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41. 发明申请

US20080139558A1 QUINOLONES USEFUL AS INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS 审中-公开
标题翻译：喹诺酮作为可诱导的氧化氮合酶抑制剂有用
公开(公告)号：US20080139558A1
公开(公告)日：2008-06-12
申请号：US11678572
申请日：2007-02-23
申请人： Nicholas D. Smith , Jeffrey R. Roppe , Celine Bonnefous , Joseph E. Payne , Hui Zhuang , Xiaohong Chen , Andrew K. Lindstrom , Sergio G. Duron , Christian A. Hassig , Stewart A. Noble
发明人： Nicholas D. Smith , Jeffrey R. Roppe , Celine Bonnefous , Joseph E. Payne , Hui Zhuang , Xiaohong Chen , Andrew K. Lindstrom , Sergio G. Duron , Christian A. Hassig , Stewart A. Noble
IPC分类号： A61K31/47 , A61K31/5377 , A61P11/06 , A61P17/04 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/14 , A61P29/02 , A61P3/10 , A61P31/00 , A61P31/12 , A61P31/22 , A61P37/00 , A61P37/08 , A61P9/10 , C07D215/227 , C07D295/00 , C07D471/04
CPC分类号： C07D405/12 , A61K31/4704 , A61K31/4709 , C07D215/227 , C07D401/06 , C07D401/12 , C07D409/12
摘要： The present invention relates to novel quinolones of Formula I that inhibit inducible NOS synthase together with methods of synthesizing and using the compounds including methods for inhibiting or modulating nitric oxide synthesis and/or lowering nitric oxide levels in a patient by administering the compounds for the treatment of disease.
摘要翻译：本发明涉及抑制诱导型NOS合酶的新型喹诺酮，以及通过给予治疗化合物来合成和使用包括抑制或调节一氧化氮合成和/或降低一氧化氮水平的方法的化合物的方法的疾病

42. 发明授权

US07273880B2 Selective NPY (Y5) antagonists 失效
标题翻译：选择性NPY（Y5）拮抗剂
公开(公告)号：US07273880B2
公开(公告)日：2007-09-25
申请号：US11040328
申请日：2005-01-20
申请人： Mohammad R. Marzabadi , Wai C. Wong , Stewart A. Noble , Yasuchika Yamaguchi
发明人： Mohammad R. Marzabadi , Wai C. Wong , Stewart A. Noble , Yasuchika Yamaguchi
IPC分类号： A61K31/426
CPC分类号： C07D277/60 , C07D277/42 , C07D417/12 , C07D513/04
摘要： This invention is directed to bicyclic and tricyclic compounds which are selective antagonists for NPY (Y5) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of a compound of this invention and a pharmaceutically acceptable carrier. The invention provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides the use of a compound of the invention for the preparation of a pharmaceutical composition for treating an abnormality, wherein the abnormality is alleviated by decreasing the activity of a human Y5 receptor.
摘要翻译：本发明涉及作为NPY（Y5）受体的选择性拮抗剂的双环和三环化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明提供通过将治疗有效量的本发明化合物和药学上可接受的载体组合而制备的药物组合物。本发明提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。本发明还提供了本发明化合物用于制备用于治疗异常的药物组合物的用途，其中所述异常通过降低人Y5受体的活性而减轻。

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