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41. 发明申请

WO2004006938A1 METHOD FOR REDUCING C-RECTIVE PROTEIN LEVELS WITH NON-ANTIBACTERIAL TETRACYCLINE FORMULATIONS 审中-公开
标题翻译：降低C-抗性蛋白质水平与非抗生素四肽制剂的方法
公开(公告)号：WO2004006938A1
公开(公告)日：2004-01-22
申请号：PCT/US2003/021740
申请日：2003-07-11
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , BROWN, David , GOLUB, Lorne, M. , LEE, Hsi-Ming , GREENWALD, Robert, A.
发明人： BROWN, David , GOLUB, Lorne, M. , LEE, Hsi-Ming , GREENWALD, Robert, A.
IPC分类号： A61K31/65
CPC分类号： A61K31/65
摘要： The present invention is for a method for decreasing C-reactive protein levels (CRP) in a mammal in need thereof. The method comprises administering an effective amount of a non-antibacterial tetracycline formulation, to the mammal. In one embodiment, the non-antibacterial tetracycline formulation is a non-antibacterial amount of an antibacterial tetracycline. In another embodiment, the non-antibacterial tetracycline formulation is a non-antibacterial tetracycline.
摘要翻译：本发明是用于降低有需要的哺乳动物中的C-反应蛋白水平（CRP）的方法。该方法包括向哺乳动物施用有效量的非抗菌四环素制剂。在一个实施方案中，非抗菌四环素制剂是非抗菌量的抗菌四环素。在另一个实施方案中，非抗菌四环素制剂是非抗菌四环素。

42. 发明申请

WO2003002111A1 INHALATION PARTICLES 审中-公开
标题翻译：吸入颗粒物
公开(公告)号：WO2003002111A1
公开(公告)日：2003-01-09
申请号：PCT/FI2002/000573
申请日：2002-06-28
申请人： ORION CORPORATION , WATANABE, Wiwik , AHONEN, Petri , KAUPPINEN, Esko , BROWN, David , JOKINIEMI, Jorma , MUTTONEN, Esa
发明人： WATANABE, Wiwik , AHONEN, Petri , KAUPPINEN, Esko , BROWN, David , JOKINIEMI, Jorma , MUTTONEN, Esa
IPC分类号： A61K31/12
CPC分类号： A61K9/0075 , A61K31/12
摘要： Crystalline particles of orazipone having a curved surface with a controlled roughness are useful e.g. for treating asthma, COPD and other respiratory diseases. The particles have a narrow particle size distribution, rough surfaces and an improved stability. The inhalation particles of the invention are particularly useful in the administration of a medicament by inhalation.
摘要翻译：具有受控粗糙度的曲面的奥氮平酮的结晶颗粒是有用的，例如用于治疗哮喘，COPD等呼吸系统疾病。颗粒具有窄的粒度分布，粗糙的表面和改进的稳定性。本发明的吸入颗粒特别可用于通过吸入给药药物。

43. 发明申请

WO2015127147A2 INHALATION DEVICE AND METHOD FOR INHALING POWDERS 审中-公开
标题翻译：用于吸入粉末的吸入装置和方法
公开(公告)号：WO2015127147A2
公开(公告)日：2015-08-27
申请号：PCT/US2015/016720
申请日：2015-02-20
申请人： BROWN, David
发明人： BROWN, David
CPC分类号： A61M15/0098 , A61M11/02 , A61M15/0003 , A61M15/003 , A61M15/0031 , A61M2202/064 , A61M2206/10 , A61M2209/06 , B05B11/062 , A61M2202/0007
摘要： The present invention discloses a method and device for dispersing powders and, in particular, to a method of dispersing inhaling powders in which a powder is positioned in a passage wherein the passage has one or more exits, one or more inlets and one or more obstructions to block the movement or to contain the powder within the device before use, whereupon a breaching pressure differential between the one or more exits and the one or more inlets of the passage is applied to breach the one or more obstructions so as to generate a flow through the passage which fully or partially aerosolizes the powder by means of the generated flow thus releasing a fully or partially aerosolized powder from the device.
摘要翻译：本发明公开了一种用于分散粉末的方法和装置，特别是一种分散吸入粉末的方法，其中粉末定位在通道中，其中通道具有一个或多个出口，一个或多个入口和一个或多个障碍物以阻止运动或在使用之前将粉末容纳在装置内，由此施加一个或多个出口与通道的一个或多个入口之间的破裂压力差以破坏一个或多个障碍物，从而产生流动通过通过所述通道，其通过产生的流完全或部分地雾化粉末，从而从装置释放完全或部分雾化的粉末。

44. 发明申请

WO2015066327A1 HYBRID FIBER/CU DISTRIBUTION POINT WITH EXTERNAL ONU-TO-DSL CONVERSION UNIT 审中-公开
标题翻译：具有外部ONU到DSL转换单元的混合光纤/ CU分配点
公开(公告)号：WO2015066327A1
公开(公告)日：2015-05-07
申请号：PCT/US2014/063155
申请日：2014-10-30
申请人： TYCO ELECTRONICS UK LTD , TYCO ELECTRONICS CORPORATION , TYCO ELECTRONICS RAYCHEM BVBA , BROWN, David , MATHER, David , SHADDOCK, Robert Neil , WEEKS, William Atley , FRANCKX, Joris , ERREYGERS, Jan Jozef Julia Maria
发明人： BROWN, David , MATHER, David , SHADDOCK, Robert Neil , WEEKS, William Atley , FRANCKX, Joris , ERREYGERS, Jan Jozef Julia Maria
IPC分类号： H04B10/29 , H04B10/25
CPC分类号： H04B10/2504 , G02B6/3817 , H04B10/27 , H04B10/272 , H04Q11/0067
摘要： A hybrid service terminal for use in a passive fiber optic network comprises a plurality of optical fiber connectors, each coupled to a respective optical fiber for receiving downstream optical frames from an Optical Line Terminal (OLT); a plurality of hybrid fiber/copper connectors, each of the hybrid fiber/copper connectors coupled to a respective one of the plurality of optical fiber connectors; and a plurality of electrical connectors configured to receive electrical signals from a multi-line converter module over a respective one of a plurality of electrical conductors. One of the plurality of hybrid fiber/copper connectors is configured to provide the downstream optical frames to the multi-line converter module for conversion to the electrical signals. Each of the plurality of electrical connectors is coupled to a respective one of the plurality of hybrid fiber/copper connectors for providing the electrical signals over a respective metallic drop cable coupled to a respective network terminal at a corresponding customer premise.
摘要翻译：用于无源光纤网络的混合服务终端包括多个光纤连接器，每个光纤连接器分别耦合到相应的光纤，用于从光线路终端（OLT）接收下行光帧; 多个混合光纤/铜连接器，所述混合光纤/铜连接器中的每一个耦合到所述多个光纤连接器中的相应一个; 以及多个电连接器，其被配置为在多个电导体中的相应一个上从多线转换器模块接收电信号。多个混合光纤/铜连接器中的一个被配置为向多线转换器模块提供下行光学帧以转换为电信号。多个电连接器中的每一个耦合到多个混合光纤/铜连接器中的相应一个，用于在相应的客户端提供耦合到相应网络终端的相应金属分支电缆上的电信号。

45. 发明申请

WO2012129409A2 STRONG RIGHTS MANAGEMENT FOR COMPUTING APPLICATION FUNCTIONALITY 审中-公开
标题翻译：计算应用功能的强权管理
公开(公告)号：WO2012129409A2
公开(公告)日：2012-09-27
申请号：PCT/US2012/030130
申请日：2012-03-22
申请人： AMAZON TECHNOLOGIES, INC. , BROOKER, Marc J. , BROWN, David , DE KADT, Christopher Richard Jaques
发明人： BROOKER, Marc J. , BROWN, David , DE KADT, Christopher Richard Jaques
IPC分类号： G06F21/24
CPC分类号： G06F21/629 , G06F21/121 , G06F2221/2115 , H04L63/20
摘要： Illegal, unauthorized, uncompensated and/or under-compensated utilization of computing application functionality may be mitigated at least in part by controlling access to executable instructions implementing the computing application functionality. The executable instructions may be executed by a set of one or more virtual machines provisioned by a multi-tenant virtual resource provider. The virtual resource provider may provision the virtual machines and other virtual resources with a set of implementation resources managed by a control plane of the virtual resource provider. The control plane may perform a number of control functions for the virtual resource provider including management and enforcement of virtual resource access policies such as one or more policies collectively specifying that the computing application functionality is to be accessed in accordance with a license or agreement between a third party provider or vendor of the computing application functionality and a user of the computing application functionality.
摘要翻译：至少部分地通过控制对实现计算应用功能的可执行指令的访问来减轻对计算应用功能的非法，未授权，未补偿和/或欠补偿的利用。可执行指令可以由由多租户虚拟资源提供商提供的一个或多个虚拟机的集合来执行。虚拟资源提供者可以为虚拟机和其他虚拟资源提供由虚拟资源提供者的控制平面管理的一组实现资源。控制平面可以为虚拟资源提供者执行多个控制功能，包括虚拟资源访问策略的管理和执行，例如一个或多个策略，共同指定计算应用功能将根据许可证或协议计算应用功能的第三方供应商或供应商以及计算应用功能的用户。

46. 发明申请

WO2012068480A2 FINANCIAL CARD METHOD, DEVICE AND SYSTEM UTILIZING BAR CODES TO IDENTIFY TRANSACTION DETAILS 审中-公开
标题翻译：财务卡方法，设备和系统利用条形码识别交易细节
公开(公告)号：WO2012068480A2
公开(公告)日：2012-05-24
申请号：PCT/US2011/061433
申请日：2011-11-18
申请人： LYONS, Garry , BROWN, David , ATKINS, Clay , CUMMINS, Oran , MARTIN, Daniel , COOKE, Alan , ELDER, Stephen
发明人： LYONS, Garry , BROWN, David , ATKINS, Clay , CUMMINS, Oran , MARTIN, Daniel , COOKE, Alan , ELDER, Stephen
IPC分类号： G06Q20/00 , G06K9/18
CPC分类号： G06Q20/3272 , G06Q20/227 , G06Q20/3276 , G06Q20/385
摘要： An electronic financial transaction arrangement using a payer device to read a machine-readable pay code in which transaction details for a specific transaction may be encoded by a pay code provider is disclosed. The machine-readable pay code may be distributed to the payer device through acoustic stimuli, or as a result of voice or human based gesture actions. A user of the payer device may also participate in the financial transaction through the indirect control of a display by reading a unique machine-readable code unique to the display. Additional transaction details for the specific transaction may be received in the payer device through near field communication, or accessed at a later time when there is established connectivity to a mobile network.
摘要翻译：公开了一种使用支付者设备读取可读付费代码的电子金融交易安排，其中特定交易的交易细节可由付款代码提供商编码。机器可读付费代码可以通过声音刺激或作为基于语音或基于人的手势动作的结果分发给付款人设备。支付者设备的用户也可以通过读取显示器唯一的唯一机器可读代码，通过对显示器的间接控制来参与金融交易。特定交易的额外交易细节可以通过近场通信在付款机设备中接收，或者在与移动网络建立连接的较晚时间被访问。

47. 发明申请

WO2011146517A3 PATIENT MONITORING AND SURVEILLANCE SYSTEM, METHODS, AND DEVICES 审中-公开
公开(公告)号：WO2011146517A3
公开(公告)日：2011-11-24
申请号：PCT/US2011/036857
申请日：2011-05-17
申请人： LIFEFLOW TECHNOLOGIES, INC. , BROWN, David , NORDIN, David , TERAN, Manuel
发明人： BROWN, David , NORDIN, David , TERAN, Manuel
IPC分类号： A61B5/02 , A61B5/0402 , A61B5/0476 , A61B5/145 , H04B7/24 , H04W88/02 , G06Q50/00
摘要： Provided herein are methods, devices and systems for the remote monitoring and/or surveillance of a patient's location, position, movement, vital signs, biopotentials, or a combination thereof using transmission of stepped-frequency radar signals, detecting reflections of the transmitted signals and processing the frequency and phase shifts.

48. 发明申请

WO2011025919A1 MIRNA BIOMARKERS OF LUNG DISEASE 审中-公开
标题翻译：肺炎病毒生物标志物
公开(公告)号：WO2011025919A1
公开(公告)日：2011-03-03
申请号：PCT/US2010/046916
申请日：2010-08-27
申请人： ASURAGEN, INC. , MAMBO, Elizabeth , BROWN, David , ADAI, Alex, T. , SANFORD, Tiffany , VOLZ, Stephanie , CHOUDHARY, Ashish
发明人： MAMBO, Elizabeth , BROWN, David , ADAI, Alex, T. , SANFORD, Tiffany , VOLZ, Stephanie , CHOUDHARY, Ashish
IPC分类号： G01N33/48
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
摘要： This application describes miRNAs that may be used as serum or plasma biomarkers for characterizing lung disease in a patient. These miRNA biomarkers may be used alone or in combination with other markers for the diagnosis, prognosis, or monitoring of diseases such as lung cancer. In one embodiment, a method for characterizing lung cancer in a patient with a lung tumor or lesion comprising the steps of: measuring the level of a miRNA in a serum sample, and determining reduced or elevated levels of the miRNA in the sample, thereby characterizing lung cancer in the patient.
摘要翻译：该应用描述了可用作表征患者肺部疾病的血清或血浆生物标志物的miRNA。这些miRNA生物标志物可以单独使用或与其他标志物组合使用，用于诊断，预后或监测诸如肺癌的疾病。在一个实施方案中，用于表征具有肺肿瘤或病变的患者中的肺癌的方法，包括以下步骤：测量血清样品中的miRNA水平，并测定样品中miRNA的降低或升高的水平，从而表征肺癌患者。

49. 发明申请

WO2010045674A1 METHODS FOR INDUCING PROGRAMMED CELL DEATH 审中-公开
标题翻译：诱导编程性细胞死亡的方法
公开(公告)号：WO2010045674A1
公开(公告)日：2010-04-29
申请号：PCT/AU2009/001374
申请日：2009-10-19
申请人： NOVOGEN RESEARCH PTY LTD , HUSBAND, Alan James , BROWN, David , MOR, Gil , TYTLER, Ewan M
发明人： HUSBAND, Alan James , BROWN, David , MOR, Gil , TYTLER, Ewan M
IPC分类号： A61K31/353 , A61P37/00 , A61P35/00 , C07D311/58
CPC分类号： A61K31/353 , A61L31/16 , A61L2300/416
摘要： The present invention relates to methods for inducing or promoting caspase-independent apoptosis in a cell, the method comprising exposing to the cell an effective amount of a compound of formula (I) as described herein. The invention also relates to methods for treating or preventing diseases and disorders by administering to subjects in need thereof an effective amount of a compound of formula I, wherein the compound induces or promotes caspase-independent apoptosis in at least one cell of the subject.
摘要翻译：本发明涉及用于在细胞中诱导或促进半胱天冬酶依赖性细胞凋亡的方法，所述方法包括向细胞暴露有效量的如本文所述的式（I）化合物。本发明还涉及通过向有需要的受试者施用有效量的式I化合物来治疗或预防疾病和病症的方法，其中该化合物在受试者的至少一个细胞中诱导或促进半胱天冬酶依赖性细胞凋亡。

50. 发明申请

WO2009155300A1 FLUID MONITOR 审中-公开
标题翻译：流体监测仪
公开(公告)号：WO2009155300A1
公开(公告)日：2009-12-23
申请号：PCT/US2009/047562
申请日：2009-06-16
申请人： LIFEFLOW TECHNOLOGIES, INC. , BROWN, David
发明人： BROWN, David
IPC分类号： A61B5/08
CPC分类号： A61B5/027 , A61B5/7285 , A61B8/0858
摘要： Devices and methods for detecting at least one flow characteristic of a fluid, for example, found at a single location in a subject and/or found between two locations in a subject. Devices include an elongate member and/or an external member for detecting the flow of fluid using electromagnetic wave emission, reflection, detection and/or signal processing to determine a flow characteristic of the fluid. Provided are devices that include a nasogastric tube for determining nearby flow in the thoracic aorta in order to determine placement of the nasogastric tube in the esophagus and methods for determination thereof.
摘要翻译：用于检测流体的至少一个流动特征的装置和方法，例如在受试者的单个位置处发现和/或在受试者的两个位置之间发现。装置包括细长构件和/或外部构件，用于使用电磁波发射，反射，检测和/或信号处理来检测流体的流动，以确定流体的流动特性。提供了包括用于确定胸主动脉附近流动的鼻胃管以确定鼻胃管在食道中的放置的装置以及用于确定其的方法。

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