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41. 发明申请

WO2012040239A1 CANNULOTOME 审中-公开
标题翻译：套管式
公开(公告)号：WO2012040239A1
公开(公告)日：2012-03-29
申请号：PCT/US2011/052411
申请日：2011-09-20
申请人： SPINE VIEW, INC. , JANSEN, Lex, P. , TO, John, T. , DAVIS, John, W. , KUME, Stewart, M. , TWARDZIK, Wendy
发明人： JANSEN, Lex, P. , TO, John, T. , DAVIS, John, W. , KUME, Stewart, M. , TWARDZIK, Wendy
IPC分类号： A61B17/16
CPC分类号： A61B1/00154 , A61B1/005 , A61B1/015 , A61B1/018 , A61B1/3135 , A61B17/00234 , A61B17/0218 , A61B17/1604 , A61B17/1637 , A61B17/1644 , A61B17/1671 , A61B17/1757 , A61B17/22031 , A61B17/320016 , A61B17/32053 , A61B17/3415 , A61B17/3423 , A61B2017/00261 , A61B2017/00398 , A61B2017/0262 , A61B2090/3937
摘要： Systems and methods for treating spinal stenosis include endoscopic access devices and bone removal devices used to perform a foraminotomy or other bone removal procedures. A bone removal device includes a cannulotome with an endoscopic imaging lumen. Optionally, an endoscope retaining device can be used to facilitate advancement of the endoscope through the cannulotome.
摘要翻译：用于治疗脊柱狭窄的系统和方法包括用于进行椎间孔切开术或其他骨移除手术的内窥镜检查装置和骨移除装置。骨去除装置包括具有内窥镜成像内腔的插管切除器。可选地，内窥镜保持装置可以用于促进内窥镜通过管腔切除器的前进。

42. 发明申请

WO2011044533A2 COATING SYSTEM AND METHOD FOR DRUG ELUTION MANAGEMENT 审中-公开
标题翻译：涂药系统和药物治疗方法
公开(公告)号：WO2011044533A2
公开(公告)日：2011-04-14
申请号：PCT/US2010/052104
申请日：2010-10-08
申请人： TO, John, Thao , BLAHA, Charles, M. , SPECIALIZED VASCULAR TECHNOLOGIES, INC.
发明人： TO, John, Thao , BLAHA, Charles, M.
IPC分类号： A61K47/30 , A61K9/22 , A61P35/00
CPC分类号： A61L31/10 , A61F2/82 , A61F2210/0004 , A61F2250/0067 , A61K31/16 , A61K31/192 , A61K31/337 , A61K31/436 , A61K31/565 , A61K31/60 , A61K31/727 , A61K38/1825 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2420/08 , C08L67/04
摘要： The teachings are directed to a medical device having a drug-retaining coating that at least substantially delays the initial elution of a drug for a time effective at forming a functional endothelium over a surface of the medical device.
摘要翻译：该教导涉及具有药物保持涂层的医疗装置，该药物保持涂层至少基本上延迟药物的初始洗脱，以在医疗装置的表面上形成功能性内皮的时间有效。

43. 发明申请

WO2010121172A1 DEVICES AND METHODS FOR ARCHED ROOF CUTTERS 审中-公开
标题翻译：装饰屋顶切割机的设备和方法
公开(公告)号：WO2010121172A1
公开(公告)日：2010-10-21
申请号：PCT/US2010/031448
申请日：2010-04-16
申请人： SPINE VIEW, INC. , BATTEN, David , TO, John, T. , NGUYEN, Hiep
发明人： BATTEN, David , TO, John, T. , NGUYEN, Hiep
IPC分类号： A61B17/32
CPC分类号： A61B17/32002 , A61B17/1615 , A61B17/1617 , A61B17/1671 , A61B2017/320064
摘要： Disclosed herein are tissue-removal devices and methods for treating spinal diseases using such devices. The tissue-removal devices may comprise a cable and/or extendable elements with a retracted and a deployed configuration. The cable and/or extendable elements may be distally supported and restrained by a support element such that the support element may be pushed transversely away when the extendable element is distally extended into its deployed configuration. An annular cutting element may be provided about the distal end of the extendable element or the support element. Various configurations of the extendable and support elements are described herein, as well as methods of using tissue- removal devices with extendable and support elements coupled by an annular cutting element for treating spinal diseases.
摘要翻译：本文公开了使用这种装置治疗脊柱疾病的组织去除装置和方法。组织去除装置可以包括具有缩回和展开构造的电缆和/或可延伸元件。电缆和/或可延伸元件可以由支撑元件远端地支撑和限制，使得当可延伸元件向远侧延伸到其展开构型时，支撑元件可被横向推开。可以围绕可延伸元件的远端或支撑元件设置环形切割元件。本文描述了可延伸和支撑元件的各种构造，以及使用具有通过环形切割元件联接以用于治疗脊柱疾病的可延伸和支撑元件的组织去除装置的方法。

44. 发明申请

WO2010115134A1 MINIMALLY INVASIVE DISCECTOMY 审中-公开
标题翻译：最小的入侵歧视
公开(公告)号：WO2010115134A1
公开(公告)日：2010-10-07
申请号：PCT/US2010/029826
申请日：2010-04-02
申请人： SPINE VIEW, INC. , TO, John, T. , ZARETZKA, Dan , FABRO, Myra , KUME, Stewart, M.
发明人： TO, John, T. , ZARETZKA, Dan , FABRO, Myra , KUME, Stewart, M.
IPC分类号： A61B17/34
CPC分类号： A61B17/32002 , A61B17/1617 , A61B17/1671 , A61B17/320725 , A61B17/320758 , A61B17/3472 , A61B17/8811 , A61B2017/00261 , A61B2017/003 , A61B2017/00331 , A61B2017/00398 , A61B2017/00685 , A61B2017/00734 , A61B2017/320064 , A61B2017/320733 , A61B2017/320775 , A61B2090/064
摘要： Systems and methods for minimally invasive discectomy procedures are described herein. The systems include a bendable flexible cannula may have a straight configuration suitable for insertion and withdrawal into spinal tissue, and a curved configuration suitable for accessing certain areas of a vertebral disc that may be difficult to reach in the straight configuration. A cannula is straightened by inserting a straight stylet therethrough. The straight stylet may have a deflectable region that facilitates its insertion into the cannula. Removal of a straight stylet from a cannula may allow the cannula to assume its curved configuration. The systems may be used with tissue removal devices, and certain variations of tissue removal devices may comprise a collector for aspiration, as well as a travel limiter to restrict inadvertent motions of the tissue removal devices within a vertebral structure.
摘要翻译：本文描述了用于微创椎间盘切除术的系统和方法。所述系统包括可弯曲的柔性套管可以具有适于插入和退回到脊髓组织中的直线构型，以及适于进入可能难以以直线构型到达的椎间盘的某些区域的弯曲构造。通过插入一个直通管心将套管拉直。直管形针可具有有助于其插入插管的可偏转区域。从插管中移除直管心可以允许套管呈现其弯曲构型。该系统可以与组织去除装置一起使用，并且组织去除装置的某些变型可以包括用于抽吸的收集器以及限制组织去除装置在椎骨结构内的无意的运动的行进限制器。

45. 发明申请

WO2010096570A2 STENT STRUT APPOSITIONER 审中-公开
标题翻译： STENT STRUT评估者
公开(公告)号：WO2010096570A2
公开(公告)日：2010-08-26
申请号：PCT/US2010/024601
申请日：2010-02-18
申请人： TO, John
发明人： TO, John
IPC分类号： A61F2/84 , A61M29/02 , A61M25/04
CPC分类号： A61F2/958 , A61B90/39 , A61F2002/9534
摘要： Devices and procedures for treating malapposed or non apposed stent strut are disclosed. In general, an angioplasty balloon catheter coupled with a uniquely shaped bump is delivered within the stent and positioned to align the bump with the malapposed or non apposed stent strut. The balloon is inflated to drive the bump against the target strut to apposed it properly against the lumen wall.
摘要翻译：公开了用于治疗不适当或非安置的支架支架的装置和程序。通常，与独特形状的凸块结合的血管成形术球囊导管在支架内传送并定位成将凸起与不适当或非安放的支架支柱对准。气囊被充气以将凸起驱动抵靠目标支柱，以将其适当地贴靠在腔壁上。

46. 发明申请

WO2010054121A2 EXTRACELLULAR MATRIX MODULATING COATINGS FOR MEDICAL DEVICES 审中-公开
标题翻译：用于医疗器械的细胞基质调节涂层
公开(公告)号：WO2010054121A2
公开(公告)日：2010-05-14
申请号：PCT/US2009/063449
申请日：2009-11-05
申请人： SPECIALIZED VASCULAR TECHNOLOGIES, INC. , TO, John,Thao , BLAHA, Charles, M. , PHAM, Loc, X.
发明人： TO, John,Thao , BLAHA, Charles, M. , PHAM, Loc, X.
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61L31/148 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/608 , C08L67/04
摘要： A unique method and coatings are provided to promote/allow early stage tissue encapsulation/endothelization of medical devices while effectively controlling excessive tissue buildup by eluting antiproliferative therapeutic agent within a body of a patient. The method involves using a therapeutic agent that suppresses excessive extracellular matrix proliferation and allows/promotes thin tissue healing/encapsulation/endothelization of the device. Optimized timing of onset of elution to match onset of excessive extracellular matrix proliferation for maximum effectiveness is achieved by delay barrier with biochemical switch.
摘要翻译：提供独特的方法和涂层以促进/允许医疗装置的早期组织包封/内皮化，同时通过在患者体内洗脱抗增殖治疗剂来有效地控制过量的组织积聚。该方法包括使用抑制过度的细胞外基质增殖的治疗剂，并允许/促进该组织的细胞愈合/包封/内皮化装置。优化的洗脱开始时间与过度的细胞外基质增殖的发生匹配以获得最大的有效性是通过生化开关的延迟屏障实现的。

47. 发明申请

WO2009126309A3 ATHERECTOMY DEVICES AND METHODS 审中-公开
标题翻译： ATHERECTOMY设备和方法
公开(公告)号：WO2009126309A3
公开(公告)日：2010-01-21
申请号：PCT/US2009002253
申请日：2009-04-10
申请人： ATHEROMED INC , TO JOHN , ESCUDERO PAUL , DANEK CHRISTOPHER
发明人： TO JOHN , ESCUDERO PAUL , DANEK CHRISTOPHER
IPC分类号： A61B17/32
CPC分类号： A61B17/320758 , A61B2017/003 , A61B2017/00309 , A61B2017/22038 , A61B2017/22068
摘要： The devices and methods generally relate to treatment of occluded body lumens. In particular, the present devices and method relate to removal of the occluding material from the blood vessels as well as other body lumens.
摘要翻译：装置和方法通常涉及封闭体腔的治疗。特别地，本发明的装置和方法涉及从血管以及其它体腔去除闭塞材料。

48. 发明申请

WO2009144580A2 COATINGS FOR PROMOTING ENDOTHELIZATION OF MEDICAL DEVICES 审中-公开
标题翻译：用于促进医疗器械内固定的涂层
公开(公告)号：WO2009144580A2
公开(公告)日：2009-12-03
申请号：PCT/IB2009/005883
申请日：2009-06-06
申请人： SPECIALIZED VASCULAR TECHNOLOGIES, INC. , BLAHA, Charles, Mathew , TO, John, Thao , PHAM, Loc, X.
发明人： BLAHA, Charles, Mathew , TO, John, Thao , PHAM, Loc, X.
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61F2250/0067 , A61L31/16 , A61L2300/114 , A61L2300/416 , A61L2300/608
摘要： Coatings are provided for promoting tissue encapsulation of medical devices, especially before antiproliferative drug therapy within a body of a patient in order to prevent excessive restenosis and while avoiding thrombosis (including late stage/stent thrombosis). Coatings of one or more layer that provide an aligned scaffolding (i.e. via aligned fibers or aligned grooves) may be used to encourage tissue deposition and/or to delay elution of drug(s) stored beneath or within. The delay phase prior to degradation, erosion, and/or absorption of the coating to release an active drug should last until an optimal amount of controlled restenosis has provided a thin endothelial layer to encapsulate the device.
摘要翻译：提供涂层以促进医疗装置的组织包封，特别是在患者体内的抗增生药物治疗之前，以防止过度再狭窄并且同时避免血栓形成（包括晚期/支架内血栓形成）。可以使用提供对准的支架（即通过对准的纤维或排列的沟槽）的一个或多个层的涂层来促进组织沉积和/或延迟储存在其下或内部的药物的洗脱。在涂层降解，侵蚀和/或吸收释放活性药物之前的延迟期应该持续到最佳量的受控再狭窄已经提供了薄的内皮层来封装该装置。

49. 发明申请

WO2008005891A3 ATHERECTOMY DEVICES AND METHODS 审中-公开
标题翻译：毛发移植装置和方法
公开(公告)号：WO2008005891A3
公开(公告)日：2008-12-18
申请号：PCT/US2007072574
申请日：2007-06-29
申请人： ATHEROMED INC , TO JOHN , DANEK CHRISTOPHER JAMES
发明人： TO JOHN , DANEK CHRISTOPHER JAMES
IPC分类号： A61B17/22
CPC分类号： A61B17/320783 , A61B17/22 , A61B17/32002 , A61B17/320708 , A61B17/320758 , A61B2017/003 , A61B2017/00318 , A61B2017/00331 , A61B2017/00685 , A61B2017/22038 , A61B2017/22039 , A61B2017/22041 , A61B2017/22044 , A61B2017/22068 , A61B2017/22094 , A61B2017/320032 , A61B2017/320716 , A61B2017/320741 , A61B2017/320775 , A61B2090/3735 , A61B2090/3784 , A61M25/0152 , A61M25/0155
摘要： The devices and methods generally relate to treatment of occluded body lumens. In particular, the present devices and method relate to removal of the occluding material from the blood vessels as well as other body lumens.
摘要翻译：该装置和方法通常涉及封闭体腔的治疗。特别地，本装置和方法涉及从血管以及其他身体内腔去除闭塞物质。

50. 发明申请

WO2008103839A3 EXPANDABLE ROTATING DEVICE AND METHOD FOR TISSUE ASPIRATION 审中-公开
标题翻译：可扩展的旋转装置和用于组织吸入的方法
公开(公告)号：WO2008103839A3
公开(公告)日：2008-11-06
申请号：PCT/US2008054602
申请日：2008-02-21
申请人： SPINE VIEW INC , CHIN SINGFATT , KIM DANIEL H , TO JOHN T
发明人： CHIN SINGFATT , KIM DANIEL H , TO JOHN T
IPC分类号： A61M1/00 , A61B17/32
CPC分类号： A61B17/32002 , A61B10/0283 , A61B17/1617 , A61B17/1671 , A61B17/320725 , A61B18/14 , A61B2017/003 , A61B2017/00685 , A61B2017/00734 , A61B2017/00986 , A61B2017/320064 , A61B2017/320733
摘要： An apparatus and method for removing tissue and/or other material from a patient includes a shaft and a tissue disrupting mechanism operatively coupled to the shaft. The shaft may be coupled to a handpiece or a robotic or remote-controlled system. The mechanism may comprise a rotatable or other movable element having a distal portion with fixed or adjustable radial dimensions. The mechanism may have one or more tissue cutting, chopping, grinding, emulsifying or disrupting features with an adjustable outer diameter for removing substantial tissues. The apparatus may be configured to urge or draw substantial material into the device upon rotation or other movement of the shaft and/or tissue, and may optionally be coupled to sources of suction or aspiration. A radiofrequency or other energy source is optionally included for tissue ablation or other tissue remodeling effects, and/or to enhance coagulation.
摘要翻译：用于从患者身上移除组织和/或其他材料的设备和方法包括轴和可操作地联接到轴的组织破坏机构。轴可以连接到手持件或机器人或远程控制系统。该机构可以包括具有固定或可调径向尺寸的远端部分的可旋转或其他可移动元件。该机构可以具有一个或多个组织切割，切割，研磨，乳化或干扰具有可调外径的特征以去除大量组织。该设备可以被配置为在轴和/或组织的旋转或其他运动时将大量材料推入或吸入到设备中，并且可以可选地连接到抽吸或抽吸源。可选地包括射频或其他能量源用于组织消融或其他组织重塑效应，和/或增强凝结。

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