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41. 发明授权

US6096070A Coated implantable medical device 失效
标题翻译：涂层可植入医疗器械
公开(公告)号：US6096070A
公开(公告)日：2000-08-01
申请号：US645646
申请日：1996-05-16
申请人： Anthony O. Ragheb , Brian L. Bates , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
发明人： Anthony O. Ragheb , Brian L. Bates , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
IPC分类号： A61B17/00 , A61F2/00 , A61K9/00 , A61K51/12 , A61L27/30 , A61L27/54 , A61L29/08 , A61L29/10 , A61L29/16 , A61L31/00 , A61L31/08 , A61L31/10 , A61L31/16 , A61L33/02 , A61M37/00 , A61N5/10 , A61F2/06
CPC分类号： A61L31/088 , A61K51/1282 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/022 , A61F2250/0068 , A61L2300/42 , A61L2300/602 , A61L2300/608 , A61N5/1002
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material posited on one surface of structure 12; and at least one porous layer 20 posited over the bioactive material layer 18 posited on one surface of structure (12) and the bioactive-material-free surface. Preferably, the structure 12 is a coronary stent. The porous layer 20 is comprised of a polymer applied preferably by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor. Also disclosed is the method of manufacture of the device 10, as well as a method of using it in medical treatments.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一层生物活性材料层18位于结构12的一个表面上; 和位于结构（12）的一个表面上的生物活性材料层18上的至少一个多孔层20和不含生物活性材料的表面。优选地，结构12是冠状动脉支架。多孔层20由优选通过蒸气或等离子体沉积施加的聚合物组成，并提供生物活性材料的受控释放。特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，其仅通过单体蒸气的冷凝就不经溶剂，热或催化剂沉积。还公开了装置10的制造方法，以及在医疗中使用该方法。

42. 发明授权

US08974522B2 Coated medical device 有权
标题翻译：涂层医疗器械
公开(公告)号：US08974522B2
公开(公告)日：2015-03-10
申请号：US13072332
申请日：2011-03-25
申请人： Brian L. Bates , Anthony O. Ragheb , Joseph M. Stewart, IV , William J. Bourdeau , Brian D. Choules , James D. Purdy , Neal E. Fearnot
发明人： Brian L. Bates , Anthony O. Ragheb , Joseph M. Stewart, IV , William J. Bourdeau , Brian D. Choules , James D. Purdy , Neal E. Fearnot
IPC分类号： A61F2/82 , A61M25/10 , A61L27/54 , A61L29/16 , A61L31/16
CPC分类号： A61M25/10 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/958 , A61F2210/0014 , A61F2210/0076 , A61F2240/001 , A61F2250/0025 , A61F2250/0026 , A61F2250/0067 , A61F2250/0081 , A61F2250/0098 , A61F2310/00011 , A61L27/54 , A61L29/08 , A61L29/085 , A61L29/16 , A61L29/18 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2400/18 , A61L2420/02 , A61L2420/06 , A61M25/1029 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2250/00
摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.
摘要翻译：一种涂覆的医疗装置（10），包括适于引入患者的通道或容器中的结构（12）。该结构优选由其上设置有生物活性材料层（18）的无孔基材（14）形成。该医疗装置优选为其上沉积有生物活性物质层的可植入支架或球囊（26）。支架可以围绕气囊定位，另一层生物活性材料放置在整个结构上并延伸超过定位的支架的端部。气囊的端部延伸超过支架的端部并且包括其上的生物活性材料，用于将生物活性材料输送到与其接触的血管壁的细胞。气囊还包括位于气囊的基部和生物活性材料层之间的一层亲水材料（58）。

43. 发明授权

US08469943B2 Coated implantable medical device 失效
公开(公告)号：US08469943B2
公开(公告)日：2013-06-25
申请号：US12902788
申请日：2010-10-12
申请人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
发明人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
IPC分类号： A61M25/00
CPC分类号： A61L33/022 , A61F2/0077 , A61F2/02 , A61F2/06 , A61F2/24 , A61F2/82 , A61F2/91 , A61F2210/0076 , A61F2250/0067 , A61F2250/0068 , A61K51/1282 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/256 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , A61N5/1002 , C08L65/04
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.

44. 发明授权

US07901453B2 Coated implantable medical device 有权
标题翻译：涂层可植入医疗器械
公开(公告)号：US07901453B2
公开(公告)日：2011-03-08
申请号：US11932113
申请日：2007-10-31
申请人： Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees, III , Thomas G. Kozma , Brian L. Bates , Thomas A. Osborne
发明人： Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees, III , Thomas G. Kozma , Brian L. Bates , Thomas A. Osborne
IPC分类号： A61F2/06
CPC分类号： A61K51/1282 , A61F2/24 , A61F2/82 , A61F2250/0068 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L33/022 , A61L2300/256 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/608 , A61L2420/08 , A61N5/1002 , C08L65/04
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer 18 of an immunosuppressive agent posited over at least one surface of the structure 12. Optionally, the device 10 can include at least one porous, preferably polymeric layer 20 posited over the layer 18 of immunosuppressive agent, and can alternatively or additionally include at least one coating layer 16 posited on one surface of the structure 12, the at least one layer 18 of immunosuppressive agent being posited in turn on at least a portion of the coating layer 16. The porous layer 20 and the coating layer 16 each provide for the controlled release of the bioactive material from the device 10. The structure 12 is preferably configured as a coronary stent. The polymer of the porous layer 20 is preferably applied by vapor or plasma deposition. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative which is deposited without solvents, heat or catalysts, but rather by condensation of a monomer vapor.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食管，气管，结肠，胆管或尿道中的结构12，以及至少一个位于结构的至少一个表面上的免疫抑制剂层18 任选地，装置10可以包括位于免疫抑制剂的层18上的至少一个多孔的，优选的聚合物层20，并且可以替代地或另外包括至少一个涂覆层16，该涂层16位于结构12的一个表面上，至少一层18的免疫抑制剂依次放置在涂层16的至少一部分上。多孔层20和涂层16各自提供生物活性材料从装置10的受控释放。结构12是优选构造为冠状动脉支架。多孔层20的聚合物优选通过蒸气或等离子体沉积来施加。特别优选的是聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不用溶剂，加热或催化剂沉积，而是通过单体蒸气的冷凝而沉积。

45. 发明授权

US07896914B2 Coated implantable medical device 有权
标题翻译：涂层可植入医疗器械
公开(公告)号：US07896914B2
公开(公告)日：2011-03-01
申请号：US11931694
申请日：2007-10-31
申请人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
发明人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2/24 , A61F2250/0068 , A61K51/1282 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L33/022 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2420/08 , A61N5/1002 , C08L65/04
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。此外，至少一个多孔层20可以放置在生物活性材料层18上方，其中多孔层包括聚合物并提供生物活性材料通过其控制释放。优选地，结构12是冠状动脉支架。多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

46. 发明授权

US07846202B2 Coated implantable medical device 有权
标题翻译：涂层可植入医疗器械
公开(公告)号：US07846202B2
公开(公告)日：2010-12-07
申请号：US11965385
申请日：2007-12-27
申请人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees, III , Thomas G. Kozma
发明人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees, III , Thomas G. Kozma
IPC分类号： A61F2/06
CPC分类号： A61F2/885 , A61F2/0077 , A61F2250/0068
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, where the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 may be posited over the bioactive material layer 18, where the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 以及至少一层生物活性材料层18，其被定位在涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。此外，至少一个多孔层20可以位于生物活性材料层18上，其中多孔层包括聚合物，并且通过其提供生物活性材料的受控释放。优选地，结构12是冠状动脉支架。多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

47. 发明申请

US20090136560A1 COATED MEDICAL DEVICE 有权
标题翻译：涂层医疗器械
公开(公告)号：US20090136560A1
公开(公告)日：2009-05-28
申请号：US12359884
申请日：2009-01-26
申请人： Brian L. Bates , Anthony O. Ragheb , Joseph M. Stewart, IV , William J. Bourdeau , Brian D. Choules , James D. Purdy , Neal E. Fearnot
发明人： Brian L. Bates , Anthony O. Ragheb , Joseph M. Stewart, IV , William J. Bourdeau , Brian D. Choules , James D. Purdy , Neal E. Fearnot
IPC分类号： A61K9/00 , A61P9/10
CPC分类号： A61M25/10 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/958 , A61F2210/0014 , A61F2210/0076 , A61F2240/001 , A61F2250/0025 , A61F2250/0026 , A61F2250/0067 , A61F2250/0081 , A61F2250/0098 , A61F2310/00011 , A61L27/54 , A61L29/08 , A61L29/085 , A61L29/16 , A61L29/18 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2400/18 , A61L2420/02 , A61L2420/06 , A61M25/1029 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2250/00
摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.
摘要翻译：一种涂覆的医疗装置（10），包括适于引入患者的通道或容器中的结构（12）。该结构优选由其上设置有生物活性材料层（18）的无孔基材（14）形成。该医疗装置优选为其上沉积有生物活性物质层的可植入支架或球囊（26）。支架可以围绕气囊定位，另一层生物活性材料放置在整个结构上并延伸超过定位的支架的端部。气囊的端部延伸超过支架的端部并且包括其上的生物活性材料，用于将生物活性材料输送到与其接触的血管壁的细胞。气囊还包括位于气囊的基部和生物活性材料层之间的一层亲水材料（58）。

48. 发明申请

US20080215138A1 COATED IMPLANTABLE MEDICAL DEVICE 有权
公开(公告)号：US20080215138A1
公开(公告)日：2008-09-04
申请号：US11931694
申请日：2007-10-31
申请人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees
发明人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61F2/24 , A61F2250/0068 , A61K51/1282 , A61L27/306 , A61L27/54 , A61L29/085 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L33/022 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2420/08 , A61N5/1002 , C08L65/04
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.

49. 发明授权

US06918927B2 Coated implantable medical device 有权
标题翻译：涂层可植入医疗器械
公开(公告)号：US06918927B2
公开(公告)日：2005-07-19
申请号：US10000659
申请日：2001-10-31
申请人： Brian L. Bates , Anthony O. Ragheb , Joseph M. Stewart, IV , William J. Bourdeau , Brian D. Choules , James D. Purdy , Neal E. Fearnot
发明人： Brian L. Bates , Anthony O. Ragheb , Joseph M. Stewart, IV , William J. Bourdeau , Brian D. Choules , James D. Purdy , Neal E. Fearnot
IPC分类号： A61L29/00 , A61F2/00 , A61F2/86 , A61K31/337 , A61K31/4545 , A61L27/54 , A61L31/16 , A61P9/10 , A61P35/00 , A61F2/06 , A61F2/02
CPC分类号： A61L27/54 , A61F2/86 , A61F2250/0067 , A61L31/16 , A61L2300/252 , A61L2300/414 , A61L2300/606
摘要： A medical device (10) includes a structure (12) adapted for introduction into a patient, the structure (12) being formed of a preferably non-porous base material (14) having a roughened or textured surface (16). The structure (12) is conveniently configured as a vascular stent with a base material (14) of stainless steel, nitinol or another suitable material. The medical device (10) also includes a layer (18) of a bioactive material posited directly upon the roughened or textured surface (16) of the base material (14) of the structure (12). The surface (16) of the base material (14) is roughened or textured by etching or by abrasion with sodium bicarbonate or another suitable grit. A preferred roughened or textured surface (16) is thought to have a mean surface roughness of about 10 μin. (about 250 nm) and a surface roughness range between about 1 μin. and about 100 μin. (about 25 nm and about 2.5 μm). The particularly preferred use of sodium bicarbonate as the abrasive to provide roughness or texture to the surface (16) of the base material (14) of the structure (12) is additionally advantageous in the low toxicity of the sodium bicarbonate to production workers, the ease of product and waste cleanup, and the biocompatibility of any residual sodium bicarbonate.
摘要翻译：医疗装置（10）包括适于引入患者的结构（12），所述结构（12）由具有粗糙或纹理表面（16）的优选无孔基材（14）形成。结构（12）方便地构造为具有不锈钢，镍钛诺或其它合适材料的基础材料（14）的血管支架。医疗装置（10）还包括直接位于结构（12）的基底材料（14）的粗糙或纹理表面（16）上的生物活性材料层（18）。基体材料（14）的表面（16）通过蚀刻或用碳酸氢钠或另一种适当的砂粒磨损而粗糙化或纹理化。优选的粗糙或纹理表面（16）被认为具有约10μin的平均表面粗糙度。（约250nm），表面粗糙度介于约1μM之间。约100多个。（约25nm和约2.5μm）。特别优选使用碳酸氢钠作为研磨剂以对结构（12）的基础材料（14）的表面（16）提供粗糙度或织构，另外在碳酸氢钠对生产工人的低毒性方面也是有利的，易于产品和废物清理，以及任何残留碳酸氢钠的生物相容性。

50. 发明授权

US06299604B1 Coated implantable medical device 有权
标题翻译：涂层可植入医疗器械
公开(公告)号：US06299604B1
公开(公告)日：2001-10-09
申请号：US09378541
申请日：1999-08-20
申请人： Anthony O. Ragheb , Brian L. Bates , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
发明人： Anthony O. Ragheb , Brian L. Bates , Neal E. Fearnot , Thomas G. Kozma , William D. Voorhees, III
IPC分类号： A61M532
CPC分类号： A61L29/085 , A61F2250/0068 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/608 , A61L2420/08 , H01L2924/3025 , C08L65/04 , H01L2924/00
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer is includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。此外，至少一个多孔层20可以位于生物活性材料层18上，其中多孔层包括聚合物并且提供通过其中的生物活性材料的受控释放。优选地，结构12是冠状动脉支架。多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

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