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41. 发明专利

AT476997T 未知
公开(公告)号：AT476997T
公开(公告)日：2010-08-15
申请号：AT06754516
申请日：2006-06-22
申请人： ABBOTT GMBH & CO KG
发明人： ROSENBERG JOERG , MAEGERLEIN MARKUS , BREITENBACH JOERG
IPC分类号： A61K47/22 , A61K9/00

42. 发明专利

HK1125861A1 IMPROVED PROCESS FOR PRODUCING A SOLID DISPERSION OF AN ACTIVE INGREDIENT 未知
公开(公告)号：HK1125861A1
公开(公告)日：2009-08-21
申请号：HK09104677
申请日：2009-05-22
申请人： ABBOTT GMBH & CO KG
发明人： KESSLER THOMAS , BREITENBACH JOERG , SCHMIDT CHRISTOPH , DEGENHARDT MATTHIAS , ROSENBERG JOERG , KRULL HARALD , BERNDL GUNTHER
IPC分类号： A61K20060101 , B29C48/395 , B29C48/45 , B29C48/455 , B29C48/67 , B29C48/76
摘要： The present invention relates to a solid dispersion comprising a biologically active ingredient and a matrix-forming agent, wherein the biologically active ingredient comprises ritonavir and the solid dispersion has been obtained by a process which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (A), (ii) at least one mixing section (B), and (iii) a discharging section (E), wherein the processing element(s) defining the mixing section (B) comprise(s) a mixing element (11, 12, 13) that is derived from a screw type element.

43. 发明专利

MX2009004858A FORMA DE DOSIFICACION DE IMATINIB PROCESADA EN FUSION. 未知
公开(公告)号：MX2009004858A
公开(公告)日：2009-05-21
申请号：MX2009004858
申请日：2007-11-08
申请人： ABBOTT GMBH & CO KG
发明人： HACH HARALD , BREITENBACH JOERG , OGORKA JOERG , STEIGER NORBERT , WESTEDT ULRICH , KNOBLOCH MARTIN , ALTENBURGER RALF , LOGGIA NICOLETTA
IPC分类号： A61K31/505 , A61K9/20
摘要： La invención proporciona una forma de dosificación que comprende una mezcla procesada en fusión de (a) una cantidad farmacéuticamente efectiva de imatinib o una sal del mismo, (b) por lo menos un aglomerante polimérico, y (c) por lo menos un surfactante no iónico farmacéuticamente aceptable. La invención ofrece formas de dosificación de imatinib con alta carga de fármaco que pueden prepararse de manera sencilla y eficiente, formas de dosificación de imatinib a partir de las cuales el principio activo es liberado en forma esencialmente independiente del pH, y formas de dosificación de imatinib de liberación prolongada.

44. 发明专利

AT431236T 未知
公开(公告)号：AT431236T
公开(公告)日：2009-05-15
申请号：AT00993390
申请日：2000-12-15
申请人： ABBOTT GMBH & CO KG
发明人： KRULL HARALD , ROSENBERG JOERG , BREITENBACH JOERG , HOFMANN JUERGEN , KLENZ RAINER , BUEHRLE HANS
IPC分类号： B29C45/54 , A61J3/06 , A61K9/20
摘要： The present invention relates to an apparatus for producing solid active ingredient-containing forms from an active ingredient-containing formulation which comprises at least one polymeric binder. The apparatus according to the invention has at least one extruder 1 for continuous plastication of the formulation and at least two injection units 2 which are provided separate from one another, each of which is connected to the extruder 1 , and through which the formulation can be injected into at least one mold 3 . In the process according to the invention for producing solid active ingredient-containing forms from an active ingredient-containing formulation which comprises at least one binder, the active ingredient-containing formulation is continuously plasticated, the plasticated formulation is fed into an injection unit 2 1 , and the formulation present in this injection unit 2 1 is injected into a mold 3 , and plasticated formulation is fed into another injection molding unit 2 2 , and the formulation present in the other injection molding unit 2 2 is injected into the mold 3 or another mold.

45. 发明专利

MX2009000048A COMPOSICION DE SOLUBILIZACION FARMACEUTICAMENTE ACEPTABLE Y FORMA DE DOSIFICACION FARMACEUTICA QUE CONTIENE LA MISMA. 未知
公开(公告)号：MX2009000048A
公开(公告)日：2009-01-23
申请号：MX2009000048
申请日：2007-07-17
申请人： ABBOTT GMBH & CO KG
发明人： SCHMIDT CHRISTOPH , BREITENBACH JOERG , ROSENBERG JOERG , MARSH KENNAN , LIEPOLD BERND , LANDER UTE
IPC分类号： A61K9/20 , A61K9/14 , A61K31/427 , A61K31/513 , A61K47/14 , A61K47/22
摘要： Se describe una composición de solubilización farmacéuticamente aceptable que comprende (i) cuando menos un compuesto de tocoferilo que tiene una fracción de polialquilenglicol y (ii) cuando menos un monoéster de ácido graso de alquilenglicol o mezcla de monoéster y diéster de ácido graso de alquilenglicol. La composición de solubilización es útil en la fabricación de una forma de dosificación farmacéutica que comprende una mezcla procesada por fusión de cuando menos un ingrediente activo, cuando menos un polímero farmacéuticamente aceptable. El ingrediente activo puede ser inhibidores de proteasa HIV. La composición de solubilización mejora la biodisponibilidad del ingrediente activo después de toma oral.

46. 发明专利

AT397447T 未知
公开(公告)号：AT397447T
公开(公告)日：2008-06-15
申请号：AT00942125
申请日：2000-06-23
申请人： ABBOTT GMBH & CO KG
发明人： ROSENBERG JOERG , BREITENBACH JOERG , LIEPOLD BERND
IPC分类号： A61K31/4525 , A61K9/08 , A61K9/16 , A61K9/20 , A61K9/26 , A61P25/24

47. 发明专利

PT1001757E ANALGESICO DE ACCAO RAPIDA 未知
公开(公告)号：PT1001757E
公开(公告)日：2006-05-31
申请号：PT98937580
申请日：1998-07-21
申请人： ABBOTT GMBH & CO KG
发明人： ZEIDLER JUERGEN , NEUMANN JOERG , BERND LIEPOLD , ROSENBERG JOERG , BERNDL GUNTHER , BREITENBACH JOERG , VOLLGRAF CHRISTIANE
IPC分类号： A61K9/20 , A61K31/192 , A61K47/02 , A61K47/32 , A61P29/00 , A61K31/19

48. 发明专利

DE60102590D1 未知
公开(公告)号：DE60102590D1
公开(公告)日：2004-05-06
申请号：DE60102590
申请日：2001-08-02
申请人： ABBOTT GMBH & CO KG
发明人： ROSENBERG JOERG , BERNDL GUNTHER , NEUMANN JOERG , BREITENBACH JOERG
IPC分类号： A61K9/00 , A61K9/20 , A61K31/496 , A61K47/10 , A61K47/30 , A61K47/32 , A61P31/10
摘要： A solid dosage form for application in the oral cavity, comprising a poorly bioavailable pharmaceutical active ingredient dispersed in a pharmaceutically acceptable matrix.

49. 发明专利

CA2479749A1 TEST SYSTEM FOR EVALUATING THE COMPATIBILITY OF BIOLOGICALLYACTIVE SUBSTANCES WITH COPOLYMERS 未知
公开(公告)号：CA2479749A1
公开(公告)日：2003-10-02
申请号：CA2479749
申请日：2003-03-19
申请人： ABBOTT GMBH & CO KG
发明人： LIEPOLD BERND , BREITENBACH JOERG
IPC分类号： G01N33/15 , A61K9/14 , A61K47/14 , A61K47/22 , A61K47/32 , G01N13/00
摘要： A test solution agent, a test system and a method for evaluating the compatibility of biologically active substances with N-vinylpyrollidone copolymers are disclosed.

50. 发明专利

BRPI0718523A2 未知
公开(公告)号：BRPI0718523A2
公开(公告)日：2013-11-19
申请号：BRPI0718523
申请日：2007-11-08
申请人： ABBOTT GMBH & CO KG , NOVARTIS AG
发明人： BREITENBACH JOERG , STEIGER NORBERT , HACH HARALD , WESTEDT ULRICH , KNOBLOCH MARTIN , ALTENBURGER RALF , LOGGIA NICOLETTA , OGORKA JOERG
IPC分类号： A61K9/20 , A61K31/505
摘要： The invention provides a dosage form, comprising a melt-processed mixture of (a) a pharmaceutically effective amount of imatinib or a salt thereof, (b) at least one polymeric binder, and (c) at least one pharmaceutically acceptable non-ionic surfactant. The invention provides imatinib dosage forms with high drug loading which can be prepared in a simple and efficient manner, imatinib dosage forms from which the active principle is released in an essentially pH-independent fashion, and extended release imatinib dosage forms.

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