 , A61B8/4461 , G01S15/8936 , G01S7/52079 , Y10S128/916
摘要： A longitudinal position translator includes a probe drive module and a linear translation module. The probe drive module is coupled operatively to an ultrasonic imaging probe assembly having a distally located ultrasound transducer subassembly in such a manner that longitudinal shifting of the transducer subassembly may be effected. The probe drive module is preferably mounted to the linear translation unit so as to be moveable between a condition whereby longitudinal shifting of the transducer subassembly can be conducted either manually or automatically. When in the automatically-operable condition, the probe drive module will be engaged with a motor-driven screw associated with the linear translation module so as to cause the probe drive module to be longitudinally displaced at a constant motor-driven rate. In this manner, the distally located ultrasound transducer is longitudinally shifted during an ultrasound scan of surrounding intravascular (or other) tissue to thereby allow axially-spaced 360.degree. data sample "slices" of the surrounding tissue to be obtained. The data samples may then be reconstructed into a three-dimensional or other two-dimensional representations of the scanned vessel to assist in diagnosis.

44. 发明授权

US5330444A Catheter tip with a low friction lining and method of use 失效
标题翻译：导管尖端具有低摩擦衬里和使用方法
公开(公告)号：US5330444A
公开(公告)日：1994-07-19
申请号：US945175
申请日：1992-09-15
申请人： William E. Webler , Viet P. Dinh
发明人： William E. Webler , Viet P. Dinh
IPC分类号： A61M25/00 , A61M29/02 , A61M5/32
CPC分类号： A61M25/0068 , A61M2025/0046 , A61M2025/0183 , A61M25/001
摘要： A monorail tip catheter includes a low friction guide wire lumen to facilitate removal of the catheter over the guide wire without buckling or kinking the guide wire. The catheter guide wire lumen is provided with a low friction lining with anchoring means, together with additional guide means to facilitate threading the guide wire into the monorail guide wire lumen.
摘要翻译：单轨末端导管包括低摩擦导丝管腔，以便于在导丝上移除导管而不使引导线弯曲或扭结。导管导丝管腔具有带有锚固装置的低摩擦衬里，以及另外的引导装置，以便于将导丝穿入单轨导丝管腔。

45. 发明授权

US4796640A Apparatus with fast response thermistor 失效
标题翻译：具有快速响应热敏电阻的装置
公开(公告)号：US4796640A
公开(公告)日：1989-01-10
申请号：US570619
申请日：1984-01-13
申请人： William E. Webler
发明人： William E. Webler
IPC分类号： A61B5/028
CPC分类号： A61B5/028 , A61B2018/00166
摘要： An apparatus for measuring the temperature of a fluid flowing within a body comprising an elongated tube sized to be received within a vein or an artery and having a peripheral wall, at least one lumen extending longitudinally within the tube and an opening in the peripheral wall which extends from the lumen to the exterior of the tube. A thermistor is mounted in the lumen adjacent the opening by a thermistor mounting body. The thermistor mounting body cooperates with the tube to at least partially define a cavity at the opening which opens radially outwardly. The thermistor is partially in the mounting body and projects radially outwardly of the mounting body into the cavity so that the portion of the thermistor which projects into the cavity is in good heat transfer relationship to the fluid flowing within the body. The thermistor has a major axis and a minor axis, and the major axis is generally transverse to the direction of the flowing fluid. The tube has a body line, and the thermistor extends radially outwardly no farther than about the body line.
摘要翻译：一种用于测量在体内流动的流体的温度的装置，包括细长管，其尺寸被设计成容纳在静脉或动脉内并具有周壁，在管内纵向延伸的至少一个内腔和周壁中的开口，从管腔延伸到管的外部。热敏电阻通过热敏电阻安装体安装在与开口相邻的内腔中。所述热敏电阻安装体与所述管配合以至少部分地限定在所述开口处的径向向外开口的空腔。热敏电阻部分地位于安装体中并且将安装体的径向向外突出到空腔中，使得突出到空腔中的热敏电阻的部分与在体内流动的流体具有良好的热传递关系。热敏电阻具有长轴和短轴，并且长轴通常横向于流动流体的方向。管具有主体线，并且热敏电阻径向向外延伸，不比身体线更远。

46. 发明授权

US4745928A Right heart ejection fraction and cardiac output catheter 失效
$Right heart ejection fraction and cardiac output catheter$
标题翻译：右心射血分数和心输出量导管
公开(公告)号：US4745928A
公开(公告)日：1988-05-24
申请号：US858448
申请日：1986-05-01
申请人： William E. Webler , Edward E. Elson , Michael D. Quinn
发明人： William E. Webler , Edward E. Elson , Michael D. Quinn
IPC分类号： A61B5/028 , A61B5/02
CPC分类号： A61B5/028 , A61B2018/00166
摘要： An apparatus for injecting a fluid into the heart and making temperature measurements within the pulmonary artery comprising an elongated flexible tube having a distal end portion, a temperature sensor mounted on the distal end portion, a peripheral wall, at least one lumen extending longitudinally within the tube and an injectate port opening in the peripheral wall proximally of the temperature sensor. The tube can be advanced through a vein, the right atrium and the right ventricle to place the distal end portion in the pulmonary artery and the injectate port in the right atrium facing generally toward the inferior vena cava. The temperature sensor is oriented on the distal end portion so as to materially reduce the likelihood that it will contact the wall of the pulmonary artery during use.
摘要翻译：一种用于将流体注射到心脏中并在肺动脉内进行温度测量的装置，包括具有远端部分的细长柔性管，安装在远端部分上的温度传感器，周壁，至少一个内腔，管和在温度传感器近侧的周壁中开口的注射口。管可以通过静脉，右心房和右心室前进，将远端部分放置在肺动脉中，右心房中的注射口通常面向下腔静脉。温度传感器定位在远端部分上，以便在使用过程中大大降低其与肺动脉壁接触的可能性。

47. 发明授权

US4632125A Right heart ejection fraction and cardiac output catheter 失效
$Right heart ejection fraction and cardiac output catheter$
标题翻译：右心射血分数和心输出量导管
公开(公告)号：US4632125A
公开(公告)日：1986-12-30
申请号：US570631
申请日：1984-01-13
申请人： William E. Webler , Edward E. Elson , Michael D. Quinn
发明人： William E. Webler , Edward E. Elson , Michael D. Quinn
IPC分类号： A61B5/028 , A61B5/02
CPC分类号： A61B5/029 , A61B5/028 , A61B2018/00166
摘要： An apparatus for injecting a fluid into the heart and making temperature measurements within the pulmonary artery comprising an elongated flexible tube having a distal end portion, a temperature sensor mounted on the distal end portion, a peripheral wall, at lest one lumen extending longitudinally within the tube and an injectate port opening in the peripheral wall proximally of the temperature sensor. The tube can be advanced through a vein, the right atrium and the right ventricle to place the distal end portion in the pulmonary artery and the injectate port in the right atrium facing generally toward the inferior vena cave. The temperature sensor is oriented on the distal end portion so as to materially reduce the likelihood that it will contact the wall of the pulmonary artery during use.
摘要翻译：一种用于将流体注射到心脏中并在肺动脉内进行温度测量的装置，包括具有远端部分的细长柔性管，安装在远端部分上的温度传感器，周壁，至少一个腔内管和在温度传感器近侧的周壁中开口的注射口。管可以通过静脉，右心房和右心室前进，将远端部分放置在肺动脉中，右心房中的注射口通常面向下腔静脉。温度传感器定位在远端部分上，以便在使用过程中大大降低其与肺动脉壁接触的可能性。

48. 发明授权

US09522257B2 Integrated controlled volume inflator device, components, and methods of use 有权
标题翻译：集成控制体积充气机装置，部件和使用方法
公开(公告)号：US09522257B2
公开(公告)日：2016-12-20
申请号：US13436724
申请日：2012-03-30
申请人： William E. Webler
发明人： William E. Webler
IPC分类号： A61M25/10
CPC分类号： A61M25/10182 , A61M25/10187
摘要： A controlled pressure inflation-deflation device inflates a balloon to occlude a blood vessel by moving a large plunger to provide incremental pressure increases within a syringe. A releasable latch moves a second plunger, positioned within a syringe formed by an inner columnar opening in the large plunger, between an occlusion position and a perfusion position. A three-position switch has a release position to allow the large plunger to move freely, an adjust position to provide the incremental pressure increases, and a lock position to lock the location of the plunger. Pressures at which various balloons (e.g., folded balloons) achieve or nearly achieve a substantially circular cross-section may be extrapolated by inflating balloons with pressures equal and/or greater than the first occlusion pressure. Balloons may be pre-inflated up to or below the first occlusion pressure to achieve a substantially circular cross-section, prior to increasing the balloon to an occlusion pressure.
摘要翻译：受控压力充气 - 放气装置通过移动大的柱塞来使球囊膨胀以封闭血管，以在注射器内提供增加的压力增加。可释放的闩锁移动位于由大柱塞内的内柱形开口形成的注射器内的第二柱塞之间，阻塞位置和灌注位置之间。三位置开关具有释放位置，以允许大柱塞自由移动，提供增量压力的调节位置增加，以及锁定位置以锁定柱塞的位置。各种气球（例如，折叠的气球）达到或几乎达到基本圆形的横截面的压力可以通过在等于和/或大于第一闭塞压力的压力下膨胀球囊来外推。在将球囊增加到闭塞压力之前，气球可以预先充气至第一闭塞压力或低于第一闭塞压力，以实现基本圆形的横截面。

49. 发明授权

US09504491B2 Catheter having window and partial balloon covering for dissecting tissue planes and injecting treatment agent to coronary blood vessel 有权
标题翻译：导管具有用于解剖组织平面和将治疗剂注射到冠状动脉血管的窗口和部分气囊覆盖物
公开(公告)号：US09504491B2
公开(公告)日：2016-11-29
申请号：US11936668
申请日：2007-11-07
申请人： Peter L. Callas , Eric J. Willis , Fozan O. El-Nounou , Florian N. Ludwig , William E. Webler , Paul M. Consigny
发明人： Peter L. Callas , Eric J. Willis , Fozan O. El-Nounou , Florian N. Ludwig , William E. Webler , Paul M. Consigny
IPC分类号： A61B17/34 , A61M25/10 , A61B17/02 , A61B17/00 , A61B17/22 , A61B17/32 , A61B18/00 , A61M25/00 , A61M25/01
CPC分类号： A61B17/3478 , A61B17/02 , A61B90/37 , A61B2017/00247 , A61B2017/22061 , A61B2017/320044 , A61B2018/00392 , A61M25/0026 , A61M25/0084 , A61M25/10 , A61M2025/0166 , A61M2025/1004
摘要： A method is provided including introducing a delivery device through a vessel wall to a treatment site within one of a peri-adventitial space or a pericardium adjacent a coronary blood vessel and delivering a treatment agent through the delivery device. The treatment agent is delivered through the delivery device according to conditions that hydraulically dissect tissue planes within the peri-adventitial space. A kit is provided including a delivery device having a needle to be advanced through one of an epicardium of a heart and a wall of a coronary blood vessel into a peri-adventitial space and a treatment agent comprising particles having an average diameter on the order of 15 microns or more to be delivered through the delivery device into the peri-adventitial space.
摘要翻译：提供了一种方法，包括将输送装置通过血管壁引入邻近冠状血管的周围空间或心包膜内的治疗部位，并通过输送装置输送治疗剂。治疗剂通过输送装置根据液压解剖周围空间内的组织平面的条件递送。提供了一种试剂盒，其包括具有针头的输送装置，所述针头通过心脏的心外膜和冠状血管的壁之一进入周围空间，以及包含平均直径为 15微米或更多，以通过输送装置输送到周围空间。

50. 发明授权

US08845519B2 Rotatable ferrules and interfaces for use with an optical guidewire 有权
标题翻译：可旋转套圈和与光导线一起使用的接口
公开(公告)号：US08845519B2
公开(公告)日：2014-09-30
申请号：US12541444
申请日：2009-08-14
申请人： William E. Webler , Andrej M. Chudy , Marc M. Jalisi , Kevin M. Phillips , Michael D. Whitt , Susan Norton
发明人： William E. Webler , Andrej M. Chudy , Marc M. Jalisi , Kevin M. Phillips , Michael D. Whitt , Susan Norton
IPC分类号： A61B1/07 , G02B6/36 , A61B5/00
CPC分类号： G02B6/3826 , A61B1/00126 , A61B5/0062 , A61B5/0084 , G02B6/4219 , G02B6/4292
摘要： Devices and methods for passing optical radiation into and out of a body lumen may include a rotatable ferrule for use in an optical guidewire and methods for using a rotatable ferrule. The rotatable ferrule may be either rotatably captured by and free to rotate within a guidewire, or may rotate upon release from a releasable, mechanically stable friction-fit engagement with a guidewire. Sterile interfaces for readily connecting and disconnecting an optical guidewire with and from other optical instrumentation while maintaining the sterility of the guidewire, and methods for using a sterile interface device are disclosed. Interface devices can be used to provide either direct or indirect optical and mechanical connection between an optical guidewire and peripheral instrumentation.
摘要翻译：用于将光学辐射传入和流出体腔的装置和方法可包括用于光导线的可旋转套圈以及使用可旋转套圈的方法。可旋转套圈可以被可旋转地捕获并且在导丝内自由旋转，或者可以在与导丝的可释放的机械稳定的摩擦配合接合释放时旋转。公开了用于在保持导线的无菌性的同时轻松地连接和断开与其他光学仪器的光导线的无菌接口，以及使用无菌接口装置的方法。接口设备可用于在光导线和外围设备之间提供直接或间接的光学和机械连接。

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