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41. 发明授权

US06884803B2 Phenylalkynes 有权
标题翻译：苯基炔
公开(公告)号：US06884803B2
公开(公告)日：2005-04-26
申请号：US10307870
申请日：2002-12-02
申请人： Richard Apodaca , Wei Xiao , Jill A. Jablonowski
发明人： Richard Apodaca , Wei Xiao , Jill A. Jablonowski
IPC分类号： C07D295/12 , A61K31/444 , A61K31/4453 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/08 , A61P11/06 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/28 , A61P27/14 , A61P27/16 , A61P37/08 , A61P43/00 , C07D203/12 , C07D209/14 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/66 , C07D213/38 , C07D215/06 , C07D215/12 , C07D239/42 , C07D273/00 , C07D273/01 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/12 , C07D471/10 , C07D491/10 , C07D491/113 , C07D403/06 , A61K31/495 , A61P25/24 , C07D295/04
CPC分类号： C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/38 , C07D215/06 , C07D273/00 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/12 , C07D471/10 , C07D491/10
摘要： Disclosed are substituted phenylalkynes of formula (I), wherein R1, R2, R3, R4, R5 and n are as defined, compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译：公开了式（I）的取代的苯基炔，其中R 1，R 2，R 3，R 4， R 5和n如上所定义，含有它们的组合物，以及制备和使用它们来治疗组胺介导的病症的方法。

42. 发明申请

US20050085487A1 Heterocyclic compounds 审中-公开
标题翻译：杂环化合物
公开(公告)号：US20050085487A1
公开(公告)日：2005-04-21
申请号：US10961247
申请日：2004-10-08
申请人： Nicholas Carruthers , Wenying Chai , Curt Dvorak , James Edwards , Cheryl Grice , Jill Jablonowski , Lars Karlsson , Haripada Khatuya , Jennifer Kreisberg , Annette Kwok , Timothy Lovenberg , Kiev Ly , Barbara Pio , Chandravadan Shah , Siquan Sun , Robin Thurmond , Jianmei Wei , Wei Xiao
发明人： Nicholas Carruthers , Wenying Chai , Curt Dvorak , James Edwards , Cheryl Grice , Jill Jablonowski , Lars Karlsson , Haripada Khatuya , Jennifer Kreisberg , Annette Kwok , Timothy Lovenberg , Kiev Ly , Barbara Pio , Chandravadan Shah , Siquan Sun , Robin Thurmond , Jianmei Wei , Wei Xiao
IPC分类号： C07D307/84 , A61K31/496 , A61P1/04 , A61P7/00 , A61P9/06 , A61P17/06 , A61P19/02 , A61P25/28 , A61P29/00 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07D209/42 , C07D401/12 , C07D403/06 , A61K31/454 , C07D413/02 , C07D417/02 , C07D43/02
CPC分类号： C07D401/12 , A61K31/496 , C07D209/42
摘要： Heterocyclic compounds and methods of making them and using them.
摘要翻译：杂环化合物及其制备方法和使用方法。

43. 发明授权

US06587881B1 Software server usage governor 有权
标题翻译：软件服务器使用总监
公开(公告)号：US06587881B1
公开(公告)日：2003-07-01
申请号：US09289054
申请日：1999-04-09
申请人： Sameet Agarwal , Wei Xiao , Michael Zwilling
发明人： Sameet Agarwal , Wei Xiao , Michael Zwilling
IPC分类号： G06F1516
CPC分类号： G06F9/505 , G06F11/3433 , G06F11/3438 , G06F11/3452 , G06F2201/87 , G06F2201/88
摘要： A system and method for controlling usage of a particular software program in a computer network environment is disclosed. The invention operates by controlling the throughput of the software as it executes on a server computer. In particular, the invention monitors the number of active requests to the software. If the number of active requests exceeds a predefined number, the software throughput on the server (e.g., requests completed per minute) is artificially restricted. As such, the present invention continues to allow further connections to the software but intentionally restricts further use by inhibiting the throughput for all connections to the software. Preferably, the present invention continues to allow the predefined number of active requests to be exceeded, but as more requests are made, the overall performance of software progressively degrades.
摘要翻译：公开了一种用于控制计算机网络环境中特定软件程序的使用的系统和方法。本发明通过在服务器计算机上执行时控制软件的吞吐量来操作。特别地，本发明监视对软件的活动请求的数量。如果活动请求的数量超过预定义的数量，则服务器上的软件吞吐量（例如，每分钟完成的请求）被人为限制。因此，本发明继续允许与软件的进一步连接，而是有意地通过禁止对软件的所有连接的吞吐量来限制进一步的使用。优选地，本发明继续允许超过预定数量的活动请求，但是随着更多请求，软件的整体性能逐渐降低。

44. 发明申请

US20140221406A1 QUINAZOLINE-7-ETHER COMPOUNDS AND METHODS OF USE 有权
标题翻译：喹唑啉-7-醚化合物及其使用方法
公开(公告)号：US20140221406A1
公开(公告)日：2014-08-07
申请号：US14118200
申请日：2012-05-17
申请人： Wang Shen , Wei Xiao , Jack Maung , Aimin Zhang , Xiaoling Zheng , Zhenzhong Wang , Qingming Guo , Yingguang Li
发明人： Wang Shen , Wei Xiao , Jack Maung , Aimin Zhang , Xiaoling Zheng , Zhenzhong Wang , Qingming Guo , Yingguang Li
IPC分类号： C07D405/12 , C07D493/04
CPC分类号： C07D405/12 , C07D493/04
摘要： The invention provides quinazoline-7-ether derivatives, particularly 4-anilinyl-6-butenamido-quinazoline-7-ether derivatives that are inhibitors of the receptor protein tyrosine kinases (RTK). The compounds are useful in the treatment of diseases and disorders where RTK activity is implicated such as a hyperproliferative diseases (e.g., cancer). Also provided are methods of preparation of the quinazoline derivatives and methods of use as therapeutic agents alone or in a drug combination.
摘要翻译：本发明提供了喹唑啉-7-醚衍生物，特别是作为受体蛋白酪氨酸激酶（RTK）抑制剂的4-苯乙烯基-6-丁烯酰氨基 - 喹唑啉-7-醚衍生物。所述化合物可用于治疗涉及RTK活性的疾病和病症，例如过度增殖性疾病（例如癌症）。还提供了制备喹唑啉衍生物的方法和单独使用或作为药物组合用作治疗剂的方法。

45. 发明授权

US08598202B2 Aryl-hydroxyethylamino-pyrimidines and triazines as modulators of fatty acid amide hydrolase 有权
标题翻译：芳基 - 羟乙基氨基 - 嘧啶和三嗪作为脂肪酸酰胺水解酶的调节剂
公开(公告)号：US08598202B2
公开(公告)日：2013-12-03
申请号：US12378734
申请日：2009-02-18
申请人： Richard Apodaca , J. Guy Breitenbucher , Alison L. Chambers , Xiaohu Deng , Natalie A. Hawryluk , John M. Keith , Neelakandha S. Mani , Jeffrey E. Merit , Joan M. Pierce , Mark Seierstad , Wei Xiao
发明人： Richard Apodaca , J. Guy Breitenbucher , Alison L. Chambers , Xiaohu Deng , Natalie A. Hawryluk , John M. Keith , Neelakandha S. Mani , Jeffrey E. Merit , Joan M. Pierce , Mark Seierstad , Wei Xiao
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D239/42 , C07D239/47 , C07D239/48 , C07D251/22 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/12
摘要： Certain aryl-hydroxyethylamino-pyrimidine and triazine compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). Methods of synthesizing such compounds are also disclosed.
摘要翻译：描述了某些芳基 - 羟乙基氨基 - 嘧啶和三嗪化合物，其可用作FAAH抑制剂。这些化合物可用于治疗由脂肪酰胺水解酶（FAAH）活性介导的疾病状态，病症和病症的药物组合物和方法，例如焦虑症，疼痛，炎症，睡眠障碍，进食障碍，能量代谢紊乱，和运动障碍（例如多发性硬化）。还公开了合成这些化合物的方法。

46. 发明申请

US20130005687A1 IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 有权
标题翻译： TRPV1的咪唑啉酮，氧杂双环和三唑基咪嗪调节剂
公开(公告)号：US20130005687A1
公开(公告)日：2013-01-03
申请号：US13611936
申请日：2012-09-12
申请人： Bryan James Branstetter , J. Guy Breitenbucher , Alec D. Lebsack , Jing Liu , Jason C. Rech , Wei Xiao
发明人： Bryan James Branstetter , J. Guy Breitenbucher , Alec D. Lebsack , Jing Liu , Jason C. Rech , Wei Xiao
IPC分类号： C07D513/04 , A61K31/519 , C07D239/48 , A61K31/5377 , C07D473/34 , A61K31/52 , C07D473/24 , C07D473/18 , C07D473/16 , C07F7/10 , A61K31/695 , A61P29/00 , A61P27/16 , A61P11/00 , A61P1/00 , A61P13/00 , A61P7/00 , A61P25/00 , A61P17/04 , A61P19/02 , A61P11/10 , A61P11/06 , C07D498/04
CPC分类号： C07D513/04 , A61K31/497 , A61K31/519 , A61K31/5377 , C07D473/16 , C07D473/18 , C07D473/24 , C07D473/34 , C07D498/04
摘要： Certain TRPV1-modulating imidazolo-, oxazolo-, and thiazolopyrimdine compounds are described. The compounds may be used in pharmaceutical compositions and methods for treating disease states, disorders, and conditions mediated by TRPV1 activity, such as pain, arthritis, itch, cough, asthma, or inflammatory bowel disease.
摘要翻译：描述了一些TRPV1调节的咪唑并，恶唑并噻唑并噻吩并嘧啶化合物。所述化合物可用于治疗由TRPV1活性介导的疾病状态，病症和状况的药物组合物和方法，例如疼痛，关节炎，瘙痒，咳嗽，哮喘或炎症性肠病。

47. 发明授权

US08339774B2 Connecting mechanism and electronic device using the same 失效
标题翻译：连接机构和电子设备使用相同
公开(公告)号：US08339774B2
公开(公告)日：2012-12-25
申请号：US12915071
申请日：2010-10-29
申请人： Jin-Wei Xiao
发明人： Jin-Wei Xiao
IPC分类号： G06F1/16
CPC分类号： G06F1/1681 , E05Y2201/448 , E05Y2900/606 , Y10T16/53845 , Y10T29/49155 , Y10T403/25
摘要： A connecting mechanism includes a first connecting member, a second connecting member, a first conduit and a second conduit. The first connecting member includes a first cylinder and a first piston movably accommodated within the first cylinder to divide the first cylinder into a first space on the one side of the first piston and a second space on the opposite side of the first piston. The second connecting member includes a second cylinder and a second piston movable accommodated within the second cylinder to divide the second cylinder into a third space on the one side of the second piston and a fourth space on the opposite side of the second piston. The first conduit communicates the first space with the third space. The second conduit communicates the second space with the fourth space. An electronic device using the connecting mechanism is also provided.
摘要翻译：连接机构包括第一连接构件，第二连接构件，第一导管和第二导管。第一连接构件包括第一气缸和可移动地容纳在第一气缸内的第一活塞，以将第一气缸分成第一活塞的一侧上的第一空间和第一活塞的相对侧上的第二空间。第二连接构件包括可容纳在第二气缸内的第二气缸和第二活塞，以将第二气缸分成第二活塞的一侧上的第三空间和第二活塞的相对侧上的第四空间。第一导管将第一空间与第三空间连通。第二导管将第二空间与第四空间连通。还提供了使用连接机构的电子设备。

48. 发明申请

US20120179025A1 CT AND MRI SYNCHRONOUS DETECTION POSITIONING NEEDLE 失效
标题翻译： CT和MRI同步检测定位针
公开(公告)号：US20120179025A1
公开(公告)日：2012-07-12
申请号：US13377044
申请日：2011-04-25
申请人： Dedong Ma , Wei Xiao , Qingshi Zeng , Ying Xing , Hongxiu Lu
发明人： Dedong Ma , Wei Xiao , Qingshi Zeng , Ying Xing , Hongxiu Lu
IPC分类号： A61B5/055 , A61M5/00 , A61B6/03
CPC分类号： A61B5/0035 , A61B5/055 , A61B6/032 , A61B6/12 , A61B17/3403 , A61B90/10 , A61B90/37 , A61B2017/3405 , A61B2090/3954 , A61B2090/3966 , A61B2090/3995 , A61M5/427 , A61M5/46
摘要： Disclosed is a CT and MRI synchronous detection positioning needle. The needle comprises a silicone tube which is internally provided with a guide needle; the two sides of the guide needle are provided with hollow cavities; each hollow cavity is internally provided with membranes dividing the hollow cavity into a plurality of small chambers which are filled with liquid, wherein a CT contrast agent is filled in a plurality of small chambers at one side of the guide needle, and an MRI contrast agent is filled in a plurality of small chambers at the other side of the guide needle. In the invention, specially designed silicone positioning needles are implanted in vivo, and synchronous comparison of different image data and pathological data is implemented by means of multi-plane reconstruction technology, so the CT and MRI synchronous detection positioning needle can be widely applied to experimental study on tumors.
摘要翻译：公开了一种CT和MRI同步检测定位针。该针包括内部设置有引导针的硅胶管; 引导针的两侧设有中空腔; 每个中空腔内部设置有将中空腔分成多个填充有液体的小室的膜，其中CT造影剂填充在引导针一侧的多个小室中，并且MRI造影剂被填充在引导针的另一侧的多个小室中。在本发明中，特别设计的硅胶定位针植入体内，通过多平面重建技术实现不同图像数据和病理数据的同步比较，CT和MRI同步检测定位针可广泛应用于实验研究肿瘤。

49. 发明申请

US20120122459A1 METHOD, APPARATUS, AND SYSTEM FOR VOICE CALL FALLBACK TO CIRCUIT SWITCHED DOMAIN 有权
标题翻译：用于语音呼叫倒退到电路切换域的方法，装置和系统
公开(公告)号：US20120122459A1
公开(公告)日：2012-05-17
申请号：US13356201
申请日：2012-01-23
申请人： Xiaobo Wu , Hai Liu , Wei Xiao
发明人： Xiaobo Wu , Hai Liu , Wei Xiao
IPC分类号： H04W36/36 , H04L12/66 , H04W68/00
CPC分类号： H04W36/0022 , H04W8/26 , H04W36/14 , H04W68/00 , H04W72/042 , H04W76/10
摘要： A method for voice call fallback to a circuit switched (CS) domain disclosed in the present invention includes: receiving a Service Request message from a calling user equipment (UE), where the Service Request message includes called number information of a voice call in a CS domain, instructing an evolved NodeB (eNB) to initiate circuit switched fallback (CSFB) handover; receiving a Handover Request message from the eNB, where the Handover Request message includes information required for CS handover, selecting a mobile switching center (MSC) and sending a packet switched (PS) to CS Handover Request message to the MSC, where the PS to CS Handover Request message carries information required for the CS handover and a called number so that the MSC calls a called UE. The corresponding apparatuses and systems are also disclosed. The technical solution of the present invention can reduce the connection delay.
摘要翻译：本发明公开的用于语音呼叫回退到电路交换（CS）域的方法包括：从主叫用户设备（UE）接收业务请求消息，其中业务请求消息包括语音呼叫的被叫号码信息 CS域，指示演进的节点B（eNB）发起电路交换回退（CSFB）切换; 从eNB接收切换请求消息，其中切换请求消息包括CS切换所需的信息，选择移动交换中心（MSC）并向MSC切换请求消息发送分组交换（PS）到MSC，其中PS到 CS切换请求消息携带CS切换所需的信息和被叫号码，使得MSC呼叫被叫UE。还公开了相应的装置和系统。本发明的技术方案可以减少连接延迟。

50. 发明申请

US20120083474A1 HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 有权
标题翻译：作为TRPA1的调节剂的杂环化合物
公开(公告)号：US20120083474A1
公开(公告)日：2012-04-05
申请号：US13375833
申请日：2010-06-04
申请人： Didier Jean-Claude Berthelot , Henricus Jacobus Maria Gijsen , Mirko Zaja , Jason Rech , Alec Lebsack , Wei Xiao , Bryan Branstetter , Guy J. Breitenbucher
发明人： Didier Jean-Claude Berthelot , Henricus Jacobus Maria Gijsen , Mirko Zaja , Jason Rech , Alec Lebsack , Wei Xiao , Bryan Branstetter , Guy J. Breitenbucher
IPC分类号： A61K31/635 , C07D403/12 , C07D401/14 , C07D409/14 , C07D413/14 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/551 , C12N5/071 , A61P29/00 , A61P27/16 , A61P1/00 , A61P13/02 , A61P11/00 , A61P19/02 , A61P11/14 , A61P11/06 , C07D403/14
CPC分类号： C07D403/14 , C07D207/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/12 , C07D409/14
摘要： Certain heterocyclic amide compounds are described. The compounds may be used in pharmaceutical compositions and methods for treating disease states, disorders, and conditions mediated by TRPA1 activity, such as pain, arthritis, itch, cough, asthma, or inflammatory bowel disease.
摘要翻译：描述了某些杂环酰胺化合物。所述化合物可用于治疗由TRPA1活性介导的疾病状态，病症和状况的药物组合物和方法，例如疼痛，关节炎，瘙痒，咳嗽，哮喘或炎症性肠病。

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