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41. 发明专利

AU764027B2 Microdevices for screening biomolecules 未知
公开(公告)号：AU764027B2
公开(公告)日：2003-08-07
申请号：AU5102499
申请日：1999-07-14
申请人： ZYOMYX INC
发明人： WAGNER PETER , AULT-RICHE DANA , NOCK STEFFEN , ITIN CHRISTIAN
IPC分类号： G01N33/566 , C12M1/34 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N37/00
摘要： Methods and devices for the parallel, in vitro screening of biomolecular activity using miniaturized microfabricated devices are provided. The biomolecules that can be immobilized on the surface of the devices of the present invention include proteins, polypeptides, nucleic acids, polysaccharides, phospholipids, and related unnatural polymers of biological relevance. These devices are useful in high-throughput drug screening and clinical diagnostics and are preferably used for the parallel screening of families of related proteins.

42. 发明专利

CA2401118A1 MICROFLUIDIC DEVICES AND METHODS 未知
公开(公告)号：CA2401118A1
公开(公告)日：2001-08-30
申请号：CA2401118
申请日：2001-02-23
申请人： ZYOMYX INC
发明人： JEDRZEJEWSKI PAUL , ZAUGG FRANK G , INDERMUHLE PIERRE F , WAGNER PETER , NOCK STEFFEN
IPC分类号： G01N33/53 , B01J19/00 , B01L3/00 , B01L3/02 , B01L99/00 , B81B1/00 , C40B40/10 , C40B60/14 , G01N35/04 , G01N35/10 , G01N37/00 , G01N35/00 , G01N1/00
摘要： A test device is disclosed having a base (22) that is a non-sample surface and sample structures (25 (a,b)) comprising pillars (20 (a,b)), wherein each pillar comprises a sample surface (24 (a,b)) and side surfaces (18 (a,b)), and wherein the sample surface (24 (a,b,)) of each pillar and the surface of the substrate (23) have the same coating.

43. 发明专利

CA2507754A1 ARRAYS OF PROTEIN-CAPTURE AGENTS AND METHODS OF USE THEREOF 未知
公开(公告)号：CA2507754A1
公开(公告)日：2000-01-27
申请号：CA2507754
申请日：1999-07-14
申请人： ZYOMYX INC
发明人： AULT-RICHE DANA , NOCK STEFFEN , WAGNER PETER , ITIN CHRISTIAN
IPC分类号： C07K17/00 , G01N33/543
摘要： Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are described. Methods of both making and using the array of protein-capture agents are also disclosed. The invention arrays are particularly useful for various proteomics applications including assessing patterns of protein expression and modification in cells.

44. 发明专利

CA2337654A1 ARRAYS OF PROTEINS AND METHODS OF USE THEREOF 未知
公开(公告)号：CA2337654A1
公开(公告)日：2000-01-27
申请号：CA2337654
申请日：1999-07-14
申请人： ZYOMYX INC
发明人： WAGNER PETER , AULT-RICHE DANA , NOCK STEFFEN , ITIN CHRISTIAN
IPC分类号： C40B40/10 , G01N33/543 , G01N33/551 , G01N33/68 , G01N37/00
摘要： Protein arrays for the parallel, in vitro screening of biomolecular activity are provided. Methods of using the protein arrays are also disclosed. On the arrays, a plurality of different proteins, such as different members of a single protein family, are immobilized on one or more organic thin films on the substrate surface. The protein arrays are particularly useful in drug development, proteomics, and clinical diagnostics.

45. 发明专利

AP3322A Cell assay kit and method 未知
公开(公告)号：AP3322A
公开(公告)日：2015-06-30
申请号：AP2010005312
申请日：2008-12-05
申请人： ZYOMYX INC
发明人： WAGNER PETER , RUIZ-TAYLOR LAURENCE , MCMANUS-MUNOZ SILVA
IPC分类号： G01N33/49 , G01N33/543 , G01N33/569
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.

46. 发明专利

ZA201004600B CELL ASSAY KIT AND METHOD 未知
公开(公告)号：ZA201004600B
公开(公告)日：2011-06-29
申请号：ZA201004600
申请日：2010-06-30
申请人： ZYOMYX INC
发明人： RUIZ-TAYLOR LAURENCE , KERNEN PETER , TOBIAS RENEE , ZAUGG FRANK , WAGNER PETER
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.

47. 发明专利

AP2010005312A0 Cell assay kit and method 未知
公开(公告)号：AP2010005312A0
公开(公告)日：2010-08-31
申请号：AP2010005312
申请日：2008-12-05
申请人： ZYOMYX INC
发明人： WAGNER PETER , ZAUGG FRANK , TOBIAS RENEE
IPC分类号： G01N33/543 , G01N33/49 , G01N33/569
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.

48. 发明专利

CA2568751A1 METHODS AND APPARATUS FOR LABEL-INDEPENDENT MONITORING OF BIOLOGICAL INTERACTIONS ON SENSITIZED SUBSTRATES 未知
公开(公告)号：CA2568751A1
公开(公告)日：2005-12-15
申请号：CA2568751
申请日：2005-06-03
申请人： ZYOMYX INC
发明人： INDERMUEHLE PIERRE , HEIDECKER MANFRED , WAGNER PETER , FOLLONIER STEPHANE
IPC分类号： G01N21/29 , B01L3/00 , B01L3/12 , G01N21/21
摘要： Sensor interrogation systems based on optical phase changes are configured to quantify analytes. Sensor chips and wells can include light scattering regions, light absorbing regions, or tilted regions to reduce or eliminate unwanted portions of an interrogation optical beam. In some examples, a spatial phase modulation is used to compensate static birefringence or to provide a selected sensor bias point. Phase changes can be detected based on state of polarization using interferometry. Optical resonator structures can be used to enhance phase changes to simplify detection of optical phase changes.

49. 发明专利

AU2004201126A1 Arrays of protein-capture agents and methods of use thereof 未知
公开(公告)号：AU2004201126A1
公开(公告)日：2004-04-22
申请号：AU2004201126
申请日：2004-03-17
申请人： ZYOMYX INC
发明人： ITIN CHRISTIAN , AULT-RICHE DANA , NOCK STEFFEN , WAGNER PETER
IPC分类号： G01N33/543

50. 发明专利

AU2003262452A1 Arrays of proteins and methods of use thereof I 未知
公开(公告)号：AU2003262452A1
公开(公告)日：2004-01-15
申请号：AU2003262452
申请日：2003-11-21
申请人： ZYOMYX INC
发明人： ITIN CHRISTIAN , NOCK STEFFENS , AULT-RICHE DANA , WAGNER PETER
IPC分类号： G01N33/543 , G01N33/551

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