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    • 44. 发明公开
    • 메포민을 포함하는 자가면역질환 예방 및 치료용 조성물
    • 用于预防和治疗包含METFORMIN的自身免疫疾病的组合物
    • KR1020130031229A
    • 2013-03-28
    • KR1020120104603
    • 2012-09-20
    • 가톨릭대학교 산학협력단
    • 주지현김영균강귀영
    • A61K31/155A61P19/02A61P17/00A61P37/00
    • PURPOSE: A metformin-containing pharmaceutical composition is provided to suppress Th17 cell differentiation and to prevent and treat autoimmune diseases. CONSTITUTION: A pharmaceutical composition for preventing and treating autoimmune diseases contains a compound of chemical formula 1 or a pharmaceutically acceptable salt thereof. The salt is hydrochloride. The autoimmune disease is caused by Th17 cells and is selected from the group consisting of psoriasis, rheumatic arthritis, systemic sclerosis, systemic lupus erythematosus, multiple sclerosis, autoimmunity myocarditis, atopic dermatitis, contact hypersensitivity, inflammatory bowel disease, and periodontal disease.
    • 目的:提供含二甲双胍的药物组合物以抑制Th17细胞分化并预防和治疗自身免疫疾病。 构成:用于预防和治疗自身免疫性疾病的药物组合物含有化学式1的化合物或其药学上可接受的盐。 盐是盐酸盐。 自身免疫性疾病由Th17细胞引起,并且选自牛皮癣,风湿性关节炎,系统性硬化症,系统性红斑狼疮,多发性硬化,自身免疫性心肌炎,特应性皮炎,接触性超敏反应,炎症性肠病和牙周病。