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41. 发明专利

NO20023788D0 未知
公开(公告)号：NO20023788D0
公开(公告)日：2002-08-09
申请号：NO20023788
申请日：2002-08-09
申请人： ABBOTT LAB
发明人： GHAYUR TARIQ , DIXON RICHARD WOODWARD , ROGUSKA MICHAEL , WHITE MICHAEL , LABKOVSKY BORIS , SALFELD JOCHEN G , DUNCAN ALEXANDER R , BROCKLEHURST SIMON MARK , MANKOVICH JOHN A , SHORROCK CELIA PATRICIA , THOMPSON JULIA ELIZABETH , LENNARD SIMON NICHOLAS
IPC分类号： A61K39/395 , A61K45/00 , C12N15/02 , A61P1/04 , A61P3/10 , A61P5/14 , A61P7/00 , A61P7/02 , A61P7/06 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/06 , A61P17/14 , A61P19/02 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P39/00 , A61P39/02 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08 , C07K
摘要： Antibodies that bind human interleukin-18 (hIL-18) are provided, in particular, antibodies that bind epitope(s) of human IL-18. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have high affinity for hIL-18 and neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-I8 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.

42. 发明专利

BR112012010241A2 imunoglobulinas de domínio variável duplo e usos das mesmas 未知
公开(公告)号：BR112012010241A2
公开(公告)日：2016-12-06
申请号：BR112012010241
申请日：2010-10-28
申请人： ABBOTT LAB
发明人： GU JIJIE , SALFELD JOCHEN G , LIU JUNJIAN , HARRIS MARIA C , MCPHERSON MICHAEL J , ISAKSON PETER C , GHAYUR TARIQ
IPC分类号： A61K39/395 , C07K16/00

43. 发明专利

ZA201306105B DUAL VARIABLE DOMAIN IMMUNOGLOBULIN (DVD-lg) 未知
公开(公告)号：ZA201306105B
公开(公告)日：2014-05-28
申请号：ZA201306105
申请日：2013-08-14
申请人： ABBOTT LAB
发明人： WU CHENGBIN , DIXON RICHARD W , GHAYUR TARIQ , SALFELD JOCHEN G
IPC分类号： A61K20060101
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.

44. 发明专利

AR082739A1 INMUNOGLOBULINAS CON DOMINIO VARIABLE DUAL Y USOS DE LAS MISMAS 未知
公开(公告)号：AR082739A1
公开(公告)日：2012-12-26
申请号：ARP110103124
申请日：2011-08-26
申请人： ABBOTT LAB
发明人： GHAYUR TARIQ , SALFELD JOCHEN G , MPHERSON MICHAEL J
IPC分类号： C07K16/46 , A61K39/00 , C12N1/15 , C12N1/21 , C12N5/16 , C12N15/13 , C12N15/85
摘要： Proteínas de unión multivalentes y multiespecíficas modificadas, métodos para elaborarlas y, específicamente, sus usos en la prevención, el diagnóstico y/o el tratamiento de enfermedades.Reivindicación 1: Una proteína de unión que tiene la capacidad de unirse a dos antígenos y que comprende una primera y una segunda cadena de polipéptidos, caracterizada porque dicha primera cadena de polipéptidos comprende un primer VD1-(X1)n-VD2-C-(X2)n, en donde VD1 es un primer dominio variable de la cadena pesada; VD2 es un segundo dominio variable de la cadena pesada; C es un dominio constante de la cadena pesada; X1 es un conector con la condición que no sea CH1; X2 es una región Fc; y en donde dicha segunda cadena de polipéptidos comprende un segundo VD1-(X1)n-VD2-C-(X2)n, en donde VD1 es un primer dominio variable de la cadena liviana; VD2 es un segundo dominio variable de la cadena liviana; C es un dominio constante de la cadena liviana; X1 es un conector; X2 no comprende una región Fc; y en donde n es 0 ó 1; y en donde la proteína de unión se puede unir a TNF y NGF; TNF y SOST; TNF y PGE2; o TNF y LPA; en donde: (a) X1 es, entre el primer y el segundo dominio variable de la cadena pesada, ASTKGP y X1 es, entre el primer y el segundo dominio variable de la cadena liviana, TVAAPSVFIFPP; (b) X1 es, entre el primer y el segundo dominio variable de la cadena pesada, ASTKGPSVFPLAP y X1 es, entre el primer y el segundo dominio variable de la cadena liviana, TVAAP; o (c) X1 es, entre el primer y el segundo dominio variable de la cadena pesada, ASTKGPSVFPLAP y X1 es, entre el primer y el segundo dominio variable de la cadena liviana, TVAAPSVFIFPP.

45. 发明专利

MX2012005037A INMUNOGLOBULINAS DE DOMINIO VARIABLE DOBLE Y USOS DE LAS MISMAS. 未知
公开(公告)号：MX2012005037A
公开(公告)日：2012-05-22
申请号：MX2012005037
申请日：2010-10-28
申请人： ABBOTT LAB
发明人： GHAYUR TARIQ , GU JIJIE , ISAKSON PETER C , HARRIS MARIA C , SALFELD JOCHEN G , MCPHERSON MICHAEL J , LIU JUANJIAN
IPC分类号： A61K39/395 , C07K16/00
摘要： La presente invención se refiere a proteínas de unión, diseñadas por ingeniería, multivalentes y multiespecíficas, métodos de fabricación, y específicamente a sus usos en la prevención, diagnóstico, y/o tratamiento de enfermedades.

46. 发明专利

UY32979A INMUNOGLOBULINAS CON DOMINIO VARIABLE DUAL Y USOS DE LAS MISMAS 未知
公开(公告)号：UY32979A
公开(公告)日：2011-02-28
申请号：UY32979
申请日：2010-10-27
申请人： ABBOTT LAB
发明人： JUNJIAN LIU , TARIQ GHAYUR , SALFELD JOCHEN G , MCPHERSON MICHAEL J , HARRIS MARIA C , ISAKSON PETER C , JIEJI GU
IPC分类号： A61K39/395 , A61P19/00 , A61P37/00 , C07K16/18 , C07K16/22 , C07K16/46 , C12N5/10 , C12N15/13 , C12N15/70 , C12N15/81 , C12N15/82 , C12N15/85
摘要： Proteínas de unión multivalentes y multiespecíficas modificadas, métodos para elaborarlas y, específicamente, sus usos en la prevención, el diagnóstico y/o el tratamiento de enfermedades.

47. 发明专利

ZA200800207B Multiple gene expression including sorf constructs and methods with polyproteins, pro-proteins, and proteolysis 未知
公开(公告)号：ZA200800207B
公开(公告)日：2009-01-28
申请号：ZA200800207
申请日：2008-01-07
申请人： ABBOTT LAB
发明人： CARSON GERALD R , SALFELD JOCHEN G , REGIER DEAN A , WENDY GION , JIJIE GU , YUNE KUNES
IPC分类号： C12N15/63 , C07H20090101 , C07H21/04 , C07K20090101 , C07K16/18 , C12N1/18 , C12N5/07 , C12N5/071 , C12P20090101 , C12P21/08
摘要： Disclosed is an expression vector for generating one or more recombinant protein products comprising a promoter regulatory element operably linked to a single open reading frame (sORF) insert; said sORF insert comprising: (a) a first nucleic acid sequence encoding a first polypeptide, (b) a first intervening nucleic acid sequence encoding a first protein cleavage site, and (c) a second nucleic acid sequence encoding a second polypeptide; wherein said intervening nucleic acid sequence encoding said first protein cleavage site is operably positioned between said first nucleic acid sequence and said second nucleic acid sequence; and wherein said expression vector is capable of expressing a sORF polypeptide cleavable at said first protein cleavage site; wherein said first protein cleavage site comprises a self-processing cleavage site comprising a hedgehog segment or modified hedgehog segment, wherein the hedgehog segment or modified hedgehog segment permits cleavage of said sORF polypeptide but not ligation of said first polypeptide and said second polypeptide.

48. 发明专利

AU2006283532A1 Dual variable domain immunoglobin and uses thereof 未知
公开(公告)号：AU2006283532A1
公开(公告)日：2007-03-01
申请号：AU2006283532
申请日：2006-08-18
申请人： ABBOTT LAB
发明人： SALFELD JOCHEN G , DIXON RICHARD W , WU CHENGBIN , GHAYUR TARIQ
IPC分类号： A61K49/00 , A61K31/192 , A61K31/343 , A61K31/365 , A61K31/4152 , A61K31/445 , A61K31/496 , A61K31/551 , A61K31/60 , A61K39/395
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.

49. 发明专利

PL188192B1 HUMAN ANTIBODIES CAPABLE TO BOND HUMAN TNF ALPHA 未知
公开(公告)号：PL188192B1
公开(公告)日：2004-12-31
申请号：PL32841197
申请日：1997-02-10
申请人： ABBOTT LAB BERMUDA LTD
发明人： SALFELD JOCHEN G , ALLEN DEBORAH J , KAYMAKCALAN ZEHRA , LABKOVSKY BORIS , MANKOVICH JOHN A , MCGUINESS BRIAN T , ROBERTS ANDREW J , SAKORAFAS PAUL , HOOGENBOOM HENDRICUS R J M , SCHOENHAUT DAVID , VAUGHAN TRISTAN J , WHITE MICHAEL , WILTON ALISON J
IPC分类号： C12N15/09 , A61K31/00 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/505 , A61K31/517 , A61K31/52 , A61K31/529 , A61K31/57 , A61K31/573 , A61K31/675 , A61K38/00 , A61K38/04 , A61K38/16 , A61K39/39 , A61K39/395 , A61P1/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P7/00 , A61P7/04 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/16 , A61P13/12 , A61P17/00 , A61P17/02 , A61P19/02 , A61P19/06 , A61P25/00 , A61P27/02 , A61P29/02 , A61P31/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P33/06 , A61P35/00 , A61P35/04 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P39/02 , C07K16/24 , C12N1/21 , C12N5/10 , C12P21/08 , G01N33/53 , G01N33/543 , G01N33/564 , G01N33/576 , G01N33/68 , C12N15/13 , C12N15/64
摘要： Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed. These antibodies have high affinity for hTNFα (e.g., Kd=10−8 M or less), a slow off rate for hTNFα dissociation (e.g., Koff=10−3 sec−1 or less) and neutralize hTNFα activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hTNFα and for inhibiting hTNFα activity, e.g., in a human subject suffering from a disorder in which hTNFα activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.

50. 发明专利

ES2198552T3 未知
公开(公告)号：ES2198552T3
公开(公告)日：2004-02-01
申请号：ES97906572
申请日：1997-02-10
申请人： ABBOTT LAB BERMUDA LTD
发明人： SALFELD JOCHEN G , ALLEN DEBORAH J , KAYMAKCALAN ZEHRA , LABKOVSKY BORIS , MANKOVICH JOHN A , MCGUINESS BRIAN T
IPC分类号： C12N15/09 , A61K31/00 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/4164 , A61K31/4178 , A61K31/505 , A61K31/517 , A61K31/52 , A61K31/529 , A61K31/57 , A61K31/573 , A61K31/675 , A61K38/00 , A61K38/04 , A61K38/16 , A61K39/39 , A61K39/395 , A61P1/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P7/00 , A61P7/04 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/16 , A61P13/12 , A61P17/00 , A61P17/02 , A61P19/02 , A61P19/06 , A61P25/00 , A61P27/02 , A61P29/02 , A61P31/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P33/06 , A61P35/00 , A61P35/04 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P39/02 , C07K16/24 , C12N1/21 , C12N5/10 , C12P21/08 , G01N33/53 , G01N33/543 , G01N33/564 , G01N33/576 , G01N33/68 , C12N15/13 , C12N15/64
摘要： Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed. These antibodies have high affinity for hTNFα (e.g., Kd=10−8 M or less), a slow off rate for hTNFα dissociation (e.g., Koff=10−3 sec−1 or less) and neutralize hTNFα activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hTNFα and for inhibiting hTNFα activity, e.g., in a human subject suffering from a disorder in which hTNFα activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.

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