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    • 44. 发明申请
    • METHOD AND DEVICE FOR DISPERSION OF ASSEMBLIES OF BIOLOGICAL MATERIAL
    • 用于分散生物材料组合的方法和装置
    • WO2011043731A1
    • 2011-04-14
    • PCT/SE2010/051083
    • 2010-10-07
    • GEORGIA TECH RESEARCH CORPORATIONSWETREE TECHNOLOGIES ABAIDUN, Cyrus, K.EGERTSDOTTER, Ulrika
    • AIDUN, Cyrus, K.EGERTSDOTTER, Ulrika
    • C12M1/33A01H4/00
    • C12M45/02
    • Methods and devices for dispersion of assemblies of biological material (such as plant embryogenic mass, plant tissue, cultured plant cells, animal tissue and/or cultured animal cells)suspended in a liquid are disclosed. The methods comprise i) subjecting the assemblies of biological material to fluid dynamics forces causing axially extensional strain and radially compressional strain and ii) subjecting the assemblies of biological material to fluid dynamics forces causing axially compressional strain and radially extensional strain fluid dynamics and iii) repeating said steps i) and ii) in sequence until assemblies of biological material is dispersed into the desired smaller size. The devices may comprise a flow channel arranged in a loop configuration for re-circulation in the flow channel, the flow channel including at least one constriction, such that the assemblies of biological material flowing through the flow channel are first subjected to axially extensional strain and radially compressional strain, and then to axially compressional strain and radially extensional strain from fluid dynamics forces.
    • 公开了悬浮在液体中的生物材料(例如植物胚发生质量,植物组织,培养的植物细胞,动物组织和/或培养的动物细胞)组装分散的方法和装置。 所述方法包括:使生物材料的组件经受流体动力学力,引起轴向拉伸应变和径向压缩应变,以及ii)使生物材料的组件受到导致轴向压缩应变和径向拉伸应变流体动力学的流体动力学力学,以及iii)重复 所述步骤i)和ii)按顺序将生物材料的组装分散成所需的较小尺寸。 所述装置可以包括以循环构造布置成用于在流动通道中重新循环的流动通道,所述流动通道包括至少一个收缩部,使得流过流动通道的生物材料的组件首先经受轴向拉伸应变,并且 径向压缩应变,然后从流体动力学轴向压缩应变和径向拉伸应变。