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41. 发明授权

US06281011B1 Methods and applications for efficient genetic suppressor elements 失效
标题翻译：高效遗传抑制因子的方法与应用
公开(公告)号：US06281011B1
公开(公告)日：2001-08-28
申请号：US09561844
申请日：2000-04-28
申请人： Igor B. Roninson , Tatyana Holzmayer , Choi Kyunghee , Andrei Gudkov
发明人： Igor B. Roninson , Tatyana Holzmayer , Choi Kyunghee , Andrei Gudkov
IPC分类号： C12N508
CPC分类号： C12N15/1079 , C12N15/1051 , C12N15/1072 , C12N15/1082 , C12N15/63 , C12N15/67 , C12Q1/6811 , C40B40/06 , C40B40/08 , C40B50/06
摘要： Methods for isolating and identifying genetic elements that are capable of inhibiting gene function are disclosed, as well as genetic elements isolated or identified according to the method of the invention and host cells modified by genetic modification using genetic suppressor elements according to the invention.
摘要翻译：公开了分离和鉴定能够抑制基因功能的遗传元件的方法，以及根据本发明的方法分离或鉴定的遗传元件和使用根据本发明的遗传抑制因子通过遗传修饰修饰的宿主细胞。

42. 发明授权

US6060244A Genes and genetic elements associated with sensitivity to chemotherapeutic drugs 失效
标题翻译：与化疗药物敏感相关的基因和遗传因素
公开(公告)号：US6060244A
公开(公告)日：2000-05-09
申请号：US929208
申请日：1997-09-09
申请人： Igor B. Roninson , Andrei Gudkov
发明人： Igor B. Roninson , Andrei Gudkov
IPC分类号： A61K38/00 , C07K14/47 , C12N9/90 , C12N15/10 , C12N15/113 , C12N15/67 , G01N33/574 , C12Q1/68
CPC分类号： C07K14/4703 , C12N15/1034 , C12N15/113 , C12N15/1137 , C12N15/1138 , C12N15/67 , C12N9/90 , C12Y599/01003 , G01N33/574 , A61K38/00 , C12N2310/18 , C12N2310/321 , G01N2800/44
摘要： The invention provides genetic suppressor elements that confer upon a cell resistance to one or more chemotherapeutic drug, methods for identifying and obtaining such elements, and methods of using such elements. The invention also provides cloned genes associated with sensitivity to chemotherapeutic drugs.
摘要翻译：本发明提供赋予细胞对一种或多种化疗药物耐药性的遗传抑制因子，用于鉴定和获得这些元件的方法以及使用这些元件的方法。本发明还提供与化疗药物敏感性相关的克隆基因。

43. 发明授权

US5994088A Methods and reagents for preparing and using immunological agents specific for P-glycoprotein 失效
公开(公告)号：US5994088A
公开(公告)日：1999-11-30
申请号：US752447
申请日：1996-11-15
申请人： Eugene Mechetner , Igor B. Roninson
发明人： Eugene Mechetner , Igor B. Roninson
IPC分类号： A61K38/00 , C07K16/28 , C12N15/06 , C12P21/04 , G01N33/50 , G01N33/569 , G01N33/53 , C12N5/20
CPC分类号： G01N33/5094 , C07K16/28 , G01N33/5008 , G01N33/5011 , G01N33/5014 , G01N33/56972 , A61K38/00 , C07K2319/00 , C12N2799/027 , G01N2333/705 , G01N2333/70596
摘要： This invention relates to immunological reagents and methods specific for a mammalian, transmembrane protein termed Pgp, having a non-specific efflux pump activity established in the art as being a component of clinically-important multidrug resistance in cancer patients undergoing chemotherapy. The invention provides methods for developing and using immunological reagents specific for certain mutant forms of Pgp and for wild-type Pgp in a conformation associated with substrate binding or in the presence of ATP depleting agents. The invention also provides improved methods for purifying hematopoietic stems cells expressing Pgp and diagnostic and therapeutic methods for cancer cells expressing Pgp.

44. 发明授权

US5972598A Methods for preventing multidrug resistance in cancer cells 失效
标题翻译：预防癌细胞多药耐药的方法
公开(公告)号：US5972598A
公开(公告)日：1999-10-26
申请号：US370724
申请日：1995-01-10
申请人： Preet Chaudhary , Alexander A. Shtil , Igor B. Roninson
发明人： Preet Chaudhary , Alexander A. Shtil , Igor B. Roninson
IPC分类号： C07H15/232 , A61K20060101 , A61K31/00 , A61K31/495 , A61K31/55 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61K38/00 , A61K45/00 , A61K45/06 , A61P35/00 , B05B7/06 , C12Q1/68 , G01N33/50
CPC分类号： A61K31/00 , A61K31/495 , A61K31/55 , A61K38/005 , A61K45/06 , B05B7/066 , C12Q1/6897 , G01N33/5011
摘要： This invention is directed to methods for preventing the emergence of multidrug resistance in tumor cells during cancer chemotherapy. In particular, it relates to the use of protein kinase inhibitors to prevent the induction of expression of the multidrug resistance gene (MDR1) encoding P-glycoprotein by chemotherapeutic drugs. MDR1 expression, which results in tumor cell resistance to subsequent treatment with certain chemotherapeutic drugs, is shown herein to be induced in response to treatment with various cytotoxic agents, including such agents that are and are not substrates for P-glycoprotein-mediated efflux from cancer cells. Inhibitors of protein kinases, in particular, protein kinase C, are shown herein to suppress this cellular response. In addition, such protein kinase inhibitors are also shown herein to inhibit expression of a gene encoding a multidrug resistance-associated protein (the MRP gene). The instant invention provides methods for using such protein kinase inhibitors to both suppress induction of MDR1 gene expression by cytotoxic drugs, and to inhibit expression of MRP. The invention also provides methods for identifying protein kinase inhibitors that have either or both of these effects on MDR1 and MRP expression. Thus, the invention provides useful methods and reagents for preventing the emergence of multidrug resistance in tumor cells treated with cytotoxic and chemotherapeutic drugs in cancer patients undergoing chemotherapy, when such protein kinase inhibitors are administered prior to or simultaneous with cytotoxic drug treatment in such individuals.
摘要翻译：本发明涉及用于预防癌症化疗期间肿瘤细胞中多药耐药性出现的方法。特别涉及使用蛋白激酶抑制剂来预防化疗药物对编码P-糖蛋白的多药耐药基因（MDR1）的表达的诱导。本文显示导致对某些化学治疗药物随后治疗的肿瘤细胞耐药性的MDR1表达，是响应于用各种细胞毒剂（包括这些并不是P糖蛋白介导的癌症流出的底物）的药物而被诱导的细胞。本文显示蛋白激酶，特别是蛋白激酶C的抑制剂以抑制这种细胞反应。此外，本文还显示了这种蛋白激酶抑制剂抑制编码多药耐药相关蛋白（MRP基因）的基因的表达。本发明提供了使用这种蛋白激酶抑制剂抑制细胞毒性药物诱导MDR1基因表达并抑制MRP表达的方法。本发明还提供用于鉴定具有这些对MDR1和MRP表达的这些作用中的一种或两种的蛋白激酶抑制剂的方法。因此，本发明提供了有用的方法和试剂，用于在这种个体的细胞毒性药物治疗之前或同时施用这种蛋白激酶抑制剂时，用于预防在接受化疗的癌症患者中用细胞毒性和化学治疗药物治疗的肿瘤细胞中多药耐药性的出现。

45. 发明授权

US5891654A Purification and manipulation of bone marrow and blood cells on the basis of P-glycoprotein expression 失效
公开(公告)号：US5891654A
公开(公告)日：1999-04-06
申请号：US483290
申请日：1995-06-07
申请人： Preet M. Chaudhary , Igor B. Roninson
发明人： Preet M. Chaudhary , Igor B. Roninson
IPC分类号： G01N33/50 , G01N33/569 , G01N33/567 , A01N1/02 , G01N33/53 , G01N37/00
CPC分类号： G01N33/5094 , G01N33/56972 , G01N2333/705 , G01N2333/70596 , Y10T436/13
摘要： The invention provides methods for purifying or manipulating bone marrow and blood cells based upon P-glycoprotein expression. The methods rely upon immunopurification procedures or upon differential accumulation of materials subject to P-glycoprotein mediated efflux.

46. 发明授权

US5866327A Association of kinensin with sensitivity to chemotherapeutic drugs 失效
标题翻译：激素与化疗药物敏感性的关系
公开(公告)号：US5866327A
公开(公告)日：1999-02-02
申请号：US486382
申请日：1995-06-07
申请人： Andrei Gudkov , Igor B. Roninson
发明人： Andrei Gudkov , Igor B. Roninson
IPC分类号： A61K38/00 , C07K14/47 , C12N9/90 , C12N15/10 , C12N15/113 , C12N15/67 , C12Q1/68 , C07H21/00 , C12N5/16
CPC分类号： C12N15/113 , C07K14/47 , C12N15/1034 , C12N15/1137 , C12N15/1138 , C12N15/67 , C12N9/90 , C12Q1/6853 , C12Q1/6855 , C12Q1/6886 , C12Y599/01003 , A61K38/00 , C12N2310/18 , C12N2310/321 , C12Q2600/106 , G01N2800/44 , Y10T436/143333
摘要： The invention provides genetic suppressor elements that confer upon a cell resistance to one or more chemotherapeutic drug, methods for identifying and obtaining such elements, and methods of using such elements. The invention also provides cloned genes associated with sensitivity to chemotherapeutic drugs, particularly a cloned human kinesin heavy chain gene involved in resistance to DNA damaging agents.
摘要翻译：本发明提供赋予细胞对一种或多种化疗药物耐药性的遗传抑制因子，用于鉴定和获得这些元件的方法以及使用这些元件的方法。本发明还提供了与对化学治疗药物的敏感性相关的克隆基因，特别是涉及DNA损伤剂抗性的克隆人驱动蛋白重链基因。

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