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41. 发明申请

WO2015009235A8 METHODS AND MATERIALS FOR AN ARTIFICIAL TRACHEAL PROSTHESIS AND/OR VOICE PROSTHESIS 审中-公开
公开(公告)号：WO2015009235A8
公开(公告)日：2015-01-22
申请号：PCT/SG2014/000251
申请日：2014-05-30
申请人： NATIONAL UNIVERSITY OF SINGAPORE , SINGAPORE HEALTH SERVICES PTE LTD
发明人： CHUI, Chee Kong , CHUA, Chin Heng Matthew , LAU, Pang Cheng David , TEO, Ee Hoon Constance
IPC分类号： A61F2/04
摘要： A tracheal prosthesis includes a scaffold formed as a material matrix including a biocompatible polymer carrying a nanomaterial; and a collagen matrix layer disposed on at least along portions of an inner lumen of the scaffold. The tracheal prosthesis can be fabricated as a patient specific device in accordance with images of the natural trachea of a target patient for whom the tracheal prosthesis is intended. A voice prosthesis includes a body carrying a passage, and a magnetic passage sealing mechanism having a ball that can selectively seal / block or open the passage. The voice prosthesis can include an outer skin that covers the body. The voice prosthesis can include a polymer carrying a nanomaterial. The voice prosthesis can be fabricated as a patient specific device in accordance with images of a fistula of a target patient for whom the voice prosthesis is intended.

42. 发明申请

WO2015002612A1 METHODS OF SCREENING USING INTERSTITIAL CELLS AND METHODS OF SUPPRESSING PROLIFERATION AND/OR TRANSFORMATION OF INTERSTITIAL CELLS 审中-公开
标题翻译：使用间质细胞筛选方法和抑制间质细胞增殖和/或转化的方法
公开(公告)号：WO2015002612A1
公开(公告)日：2015-01-08
申请号：PCT/SG2014/000318
申请日：2014-07-01
申请人： SINGAPORE HEALTH SERVICES PTE LTD
发明人： SHIM, Se Ngie Winston , WONG, En Hou Philip
IPC分类号： G01N33/483 , G01N33/50
CPC分类号： G01N33/6872 , G01N33/5044
摘要： The present invention provides a method for screening an agent as a drug candidate for suppressing proliferation and/or transformation of interstitial cells, comprising the steps of: (i) contacting an interstitial cell with the agent; and (ii) determining the ability of the agent to modulate the activity and/or expression of at least one potassium channel of interstitial cells, by comparing the interstitial cell that has been contacted with the agent, to a control interstitial cell that has not been contacted with the agent, thereby determining the suitability of the agent as a drug candidate for suppressing proliferation and/or transformation of interstitial cells. The invention also relates to a method for suppressing proliferation and/or transformation of interstitial cells. The invention also relates to a method of screening for an agent as a drug candidate for modulating endogenous H 2 S production in interstitial cells.
摘要翻译：本发明提供筛选作为用于抑制间质细胞的增殖和/或转化的候选药物的药剂的方法，其包括以下步骤：（i）使间质细胞与药剂接触; 和（ii）通过将已经与所述试剂接触的间质细胞与尚未存在的对照间质细胞进行比较，确定所述试剂调节间质细胞的至少一个钾通道的活性和/或表达的能力与药剂接触，由此确定药剂作为用于抑制间质细胞的增殖和/或转化的候选药物的适合性。本发明还涉及用于抑制间质细胞的增殖和/或转化的方法。本发明还涉及筛选作为调节间质细胞内源性H 2 S产生的候选药物的药剂的方法。

43. 发明申请

WO2014143907A1 NOVEL DOSING REGIMENS OF CELGOSIVIR FOR THE TREATMENT OF DENGUE 审中-公开
标题翻译： CIGGOSIVIR的新剂量方案用于治疗登革热
公开(公告)号：WO2014143907A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/028076
申请日：2014-03-14
申请人： 60° PHARMACEUTICALS LLC , NATIONAL UNIVERSITY OF SINGAPORE , SINGAPORE HEALTH SERVICES PTE LTD , VASUDEVAN, Subhash , SUNG, Cynthia , RATHORE, Abhay , WATANABE, Satoru , LOW, Jenny , OOI, Eng Eong
发明人： VASUDEVAN, Subhash , SUNG, Cynthia , RATHORE, Abhay , WATANABE, Satoru , LOW, Jenny , OOI, Eng Eong , DOW, Geoffrey S. , MORRISH, Glynn , REID, Mark
IPC分类号： A61P31/14
CPC分类号： A61K31/437 , Y02A50/385
摘要： Methods of treating a dengue virus (DENV) infection in a human subject, comprising administering to the human subject a compound of Formula (I), or pharmaceutical composition comprising a compound of Formula (I):A compound of Formula (I) can be administered within onset of fever to 72 hours of fever onset due to dengue infection and then every 6 to12 hours until there is an improvement in the infection or between from about 1 day to about 10 days. The methods of the invention can be used to treat primary and secondary DENV1-4 viral infections.
摘要翻译：治疗人受试者登革热病毒（DENV）感染的方法，包括向人类受试者施用式（I）化合物或包含式（I）化合物的药物组合物：式（I）化合物可以是由于登革热感染而发热至72小时，然后每6至12小时施用，直到感染改善或约1天至约10天。本发明的方法可用于治疗原发性和继发性DENV1-4病毒感染。

44. 发明申请

WO2014039013A8 TETRABRANCHED PEPTIDES AND ANALOGUES AS A NEW CLASS OF ANTIMICROBIALS AND THEIR PREPARATION THEREOF 审中-公开
公开(公告)号：WO2014039013A8
公开(公告)日：2014-03-13
申请号：PCT/SG2013/000390
申请日：2013-09-09
申请人： AGENCY OF SCIENCE, TECHNOLOGY AND RESEARCH , SINGAPORE HEALTH SERVICES PTE LTD
发明人： BEUERMAN, Roger , LIU, Shouping , RAJAMANI, Lakshminarayanan , VERMA, Chandra , LI, Jianguo
IPC分类号： C07K14/00 , C07K7/00 , A61K38/04 , A61K38/16 , A61L12/14 , A61P31/04
摘要： The invention relates to an isolated peptide tetramer comprising the formula [(RGRKWRR)2K]2KK and its derivatives thereof. The derivatives may comprise at least one amino acid substitution, at least one amino acid deletion, a rearrangement of the peptide monomer and/or at least one non-proteogenic amino acid modification in at least one peptide monomer. The isolated peptide tetramer and derivatives thereof have antimicrobial (antibacterial, antifungal and/or anti-protozoan) properties.

45. 发明申请

WO2014021786A1 ARTERIAL CANNULA WHICH ALLOWS PERFUSION ALONG OPPOSING DIRECTIONS WITHIN A CANNULATED VESSEL 审中-公开
标题翻译：在CANNULATION VESSEL中的对照方向允许吸收的动脉粥样硬化
公开(公告)号：WO2014021786A1
公开(公告)日：2014-02-06
申请号：PCT/SG2013/000328
申请日：2013-08-05
申请人： SINGAPORE HEALTH SERVICES PTE LTD , NATIONAL UNIVERSITY OF SINGAPORE , CHAO, Tar Toong, Victor , HO, Pei , LIM, Chong Hee
发明人： CHAO, Tar Toong, Victor , HO, Pei , LIM, Chong Hee
IPC分类号： A61M25/01 , A61M25/08
CPC分类号： A61M1/3659 , A61M25/0029 , A61M25/0043 , A61M25/0052 , A61M25/0054 , A61M25/04 , A61M2025/0008
摘要： A cannula includes at least one opening at a distal tip, and further includes multiple fenestrations that are maintainable in position substantially immediately or slightly beyond a site or point of cannula entry into a vessel. The fenestrations, in combination with the opening(s) at the cannula's distal tip, enable the simultaneous perfusion of blood into the cannulated vessel along multiple directions, including opposing or anti-parallel blood flow directions relative to a central axis of the cannulated vessel. During a medical procedure (e.g., an extra-corporeal membrane oxygenation (ECMO) procedure) blood introduced into a vessel such as the femoral artery by way of the cannula can thus exit the cannula in a manner that provides concurrent blood flow in a first direction towards the heart and a second direction away from the heart.
摘要翻译：插管包括在远侧末端处的至少一个开口，并且还包括可基本上立即或稍微超过套管进入血管的位置或点的位置维持的多个开窗。开口与套管远侧末端的开口结合使得能够沿多个方向将血液同时灌注到插管血管中，包括相对于插管血管的中心轴线的相反或反平行的血液流动方向。在医疗过程（例如，体外膜氧合（ECMO）程序）中，通过套管引入诸如股动脉的血管的血液因此可以以在第一方向上提供同时血流的方式离开套管朝着心脏方向前进，另一个方向远离心脏。

46. 发明申请

WO2013172793A1 UMBILICAL CORD MESENCHYMAL STEM CELL EXOSOMES 审中-公开
标题翻译：脐带神经干细胞EXOSOMES
公开(公告)号：WO2013172793A1
公开(公告)日：2013-11-21
申请号：PCT/SG2013/000203
申请日：2013-05-17
申请人： AGENCY FOR SCIENCE, TECHNOLOGY & RESEARCH , SINGAPORE HEALTH SERVICES PTE LTD
发明人： LIM, Sai Kiang , TAN, Kok Hian
IPC分类号： C12N5/0775 , A61K35/44
CPC分类号： C12N5/0668 , A61K35/28 , A61K35/51 , C12N5/0665 , C12N2500/02 , C12N2510/04
摘要： We describe a method of cell culture of an umbilical mesenchymal stem cell (MSC). The method comprises the steps of providing an umbilical mesenchymal stem cell (MSC) and culturing the umbilical mesenchymal stem cell in a cell culture medium under hypoxic conditions. The umbilical mesenchymal stem cell may be transformed with an oncogene such as c-myc. Conditioned media and exosomes obtained from the umbilical mesenchymal stem cell may be used for therapy.
摘要翻译：我们描述了脐带间充质干细胞（MSC）的细胞培养方法。该方法包括在缺氧条件下在细胞培养基中提供脐带间充质干细胞（MSC）并培养脐带间充质干细胞的步骤。可以用诸如c-myc的致癌基因转化脐带间充质干细胞。从脐带间充质干细胞获得的条件培养基和外来体可用于治疗。

47. 发明申请

WO2013077814A2 NATURAL-KILLER/T-CELL LYMPHOMA (NKTCL) SUSCEPTIBILITY PREDICTION, DIAGNOSIS AND THERAPY 审中-公开
标题翻译：自然杀伤细胞/ T细胞淋巴瘤（NKTCL）感染预测，诊断和治疗
公开(公告)号：WO2013077814A2
公开(公告)日：2013-05-30
申请号：PCT/SG2012/000444
申请日：2012-11-26
申请人： SINGAPORE HEALTH SERVICES PTE LTD
发明人： TEH, Bin Tean , LIM, Soon Thye
IPC分类号： A61K31/00 , C12Q1/68
CPC分类号： C12Q1/6886 , A01K67/0275 , A01K2267/0331 , A61K31/165 , A61K31/277 , A61K31/519 , C12Q2600/156 , C12Q2600/158 , G01N33/5011 , G01N33/57407 , G01N33/57426 , G01N2333/912 , G01N2333/91215 , G01N2800/50
摘要： Natural-KilleifT-Cell Lymphoma (NKTCL) susceptibility prediction, diagnosis and therapy. The invention relates to a method for predicting Natural Killer T-cell Lymphoma (NKTCL) susceptibility and/or diagnosing NKTCL in a subject comprising testing for JAK mutations. The invention also relates to a method of screening for candidate agents capable of treating NKTCL using a cell line comprising at least one JAK mutation. The invention includes an NKTCL animal model comprising at least one JAK mutation. The invention also includes JAK inhibitors for treating NKTCL.
摘要翻译：自然杀伤细胞淋巴瘤（NKTCL）易感性预测，诊断和治疗。本发明涉及用于预测受试者中自然杀伤T细胞淋巴瘤（NKTCL）易感性和/或诊断NKTCL的方法，包括测试JAK突变。本发明还涉及使用包含至少一个JAK突变的细胞系筛选能够治疗NKTCL的候选试剂的方法。本发明包括包含至少一个JAK突变的NKTCL动物模型。本发明还包括用于治疗NKTCL的JAK抑制剂。

48. 发明申请

WO2013043130A1 METHOD AND/OR PROBE FOR DETERMINING GLAUCOMA SUSCEPTIBILITY AND/OR PREDICTING/DETECTING SHALLOW ANTERIOR CHAMBER DEPTH 审中-公开
标题翻译：用于确定玻璃体不稳定性和/或预测/检测肺前壁深度的方法和/或探针
公开(公告)号：WO2013043130A1
公开(公告)日：2013-03-28
申请号：PCT/SG2012/000351
申请日：2012-09-24
申请人： SINGAPORE HEALTH SERVICES PTE LTD , AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： AUNG, Tin , VITHANA, Eranga , KHOR, Chiea-Chuen
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention provides a method and/or probe for predicting and/or detecting a shallow anterior chamber depth and/or determining susceptibility to glaucoma in a subject, comprising determining the genotype of the subject for at least one nucleic acid variation in ATP-binding cassette sub-family C member 5 (ABCC5) gene, wherein the nucleic acid variation is correlated with anterior chamber depth and/or susceptibility to angle closure glaucoma.
摘要翻译：本发明提供了一种用于预测和/或检测浅前房深度和/或确定受试者对青光眼的易感性的方法和/或探针，包括确定受试者的至少一种ATP结合核酸变异的基因型盒亚系C成员5（ABCC5）基因，其中核酸变异与前房深度和/或对闭角型青光眼的敏感性相关。

49. 发明申请

WO2013036207A1 DERIVATIVES OF XANTHONE COMPOUNDS 审中-公开
标题翻译： XANTHONE化合物衍生物
公开(公告)号：WO2013036207A1
公开(公告)日：2013-03-14
申请号：PCT/SG2012/000328
申请日：2012-09-10
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , ZOU, Hanxun , RAJANMANI, Lakshminiarayan , ZHOU, Lei , TANG, Chang Chui Charles , KOH, Jun Jie , TAN, Tiang Hwee Donald , VERMA, Chandra , BEUERMAN, Roger W. , LIU, Shouping , PADMANABHAN, Saraswathi , SINGAPORE HEALTH SERVICES PTE LTD
发明人： ZOU, Hanxun , RAJANMANI, Lakshminiarayan , ZHOU, Lei , TANG, Chang Chui Charles , KOH, Jun Jie , TAN, Tiang Hwee Donald , VERMA, Chandra , BEUERMAN, Roger W. , LIU, Shouping , PADMANABHAN, Saraswathi
IPC分类号： C07D311/86 , A61K31/403 , A61K31/4178 , A61K31/4025 , A61K31/4433 , A61K31/496 , A61K31/541 , A61K31/5355 , A61K31/352 , C07D405/10 , C07D417/10 , C07D413/10
CPC分类号： C07D311/78 , A61K31/352 , A61K31/4025 , A61K31/404 , A61K31/4155 , A61K31/4178 , A61K31/4196 , A61K31/4545 , A61K31/5377 , A61K31/541 , A61K38/05 , C07D311/86 , C07D405/10 , C07D405/14 , C07D413/10 , C07D417/10 , C07K5/06
摘要： The present invention relates to xanthone analogs. Such compounds may be used in the treatment of bacterial infections.
摘要翻译：本发明涉及呫吨酮类似物。这些化合物可用于治疗细菌感染。

50. 发明申请

WO2012039685A1 A NANOPROBE COMPRISING GOLD COLLOID NANOPARTICLES FOR MULTIMODALITY OPTICAL IMAGING OF CANCER AND TARGETED DRUG DELIVERY FOR CANCER 审中-公开
标题翻译：包括用于癌症多发性光学成像和针对癌症的药物递送的金色胶体纳米颗粒的纳米微粒
公开(公告)号：WO2012039685A1
公开(公告)日：2012-03-29
申请号：PCT/SG2011/000330
申请日：2011-09-23
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , SINGAPORE HEALTH SERVICES PTE LTD , PRAVEEN, Nagamani , THONIYOT, Praveen , OLIVO, Malini
发明人： PRAVEEN, Nagamani , THONIYOT, Praveen , OLIVO, Malini
IPC分类号： B82B1/00 , B82Y5/00 , B82Y40/00 , B82B3/00 , B82Y15/00
CPC分类号： A61K49/0058 , A61K41/0057 , A61K47/6845 , A61K47/6923 , B82Y5/00 , B82Y15/00 , B82Y40/00 , G01N33/587
摘要： The present invention is directed to a nanoparticle loaded with a light sensitive molecule and a method of preparing the nanoparticle, wherein the nanoparticle is a colloidal gold nanoparticle and the light sensitive molecule is non-covalently adsorbed to the surface of the nanoparticle. The present invention is also directed to a nanoprobe comprising the nanoparticle and further comprising a targeting moiety covalently coupled to the surface of the nanoparticle. Additionally, the present invention is directed to an imaging method comprising administering the nanoprobe to a subject and collecting imaging data of the subject or part of the subject with optical multimodality imaging. A method of treating cancer in a subject comprising administering the nanoprobe and performing photodynamic therapy on the subject is further disclosed.
摘要翻译：本发明涉及负载有光敏分子的纳米颗粒和制备纳米颗粒的方法，其中纳米颗粒是胶体金纳米颗粒，并且光敏分子非共价吸附到纳米颗粒的表面。本发明还涉及包含纳米颗粒的纳米探针，并且还包含与纳米颗粒的表面共价偶联的靶向部分。此外，本发明涉及一种成像方法，其包括对受试者施用纳米探针，并用光学多模态成像收集受试者或受试者的一部分的成像数据。进一步公开了一种在受试者中治疗癌症的方法，包括对所述受试者施用所述纳米探针并进行光动力学治疗。

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