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41. 发明公开

KR1020120055509A 누공 치료를 위한 자가 및 동종의 지방 유래 스트로마 줄기세포 조성물 无效
标题翻译：自体和同种异体组织衍生的结肠干细胞组合物，用于治疗FISTULA
公开(公告)号：KR1020120055509A
公开(公告)日：2012-05-31
申请号：KR1020120038340
申请日：2012-04-13
申请人： (주)안트로젠
发明人： 이성구 , 김미형
IPC分类号： A61K35/36 , A61K35/12 , A61P17/02 , C12N5/0775
CPC分类号： C12N5/0667 , A61K35/12 , A61K35/28 , C12N2501/115
摘要： PURPOSE: A local originated stroma stem cell composition of allogenic for treating people having fistulous opening is provided to improve multipotency and immunomodulatory activity, thereby enabling use in clinic. CONSTITUTION: A local originated stroma stem cell composition of allogenic for treating people having fistulous opening comprises local formation originated stroma stem cell of allogenic. The stem cell is successive culturing at least 1 succeeding. More than 50% of the local stem cell composition is positive towards CD10, CD13, CD29, CD44, CD59, CD71, CD90, CD105 and Oct 4, and negative towards CD34, CD45, CD104, CD106 and Stro-1. More than 80% of the local stem cell composition is positive towards CD10, CD13, CD29, CD44, CD59, CD71, CD90, CD105 and Oct 4, and negative towards CD34, CD45, CD104, CD106 and Stro-1.
摘要翻译：目的：提供用于治疗患有瘘口的人的同种异体的本地起源的基质干细胞组合物，以改善多能性和免疫调节活性，从而使其能够在临床中使用。构成：用于治疗具有瘘孔的人的同种异体的局部起源的基质干细胞组成包括局部形成起源的同种异体的基质干细胞。干细胞连续培养至少1次。超过50％的局部干细胞组成对CD10，CD13，CD29，CD44，CD59，CD71，CD90，CD105和Oct 4呈阳性，对CD34，CD45，CD104，CD106和Stro-1呈阴性。超过80％的局部干细胞组成对CD10，CD13，CD29，CD44，CD59，CD71，CD90，CD105和Oct 4呈阳性，而对CD34，CD45，CD104，CD106和Stro-1呈阴性。

42. 发明公开

KR1020100118491A 누공 치료를 위한 자가 및 동종의 지방 유래 스트로마 줄기세포 조성물 有权
标题翻译：自体和同种异体组织衍生的结肠干细胞组合物，用于治疗FISTULA
公开(公告)号：KR1020100118491A
公开(公告)日：2010-11-05
申请号：KR1020090050869
申请日：2009-06-09
申请人： (주)안트로젠
发明人： 이성구 , 김미형
IPC分类号： C12N5/071 , A61K35/12 , A61P9/14
CPC分类号： C12N5/0667 , A61K35/12 , A61K35/28 , C12N2501/115
摘要： PURPOSE: A human adipose-derived stromal stem cell composition for treating fistula is provided to suppress immune response and to clinically use. CONSTITUTION: An adipose stem cell composition for treating fistula contains autologous fat-derived stromal stem cell. The stem cell is sub-cultured. 50% or more of the composition is positive to CD10, CD13, CD29, CD44, CD59, CD71, CD90, CD105 and Oct 4 and is negative to CD34, CD45, CD104, CD106 and Stro-1. A method for preparing the composition comprises: a step of preparing adipose from a subject; a step of isolating SVF(stromal vascular fraction) from the adipose; a step of culturing the SVF in a stromal medium; a step of culturing the SVF in a medium containing EGF or bFGF; and a step of sub-culturing the SVS.
摘要翻译：目的：提供用于治疗瘘的人类脂肪来源的基质干细胞组合物，以抑制免疫应答和临床使用。构成：用于治疗瘘的脂肪干细胞组合物含有自体脂肪来源的基质干细胞。干细胞被亚培养。 50％以上的组合物对CD10，CD13，CD29，CD44，CD59，CD71，CD90，CD105和Oct 4呈阳性，对CD34，CD45，CD104，CD106和Stro-1呈阴性。制备组合物的方法包括：从受试者制备脂肪的步骤; 从脂肪中分离SVF（基质血管部分）的步骤; 在基质培养基中培养SVF的步骤; 在含有EGF或bFGF的培养基中培养SVF的步骤; 以及分培养SVS的步骤。

43. 发明公开

KR1020100025658A 피하 연부조직 재생을 위한 분화된 미성숙 지방세포를 포함하는 세포 조성물 无效
标题翻译：包含用于再生软组织的差异性直立体细胞的组合物
公开(公告)号：KR1020100025658A
公开(公告)日：2010-03-10
申请号：KR1020080084295
申请日：2008-08-28
申请人： (주)안트로젠
发明人： 이성구 , 김미형 , 김인옥
IPC分类号： C12N5/071 , C12N5/07 , C12N5/02 , C12N5/00
摘要： PURPOSE: A cell composition for regeneration of subcutaneous soft tissue and a method for transplanting cells are provided to transplant the composition to subcutaneous site and treat cosmetic defect by aging of deletion of the subcutaneous site. CONSTITUTION: An adipocyte composition for regenerating subcutaneous soft tissue contains immature adipocytes having 20-40 um of diameter which is obtained by differentiating adipose-derived adipose stem cells. The composition additionally contains adipose-derived cells. The adipose-derived cells are adipose stem cell which is obtained by adhering a stromal vascular fraction(SVF) in a culture vessel. The adipose-derived cells are adipose-derived stem cells which expresse CD10, CD13, CD29, CD44, CD59, CD71, CD90 or CD105. A method for producing the adipocyte composition comprises: a step of collecting adipose from a subject; a step of isolating the SVF from the adipose; a step of culturing the SVF in a culture vessel to differentiate adipose stem cells; and a step of collecting differentiated immature adipocytes.
摘要翻译：目的：提供用于皮下软组织再生的细胞组合物和移植细胞的方法，将组合物移植到皮下部位，并通过老化皮下部位的缺失来治疗化妆品缺陷。构成：用于再生皮下软组织的脂肪细胞组合含有通过分化脂肪来源的脂肪干细胞获得的具有20-40μm直径的未成熟脂肪细胞。该组合物另外含有脂肪来源的细胞。脂肪来源的细胞是通过将培养容器中的基质血管部分（SVF）粘附而获得的脂肪干细胞。脂肪来源的细胞是表达CD10，CD13，CD29，CD44，CD59，CD71，CD90或CD105的脂肪来源的干细胞。脂肪细胞组合物的制造方法包括：从受试者收集脂肪的步骤; 从脂肪分离SVF的步骤; 在培养容器中培养SVF以分化脂肪干细胞的步骤; 以及收集分化不成熟脂肪细胞的步骤。

44. 发明公开

KR1020070070445A 심근 조직 재생을 위한 세포의 생산 방법 无效
标题翻译：制备用于心脏组织再生的细胞的方法
公开(公告)号：KR1020070070445A
公开(公告)日：2007-07-04
申请号：KR1020050133001
申请日：2005-12-29
申请人： (주)안트로젠
发明人： 이성구 , 김미형 , 김택승
IPC分类号： C12N5/071 , C12N5/22
CPC分类号： C12N5/0657 , A61K35/12 , C12N2500/38 , C12N2501/105 , C12N2501/115 , C12N2501/155 , C12N2501/235 , C12N2501/39 , C12N2506/1353
摘要： A method for preparing a cell for heart tissue regeneration is provided to optimize engraftment and survival rate of the cell in the heart muscle, and differentiate the cell into the heart muscle, so that myocardial infarction is prevented and treated. The method for preparing the cells for heart tissue regeneration comprises the steps of: (a) supplying immortalization-inhibited bone marrow stem cells; (b) subculturing the bone marrow stem cells while the cells maintain characteristics of the bone marrow stem cell; (c) culturing the bone marrow stem cells in a cardiac specific medium which induces commitment of the bone marrow stem cell into a cardiomyocyte while the cell maintains characteristics of bone marrow mesenchymal stem cell until 80-90% of the bone marrow stem cells are induced into the cardiomyocytes; and (d) collecting the cells of step(c) when the cultured cells show a marker specific to the bone marrow mesenchymal stem cell.
摘要翻译：提供了一种制备心脏组织再生细胞的方法，以优化心肌细胞的移植和存活率，并将细胞分化为心肌，从而预防和治疗心肌梗死。用于制备心脏组织再生细胞的方法包括以下步骤：（a）供应永生化抑制性骨髓干细胞; （b）传代培养骨髓干细胞，同时细胞维持骨髓干细胞的特征; （c）在心脏特异性培养基中培养骨髓干细胞，其诱导骨髓干细胞承载到心肌细胞中，同时细胞维持骨髓间充质干细胞的特征，直到引起骨髓干细胞的80-90％进入心肌细胞; 和（d）当培养的细胞显示出对骨髓间充质干细胞特异的标志物时，收集步骤（c）的细胞。

45. 实用新型

KR200480841Y1 조립식 플레이 텐트 有权
标题翻译：玩帐篷
公开(公告)号：KR200480841Y1
公开(公告)日：2016-07-12
申请号：KR2020150002790
申请日：2015-04-29
申请人： 김미형
发明人： 김미형 , 신강욱
IPC分类号： E04H15/00 , A47D13/06
摘要： 본고안은조립식플레이텐트에관한것으로, 더욱상세하게는상호조립을통해간단하게골격프레임을구성할수 있는조립식플레이텐트에관한것이다. 본고안에따른조립식플레이텐트는원뿔또는다각뿔형상의텐트를형성하는골격프레임과, 상기골격프레임에고정되는커버부를구비하며, 상기골격프레임은제1 연결부와, 상기제1 연결부의양측단부로부터하방으로연장되는두 개의제1 지지부재를포함하는제1 프레임세트와, 상기제1 연결부와교차되는방향으로연결되는제2 연결부와, 상기제2 연결부의양측하단으로부터하방으로연장되는두 개의제2 지지부재를포함하는제2 프레임세트를포함하며, 상기제1 지지부재와제2 지지부재는각각상기제1 연결부와제2 연결부로부터하방으로연장될수록상호이격거리가점점벌어지도록경사지게연장되고, 상기제1 연결부에는상단으로부터하방으로인입된제1 체결홈이형성되고, 상기제2 연결부에는하단으로부터상방으로인입되는제2 체결홈이형성되어상기제1 체결홈과제2 체결홈이상호끼워지는형태로체결된다.

46. 外观设计

KR3008084420000S 有权
公开(公告)号：KR3008084420000S
公开(公告)日：2015-08-03
申请号：KR3020140052206
申请日：2014-10-31
申请人： 김미형
设计人： 김미형

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