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41. 发明申请

US20100076063A1 GENETIC MODIFICATION OF TARGETED REGIONS OF THE CARDIAC CONDUCTION SYSTEM 有权
标题翻译：心脏导管系统目标区域的遗传修饰
公开(公告)号：US20100076063A1
公开(公告)日：2010-03-25
申请号：US12578198
申请日：2009-10-13
申请人： Vinod Sharma , Walter H. Olson
发明人： Vinod Sharma , Walter H. Olson
IPC分类号： A61K31/7088 , A61P9/10
CPC分类号： C07K14/705 , A61K38/00 , A61K38/177
摘要： Disclosed are compositions, methods and systems for preventing or treating cardiac dysfunction, particularly cardiac pacing dysfunction by genetic modification of cells of targeted regions of the cardiac conduction system. In particular, a bio-pacemaker composition is delivered to cardiac cells to increase the intrinsic pacemaking rate of the cells, wherein the bio-pacemaker composition increases expression of a channel or subunit thereof that produces funny current and a T-type Ca2+ channel or subunit thereof, and expresses one or more molecules that suppresses the expression of the wild type potassium channel.
摘要翻译：公开了用于预防或治疗心脏功能障碍的组合物，方法和系统，特别是心脏起搏功能障碍，通过心脏传导系统的靶向区域的细胞的遗传修饰。特别地，将生物起搏器组合物递送到心脏细胞以增加细胞的固有起搏速率，其中生物起搏器组合物增加产生滑稽电流的通道或其亚基的表达，以及T型Ca 2+通道或亚基并表达抑制野生型钾通道表达的一种或多种分子。

42. 发明申请

US20100047915A1 IDENTIFYING PATIENTS AT RISK FOR LIFE THREATENING ARRHYTHMIAS 审中-公开
标题翻译：识别患有ARRHYTHMIAS生命危险的患者
公开(公告)号：US20100047915A1
公开(公告)日：2010-02-25
申请号：US12606173
申请日：2009-10-26
申请人： Orhan Soykan , Amy C. Dearking , Timothy H. Robinson , Walter H. Olson , Vinod Sharma
发明人： Orhan Soykan , Amy C. Dearking , Timothy H. Robinson , Walter H. Olson , Vinod Sharma
IPC分类号： G01N33/00
CPC分类号： G01N33/6893 , G01N2800/326
摘要： The invention is a method for identifying proteins associated with sudden cardiac death (SCD) and for assessing a patient's risk of SCD by determining the amount of one or more SCD-associated proteins in the patient. Typically, the patient submits a sample, such as a blood sample, which is tested for one or more SCD-associated proteins. Based upon the results of the tests, the patient's risk of SCD may be assessed.
摘要翻译：本发明是鉴定与心脏猝死相关的蛋白质（SCD）的方法，并且通过确定患者中一种或多种与SCD相关的蛋白质的量来评估患者的SCD风险。通常，患者提交样品，例如血液样品，其被测试一种或多种与SCD相关的蛋白质。根据测试结果，可以评估患者SCD的风险。

43. 发明授权

US07608458B2 Identifying patients at risk for life threatening arrhythmias 失效
标题翻译：识别处于危及生命的心律失常风险的患者
公开(公告)号：US07608458B2
公开(公告)日：2009-10-27
申请号：US11157549
申请日：2005-06-21
申请人： Orhan Soykan , Amy C. Dearking , Timothy H. Robinson , Walter H. Olson , Vinod Sharma
发明人： Orhan Soykan , Amy C. Dearking , Timothy H. Robinson , Walter H. Olson , Vinod Sharma
IPC分类号： G01N33/00
CPC分类号： G01N33/6893 , G01N2800/326
摘要： The invention is a method for identifying proteins associated with sudden cardiac death (SCD) and for assessing a patient's risk of SCD by determining the amount of one or more SCD-associated proteins in the patient. Typically, the patient submits a sample, such as a blood sample, which is tested for one or more SCD-associated proteins. Based upon the results of the tests, the patient's risk of SCD may be assessed.
摘要翻译：本发明是鉴定与心脏猝死相关的蛋白质（SCD）的方法，并且通过确定患者中一种或多种与SCD相关的蛋白质的量来评估患者的SCD风险。通常，患者提交样品，例如血液样品，其被测试一种或多种与SCD相关的蛋白质。根据测试结果，可以评估患者SCD的风险。

44. 发明授权

US07583468B2 Method and apparatus of dual stage servo control with dual control paths and decoupling feedback for track following in a hard disk drive 失效
标题翻译：具有双重控制路径的双级伺服控制方法和装置，以及硬盘驱动器中跟踪跟踪的去耦反馈
公开(公告)号：US07583468B2
公开(公告)日：2009-09-01
申请号：US11270940
申请日：2005-11-10
申请人： Vinod Sharma , Hyung Jai Lee , Dong Jun Lee
发明人： Vinod Sharma , Hyung Jai Lee , Dong Jun Lee
IPC分类号： G11B5/596
CPC分类号： G11B5/5552 , G11B5/596
摘要： A magnetic head follows a track in a hard disk drive as positioned by micro-actuator and voice coil motor. Embodiments operate two control paths. The micro-actuator control path generates a version of micro-actuator control signal stimulating the micro-actuator. The voice coil motor control path generates a version of voice coil control signal, amplified based upon tuning gain to stimulate voice coil motor. A decoupling feedback filter decouples these control paths, using the micro-actuator control signal version. Either control path may include a notch filter. A track following command, with PES removed, directs the micro-actuator control. The servo-controller may digitally support the invention, which may include the servo-controller program system. An implementation may be optimized within a hard disk drive, possibly as part of the manufacturing process. The hard disk drive is a product of that process.
摘要翻译：磁头跟随由微型致动器和音圈电机定位的硬盘驱动器中的轨道。实施例操作两个控制路径。微致动器控制路径产生刺激微致动器的微致动器控制信号的形式。音圈电机控制路径产生一个版本的音圈控制信号，根据调谐增益放大，以刺激音圈电机。去耦反馈滤波器使用微执行器控制信号版本解耦这些控制路径。控制路径可以包括陷波滤波器。一个跟踪命令，取消了PES，指示微执行器控制。伺服控制器可以数字支持本发明，其可以包括伺服控制器程序系统。可以在硬盘驱动器内优化实现，可能是制造过程的一部分。硬盘驱动器是该进程的产物。

45. 发明授权

US07415307B2 Ischemia detection based on cardiac conduction time 有权
标题翻译：基于心脏传导时间的缺血检测
公开(公告)号：US07415307B2
公开(公告)日：2008-08-19
申请号：US10284900
申请日：2002-10-31
申请人： Vinod Sharma , Walter H. Olson
发明人： Vinod Sharma , Walter H. Olson
IPC分类号： A61N1/00
CPC分类号： A61B5/05 , A61B5/7203 , A61N1/362
摘要： Methods and process for detection of myocardial ischemia involve detection and analysis of changes in electrical conduction velocity within the heart to monitor changes in the condition of the cardiac muscle and indicate possible ischemia. Conduction velocity slows considerably when oxygen supply to the heart is reduced. Analysis of electrical conduction velocity can be used to verify the occurrence of myocardial ischemia in a more reliable manner. Changes in conduction velocity may be monitored based on conduction time between electrodes positioned in the left and right ventricles of the heart. The electrodes may be endocardial or epicardial electrodes. In general, the techniques may involve launching a stimulation waveform at one electrode and sensing a local cardiac depolarization at another electrode to assess conduction time.
摘要翻译：用于检测心肌缺血的方法和过程涉及检测和分析心脏内电传导速度的变化，以监测心肌状况的变化并指示可能的缺血。当心脏供氧减少时，传导速度显着减慢。电传导速度分析可以更可靠地验证心肌缺血的发生。可以基于位于心脏左心室和右心室的电极之间的传导时间来监测传导速度的变化。电极可以是心内膜或心外膜电极。通常，这些技术可以涉及在一个电极处发射刺激波形并感测另一个电极处的局部心脏去极化以评估传导时间。

46. 发明申请

US20080103537A1 ELECTRONIC AND BIOLOGICAL PACEMAKER SYSTEMS 有权
标题翻译：电子与生物学系统
公开(公告)号：US20080103537A1
公开(公告)日：2008-05-01
申请号：US11554770
申请日：2006-10-31
申请人： Daniel C. Sigg , Timothy G. Laske , Vinod Sharma , Orhan Soykan
发明人： Daniel C. Sigg , Timothy G. Laske , Vinod Sharma , Orhan Soykan
IPC分类号： A61N1/00
CPC分类号： A61N1/362 , A61N1/3627
摘要： Heart pacing systems include at least one electronic or biological pacemaker as a primary pacemaker, and at least one electronic or biological pacemaker as a backup pacemaker. When implanted, the primary pacemaker(s) produce primary pacing stimuli that modulate cardiac function. The backup pacemaker(s) provide backup pacing stimuli when the electronic pacemaker is unable to modulate cardiac function at the predetermined pacing rate. The heart pacing systems are implemented by implantation in regions where they can provide pacing stimuli to cardiac tissue.
摘要翻译：心脏起搏系统包括至少一个电子或生物起搏器作为主要起搏器，以及至少一个电子或生物起搏器作为备用起搏器。当植入时，主起搏器产生调节心脏功能的主要起搏刺激。当电子起搏器不能以预定起搏速度调节心脏功能时，备用起搏器提供备用起搏刺激。心脏起搏系统通过植入在可以为心脏组织提供起搏刺激的区域中实现。

47. 发明授权

US07336436B2 Head gimbal assemblies for very low flying height heads with optional micro-actuators in a hard disk drive 失效
标题翻译：用于非常低飞行高度头的头万向节组件，在硬盘驱动器中具有可选的微执行器
公开(公告)号：US07336436B2
公开(公告)日：2008-02-26
申请号：US10903730
申请日：2004-07-29
申请人： Vinod Sharma , Haesung Kwon , Hyung Jai Lee
发明人： Vinod Sharma , Haesung Kwon , Hyung Jai Lee
IPC分类号： G11B5/60 , G11B21/21
CPC分类号： G11B5/4826 , G11B5/4853 , G11B5/486 , G11B5/5552 , G11B5/58 , Y10T29/49025
摘要： Head gimbal assembly (HGA) may include a piezo layer mechanically coupled with the slider or include a piezo element mechanically coupled by the flexure to the slider top near the read-write head. A bridge flex circuit is included, providing a piezo-control bundle to at least one piezo layer lead. A flex circuit assembly may further provide a piezo control bundle, shared with piezo control bundles for multiple read-write heads. HGA may include a micro-actuator to position read-write head near track on accessed, rotating disk surface. Flex circuit assembly may provide a source control bundle, shared with the micro-actuator control bundles for multiple read-write heads. When accessing, all micro-actuators perform same positioning action, insuring proper positioning of read-write head. This applies to both co-located and non co-located micro-actuators. Wire bundles may include one or two active signal wires. Voice coil actuators and hard disk drives, and their manufacture, are included.
摘要翻译：头部万向节组件（HGA）可以包括与滑块机械耦合的压电层，或者包括通过挠性机构耦合到读写头附近的滑块顶部的压电元件。包括桥梁柔性电路，为至少一个压电层引线提供压电控制束。柔性电路组件还可以提供与用于多个读写头的压电控制束共享的压电控制束。 HGA可以包括微致动器以将读写头靠近所访问的旋转盘表面上的轨迹。 Flex电路组件可以提供与多个读写头的微执行器控制束共享的源控制束。当访问时，所有微执行器执行相同的定位动作，确保读写头的正确定位。这适用于同位置和非共定位微致动器。电线束可以包括一个或两个有源信号线。包括音圈执行器和硬盘驱动器及其制造。

48. 发明申请

US20070263314A1 Apparatus and method for head gimbal assembly sharing power to slider amplifier and micro-actuator in a hard disk drive 有权
标题翻译：用于磁头万向节组件的装置和方法，其与滑块放大器和微型致动器在硬盘驱动器中共享
公开(公告)号：US20070263314A1
公开(公告)日：2007-11-15
申请号：US11482640
申请日：2006-07-06
申请人： Brian D. Strom , Na Young Kim , Sung Chang Lee , Vinod Sharma , Joseph Chang
发明人： Brian D. Strom , Na Young Kim , Sung Chang Lee , Vinod Sharma , Joseph Chang
IPC分类号： G11B21/02 , G11B5/596 , G11B21/24
CPC分类号： G11B5/4826 , G11B5/3967 , G11B5/4853 , G11B5/4873 , G11B5/5556 , G11B5/6005
摘要： The head gimbal assembly includes a slider and a micro-actuator assembly sharing power for the micro-actuator assembly to aid in positioning the slider and for an amplifier included in the slider to generate an amplified read signal when the slider read accesses data on a rotating disk surface included in a hard disk drive. The slider includes a read-write head providing a read differential signal pair to an amplifier to generate an amplified read signal reported when read accessing a rotating disk surface near the slider, which includes a read head employing a spin valve or employing a tunneling valve. Hard disk drive including a head stack assembly, which includes at least one of the head gimbal assemblies. Manufacturing the head gimbal assembly, the head stack assembly, and the hard disk drive, as well as these items as products of the invention's manufacturing processes.
摘要翻译：头万向架组件包括滑动器和微致动器组件，该微致动器组件用于微致动器组件的功率，以帮助定位滑动器，并且对于包括在滑动器中的放大器，当滑块读取访问旋转的数据时产生放大的读取信号磁盘表面包含在硬盘驱动器中。该滑动器包括读取头，该读写头向放大器提供读取的差分信号对以产生当读取访问滑块附近的旋转盘表面时报告的放大的读取信号，该读取信号包括采用自旋阀或采用隧道阀的读取头。包括头堆叠组件的硬盘驱动器，其包括头万向架组件中的至少一个。制造头万向架组件，磁头组组件和硬盘驱动器，以及作为本发明制造工艺的产品的这些项目。

49. 发明授权

US07248441B2 Disk drive actuator parking method using impact rebound crash stop with bias tab and pusher and crash stop faces 失效
标题翻译：磁盘驱动器执行器停车方法使用冲击反弹碰撞停止，带有偏压片和推动器和碰撞停止面
公开(公告)号：US07248441B2
公开(公告)日：2007-07-24
申请号：US10880063
申请日：2004-06-28
申请人： Joseph Chang , Ron Kirkish , Vinod Sharma , Frank I. Morris , Bipin V. Gami
发明人： Joseph Chang , Ron Kirkish , Vinod Sharma , Frank I. Morris , Bipin V. Gami
IPC分类号： G11B5/54 , G11B21/22
CPC分类号： G11B21/22 , G11B5/54 , Y10T29/49025 , Y10T29/49032
摘要： The invention includes an impact rebound crash stop pivoting about a pivot between the top and bottom yoke of an actuator magnet assembly. The impact rebound crash stop includes a latch bias tab magnetically attracted to the voice coil magnet when it is near. The invention further includes a proximity latch allowing the actuator to stay on the ramp when not in use. The invention includes the operation of actuator arms embedding part of the magnetic proximity latch, actuators, and disk drives using the crash stop and proximity latch.
摘要翻译：本发明包括围绕致动器磁体组件的顶部和底部轭之间的枢轴枢转的冲击回弹碰撞停止。冲击反弹碰撞停止包括在靠近音圈磁铁时磁性吸引的闩锁偏置片。本发明还包括允许致动器在不使用时停留在斜坡上的接近闩锁。本发明包括使用碰撞停止和接近闩锁嵌入磁接近闩锁，致动器和磁盘驱动器的一部分的致动器臂的操作。

50. 发明授权

US07012785B2 Method and apparatus for head slider and suspension reducing air flow turbulence about the slider when accessing a rotating disk in a disk drive 失效
标题翻译：用于磁头滑块和悬架的方法和装置，当访问磁盘驱动器中的旋转盘时，减少关于滑块的气流湍流
公开(公告)号：US07012785B2
公开(公告)日：2006-03-14
申请号：US10266539
申请日：2002-10-07
申请人： Vinod Sharma , Joseph Chang , Debasis Baral
发明人： Vinod Sharma , Joseph Chang , Debasis Baral
IPC分类号： G11B5/60
CPC分类号： G11B5/6005 , G11B5/6082
摘要： The invention includes head gimbal assemblies, actuators, and disk drives containing at least one airfoil boundary reducing air flow turbulence about a slider induced by said head gimbal assembly accessing a rotating disk surface.
摘要翻译：本发明包括头万向架组件，致动器和磁盘驱动器，其包含至少一个翼型边界，以减少由所述头部万向架组件接触到旋转盘表面而引起的滑块的气流湍流。

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