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41. 发明授权

US07083953B2 Method for the production of p-Hydrozybenzoate in species of Pseudomonas and Agrobacterium 失效
标题翻译：在假单胞菌和农杆菌物种中生产对羟基苯甲酸酯的方法
公开(公告)号：US07083953B2
公开(公告)日：2006-08-01
申请号：US10464952
申请日：2003-06-19
申请人： Arie Ben-Bassat , Monica Cattermole , Anthony A. Gatenby , Katharine J. Gibson , M. Isabel Ramos-Gonzalez , Juan L. Ramos , Sima Sariaslani
发明人： Arie Ben-Bassat , Monica Cattermole , Anthony A. Gatenby , Katharine J. Gibson , M. Isabel Ramos-Gonzalez , Juan L. Ramos , Sima Sariaslani
IPC分类号： C12P17/14 , C12P7/00 , C12N15/00 , C12N5/00 , C12N9/00
CPC分类号： C12P7/62 , C12N15/52 , C12P7/42
摘要： Bacterial strains transformed with the pcu genes are useful for the production of para-hydroxybenzoate (PHBA). Applicant has provided the p-cresol utilizing (pcu) and tmoX gene sequences from Pseudomonas mendocina KR-1, the proteins encoded by these sequences, recombinant plasmids containing such sequences, and bacterial host cells containing such plasmids or integrated sequences. Method for the use of these materials to produce PHBA are also disclosed.
摘要翻译：用pcu基因转化的细菌菌株可用于生产对羟基苯甲酸酯（PHBA）。申请人提供了使用来自假单胞菌KR-1的对甲酚（pcu）和tmoX基因序列，由这些序列编码的蛋白质，含有此类序列的重组质粒和含有此类质粒或整合序列的细菌宿主细胞。还公开了使用这些材料制备PHBA的方法。

42. 发明授权

US06368804B1 Method for stabilizing nitrilase activity and preserving microbial cells 有权
标题翻译：稳定腈水解酶活性和保存微生物细胞的方法
公开(公告)号：US06368804B1
公开(公告)日：2002-04-09
申请号：US09614914
申请日：2000-07-12
申请人： Arie Ben-Bassat , Robert Dicosimo , Robert Donald Fallon
发明人： Arie Ben-Bassat , Robert Dicosimo , Robert Donald Fallon
IPC分类号： C12N120
CPC分类号： C12N11/10 , C12N1/04 , C12N9/78 , C12N9/96 , C12N11/04 , C12N11/08 , C12P13/00
摘要： A method for preserving immobilized or unimmobilized microbial cells having nitrilase activity and for stabilizing the nitrilase activity of unimmobilized or immobilized microbial cells has been developed. The unimmobilized or immobilized microbial cells are stored in an aqueous solution containing from about 0.10 M to the saturation concentration of an inorganic salt of bicarbonate or carbonate, including ammonium, sodium and potassium salts of bicarbonate or carbonate. Aqueous suspensions containing at least 100 mM bicarbonate or carbonate limit microbial contamination of the stored enzyme catalyst, as well as stabilize the desired nitrilase activity of the uninmmobilized or immobilized cells. Microorganisms which are characterized by an nitrilase activity and are stabilized and preserved by this method include Acidovorax facilis 72-PF-15 (ATCC 55747), Acidovorax facilis 72-PF-17 (ATCC 55745), Acidovorax facilis 72W (ATCC 55746), and transformed microbial cells having nitrilase activity, preferably E. coli SS1001 (ATCC PTA-1177) which is transformed with Acidovorax facilis 72W nitrilase activity.
摘要翻译：已经开发了用于保存具有腈水解酶活性的固定或未固化的微生物细胞并稳定未固定或固定的微生物细胞的腈水解酶活性的方法。将未固定或固定的微生物细胞储存在含有约0.10M的水溶液中，使饱和浓度为碳酸氢盐或碳酸盐的无机盐，包括碳酸氢盐或碳酸盐的铵，钠和钾盐。含有至少100mM碳酸氢盐或碳酸氢盐的水性悬浮液限制所储存的酶催化剂的微生物污染物，以及稳定未固定化或固定的细胞的所需腈水解酶活性。其特征在于腈水解酶活性并通过该方法稳定和保存的微生物包括Acidovorax facilis 72-PF-15（ATCC 55747），Acidovorax facilis 72-PF-17（ATCC 55745），Acidovorax facilis 72W（ATCC 55746）和转化的具有腈水解酶活性的微生物细胞，优选用Acidovorax facilis 72W腈水解酶活性转化的大肠杆菌SS1001（ATCC PTA-1177）。

43. 发明授权

US5811381A Cellulase compositions and methods of use 失效
标题翻译：纤维素酶组合物和使用方法
公开(公告)号：US5811381A
公开(公告)日：1998-09-22
申请号：US731170
申请日：1996-10-10
申请人： Mark Aaron Emalfarb , Arie Ben-Bassat , Richard P. Burlingame , Vladimir Mikhaylovich Chernoglazov , Oleg Nicolaevich Okounev , Philip T. Olson , Arkady Panteleimonovich Sinitsyn , Irina Vladimirovna Solovjeva
发明人： Mark Aaron Emalfarb , Arie Ben-Bassat , Richard P. Burlingame , Vladimir Mikhaylovich Chernoglazov , Oleg Nicolaevich Okounev , Philip T. Olson , Arkady Panteleimonovich Sinitsyn , Irina Vladimirovna Solovjeva
IPC分类号： C12N15/09 , C07K14/37 , C11D3/386 , C11D11/00 , C12N1/14 , C12N1/15 , C12N1/19 , C12N1/20 , C12N1/21 , C12N5/10 , C12N9/24 , C12N9/42 , C12N15/56 , C12Q1/68 , C12R1/645 , D06L3/11 , D06M16/00 , D06P5/02 , D06P5/15 , D21C9/10 , A61K38/47
CPC分类号： D06P5/158 , C11D11/0017 , C11D3/38645 , C12N9/2437 , C12R1/645 , C12Y302/01004 , D06L3/11 , D06M16/003 , D06P5/02 , D06M2101/06
摘要： The subject invention relates to novel compositions of neutral and/or alkaline cellulase and methods for obtaining neutral and/or alkaline cellulase compositions from Chrysosporium cultures, in particular Chrysosporium lucknowense. This invention also provides mutants and methods of generating mutants of Chrysosporium capable of producing neutral and/or alkaline cellulose. This invention also relates to the genes encoding the enzymes comprising the neutral and/or alkaline cellulase composition. In addition, this invention provides methods of culturing Chrysosporium to produce neutral and/or alkaline cellulases. The neutral and/or alkaline cellulase compositions of the subject invention can be used in a variety of processes including stone washing of clothing, detergent processes, deinking and biobleaching of paper & pulp and treatment of waste streams.
摘要翻译：本发明涉及中和和/或碱性纤维素酶的新型组合物和从Chrysosporium培养物，特别是Chrysosporium lucknowense获得中性和/或碱性纤维素酶组合物的方法。本发明还提供了能产生中性和/或碱性纤维素的Chrysosporium突变体的突变体和方法。本发明还涉及编码包含中性和/或碱性纤维素酶组合物的酶的基因。此外，本发明提供培养Chrysosporium以产生中性和/或碱性纤维素酶的方法。本发明的中性和/或碱性纤维素酶组合物可以用于各种工艺，包括洗衣服，洗涤剂工艺，纸和纸浆的脱墨和生物漂白以及废物流的处理。

44. 发明授权

US5487989A Ethanol production by recombinant hosts 失效
公开(公告)号：US5487989A
公开(公告)日：1996-01-30
申请号：US946290
申请日：1992-09-17
申请人： David E. Fowler , Philip G. Horton , Arie Ben-Bassat
发明人： David E. Fowler , Philip G. Horton , Arie Ben-Bassat
IPC分类号： C12M1/02 , C12N1/21 , C12N9/04 , C12N9/24 , C12N9/88 , C12N15/52 , C12P7/06 , C12P7/10 , G06T1/00 , C12N9/42 , C12P7/14
CPC分类号： C12N9/0006 , C12N15/52 , C12N9/2437 , C12N9/248 , C12N9/88 , C12P7/065 , C12P7/10 , C12Y302/01004 , C12Y302/01037 , G06T1/00 , Y02E50/16 , Y02E50/17 , Y10S435/852
摘要： Novel plasmids comprising genes which code for the alcohol dehydrogenase and pyruvate decarboxylase are described. Also described are recombinant hosts which have been transformed with genes coding for alcohol dehydrogenase and pyruvate. By virtue of their transformation with these genes, the recombinant hosts are capable of producing significant amounts of ethanol as a fermentation product. Also disclosed are methods for increasing the growth of recombinant hosts and methods for reducing the accumulation of undesirable metabolic products in the growth medium of these hosts. Also disclosed are recombinant host capable of producing significant amounts of ethanol as a fermentation product of oligosaccharides and plasmids comprising genes encoding polysaccharases, in addition to the genes described above which code for the alcohol dehydrogenase and pyruvate decarboxylase. Further, methods are described for producing ethanol from oligomeric feedstock using the recombinant hosts described above. Also provided is a method for enhancing the production of functional proteins in a recombinant host comprising overexpressing an adhB gene in the host. Further provided are process designs for fermenting oligosaccharide-containing biomass to ethanol.

45. 发明授权

US5114849A Protectants for microbial fermentation 失效
标题翻译：保护微生物发酵
公开(公告)号：US5114849A
公开(公告)日：1992-05-19
申请号：US604587
申请日：1990-10-26
申请人： Arie Ben-Bassat , Kent D. Coddington , Donald C. Johnson
发明人： Arie Ben-Bassat , Kent D. Coddington , Donald C. Johnson
IPC分类号： C12N1/20 , C08L101/16 , C12N1/21 , C12N1/38 , C12P1/00 , C12P19/04 , C12R1/02
CPC分类号： C12N1/38 , C12P19/04
摘要： The present invention provides an improved process for the production of microbial cellulose where a cellulose-producing organism is grown under agitated conditions in the presence of a polyacrylamide-containing polymer.
摘要翻译：本发明提供了生产微生物纤维素的改进方法，其中在聚丙烯酰胺聚合物存在下，在搅拌条件下生产纤维素生产生物。

46. 发明授权

US4870017A Bacterial methionine N-terminal peptidase 失效
标题翻译：细菌甲硫氨酸N端肽酶
公开(公告)号：US4870017A
公开(公告)日：1989-09-26
申请号：US778414
申请日：1985-09-20
申请人： Arie Ben-Bassat , Keith A. Bauer , Shing Chang , Sheng-Yung Chang
发明人： Arie Ben-Bassat , Keith A. Bauer , Shing Chang , Sheng-Yung Chang
IPC分类号： C12N15/09 , C07K14/195 , C07K14/41 , C07K14/415 , C07K14/435 , C07K14/55 , C07K16/00 , C12N1/20 , C12N9/48 , C12N15/57 , C12N15/70 , C12P21/02 , C12P21/06 , C12R1/19
CPC分类号： C12P21/02 , C07K14/415 , C07K14/55 , C12N15/70 , C12N9/48
摘要： Methods of obtaining N-terminal methionine-free proteins are described. The methods employ a novel enzyme, E. coli methionine aminopeptidase either in vitro or in vivo. For in vivo application, plasmid-borne DNA encoding the peptidase is transformed into a bacterial host which produces the desired protein.
摘要翻译：描述了获得N-末端不含甲硫氨酸的蛋白质的方法。该方法在体外或体内采用新型的酶，大肠杆菌甲硫氨酸氨基肽酶。对于体内应用，将编码肽酶的质粒携带的DNA转化成产生所需蛋白质的细菌宿主。

47. 发明授权

US4656132A Method of improving the yield of heterologous protein produced by cultivating recombinant bacteria 失效
标题翻译：提高培养重组细菌产生的异源蛋白质产量的方法
公开(公告)号：US4656132A
公开(公告)日：1987-04-07
申请号：US594250
申请日：1984-03-28
申请人： Arie Ben-Bassat , Glenn Dorin , Keith Bauer , Leo Lin
发明人： Arie Ben-Bassat , Glenn Dorin , Keith Bauer , Leo Lin
IPC分类号： C12N15/09 , A61K38/00 , A61K38/21 , C07K14/52 , C12N1/38 , C12N15/00 , C12P21/00 , C12P21/02 , C12R1/19
CPC分类号： C12N1/38 , C07K14/52
摘要： A method for improving the yield of heterologous protein such as IFN-.alpha., IFN-.beta., and IL-2, produced by recombinant bacteria by supplementing the nutrient medium in which the bacteria are grown with a water soluble alcohol and/or amino acid mixture during the terminal phase of the cultivation.
摘要翻译：通过用水溶性醇和/或氨基酸混合物补充细菌生长的营养培养基来提高由重组细菌产生的异源蛋白如IFN-α，IFN-β和IL-2的产量的方法在栽培的最后阶段。

48. 发明申请

US20130004479A1 ENZYMATIC PERACID GENERATION FORMULATION 有权
标题翻译：环保生产配方
公开(公告)号：US20130004479A1
公开(公告)日：2013-01-03
申请号：US13609504
申请日：2012-09-11
申请人： Robert Dicosimo , Arie Ben-Bassat , William R. Cahill , David George Dipietro , Eugenia Costa Hann , Mark S. Payne , Richard Alan Reynolds , Raymond Richard Zolandz
发明人： Robert Dicosimo , Arie Ben-Bassat , William R. Cahill , David George Dipietro , Eugenia Costa Hann , Mark S. Payne , Richard Alan Reynolds , Raymond Richard Zolandz
IPC分类号： D06L3/11 , C12S11/00 , C11D3/60 , C12S9/00 , A01N37/16 , A01P1/00
CPC分类号： C12N9/18 , A61L2/183 , A61L2/186 , A61L2/22 , A61L2202/24 , C11D3/06 , C11D3/10 , C11D3/201 , C11D3/2017 , C11D3/2044 , C11D3/2048 , C11D3/2068 , C11D3/2079 , C11D3/2082 , C11D3/2086 , C11D3/2093 , C11D3/221 , C11D3/226 , C11D3/32 , C11D3/361 , C11D3/38636 , C11D3/3947 , C11D17/041 , C12P7/40 , C12Y301/01001 , Y02E50/16
摘要： Disclosed herein are multi-component formulations for enzymatically producing aqueous solutions of peroxycarboxylic acids suitable for use in, e.g., disinfectant and/or bleaching applications. The multi-component peroxycarboxylic acid formulations comprise at least one carbohydrate esterase family 7 enzyme having perhydrolytic activity.
摘要翻译：本文公开了用于酶促生产适用于例如消毒剂和/或漂白应用的过氧羧酸的水溶液的多组分制剂。多组分过氧羧酸制剂包含至少一种具有过水解活性的碳水化合物酯酶家族7酶。

49. 发明授权

US08148314B2 Stabilization of perhydrolases 有权
公开(公告)号：US08148314B2
公开(公告)日：2012-04-03
申请号：US13213642
申请日：2011-08-19
申请人： Robert Dicosimo , Arie Ben-Bassat , Mark S. Payne , Raymond Richard Zolandz
发明人： Robert Dicosimo , Arie Ben-Bassat , Mark S. Payne , Raymond Richard Zolandz
IPC分类号： C12P7/40 , C12N9/00 , D06L1/02 , C11D3/386 , C07H21/04
CPC分类号： C12N9/18 , A61L2/183 , A61L2/186 , A61L2/22 , A61L2202/24 , C11D3/06 , C11D3/10 , C11D3/201 , C11D3/2017 , C11D3/2044 , C11D3/2048 , C11D3/2068 , C11D3/2079 , C11D3/2082 , C11D3/2086 , C11D3/2093 , C11D3/221 , C11D3/226 , C11D3/32 , C11D3/361 , C11D3/38636 , C11D3/3947 , C11D17/041 , C12P7/40 , C12Y301/01001 , Y02E50/16
摘要： Disclosed herein is a method for stabilization of the perhydrolase activity of the CE-7 esterase in a formulation with a carboxylic acid ester that employs the addition of a buffering agent, substantially undissolved, to the mixture of the CE-7 esterase and the carboxylic acid ester. Further, disinfectant and laundry care formulations comprising the peracids produced by the processes described herein are provided.

50. 发明授权

US08030038B2 Stabilization of perhydrolases 有权
标题翻译：过水解酶的稳定化
公开(公告)号：US08030038B2
公开(公告)日：2011-10-04
申请号：US12572086
申请日：2009-10-01
申请人： Robert DiCosimo , Arie Ben-Bassat , Mark S. Payne , Raymond Richard Zolandz
发明人： Robert DiCosimo , Arie Ben-Bassat , Mark S. Payne , Raymond Richard Zolandz
IPC分类号： C12P7/40 , C12N9/00 , D06L1/02 , C11D3/386 , C07H21/04
CPC分类号： C12N9/18 , A61L2/183 , A61L2/186 , A61L2/22 , A61L2202/24 , C11D3/06 , C11D3/10 , C11D3/201 , C11D3/2017 , C11D3/2044 , C11D3/2048 , C11D3/2068 , C11D3/2079 , C11D3/2082 , C11D3/2086 , C11D3/2093 , C11D3/221 , C11D3/226 , C11D3/32 , C11D3/361 , C11D3/38636 , C11D3/3947 , C11D17/041 , C12P7/40 , C12Y301/01001 , Y02E50/16
摘要： Disclosed herein is a method for stabilization of the perhydrolase activity of the CE-7 esterase in a formulation with a carboxylic acid ester that employs the addition of a buffering agent, substantially undissolved, to the mixture of the CE-7 esterase and the carboxylic acid ester. Further, disinfectant and laundry care formulations comprising the peracids produced by the processes described herein are provided.
摘要翻译：本文公开了一种在具有羧酸酯的制剂中稳定CE-7酯酶的过水解酶活性的方法，其使用向CE-7酯酶和羧酸的混合物中添加基本上未溶解的缓冲剂酯。此外，提供包含通过本文所述方法生产的过酸的消毒剂和衣物护理制剂。

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