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41. 发明授权

US11564912B2 Methods for treating irritable bowel syndrome (IBS) 有权
公开(公告)号：US11564912B2
公开(公告)日：2023-01-31
申请号：US17892982
申请日：2022-08-22
申请人： Salix Pharmaceuticals, Inc.
发明人： William P. Forbes , Enoch Bortey
IPC分类号： A61K31/437
摘要： The present invention provides new methods and kits for treating IBS; treating IBS in females; treating IBS in older subjects; and treating IBS in non-white subjects.

42. 发明授权

US11129817B2 Solid dispersion forms of rifaximin 有权
公开(公告)号：US11129817B2
公开(公告)日：2021-09-28
申请号：US17174829
申请日：2021-02-12
申请人： Salix Pharmaceuticals, Inc.
发明人： Pam Golden , Mohammed A. Kabir
IPC分类号： A61K31/437 , A61K9/28 , A61K9/00 , A61P1/16 , A61K9/10 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/38
摘要： Provided herein are solid dispersions comprising rifaximin and pharmaceutical compositions and uses thereof.

43. 发明申请

US20200206199A1 METHODS FOR TREATING IRRITABLE BOWEL SYNDROME (IBS) 审中-公开
公开(公告)号：US20200206199A1
公开(公告)日：2020-07-02
申请号：US16738392
申请日：2020-01-09
申请人： Salix Pharmaceuticals, Inc.
发明人： William Forbes , Enoch Bortey
IPC分类号： A61K31/437
摘要： The present invention provides new methods and kits for treating IBS; treating IBS in females; treating IBS in older subjects; and treating IBS in non-white subjects.

44. 发明申请

US20200163958A1 USE OF METHYLNALTREXONE TO ATTENUATE TUMOR PROGRESSION 审中-公开
公开(公告)号：US20200163958A1
公开(公告)日：2020-05-28
申请号：US16667300
申请日：2019-10-29
申请人： Salix Pharmaceuticals, Inc. , The University Of Chicago
发明人： Jonathan Moss , Lorin K. Johnson
IPC分类号： A61K31/485 , A61K49/00 , A61K45/06 , A61K9/20 , A61K9/00 , A61B5/00
摘要： Presented herein are methods for preventing or treating tumor growth, tumor metastasis and/or abnormal proliferation of tumor cells in a subject, wherein the methods involve administration of a pharmaceutical composition comprising methylnaltrexone. Also presented herein are methods for inhibiting or slowing the growth of a tumor in a subject, wherein the methods include selecting a subject who is a suitable candidate for treatment with methylnaltrexone, and administering a composition comprising methylnaltrexone to the subject.

45. 发明申请

US20190240229A1 GASTRIC AND COLONIC FORMULATIONS AND METHODS FOR MAKING AND USING THEM 审中-公开
公开(公告)号：US20190240229A1
公开(公告)日：2019-08-08
申请号：US16149927
申请日：2018-10-02
申请人： Salix Pharmaceuticals, Inc.
发明人： Thomas Julius Borody , Sanjay Ramrakha , John Saxon , Antony Wettstein
IPC分类号： A61K31/538 , A61K45/06 , A61K31/047 , A61K31/4402 , A61K31/4412
CPC分类号： A61K31/538 , A61K31/047 , A61K31/4402 , A61K31/4412 , A61K45/06 , A61K2300/00
摘要： In alternative embodiments, the invention provides compositions, e.g., formulations, used for gastric, gastrointestinal and/or colonic treatments or lavage, e.g., orthostatic lavage, e.g., for inducing the purgation (e.g., cleansing) of a gastrointestinal (GI) tract, including a colon; and methods for making and using them. In alternative embodiments, compositions and methods of the invention are used for the amelioration, treatment and/or prevention of constipation, for the treatment of abdominal pain, particularly non-specific abdominal pain, and diarrhea, including diarrhea caused by a drug side effect, a psychological condition, a disease or a condition such as Crohn's Disease, a poison, a toxin or an infection, e.g., a toxin-mediated traveler's diarrhea. In alternative embodiments, the invention provides pharmaceuticals and products (articles) of manufacture for delivering these compositions and formulations to an individual, e.g., a human or an animal.

46. 发明授权

US10328088B2 Use of aminosalicylates in diarrhoea-predominent irritable bowel syndrome 有权
公开(公告)号：US10328088B2
公开(公告)日：2019-06-25
申请号：US15907566
申请日：2018-02-28
申请人： Salix Pharmaceuticals, Inc.
发明人： Nicolas Peter Shortis
IPC分类号： A61K31/437 , A61K31/655 , A61K31/166 , A61K31/606 , A61K31/635 , A61K45/06
摘要： A method for the treatment or prophylaxis of non-inflammatory bowel diseases, diarrhoea-predominant irritable bowel syndrome or other non-specific bowel disorder is disclosed comprising administering to a patient in need of such treatment or prophylaxis an effective amount of balsalazide, or a 4-ASA or 5-ASA compound modified to include a 4-ABA side chain, or a salt or a derivative thereof, or a composition comprising balsalazide the modified compound, or a salt or a derivative thereof together with a suitable carrier. Use of balsalazide, a 4-ASA or 5-ASA compound modified to include a 4-ABA side chain, or a salt or derivative thereof, for the manufacture of a medicament for the treatment or prophylaxis of non-inflammatory bowel diseases, diarrhoea-pre-dominant Irritable Bowel Syndrome or other non-specific bowel disorder is also disclosed.

47. 发明申请

US20160000765A1 METHODS FOR TREATING BOWEL DISEASES 审中-公开
公开(公告)号：US20160000765A1
公开(公告)日：2016-01-07
申请号：US14799018
申请日：2015-07-14
申请人： Salix Pharmaceuticals, Inc.
发明人： William Forbes , Lorin K. Johnson
IPC分类号： A61K31/437
CPC分类号： A61K31/437 , A61K31/395 , A61K31/4184 , C12Q1/6883 , C12Q2600/156
摘要： The present invention provides new methods of treating bowel disease (BD) by increasing a durability of response; treating BD in males; treating BD in adolescent subjects; treating bloating due to BD in males; and methods of maintaining remission of BD.

48. 发明申请

US20150216806A1 LAXATIVE COMPOSITIONS AND METHODS FOR TREATING CONSTIPATION AND RELATED GASTROINTESTINAL DISEASES AND CONDITIONS 审中-公开
标题翻译：治疗组织和相关胃肠疾病和病症的风味组合物和方法
公开(公告)号：US20150216806A1
公开(公告)日：2015-08-06
申请号：US14424515
申请日：2013-08-29
申请人： SALIX PHARMACEUTICALS, INC.
发明人： Thomas Julius Borody
IPC分类号： A61K9/48 , A61K31/437 , A61K9/50 , A61K31/655 , A61K31/454 , A61K31/538 , A61K38/08
CPC分类号： A61K9/48 , A61K9/28 , A61K9/4891 , A61K9/50 , A61K31/165 , A61K31/195 , A61K31/437 , A61K31/454 , A61K31/485 , A61K31/538 , A61K31/655 , A61K35/741 , A61K38/08 , A61K38/14 , A61K45/06 , A61K2035/115 , Y02A50/473 , A61K2300/00
摘要： In alternative embodiments, the invention provides compositions, e.g., formulations or preparations, used for treating, ameliorating or preventing constipation and other disorders with related gastrointestinal symptoms. In alternative embodiments, the invention provides compositions, e.g., formulations or preparations, used for treating, ameliorating or preventing conditions which benefit from increasing or speeding bowel transit, including for example: cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, Chronic Fatigue Syndrome (CFS), bloating, proctalgia fugax, small intestinal bacterial overgrowth (SIBO) and large intestinal bacterial overgrowth (LIBO), chronic nausea, functional dyspepsia and bloating. In alternative embodiments, the invention provides compositions, e.g., formulations or preparations, used for treating, ameliorating or preventing a constipation, a functional constipation, Irritable Bowel Syndrome (IBS)-constipation, a diverticulosis-associated constipation, a pseudo obstruction, a slow-transit constipation, a stasis with overflow and/or a diabetic gastro-paresis. In alternative embodiments, the invention provides pharmaceuticals and products (articles) of manufacture for delivering these compositions and formulations to an individual, e.g., a human or an animal.
摘要翻译：在替代实施方案中，本发明提供了用于治疗，改善或预防便秘和其它具有相关胃肠道症状的疾病的组合物，例如制剂或制剂。在替代实施方案中，本发明提供组合物，例如用于治疗，改善或预防有益于增加或加快肠道转运的病症的制剂或制剂，包括例如：环状呕吐，反流性食管炎，自闭症肠病，肠胃气胀，口臭，慢性疲劳综合征（CFS），腹胀，垂体痛，小肠细菌过度生长（SIBO）和大肠细菌过度生长（LIBO），慢性恶心，功能性消化不良和腹胀。在替代实施方案中，本发明提供了用于治疗，改善或预防便秘，功能性便秘，肠易激综合征（IBS） - 组合，憩室症相关便秘，伪梗阻，慢性转运便秘，有溢出的淤滞和/或糖尿病胃麻痹症。在替代实施方案中，本发明提供用于将这些组合物和制剂递送给个体例如人或动物的药物和制品（制品）。

49. 发明申请

US20140349983A1 METHOD FOR TREATING ULCERATIVE COLITIS 审中-公开
标题翻译：治疗精神分裂症的方法
公开(公告)号：US20140349983A1
公开(公告)日：2014-11-27
申请号：US14448872
申请日：2014-07-31
申请人： Salix Pharmaceuticals, Inc.
发明人： William P. Forbes , Enoch Bortey , Craig Paterson , Pam Golden
IPC分类号： A61K31/58 , A61M31/00 , A61K9/00
CPC分类号： A61K9/0031 , A61K31/58 , A61M31/00
摘要： Provided herein are methods of treating and inducing ulcerative colitis in a subject. Also provided are methods of treating subjects with mild to moderate active ulcerative colitis, including ulcerative proctitis and proctosigmoiditis. Also provided are methods of administering budesonide to a subject to treat ulcerative colitis, including ulcerative proctitis and proctosigmoiditis.
摘要翻译：本文提供了治疗和诱导受试者的溃疡性结肠炎的方法。还提供了治疗轻度至中度活动性溃疡性结肠炎的受试者的方法，包括溃疡性直肠炎和原发性肠梗阻炎。还提供了将布地奈德施用于受试者以治疗溃疡性结肠炎（包括溃疡性直肠炎和原发性肠胃炎）的方法。

50. 发明申请

US20210275507A1 METHODS OF TREATING HEPATIC ENCEPHALOPATHY 有权
公开(公告)号：US20210275507A1
公开(公告)日：2021-09-09
申请号：US17213678
申请日：2021-03-26
申请人： Salix Pharmaceuticals, Inc.
发明人： William Forbes
IPC分类号： A61K31/437 , A61K31/08 , A61K31/352 , A61K31/395 , A61K31/4164 , A61K31/426 , A61K31/4439 , A61K31/606 , A61K31/7016 , A61K31/785 , A61K38/14 , A61K38/31 , A61K45/06
摘要： The application describes treatment of hepatic encephalopathy using gastrointestinal specific antibiotics. One example of a gastrointestinal specific antibiotic is rifaximin.

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