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41. 发明申请

US20110123553A1 Use of LINGO-4 Antagonists in the Treatment of Conditions Involving Demyelination 审中-公开
标题翻译：使用LINGO-4拮抗剂治疗与脱髓鞘有关的病症
公开(公告)号：US20110123553A1
公开(公告)日：2011-05-26
申请号：US12741957
申请日：2008-11-10
申请人： Sha Mi , R. Blake Pepinsky , John McCoy
发明人： Sha Mi , R. Blake Pepinsky , John McCoy
IPC分类号： A61K39/395 , C12N5/00 , A61P25/28 , A61P25/16 , A61P25/00 , C12N15/87 , A61K48/00
CPC分类号： A61K38/1709 , A61K31/70 , A61K38/00 , A61K39/3955 , A61K48/00 , C07K14/47 , C07K14/70503 , C07K16/18 , C07K2317/76 , C07K2319/30 , C12N5/0622 , C12N2501/998 , C12N2502/08 , Y02A50/406
摘要： The invention provides methods of treating diseases, disorders or injuries involving demyelination and dysmyelination, including multiple sclerosis, by the administration of a LINGO-4 antagonist.
摘要翻译：本发明提供了通过施用LINGO-4拮抗剂治疗涉及脱髓鞘和脱髓鞘疾病（包括多发性硬化）的疾病，病症或损伤的方法。

42. 发明授权

US07785829B2 Nogo receptor binding protein 有权
标题翻译： Nogo受体结合蛋白
公开(公告)号：US07785829B2
公开(公告)日：2010-08-31
申请号：US10553685
申请日：2004-03-17
申请人： Sha Mi , John McCoy , R. Blake Pepinsky , Daniel H. S. Lee
发明人： Sha Mi , John McCoy , R. Blake Pepinsky , Daniel H. S. Lee
IPC分类号： C12P21/06 , C07H21/02 , C07K14/00
CPC分类号： G01N33/56966 , A61K38/00 , C07K14/4702 , C07K14/70571 , C07K16/18 , C07K16/2803 , C07K2319/30 , C12N5/0619 , C12N2500/46 , G01N33/5058 , G01N33/6896
摘要： The invention provides Sp35 polypeptides and fusion proteins thereof, Sp35 antibodies and antigen-binding fragments thereof and nucleic acids encoding the same. The invention also provides compositions comprising, and methods for making and using, such Sp35 antibodies, antigen-binding fragments thereof, Sp35 polypeptides and fusion proteins thereof.
摘要翻译：本发明提供了Sp35多肽及其融合蛋白，Sp35抗体及其抗原结合片段和编码其的核酸。本发明还提供了包含此类Sp35抗体，其抗原结合片段，Sp35多肽及其融合蛋白的制备和使用方法。

43. 发明申请

US20090175872A1 Treatment of Conditions Involving Demyelination 审中-公开
标题翻译：治疗涉及脱髓鞘的病症
公开(公告)号：US20090175872A1
公开(公告)日：2009-07-09
申请号：US12095857
申请日：2006-12-01
申请人： Sha Mi , R. Blake Pepinsky , John McCoy
发明人： Sha Mi , R. Blake Pepinsky , John McCoy
IPC分类号： A61K39/395 , C12N5/06 , A61K38/16 , A61K31/7088 , C12N15/87 , A61K35/12
CPC分类号： C07K16/28 , A01K67/0275 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0393 , A61K2039/505 , C07K14/4702 , C07K16/18 , C07K16/2863 , C07K16/32 , C07K16/40 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C12N15/8509
摘要： The invention provides methods of treating diseases, disorders or injuries involving demyelination and dysmyelination, including multiple sclerosis, by the administration of an Sp35 antagonist. Additional methods include methods for inhibiting the binding of the Sp35 polypeptide with the ErbB2 polypeptide and a method for increasing ErbB2 phosphorylation by contacting oligodendrocytes with an effective amount of a composition comprising an Sp35 antagonist of the invention. Further embodiments of the invention include methods of inhibiting the binding of the Sp35 polypeptide with the ErbB2, increasing ErbB2 phosphorylation and promoting oligodendrocyte differentiation comprising contacting oligodendrocyte or oligodendrcoyte progenitor cells with an ErbB2 binding agent.
摘要翻译：本发明提供了通过施用Sp35拮抗剂治疗涉及脱髓鞘和髓鞘脱离（包括多发性硬化）的疾病，病症或损伤的方法。另外的方法包括用于抑制Sp35多肽与ErbB2多肽的结合的方法以及通过使少突胶质细胞与有效量的包含本发明的Sp35拮抗剂的组合物接触来增加ErbB2磷酸化的方法。本发明的其它实施方案包括抑制Sp35多肽与ErbB2的结合，增加ErbB2磷酸化和促进少突胶质细胞分化的方法，其包括将少突胶质细胞或少突胶质细胞祖细胞与ErbB2结合剂接触。

44. 发明申请

US20090007510A1 Internally colored block and process 审中-公开
标题翻译：内部彩色块和过程
公开(公告)号：US20090007510A1
公开(公告)日：2009-01-08
申请号：US12217673
申请日：2008-07-09
申请人： John McCoy , Deborah Elliott
发明人： John McCoy , Deborah Elliott
IPC分类号： E04C1/42
CPC分类号： E04B5/46 , E04C1/42
摘要： Internally colored glass and glass-like blocks (10) and the method for making them. No means for coating the internal cavities (26) of clear glass and glass-like hollow blocks has been available. Color coating provides aesthetically pleasing structures. Internally colored glass and glass-like blocks may be used in building internal room dividers, providing colorful building designs and for providing color relief in heretofore otherwise drab structures.
摘要翻译：内部彩色玻璃和玻璃状块（10）及其制作方法。没有用于涂覆透明玻璃和玻璃状中空块的内部空腔（26）的方法已经可用。彩色涂层提供美观的结构。内部彩色玻璃和玻璃状块可用于建造室内分隔器，提供丰富多彩的建筑设计，并在迄今为止以其他方式提供彩色浮雕结构。

45. 发明申请

US20080143201A1 METHODS AND APPARATUS FOR COOLING AN ELECTRIC MOTOR 审中-公开
标题翻译：用于冷却电动机的方法和装置
公开(公告)号：US20080143201A1
公开(公告)日：2008-06-19
申请号：US11612134
申请日：2006-12-18
申请人： Gannon Ramy , John McCoy
发明人： Gannon Ramy , John McCoy
IPC分类号： H02K5/20 , H02K9/02
CPC分类号： H02K5/20 , H02K5/15 , H02K5/26 , H02K9/19
摘要： An electric motor includes a frame having opposing first and second ends, and an endshield coupled to at least one of the first frame end and the second frame end. The endshield includes a body and at least one endshield channel extending through the body and configured to carry a cooling fluid to facilitate cooling the electric motor.
摘要翻译：电动机包括具有相对的第一和第二端部的框架，以及耦合到第一框架端部和第二框架端部中的至少一个的端部框架。末端罩包括主体和至少一个延伸穿过主体并构造成承载冷却流体以便于冷却电动机的末端通道。

46. 发明授权

US6143524A Peptide and protein fusions to thioredoxin, thioredoxin-like molecules, and modified thioredoxin-like molecules 失效
标题翻译：肽和蛋白质融合到硫氧还蛋白，硫氧还蛋白样分子和改良的硫氧还蛋白样分子
公开(公告)号：US6143524A
公开(公告)日：2000-11-07
申请号：US810436
申请日：1997-03-04
申请人： John McCoy , Elizabeth DiBlasio-Smith , Kathleen Grant , Edward R. LaVallie
发明人： John McCoy , Elizabeth DiBlasio-Smith , Kathleen Grant , Edward R. LaVallie
IPC分类号： C07K14/00 , C07K14/475 , C07K14/51 , C07K14/52 , C07K14/53 , C07K14/54 , C07K14/55 , C12N1/06 , C12N9/02 , C12N15/24 , C12N15/62 , C12N15/63
CPC分类号： C12N9/0036 , C07K14/00 , C07K14/475 , C07K14/51 , C07K14/52 , C07K14/523 , C07K14/53 , C07K14/54 , C07K14/5403 , C07K14/5406 , C07K14/5409 , C07K14/5412 , C07K14/5431 , C07K14/55 , C12N1/066 , C12N15/62 , C12Y108/01008 , C07K2319/00 , C07K2319/02 , C07K2319/20 , C07K2319/35 , C07K2319/75
摘要： Provided is a fusion molecule comprising a DNA sequence encoding a thioredoxin-like protein fused to a DNA sequence encoding a second peptide or protein. The peptide or protein may be fused to the amino terminus of the thioredoxin-like molecule, the carboxyl terminus of the thioredoxin-like molecule, or within the thioredoxin-like molecule, for example at the active-site loop of the molecule. The fusion molecule may be modified to introduce one or more metal-binding/chelating amino-acid residues to aid in purification. Expression of this fusion molecule under the control of a regulatory sequence capable of directing its expression in a desired host cell, produces high levels of stable and soluble fusion protein. The fusion protein, located in the bacterial cytoplasm, may be selectively released from the cell by osmotic shock or freeze/thaw procedures. It may be optionally cleaved to liberate the soluble, correctly folded heterologous protein from the thioredoxin-like portion.
摘要翻译：提供了包含编码与编码第二肽或蛋白质的DNA序列融合的硫氧还蛋白样蛋白质的DNA序列的融合分子。肽或蛋白质可以与硫氧还蛋白样分子的氨基末端，硫氧还蛋白样分子的羧基末端或硫氧还蛋白样分子内的融合，例如在分子的活性位点环上。可以修饰融合分子以引入一种或多种金属结合/螯合氨基酸残基以有助于纯化。在能够将其表达在所需宿主细胞中的调节序列控制下的该融合分子的表达产生高水平的稳定和可溶性融合蛋白。位于细菌细胞质中的融合蛋白可通过渗透休克或冷冻/解冻程序从细胞中选择性释放。可以任选地切割以从硫氧还蛋白样部分释放可溶性的，正确折叠的异源蛋白质。

47. 发明授权

US6014200A High throughput electron beam lithography system 失效
标题翻译：高通量电子束光刻系统
公开(公告)号：US6014200A
公开(公告)日：2000-01-11
申请号：US28721
申请日：1998-02-24
申请人： Michael R. Sogard , John McCoy
发明人： Michael R. Sogard , John McCoy
IPC分类号： H01J37/09 , G03F7/20 , H01J37/147 , H01J37/305 , H01J37/317 , H01L21/027 , G03B27/42 , G03B27/54 , A61N5/00
CPC分类号： H01J37/3174 , B82Y10/00 , B82Y40/00 , H01J37/3177 , H01J2237/31776
摘要： An electron beam lithography system having a beamlet shaping section that includes a first multi-aperture array having m rows and n columns of apertures having a first shape and a second multi-aperture array with m rows and n columns of apertures having a second shape. Electron beamlets formed by the first multi-aperture array are deflected by a deflector unit before passing through the second multi-aperture array. The superposition of the electron beamlets on the second multi-aperture produces electron beamlets having a selected shape. Deflection logic on an active beam aperture array blank selected electron beamlets. The deflection logic can be updated with the next logic pattern as the current logic pattern is being executed. The unblanked electron beamlets are directed onto a surface to be exposed. The deflection logic on the active beam aperture array, and the multi-aperture arrays, are shielded from electrons and x-rays generated by the electrons striking surfaces within the electron beam lithography system. Sensitive deflection logic is radiation hardened to prevent degradation.
摘要翻译：一种具有子束成形部分的电子束光刻系统，该子束成形部分包括具有m行和n列的具有第一形状的孔的第一多孔径阵列和具有m行和n列的具有第二形状的孔的第二多孔径阵列。由第一多孔径阵列形成的电子束由穿过第二多孔径阵列之前的偏转器单元偏转。电子束在第二多孔上的叠加产生具有选定形状的电子束。有源光束孔径阵列上的偏转逻辑选择电子束。随着当前逻辑模式正在执行，偏转逻辑可以用下一个逻辑模式进行更新。未钝化的电子子束被引导到待暴露的表面上。有源光束孔径阵列和多孔径阵列上的偏转逻辑与电子束光刻系统内的电子撞击表面产生的电子和x射线屏蔽。敏感偏转逻辑是辐射硬化以防止退化。

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