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41. 发明申请

WO2013106398A1 PURIFICATION OF HERPES VIRUS 审中-公开
标题翻译：净化病毒
公开(公告)号：WO2013106398A1
公开(公告)日：2013-07-18
申请号：PCT/US2013/020780
申请日：2013-01-09
申请人： SANOFI PASTEUR BIOLOGICS, LLC
发明人： MUNDLE, Sophia , ANDERSON, Stephen , DELAGRAVE, Simon
IPC分类号： C12N7/02 , C12N7/00 , B01D15/00
CPC分类号： A61K39/245 , A61K39/12 , A61K2039/5254 , B01D15/363 , C12N7/00 , C12N2710/16634 , C12N2710/16651 , C12N2710/16671
摘要： The present disclosure provides a method to prepare purified enveloped viral particle preparations employing ion exchange chromatography and tangential flow filtration.
摘要翻译：本公开提供了使用离子交换层析和切向流过滤来制备纯化的包膜病毒颗粒制剂的方法。

42. 发明申请

WO2012158639A3 RECOMBINANT FUSION PROTEINS AND METHODS FOR USE THEREOF FOR TREATMENT OR PREVENTION OF PAPILLOMAVIRUS INFECTION 审中-公开
标题翻译：重组融合蛋白及其用于治疗或预防毛霉病感染的方法
公开(公告)号：WO2012158639A3
公开(公告)日：2013-01-17
申请号：PCT/US2012037831
申请日：2012-05-14
申请人： SANOFI PASTEUR BIOLOGICS LLC , KALNIN KIRILL , KLEANTHOUS HAROLD , YAN YANHUA
发明人： KALNIN KIRILL , KLEANTHOUS HAROLD , YAN YANHUA
IPC分类号： C07K19/00 , A61K39/02 , A61K39/12 , A61P31/20 , C07K14/025 , C07K14/195 , C12N15/62
CPC分类号： A61K39/12 , A61K2039/6068 , C07K14/255 , C07K2319/00 , C07K2319/21 , C12N2710/20022 , C12N2710/20034
摘要： The present invention relates to methods and compositions for production of fusion protein constructs useful for the treatment and/or prevent of infection, disease, and/or any related sequelae caused by or associated with transmission of one or more of the various types of human papillomavirus. The present invention further provides nucleic acid sequences that encode said compositions and fusion protein constructs as well as methods of therapeutic use and/or prophylactic use of said compositions and fusion protein constructs.
摘要翻译：本发明涉及用于生产可用于治疗和/或预防感染，疾病和/或任何相关后遗症的融合蛋白构建体的方法和组合物，其由一种或多种不同类型的人乳头状瘤病毒。本发明还提供编码所述组合物和融合蛋白构建体的核酸序列以及所述组合物和融合蛋白构建体的治疗用途和/或预防性使用的方法。

43. 发明申请

WO2016028776A1 ALKYLATED INFLUENZA VACCINES 审中-公开
标题翻译：碱性流感疫苗
公开(公告)号：WO2016028776A1
公开(公告)日：2016-02-25
申请号：PCT/US2015/045689
申请日：2015-08-18
申请人： SANOFI PASTEUR BIOLOGICS LLC
发明人： MILNER, Brooke , HAINES, Jonathan , HAUSER, Steven , POLI, Janet
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K2039/5252 , A61K2039/70 , C12N7/00 , C12N2760/16034 , C12N2760/16063
摘要： The present invention provides, among other things, improved influenza vaccines based on hemagglutinins containing one or more alkylated cysteine residues. In particular, the present invention provides influenza vaccines containing hemagglutinins treated with an alkylating agent and methods of making the same. Inventive influenza vaccines provided by the present invention have a remarkable ability to retain potency as determined by Single Radial Immunodiffusion (SRID) assay upon storage.
摘要翻译：本发明尤其提供了基于含有一个或多个烷基化半胱氨酸残基的血细胞凝集素的改进的流感疫苗。特别地，本发明提供含有用烷基化剂处理的血凝素的流感疫苗及其制备方法。由本发明提供的本发明的流感疫苗具有显着的保留效力的能力，如通过单径向免疫扩散（SRID）测定法确定的。

44. 发明申请

WO2014144292A3 ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXINS AND METHODS OF USING THE SAME 审中-公开
公开(公告)号：WO2014144292A3
公开(公告)日：2014-09-18
申请号：PCT/US2014/028637
申请日：2014-03-14
申请人： SANOFI PASTEUR BIOLOGICS , LLC , VALNEVA
发明人： ANDERSON, Stephen, F. , ANOSOVA, Natalie , BELTRAMINELLI, Nicola , GARRONE, Pierre , KLEANTHOUS, Harold , ZHANG, Jianxin
IPC分类号： A61K39/08
摘要： Monoclonal antibodies or antigen-binding fragments thereof, that bind to Clostridium difficile ( C. difficile ) toxin A or toxin B and methods of using the same to detect or treat C. difficile infections and/or C. difficile -associated disease. C difficile is a gram positive, anaerobic bacterium that causes gastrointestinal disease in humans. The bacteria are transmitted through feces and spread to food and other surfaces when people who are infected do not thoroughly wash their hands.

45. 发明申请

WO2013184900A3 IMMUNOGENIC COMPOSITIONS AND RELATED METHODS 审中-公开
标题翻译：免疫组化及相关方法
公开(公告)号：WO2013184900A3
公开(公告)日：2014-09-04
申请号：PCT/US2013044488
申请日：2013-06-06
申请人： SANOFI PASTEUR BIOLOGICS LLC
发明人： LAM HUBERT , YETHON JEREMY
IPC分类号： C07K16/12 , A61K39/085
CPC分类号： C07K16/1271 , A61K39/085 , A61K2039/505 , C07K2317/33 , C07K2317/34 , C07K2317/76
摘要： This disclosure relates to polypeptides that may be used as immunogens in immunogenic compositions (e.g., vaccines) for eliciting an immune response in a subject against staphylococci (such as coagulase-negative staphylococci (CoNS) and/or S. aureus species). The immune response elicited (e.g., antibodies) inhibits biofilm development and may be sufficient for treating and/or preventing disease resulting from an infection by a Staphylococcus species. Binding agents that bind to these polypeptides are also provided. Exemplary polypeptides include but are not limited to SEQ ID NOs: 1-38 and fragments and derivatives thereof. Immunogenic compositions including one or more polypeptides are provided, as are methods for their use (e.g., to induce an immune response to staphylococci in a subject by administering to the subject a composition as described herein). Administration of the compositions of the present disclosure to a subject may elicit an immune response against a number of Staphylococcus species and/or strains.
摘要翻译：本公开涉及可用作免疫原性组合物（例如疫苗）中的免疫原的多肽，其用于引发受试者针对葡萄球菌（例如凝固酶阴性葡萄球菌（CoNS）和/或金黄色葡萄球菌）的免疫应答。引发的免疫应答（例如抗体）抑制生物膜发育，并且可能足以治疗和/或预防由葡萄球菌属物种感染引起的疾病。还提供了结合这些多肽的结合剂。示例性多肽包括但不限于SEQ ID NO：1-38及其片段和衍生物。提供了包括一种或多种多肽的免疫原性组合物，如它们的使用方法（例如，通过向受试者施用本文所述的组合物来诱导受试者对葡萄球菌的免疫应答）。将本公开的组合物施用于受试者可引起针对许多葡萄球菌和/或菌株的免疫应答。

46. 发明申请

WO2013177172A2 HERPESVIRUS COMPOSITIONS AND RELATED METHODS 审中-公开
标题翻译： HERPESVIRUS组合物及相关方法
公开(公告)号：WO2013177172A2
公开(公告)日：2013-11-28
申请号：PCT/US2013042039
申请日：2013-05-21
申请人： SANOFI PASTEUR LTD , SANOFI PASTEUR BIOLOGICS LLC
发明人： ANDERSON STEPHEN , DELAGRAVE SIMON , HAMBERGER JOHN , LI QINGLIAN , MUNDLE SOPHIA , RAHMAN NAUSHEEN
IPC分类号： A61K39/245
CPC分类号： A61K39/245 , A61K9/0019 , A61K39/12 , A61K47/183 , A61K47/26 , A61K2039/5254 , C12N7/00 , C12N2710/16034 , C12N2710/16611 , C12N2710/16634 , C12N2710/16651
摘要： The present disclosure relates to liquid and dried compositions comprising a live, attenuated or genetically modified herpesvirus and methods of preparing such compositions, in one aspect, the composition comprises at ieast two or more pharmaceutically acceptable exctpients, at ieast one of which is histidsne and at least one of which is a sugar or sugar alcohol. The composstions retain a sufficiently high infectious titre following storage or large-scale manufacturing steps, such as lyophilization.
摘要翻译：本公开涉及包含活的，减毒的或遗传修饰的疱疹病毒的液体和干燥的组合物以及制备这种组合物的方法。一方面，该组合物至少包含两种或更多种药学上可接受的除外，其中至少一种是组胺，其中最少的一种是糖或糖醇。组合物在储存或大规模生产步骤如冻干后保留足够高的感染滴度。

47. 发明申请

WO2013106337A1 PURIFICATION OF FLAVIVIRUSES 审中-公开
标题翻译：脓毒症的净化
公开(公告)号：WO2013106337A1
公开(公告)日：2013-07-18
申请号：PCT/US2013/020686
申请日：2013-01-08
申请人： SANOFI PASTEUR BIOLOGICS, LLC
发明人： MUNDLE, Sophia , ANDERSON, Stephen
IPC分类号： C12N7/02 , C12N7/00 , B01D15/00
CPC分类号： C12N7/00 , B01D15/363 , B01D61/145 , B01D2315/10 , B01D2315/16 , C12N15/86 , C12N2770/24133 , C12N2770/24134 , C12N2770/24143 , C12N2770/24151
摘要： The present invention provides a method to prepare purified enveloped (e.g., flavivirus) viral particle preparations employing ion exchange chromatography and tangential flow filtration.
摘要翻译：本发明提供了使用离子交换层析和切向流过滤来制备纯化的包膜（例如黄病毒）病毒颗粒制剂的方法。

48. 发明申请

WO2017053239A1 PURIFICATION OF RESPIRATORY SYNCYTIAL VIRUS 审中-公开
标题翻译：呼吸道感染病毒的纯化
公开(公告)号：WO2017053239A1
公开(公告)日：2017-03-30
申请号：PCT/US2016/052515
申请日：2016-09-19
申请人： SANOFI PASTEUR BIOLOGICS, LLC
发明人： MUNDLE, Sophia, Tara
IPC分类号： C07K14/135 , C12N7/02 , C12N15/45
CPC分类号： C12N7/00 , B01D15/34 , B01D15/3847 , B01D61/145 , B01D71/68 , C12N2760/00021 , C12N2760/00051 , C12N2760/00064
摘要： Disclosed herein are methods for the purification of Respiratory Syncytial Virus (RSV) particles from a host cell culture comprising treating the host cell culture with an endonuclease, filtering the material to remove cellular debris and/or aggregated material, applying the material to a core bead chromatography resin, and recovering the purified RSV particles. Also disclosed herein are pharmaceutical compositions comprising purified RSV.
摘要翻译：本文公开了从宿主细胞培养物纯化呼吸道合胞病毒（RSV）颗粒的方法，包括用内切核酸酶处理宿主细胞培养物，过滤材料以除去细胞碎片和/或聚集的材料，将该材料施加到芯珠色谱树脂，并回收纯化的RSV颗粒。本文还公开了包含纯化的RSV的药物组合物。

49. 发明申请

WO2016183312A1 ICP0-MEDIATED ENHANCED EXPRESSION SYSTEM 审中-公开
标题翻译： ICP0介质增强表达系统
公开(公告)号：WO2016183312A1
公开(公告)日：2016-11-17
申请号：PCT/US2016/032082
申请日：2016-05-12
申请人： SANOFI PASTEUR BIOLOGICS, LLC
发明人： DELAGRAVE, Simon , LAI, CharChang
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , C12N2710/16622 , C12N2710/16634 , C12N2710/16651
摘要： Methods and compositions for increasing the production of recombinant proteins by introducing ICP0 to cells capable of producing a recombinant protein are encompassed. In one method, the recombinant protein is a protein that is required for the replication of a replication defective virus, wherein the recombinant protein is provided to the replication defective virus in trans .
摘要翻译：包括通过将ICP0引入能够产生重组蛋白的细胞来增加重组蛋白质生产的方法和组合物。在一种方法中，重组蛋白是复制缺陷病毒复制所需的蛋白质，其中重组蛋白质以反式提供给复制缺陷型病毒。

50. 发明申请

WO2015184272A3 EXPRESSION AND CONFORMATIONAL ANALYSIS OF ENGINEERED INFLUENZA HEMAGGLUTININ 审中-公开
标题翻译：工程化流感病毒HEMAGGLUTININ的表达和一致性分析
公开(公告)号：WO2015184272A3
公开(公告)日：2016-01-21
申请号：PCT/US2015033205
申请日：2015-05-29
申请人： SANOFI PASTEUR BIOLOGICS LLC
发明人： CORTES-GARCIA GUADALUPE , ALEFANTIS TIMOTHY , PARRINGTON MARK
IPC分类号： G01N33/569 , C07K14/11 , C07K16/10
CPC分类号： C07K14/005 , A61K39/12 , A61K39/145 , A61K2039/57 , C07K16/1018 , C07K2317/76 , C12N7/00 , C12N2760/16022 , C12N2760/16034 , C12N2760/16122 , C12N2760/16134 , C12N2760/16151 , G01N33/56983 , G01N2333/11
摘要： The present invention provides, among other things, compositions and methods for analyzing the expression and conformation of engineered influenza hemagglutinin. In particular, the present invention provides methods of screening in silico designed HA antigens using neutralizing antibody panels specific to conserved epitopes. In some embodiments, the HAs are down selected for inclusion in universal influenza vaccines based upon their binding to neutralizing antibody panels in immunostaining assays.
摘要翻译：本发明尤其提供了用于分析工程流感血凝素的表达和构象的组合物和方法。特别地，本发明提供了使用对保守表位特异的中和抗体片段筛选设计的电泳抗体的方法。在一些实施方案中，基于在免疫染色测定中与中和抗体片段的结合，将HA降低选择以包含在通用流感疫苗中。

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