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    • 41. 发明公开
    • 결합조직 재생용 조성물 및 결합조직을 재생하는 방법
    • 组织和结缔组织再生的方法
    • KR1020160129108A
    • 2016-11-08
    • KR1020167030362
    • 2012-04-13
    • 가톨릭대학교 산학협력단
    • 김석중조미라
    • A61K38/36A61K31/728A61K38/48A61K38/39A61K31/55
    • A61K31/55A61K31/728
    • 본발명은결합조직재생용조성물및 결합조직을재생하는방법에관한것으로, 보다구체적으로히아루론산과피브리노겐을아텔로콜라겐또는골수세포와혼합하여결합조직손상부위에주입함으로써손상부위의결합조직을재생시킬수 있는결합조직재생용조성물및 결합조직을재생하는방법에관한것이다. 본발명에따른결합조직재생용조성물은결합조직의손상부위를효과적으로재생시킬수 있으며, 특히낮은재생활성을갖는연골재생에유효한효능을나타낸다. 또한, 천연물질을사용하므로인체에무해하며, 자연연골과유사한조직공학적연골을재생하여손상된연골조직을효과적으로수복할수 있는연골치료제로유용하게사용될수 있다.
    • 本发明涉及一种用于再生结缔组织的组合物和一种用于再生结缔组织的方法,更具体地,涉及一种用于再生结缔组织的组合物和一种再生结缔组织的方法,其中该组合物通过将hyarulonic acid 和纤维蛋白原与成纤维细胞或骨髓细胞,并注射到结缔组织的损伤部分,从而再生损伤部分的结缔组织。 根据本发明的用于再生结缔组织的组合物可以有效地再生结缔组织的损伤部分,并且具体可能表现出在再生能力低的软骨再生中的活性。 此外,本发明的组合物使用天然材料,因此对人体无害。 本发明的组合物可以再生类似于天然软骨的组织工程化软骨,因此可以有价值地用作可有效修复受损软骨组织的软骨治疗剂。
    • 42. 发明公开
    • 무릎관절 교정기
    • 适合KNEE联系
    • KR1020110060611A
    • 2011-06-08
    • KR1020090117237
    • 2009-11-30
    • 가톨릭대학교 산학협력단
    • 김석중
    • A61F5/04A61F5/042
    • A61F5/0106
    • PURPOSE: A knee joint aid is provided to have a structure of applying power to the knee joint in order to straighten bent legs. CONSTITUTION: A knee joint aid comprises: a rear band(1) which surrounds the rear of the knee joint and protects the knee joint; a front band(10) which is connected to the rear band, surrounds the front of the knee joint and protects the knee joint; and a support stand(20) supports the side of the knee joint corresponding to an interval between the front band and rear band and provides elastic force. The support stand is formed in a plate shape that both ends thereof are bent around the central part thereof.
    • 目的:提供膝关节辅助装置以具有向膝关节施力的结构,以便使弯曲的腿伸直。 构成:膝关节辅助包括:围绕膝关节后部并保护膝关节的后带(1); 连接到后带的前带(10)围绕膝关节的前部并保护膝关节; 并且支撑架(20)支撑对应于前带和后带之间的间隔的膝关节的侧面并提供弹力。 支撑架形成为其两端围绕其中心部弯曲的板状。
    • 45. 发明授权
    • STAT3 억제제가 처리된 간엽줄기세포를 유효성분으로 포함하는 면역질환의 예방 또는 치료용 조성물
    • STAT3用于预防或治疗免疫疾病的组合物,包括间充质干细胞治疗的stat3抑制剂
    • KR101705412B1
    • 2017-02-09
    • KR1020140144100
    • 2014-10-23
    • 가톨릭대학교 산학협력단
    • 조미라박성환양철우박민정윤덕규김석중이선영이은정김재경나현식이승훈
    • A61K31/7135A61K31/70A61P29/00A61P37/00
    • 본발명은 STAT3 억제제가처리된간엽줄기세포를유효성분으로포함하는면역질환의예방또는치료용세포치료제조성물에관한것이다. 본발명에따른 STAT3 억제제가처리된간엽줄기세포는간엽줄기세포에서의염증성사이토카인및 염증유발인자의발현과생성을효과적으로억제할수 있고, 병인조건하에서미분화 T 세포와공조배양할경우, T 세포의세포독성 Th17 및 Th1 세포로의분화를억제하는효과가있으며, 비정상적으로활성화된면역세포의기능을억제하고염증반응을제어하는특성을갖는면역조절 T 세포(Treg)의분화및 활성을증진시키는효과가우수한특징이있다. 따라서 STAT3 억제제가처리된간엽줄기세포는각종면역반응의조절이상으로유발되는자가면역질환, 염증성질환및 이식거부질환과같은면역질환을예방또는치료할수 있는세포치료제조성물로사용할수 있는효과가있다.
    • 本发明涉及含有STAT3抑制剂作为预防或治疗免疫疾病的活性成分的间充质干细胞的组合物。 根据本发明,用STAT3抑制剂处理的间充质干细胞可以有效控制间充质干细胞中炎性细胞因子的表达和产生以及引起炎症的因子; 具有抑制T细胞分化为细胞毒性Th17细胞和细胞毒性Th1细胞的效果,如果在病因学条件下与未分化T细胞共培养; 抑制异常活化的免疫细胞的功能; 并且具有促进免疫调节性T细胞(Treg)的分化和活性的极好作用,其抑制异常活化的免疫细胞的功能并控制炎症反应。 因此,用STAT3抑制剂处理的间充质干细胞可用于细胞治疗剂组合物,其可以预防或治疗由各种调节异常引起的自身免疫性疾病,炎性疾病和移植排斥障碍等免疫疾病 免疫反应。
    • 47. 发明公开
    • 결합조직 재생용 조성물 및 결합조직을 재생하는 방법
    • 用于再生连接组织的组合物和方法
    • KR1020130135340A
    • 2013-12-10
    • KR1020137026475
    • 2012-04-13
    • 가톨릭대학교 산학협력단
    • 김석중조미라
    • A61K31/55A61K31/728A61P7/02A61P7/00
    • A61K31/55A61K31/728
    • The present invention relates to a composition and a method for the regeneration of connective tissues, more specifically a composition and a method for the regeneration of connective tissues which mix hyaluronic acid and fibrinogen with attelo collagen or marrow cells and inject the mixture into a damaged portion of the connective tissues for regenerating the connective tissues around the damaged portion. The composition for the regeneration of the connective tissues effectively regenerates the damaged portion of the connective tissues, and has an active function in regenerating the cartilage which has low regeneration activity. The composition is harmless to human body by using natural materials, and can be used as a cartilage treatment agent for effectively recovering damaged cartilage tissues by regenerating the cartilage through tissue engineering which is similar to the natural cartilage.
    • 本发明涉及结缔组织再生的组合物和方法,更具体地说是将透明质酸和纤维蛋白原与原始胶原或骨髓细胞混合并将混合物注入损伤部分的结缔组织再生的组合物和方法 的结缔组织用于再生损伤部分周围的结缔组织。 用于再生结缔组织的组合物有效地再生结缔组织的损伤部分,并且具有再生具有低再生活性的软骨的活性功能。 该组合物通过使用天然材料对人体无害,可用作软骨处理剂,用于通过与软骨类似的组织工程再生软骨来有效地回收损伤的软骨组织。
    • 48. 发明公开
    • 골절부위 지지용 클램프
    • 支持断裂区域的夹具
    • KR1020120111084A
    • 2012-10-10
    • KR1020110029375
    • 2011-03-31
    • 가톨릭대학교 산학협력단
    • 김석중김민현
    • A61B17/82A61B17/86A61B17/64
    • A61B17/808A61B17/8866
    • PURPOSE: A clamp for fracture portion support is provided to steadily support a slope fracture portion by fixing a supporting unit of a supporting stand to a bone using a screw. CONSTITUTION: A first support stand(11) supports a slope fracture portion. A supporting unit is included on both ends of left and right lower sides of the first support stand. A second support stand(12) is formed into a structure same as the first support stand. The second support stand is separately installed from the first support stand. A connecting stand(20) connects the upper side of the first support stand to the upper side of the second support stand.
    • 目的:提供一种用于断裂部分支撑的夹具,通过使用螺钉将支撑架的支撑单元固定到骨头上来稳定地支撑倾斜断裂部分。 构成:第一支撑架(11)支撑一个倾斜断裂部分。 支撑单元包括在第一支撑架的左右两侧的两端。 第二支撑架(12)形成为与第一支撑架相同的结构。 第二支架与第一支架分开安装。 连接支架(20)将第一支撑架的上侧与第二支撑架的上侧连接。