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    • 43. 发明公开
    • 케모카인을 함유하는 성체 멜라닌 세포 이동 촉진용 조성물, 케모카인 유전자를 이용하여 피부 활성물질 탐색용 키트 및 이를 이용하여 피부 활성물질을 탐색하는 방법
    • 用于促进包含化合物的成熟MELANOCYTE迁移的组合物,含有化学基因的皮肤活性成分的检测试剂盒和使用化学代谢基因检测皮肤活性成分的方法
    • KR1020130056955A
    • 2013-05-31
    • KR1020110122622
    • 2011-11-23
    • (주)아모레퍼시픽
    • 이은경한지연김광미이태룡
    • C12N5/071C07K14/52G01N33/53C12N15/63
    • PURPOSE: A composition is provided to promote the migration of melanocytes in skin and hair, to relieve and treat a lesion in hypopigmentary diseases such as vitiligo and grey hair, and to quickly and simply screen the skin vitalizing substance. CONSTITUTION: A composition for promoting adult melanocyte migration contains chemokine which is selected from a group consisting of CTACK, I-TAC, Lptn, PARC, SDF1, and TARC. The composition is used for treating hypopigmentary diseases. A kit for detecting a skin vitalizing substance contains a chemokine-specific antibody, a secondary antibody, a chromogenic label, and skin cells. The kit is used for detecting the skin vitalizing substance by screening a material which regulates expression of chemokine in skin cells. A method for detecting skin vitalizing substance comprises: a step of treating the skin cells with a candidate material and identifying expression of chemokine; and a step of isolating and purifying a material which reduces expression of chemokine. [Reference numerals] (AA) Human melanocyte migration(%); (BB) Control group; (CC) Treatment material
    • 目的:提供一种组合物,以促进黑色素细胞在皮肤和头发中的迁移,以缓解和治疗色素沉着疾病如白癜风和灰白色的病变,并快速简单地筛选皮肤活化物质。 构成:用于促进成年黑素细胞迁移的组合物含有选自CTACK,I-TAC,Lptn,PARC,SDF1和TARC的趋化因子。 该组合物用于治疗色素沉着病。 用于检测皮肤活化物质的试剂盒含有趋化因子特异性抗体,二抗,显色标记和皮肤细胞。 该试剂盒用于通过筛选调节趋化因子在皮肤细胞中的表达的材料来检测皮肤活化物质。 用于检测皮肤活化物质的方法包括:用候选物质处理皮肤细胞并鉴定趋化因子的表达的步骤; 以及分离和纯化减少趋化因子表达的材料的步骤。 (AA)人类黑素细胞迁移(%); (BB)对照组; (CC)处理材料
    • 44. 发明公开
    • 피부 색소 침착 조절물질을 스크리닝하는 방법
    • 用于调节皮肤颜色的材料的筛选方法
    • KR1020130051353A
    • 2013-05-20
    • KR1020110116647
    • 2011-11-09
    • (주)아모레퍼시픽
    • 최현정최현한지연박주열신동욱이태룡노민수김광미
    • G01N33/68G01N33/15G01N33/53C12N15/115
    • PURPOSE: A method for screening a material which regulates skin pigmentation is provided to screen a material for regulating skin pigmentation, and to effectively treat hyperpigmentation or hypopigmentation by regulating intracellular and intercellular signal transduction faction and transcription factor. CONSTITUTION: A method for screening a material which regulates skin pigmentation comprises: a step of treating one or more gene selected from the group consisting of IFN gamma, IL4, IL17, IL6, STAT3, STAT6, JAK1, JAK2, and JAK3 with a candidate material; and a step of selecting a candidate material which enhances or reduces gene expression as a material which regulates skin pigmentation. A candidate material which enhances gene expression is selected as a useful material which possibly suppresses pigmentation. A candidate material which reduces gene expression is selected as a useful material which possibly enhances skin pigmentation. [Reference numerals] (AA) Comparative example; (BB) Example 1; (CC) Example 2; (DD) Example 3
    • 目的:提供一种筛选调节皮肤色素沉着的材料的方法,筛选调节皮肤色素沉着的材料,并通过调节细胞内和细胞间信号转导系和转录因子有效治疗色素沉着过度或色素沉着不足。 构成:筛选调节皮肤色素沉着的材料的方法包括:用候选物质治疗选自IFNγ,IL4,IL17,IL6,STAT3,STAT6,JAK1,JAK2和JAK3的一种或多种基因的步骤 材料; 以及选择增强或降低基因表达作为调节皮肤色素沉着的材料的候选物质的步骤。 选择增强基因表达的候选物质作为可能抑制色素沉着的有用材料。 选择减少基因表达的候选物质作为可能增强皮肤色素沉着的有用材料。 (附图标记)(AA)比较例; (BB)实施例1; (CC)实施例2; (DD)实施例3
    • 48. 发明授权
    • 생약재 추출물을 함유하는 피부 외용제 조성물
    • 用于外用的皮肤组合物,含有植物提取物
    • KR100998993B1
    • 2010-12-09
    • KR1020090101108
    • 2009-10-23
    • (주)아모레퍼시픽
    • 김광미김승훈이병곤
    • A61K36/70A61P17/06
    • 본 발명은 생약재 추출물을 함유하는 피부 외용제 조성물에 관한 것으로, 더욱 상세하게는, 세신(
      Asiasari Radix ), 소엽(
      Perillae Herba ), 소자(
      Perillae Semen ), 승마(
      Cimicifugae Rhizoma ), 왕불유행(
      Melandrii Herba ), 용규(
      Solani Nigri Herba ), 우방자(
      Arctii Semen ), 위릉채(
      Potentillae Radix ), 육계(
      Cinnamomi Cortex Spissus ), 적복령(
      Hoelen rubra ), 적소두(
      Phaseoli angularis Semen ), 초과(
      Ammomi Tsao-ko Frucuts ), 초두구(
      Alpiniae Katsumadaii Semen ), 메밀(
      Fagopyrum esculentum ), 명아주(
      Chenopodium album var. centrorubrum ), 범꼬리(
      Bistorta manshuriensis ), 상사화(
      Lycoris squamigera ), 섬백리향(
      Thymus quinquecostatus var. japonica ), 쑥방망이(
      Senecio argunensis ) 및 참나물(
      Pimpinella brachycarpa ) 중에서 선택된 1종 이상의 생약재 추출물을 유효성분으로 함유하는 피부 외용제로서, T 임파구 매개성 면역반응 억제능력에 의해 아토피성 피부염, 접촉성 피부염 및 건선 등의 피부질환을 치료 또는 예방하기 위해 사용될 수 있다.
      세신 * 소엽 * 소자 * 승마 * 왕불유행 * 용규 * 우방자 * 위릉채 * 육계 * 적복령 * 적소두 * 초과 * 초두구 * 메밀 * 명아주 * 범꼬리 * 상사화 * 섬백리향 * 쑥방망이 * 참나물 * 면역반응억제 * 아토피성 피부염 * 접촉성 피부염 * 건선
    • 50. 发明公开
    • 생약재 추출물을 함유하는 피부 외용제 조성물
    • 用于外部施用的皮肤组合物,含有植物提取物
    • KR1020090127854A
    • 2009-12-14
    • KR1020090101108
    • 2009-10-23
    • (주)아모레퍼시픽
    • 김광미김승훈이병곤
    • A61K36/70A61P17/06
    • A61K8/97A61K36/00A61K36/36A61K36/53A61K36/70A61Q19/00A61Q19/005Y10S514/844Y10S514/857Y10S514/863
    • PURPOSE: A skin external composition containing medicinal herb extract is provided to suppress proliferation of interleukin-2 and -4 and T lymphocyte and treat or prevent dermatitis such as atopic dermatitis, contact dermatitis and psoriasis. CONSTITUTION: A skin external composition for treating or preventing atopic dermatitis, contact dermatitis or psoriasis contains Bistorta manshuriensis extract as an active ingredient in 0.001~10 weight% based on total weight. A method for preparing Bistorta manshuriensis extract comprises: a step of pulverizing Bistorta manshuriensis and pulverizing a step of adding 95% of ethanol and heating at 80°C for two hours; a step of placing the extract at room temperature for one hour and filtering; and a step of evaporating and concentrating.
    • 目的:提供含有药草提取物的皮肤外用组合物,以抑制白细胞介素-2和-4和T淋巴细胞的增殖,治疗或预防皮炎如特应性皮炎,接触性皮炎和牛皮癣。 构成:用于治疗或预防特应性皮炎,接触性皮炎或牛皮癣的皮肤外用组合物,以总重量的0.001〜10重量%含有活性成分的黑曲霉(Bistorta manshuriensis)提取物。 一种制备黑曲霉提取物的方法,包括:粉碎双歧杆菌并粉碎加入95%乙醇并在80℃加热2小时的步骤; 将提取物在室温下放置1小时并过滤的步骤; 和蒸发浓缩的步骤。