专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明公开

EP0786454A1 THIOQUINOLONE DERIVATIVE 失效
标题翻译： THIOCHINOLON，衍生金融工具
公开(公告)号：EP0786454A1
公开(公告)日：1997-07-30
申请号：EP95933632.2
申请日：1995-10-06
申请人： ZENYAKU KOGYO KABUSHIKI KAISHA
发明人： KONISHI, Masataka, Kenkyusho of Zenyaku Kogyo KK , FUKUDA, Naoki, Kenkyusho of Zenyaku Kogyo KK , OKU, Yukio, Kenkyusho of Zenyaku Kogyo KK , YAMAZAKI, Hiroaki, Kenkyusho of Zenyaku Kogyo KK , IMAIZUMI, Kazuhiro, Kenkyusho of Zenyaku Kogyo KK , KOBAYASHI, Hideshi, Kenkyusho of Zenyaku Kogyo KK
IPC分类号： C07D215/36 , C07D215/38 , C07D221/08 , C07D491/048 , A61K31/47 , A61K31/435
CPC分类号： C07D401/12 , C07D215/36 , C07D215/38 , C07D221/08 , C07D471/04 , C07D491/04
摘要： Disclosed is a thioquinolone derivative which exhibits highly selective antibacterial activity against Helicobacter pylori and which is represented by the formula I

wherein R 1 and R 2 respectively represent hydrogen atom or R 1 and R 2 are joined to form ―O―(CH 2 ) 2 -;
R 3 represents halogen atom, C 1 -C 12 alkyl group, C 1 -C 12 alkoxy group, lower alkylsulfonyloxy group, carboxy lower alkoxy group, lower alkylthio group, benzyloxy group, benzylthio group, phenoxy group, styryl group, nitro group, phenyl group, naphthyl group, piperazinyl group, morpholino group or hydroxyl group or represents ―CH 2 R 5 , ―COR 6 or ―NR 7 R 8 wherein R 5 represents benzyl group, phenyl group, hydroxyl group, lower alkoxy group, lower alkylcarbonyloxy group, phenoxy group, di-lower alkylamino group or benzimidazolylthio group, R 6 represents lower alkyl group or amino group and R 7 and R 8 respectively represent lower alkyl group; and
R 4 represents hydrogen atom or lower alkyl group or is coupled with R 3 to form cyclohexene ring, benzene ring or pyridine ring,
R 3 being not halogen atom at any of positions 5 to 8, methyl group at position 6 or methoxy group at position 6 of the quinoline ring when R 1 , R 2 and R 4 are respectively hydrogen atom,
R 3 and R 4 being not at positions 6 and 7 or positions 6 and 8 of the quinoline ring when R 1 and R 2 are respectively hydrogen atom and R 4 is lower alkyl group.
摘要翻译：本发明公开了一种对幽门螺旋杆菌具有高度选择性抗菌活性的噻喹诺酮衍生物，其由式I 表示，其中R1和R2分别表示氢原子或R1和R2连接形成-O-（CH 2）2 - ; R3表示卤原子，C1-C12烷基，C1-C12烷氧基，低级烷基磺酰氧基，羧基低级烷氧基，低级烷硫基，苄氧基，苄硫基，苯氧基，苯乙烯基，硝基，苯基，萘基，哌嗪基，吗啉代基或羟基，或表示-CH 2 R 5，-COR 6或-NR 7 R 8，其中R 5表示苄基，苯基，羟基，低级烷氧基，低级烷基羰基氧基，苯氧基，二低级烷基氨基或苯并咪唑硫基 R6代表低级烷基或氨基，R7和R8分别代表低级烷基; R4代表氢原子或低级烷基，或与R3结合形成环己烯环，苯环或吡啶环，R3不为5至8位任何位置的卤素原子，6位甲基或6位甲氧基当R1，R2和R4分别为氢原子，当R1和R2分别为氢原子且R4为低级烷基时，R3和R4不在喹啉环的6位和7位或6位和8位的喹啉环。

42. 发明公开

EP0230474A1 BIS-DIOXOPIPERAZINE DERIVATIVES AND DRUG COMPOSITION CONTAINING SAME 失效
标题翻译：双 - 二氧代哌嗪衍生物和含有它们的药物组合物
公开(公告)号：EP0230474A1
公开(公告)日：1987-08-05
申请号：EP86904348.9
申请日：1986-06-25
申请人： ZENYAKU KOGYO KABUSHIKI KAISHA
发明人： CAI, Jun-Chao, Laboratory of Zenyaku K. K. , TAKASE, Muneaki
IPC分类号： C07D241/08 , C07D401/14 , A61K31/495 , A61K31/535 , A61K31/54
CPC分类号： C07D241/08
摘要： Novel bis-dioxopiperazine derivatives represented by general formula (1),
wherein R 1 represents a lower alkyl group: A represents an oxygen atom, a sulfur atom, CH-R 2 or -N-R 3 (wherein R 2 represents a hydrogen atom, a lower alkyl group or a phenyl group, and R 3 represents a lower alkyl group, a phenyl group or a benzyl group), and X and Y, which may be the same or different, each represents a hydrogen atom or a lower alkyl group. These compounds have a wide oncostatic spectrum. A drug composition containing them as oncostatic ingredient is also disclosed.
摘要翻译：由通式（1）表示的新型双 - 二氧代哌嗪衍生物，其中R1代表低级烷基：A代表氧原子，硫原子，CH-R2或-NR3（其中R2代表氢原子，低级烷基基团或苯基，并且R3表示低级烷基，苯基或苄基），并且X和Y可以相同或不同，各自表示氢原子或低级烷基。这些化合物具有广泛的抑瘤谱。还公开了含有它们作为镇痛成分的药物组合物。

43. 发明公开

EP0138058A1 Novel 1,4-thiazine derivative 有权
标题翻译： 1,4-噻嗪衍。
公开(公告)号：EP0138058A1
公开(公告)日：1985-04-24
申请号：EP84110868.1
申请日：1984-09-12
申请人： ZENYAKU KOGYO KABUSHIKI KAISHA
发明人： Takase, Muneaki , Yoshioka, Kimitomo , Yamazaki, Hiroaki
IPC分类号： C07D417/04 , A61K31/54
CPC分类号： C07D417/04
摘要： Disclosed is a novel 1,4-thiazine derivative represented by the following general formula I and a pharmaceutically acceptable acid addition salt thereof:
wherein R 1 , R 2 and R 3 respectively represent a hydrogen atom or a lower alkyl group. Also disclosed are processes for preparation of a novel thiazine derivative represented by the general formula I, which comprise reacting a compound of the general formula III with a compound of the general formula A-X' in a compound containing a pyridinyl group as a solvent to obtain a compound of the general formula II:
wherein R,, R 2 and R 3 are as defined above, A represents a group
in which X represents a halogen atom and n is a number of 1 to 3, and X' represents a halogen atom which may be the same as or different from X, and reacting the compound of the general formula II with sulfur at elevated temperature or stirring the compound of the general formula II in a solution system comprising zinc and a carboxylic acid. Further disclosed is a cardiotonic agent comprising a pharmaceutically acceptable excipient and, as the active component thereof, an effective amount of the novel 1,4-thiazine derivative having the general formula I.

44. 发明公开

EP1741714A1 HETEROCYCLIC COMPOUND AND ANTI-MALIGNANT-TUMOR AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT 有权
标题翻译：密封胶VITBINDUNG MITTEL GEGEN MALIGNE TUMORE，DAS DIESEENTHÄLT
公开(公告)号：EP1741714A1
公开(公告)日：2007-01-10
申请号：EP05727794.9
申请日：2005-03-30
申请人： ZENYAKU KOGYO KABUSHIKI KAISHA
发明人： KAWASHIMA, S.; c/o Laboratory ZENYAKU KOGYO K. K. , MATSUNO, T.; c/o Laboratory ZENYAKU KOGYO K. K. , YAGUCHI, S.; c/o Laboratory ZENYAKU KOGYO K. K. , TSUCHIDA, Y.; c/o Laboratory ZENYAKU KOGYO K. K. , SAITOH, K.; c/o Laboratory ZENYAKU KOGYO K. K. , WATANABE, T.; c/o Laboratory ZENYAKU KOGYO K. K.
IPC分类号： C07D413/14 , A61K31/5377 , A61P35/00 , C07D403/04
CPC分类号： A61K31/5377 , C07D403/04
摘要： Heterocyclic compounds represented by the formula I and anti-malignant-tumor agents containing the heterocyclic compounds as effective components:

wherein X represents nitrogen atom or CH; Y represents C 1 -C 6 alkyl; R 1 represents morpholino (which may be substituted with one to four C 1 -C 6 alkyl); and R 2 and R 3 each represent hydrogen atom or C 1 -C 6 alkyl.
摘要翻译：由式I表示的杂环化合物和含有杂环化合物的抗恶性肿瘤剂作为有效成分：其中X表示氮原子或CH; Y表示C 1 -C 6烷基; R 1表示吗啉代（其可以被一至四个C 1 -C 6烷基取代）; R 2和R 3各自表示氢原子或C 1 -C 6烷基。

45. 发明授权

EP1389617B1 HETEROCYCLIC COMPOUND AND ANTITUMOR AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT 有权
标题翻译：杂环化合物及抗肿瘤意味着这个作为活性成分
公开(公告)号：EP1389617B1
公开(公告)日：2007-01-03
申请号：EP02722829.5
申请日：2002-04-26
申请人： ZENYAKU KOGYO KABUSHIKI KAISHA
发明人： KAWASHIMA, S., Kenkyusho of Zenyaku Kogyo K. K. , MATSUNO, T., Kenkyusho of Zenyaku Kogyo K. K. , YAGUCHI, S., Kenkyusho of Zenyaku Kogyo K. K. , SASAHARA, H., Kenkyusho of Zenyaku Kogyo K. K. , WATANABE, T., Kenkyusho of Zenyaku Kogyo K. K.
IPC分类号： C07D403/04 , C07D413/14 , C07D417/14 , A61K31/5377 , A61K31/541 , A61P35/00
CPC分类号： C07D403/04 , C07D403/14 , C07D413/14 , C07D417/14
摘要： A heterocyclic compound represented by the general formula (I) (I) {wherein X represents nitrogen or CH; R1 represents CHnF3-n (n is 1 or 2), hydroxylated C1-6 alkyl, or NHR6 [R6 represents hydrogen or COR (R represents hydrogen, C1-6 alkyl, or C1-6 alkoxy)]; R2 represents morpholino (optionally substituted by one to four C1-6 alkyls), thiomorpholino, piperidino, pyrrolidinyl (optionally substituted by hydroxylated C1-6 alkyl), oxazolidinyl (optionally substituted by one or two C1-6 alkyls), or tetrahydro-1, 4-thiazin-1-oxo-4-yl; R3 and R4 each represents hydrogen or C1-6 alkyl; and R5 represents hydrogen, amino, or hydroxy} or a pharmaceutically acceptable salt thereof; and an antitumor agent containing the heterocyclic compound as the active ingredient.

47. 发明公开

EP1389617A1 HETEROCYCLIC COMPOUND AND ANTITUMOR AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT 有权
标题翻译：防霉剂VERBINDUNG UND ANTITUMORMITTEL，DAS DIESE ALS WIRKSTOFFENTHÄLT
公开(公告)号：EP1389617A1
公开(公告)日：2004-02-18
申请号：EP02722829.5
申请日：2002-04-26
申请人： ZENYAKU KOGYO KABUSHIKI KAISHA
发明人： KAWASHIMA, S., Kenkyusho of Zenyaku Kogyo K. K. , MATSUNO, T., Kenkyusho of Zenyaku Kogyo K. K. , YAGUCHI, S., Kenkyusho of Zenyaku Kogyo K. K. , SASAHARA, H., Kenkyusho of Zenyaku Kogyo K. K. , WATANABE, T., Kenkyusho of Zenyaku Kogyo K. K.
IPC分类号： C07D403/04 , C07D413/14 , C07D417/14 , A61K31/5377 , A61K31/541 , A61P35/00
CPC分类号： C07D403/04 , C07D403/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to heterocyclic compounds represented by the formula I or pharmaceutically acceptable salts thereof and antitumor agents containing the heterocyclic compounds as effective components:
wherein X represents nitrogen atom or CH; R 1 represents CH n F 3-n (wherein n is 1 or 2), hydroxy C 1 -C 6 alkyl, NHR 6 [wherein R 6 represents hydrogen atom or COR (wherein R represents hydrogen atom, C 1 -C 6 alkyl or C 1 -C 6 alkoxy)]; R 2 represents morpholino (which may be substituted with one to four C 1 -C 6 alkyl), thiomorpholino, piperidino, pyrrolidinyl (which may be substituted with hydroxy C 1 -C 6 alkyl), oxazolidinyl (which may be substituted with one or two C 1 -C 6 alkyl) or tetrahydro-1,4-thiazin-1-oxo-4-yl; R 3 and R 4 each represent hydrogen atom or C 1 -C 6 alkyl; and R 5 represents hydrogen atom, amino or hydroxyl.
摘要翻译：本发明涉及由式I表示的杂环化合物或其药学上可接受的盐和含有杂环化合物作为有效成分的抗肿瘤剂：其中X表示氮原子或CH; R 1表示CH n F 3-n（其中n为1或2），羟基C 1 -C 6烷基，NHR 6，其中R 6表示氢原子或COR（其中R表示氢原子，C 1 -C 6烷基或C 1 -C 6烷氧基） R 2表示吗啉代（其可以被一至四个C 1 -C 6烷基取代），硫代吗啉代，哌啶子基，吡咯烷基（其可以被羟基C 1 -C 6烷基取代），恶唑烷基（其可以被一个或两个C 1 -C 6烷基）或四氢-1,4-噻嗪-1-氧代-4-基; R 3和R 4各自表示氢原子或C 1 -C 6烷基; R5表示氢原子，氨基或羟基。

48. 发明公开

EP1219621A1 AZAINDOLIZINONE DERIVATIVES AND CEREBRAL FUNCTION IMPROVERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT 有权
标题翻译：用于改善认知技能AZAINDOLIZINON衍生物及代理人，同样作为活性成分包括
公开(公告)号：EP1219621A1
公开(公告)日：2002-07-03
申请号：EP00948260.5
申请日：2000-07-28
申请人： ZENYAKU KOGYO KABUSHIKI KAISHA
发明人： Kawashima, Seiichiro Kenkyusho of Zenyaku K.K.K. , Matsuno, Toshiyuki Kenkyusho of Zenyaku K.K.K. , Fukuda, Naoki Kenkyusho of Zenyaku Kogyo K.K. , Saitoh, Kenichi Kenkyusho of Zenyaku Kogyo K.K. , Yamaguchi, Yoshimasa Kenkyusho of Zenyaku Kogyo KK , Higashi, Masaya Kenkyusho of Zenyaku Kogyo K.K.
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61P25/28 , A61P25/16
CPC分类号： C07D471/04
摘要： Azaindolizinon derivatives or pharmaceutically acceptable salts thereof represented by the formula I:
wherein

R 1 represents hydrogen atom, halogen atom or C 1 -C 6 alkyl,
R 2 represents hydrogen atom, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, hydroxy, halogen atom, amino, acetylamino, benzylamino, trifluoromethyl or -O-(CH 2 ) n -R 5 (R 5 represents vinyl, C 3 -C 8 cycloalkyl or phenyl, n being 0 or 1),
R 3 and R 4 respectively represent C 1 -C 6 alkyl or -CH(R 7 )-R 6 (wherein R 6 represents vinyl, ethynyl, phenyl (which may be substituted with C 1 -C 6 alkyl, C 1 -C 6 alkoxy, hydroxy, one or two halogen atoms, di C 1 -C 6 alkylamino, cyano, nitro, carboxy or phenyl), phenethyl, pyridyl, thienyl or furyl and R 7 represents hydrogen atom or C 1 -C 6 alkyl) or R 3 is coupled with R 4 to form indan or dihydrophenalene.
摘要翻译： Azaindolizinon由式I或其表示的衍生物或其药学上可接受的盐： worin R1 darstellt氢原子，卤素原子或C1-C6烷基，R2 darstellt氢原子，C1-C6烷基，C1-C6烷氧基，羟基，卤原子，氨基，乙酰氨基，苄基氨基，三氟甲基或-O-（CH 2）N-R5（R5 darstellt乙烯基，C3-C8环烷基或苯基，n为0或1），R 3和R 4分别表示C1-C6烷基或-CH（R 7） -R 6（worin R6 darstellt乙烯基，乙炔基，苯基（可以被取代的具有C1-C6烷基，C1-C6烷氧基，羟基，一个或两个卤素原子，二C 1 -C 6烷基氨基，氰基，硝基，羧基或苯基），苯乙基，吡啶基，噻吩基或呋喃基和R7 darstellt氢原子或C1-C6烷基），或R 3被加上，R 4以形成茚满或dihydrophenalene。

49. 发明公开

EP0926139A1 QUINOLINE SULFIDE DERIVATIVES 失效
标题翻译：喹啉衍生物
公开(公告)号：EP0926139A1
公开(公告)日：1999-06-30
申请号：EP97933841.5
申请日：1997-07-30
申请人： ZENYAKU KOGYO KABUSHIKI KAISHA
发明人： KAWASHIMA, Seiichiro, Kenkyusho of Zenyaku Kogyo , TERADA, Sumio, Kenkyusho of Zenyaku Kogyo K.K. , SAITO, Ken-ichi, Kenkyusho of Zenyaku Kogyo K.K. , SUZUKI, Toshiaki, Kenkyusho of Zenyaku Kogyo K.K. , SASAHARA, Hiroya, Kenkyusho of Zenyaku Kogyo K.K. , KANDA, Toshihisa, Kenkyusho of Zenyaku Kogyo K.K. , INOUE, Tsuneo, Kenkyusho of Zenyaku Kogyo K.K.
IPC分类号： C07D215/36 , C07D401/12 , A61K31/47
CPC分类号： C07D215/36
摘要： The present invention is directed to quinoline sulfide derivatives with antibacterial activities selectively against Hp , obtained by reacting quinoline-4(1H)-thione derivatives with halides and represented by the formula I

wherein R 1 represents hydrogen or halogen atom, C 1 -C 6 alkoxy, C 1 -C 6 alkylthio or di C 1 -C 6 alkylamino; R 2 and R 3 respectively represent hydrogen atom or C 1 -C 6 alkyl; one of R 4 and R 5 represents hydroxyl group and the other represents hydrogen atom or CR 4 R 5 represents carbonyl; and
m and n are integers, m being 1 or 2, n being 0 or 1.
摘要翻译：本发明涉及通过喹啉-4（1H） - 硫酮衍生物与卤化物反应而获得的具有选择性抗Hp的抗菌活性的喹啉硫化物衍生物，其中R1表示氢或卤素原子，C1-C6烷氧基，C1 -C6烷硫基或二C1-C6烷氨基; R2和R3分别代表氢原子或C1-C6烷基; R4和R5中的一个代表羟基，另一个代表氢原子或CR4R5代表羰基; m和n是整数，m是1或2，n是0或1。

50. 发明授权

EP0491053B1 WATER-SOLUBLE BIS-DIOXOPIPERAZINE DERIVATIVES WITH ANTITUMORAL PROPERTIES 失效
标题翻译：具有抗肿瘤作用的水溶性BIS DIOXOPIPERAZINDERIVATE
公开(公告)号：EP0491053B1
公开(公告)日：1996-02-07
申请号：EP91911753.1
申请日：1991-07-03
申请人： ZENYAKU KOGYO KABUSHIKI KAISHA
发明人： TAKASE, Muneaki, 24-13, Oizumi-machi 1-chome , NARITA, Toshiharu, 10-9, Aobacho 3-chome , KOMATSU, Toshihiko, 2-1, Uwado-shinmachi
IPC分类号： C07D241/08 , C07D403/14 , C07D417/14
CPC分类号： C07D403/14 , C07D241/08 , C07D417/14
摘要： An acid addition salt of a bis-dioxopiperazine derivative represented by general formula (I), wherein R1 represents C¿1? to C6 alkyl; R?2¿ represents hydrogen or (a); R3 represents hydrogen, C¿1? to C6 alkyl or -(CH2)n-A, wherein A represents carboxyl, benzyloxycarbonyl, mercapto, amino, benzyloxycarbonylamino or (b), wherein X represents hydrogen, trifluoromethyl, hydroxy, acetoxy or benzyloxy, and n represents an integer of 1 to 4; and R?4¿ represents hydrogen or alternatively R?4 and R3¿ are combined together to represent a 5-membered cyclic group optionally containing sulfur.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式