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41. 发明授权

US07648988B2 Substituted pteridines for the treatment of inflammatory diseases 有权
标题翻译：用于治疗炎性疾病的替代蝶啶
公开(公告)号：US07648988B2
公开(公告)日：2010-01-19
申请号：US12031396
申请日：2008-02-14
申请人： Horst Dollinger , Domnic Martyres , Juergen Mack , Peter Nickolaus , Birgit Jung
发明人： Horst Dollinger , Domnic Martyres , Juergen Mack , Peter Nickolaus , Birgit Jung
IPC分类号： C07D475/08 , A61K31/4985 , A61K31/541 , A61K31/5355 , A61P1/00 , A61P11/00 , A61P35/00 , A61P29/00 , A61P25/00 , A61P25/02
CPC分类号： C07D475/08
摘要： Described are new pteridine compounds of the formula 1, where the variables are as described herein. The compounds are useful for the treatment of: respiratory or gastrointestinal complaints or diseases; inflammatory diseases of the joints, skin or eyes; diseases of the peripheral or central nervous system; and cancers. Also described are pharmaceutical compositions which contain these compounds.
摘要翻译：描述了式1的新的蝶啶化合物，其中变量如本文所述。该化合物可用于治疗：呼吸道或胃肠道疾病或疾病; 关节，皮肤或眼睛的炎症性疾病; 外周或中枢神经系统疾病; 和癌症。还描述了含有这些化合物的药物组合物。

42. 发明授权

US07550472B2 Substituted pteridines for the treatment of inflammatory diseases 有权
标题翻译：用于治疗炎性疾病的替代蝶啶
公开(公告)号：US07550472B2
公开(公告)日：2009-06-23
申请号：US11282535
申请日：2005-11-18
申请人： Horst Dollinger , Juergen Mack , Domnic Martyres , Birgit Jung , Peter Nickolaus
发明人： Horst Dollinger , Juergen Mack , Domnic Martyres , Birgit Jung , Peter Nickolaus
IPC分类号： A01N43/90 , A61K31/519
CPC分类号： C07D475/08
摘要： The invention relates to new pteridines which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.
摘要翻译：本发明涉及适用于治疗呼吸道或胃肠道疾病，关节，皮肤或眼睛的炎性疾病，外周或中枢神经系统或癌症的疾病以及含有这些化合物的药物组合物的新型蝶啶。

43. 发明申请

US20080153833A1 Substituted pteridines for the treatment of inflammatory diseases 有权
标题翻译：用于治疗炎性疾病的替代蝶啶
公开(公告)号：US20080153833A1
公开(公告)日：2008-06-26
申请号：US12031396
申请日：2008-02-14
申请人： Horst Dollinger , Juergen Mack , Domnic Martyres , Birgit Jung , Peter Nickolaus
发明人： Horst Dollinger , Juergen Mack , Domnic Martyres , Birgit Jung , Peter Nickolaus
IPC分类号： A61K31/4985 , C07D475/00 , A61P11/00 , A61P1/00 , A61P25/00 , A61P35/00
CPC分类号： C07D475/08
摘要： The invention relates to new pteridines which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.
摘要翻译：本发明涉及适用于治疗呼吸道或胃肠道疾病，关节，皮肤或眼睛的炎性疾病，外周或中枢神经系统或癌症的疾病以及含有这些化合物的药物组合物的新型蝶啶。

44. 发明申请

US20070015749A1 Use of Substituted Pteridines for the treatment of respiratory diseases 审中-公开
标题翻译：使用取代的蝶啶用于治疗呼吸系统疾病
公开(公告)号：US20070015749A1
公开(公告)日：2007-01-18
申请号：US11533108
申请日：2006-09-19
申请人： Peter NICKOLAUS , Christopher Meade , Domnic Martyres , Juergen Mack , Birgit Jung , Horst Dollinger , Georg Dahmann
发明人： Peter NICKOLAUS , Christopher Meade , Domnic Martyres , Juergen Mack , Birgit Jung , Horst Dollinger , Georg Dahmann
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/525
CPC分类号： A61K31/525 , A61K31/519 , A61K31/5377 , A61K31/541
摘要： The invention relates to the use of pteridines for the treatment of inflammatory and obstructive respiratory complaints, preferably asthma or COPD, as well as pharmaceutical compositions containing these compounds.
摘要翻译：本发明涉及使用蝶啶用于治疗炎性和阻塞性呼吸道感染，优选哮喘或COPD，以及含有这些化合物的药物组合物。

45. 发明申请

US20130237527A1 COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4-INHIBITORS AND EP4-RECEPTOR-ANTAGONISTS 有权
标题翻译：包含PDE4抑制剂和EP4受体拮抗剂的药物组合
公开(公告)号：US20130237527A1
公开(公告)日：2013-09-12
申请号：US13639626
申请日：2011-04-01
申请人： Peter Nickolaus
发明人： Peter Nickolaus
IPC分类号： A61K31/519 , A61K31/4745 , A61K31/55 , C07D495/04
CPC分类号： A61K31/519 , A61K31/437 , A61K31/44 , A61K31/4745 , A61K31/498 , A61K31/55 , A61K45/06 , C07D495/04 , A61K2300/00
摘要： The present invention relates to new medicament combinations which contain in addition to one or more PDE4-inhibitors (1) at least one EP4 receptor antagonist (2), as well as the use thereof for the treatment of preferably respiratory complaints such as particularly COPD, chronic sinusitis and asthma.The invention relates in particular to those medicament combinations which contain at least one EP4 receptor antagonist (2), in addition to one or more, preferably one, PDE4 inhibitor of general formula 1 wherein X is SO or SO2, but preferably SO, and wherein R3 denotes an optionally substituted, mono- or bicyclic, unsaturated, partly saturated or saturated heterocyclic group or an optionally substituted, mono- or bicyclic heteroaryl and wherein R1 and R2 have the meanings given in claim 1, the preparation thereof and the use thereof for the treatment of respiratory complaints.
摘要翻译：本发明涉及除了一种或多种PDE4-抑制剂（1）至少一种EP4受体拮抗剂（2）外，还包含用于治疗优选呼吸道疾病如COPD，慢性鼻窦炎和哮喘。本发明特别涉及含有至少一种EP4受体拮抗剂（2）的那些药物组合物，除了一种或多种，优选一种通式1的PDE4抑制剂，其中X是SO或SO 2，但优选为SO，其中 R 3表示任选取代的单或双环不饱和的部分饱和或饱和杂环基或任选取代的单环或双环杂芳基，其中R1和R2具有权利要求1中给出的含义，其制备及其用途治疗呼吸道疾病。

46. 发明申请

US20130059866A1 NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA 审中-公开
公开(公告)号：US20130059866A1
公开(公告)日：2013-03-07
申请号：US13402996
申请日：2012-02-23
申请人： Horst Dollinger , Rogelio Perez Frutos , Soojin Kim , Jason Alan Mulder , Peter Nickolaus , Nitinchandra D. Patel , Pascale Pouzet , Chris Hugh Senanayake , Thomas Gabriel Tampone , Xudong Wei , Ulrike Werthmann , Bing-Shiou Yang
发明人： Horst Dollinger , Rogelio Perez Frutos , Soojin Kim , Jason Alan Mulder , Peter Nickolaus , Nitinchandra D. Patel , Pascale Pouzet , Chris Hugh Senanayake , Thomas Gabriel Tampone , Xudong Wei , Ulrike Werthmann , Bing-Shiou Yang
IPC分类号： A61K31/519 , A61P11/00 , A61P1/00 , A61P19/02 , A61P17/00 , A61P27/02 , A61P25/00 , A61P11/06 , A61P1/04 , A61P25/28 , A61P25/18 , A61P25/16 , A61P25/04 , C07C213/02 , C07D401/04 , C07D495/04
CPC分类号： C07D495/04 , A61K31/519 , A61K45/06 , C07B2200/13 , C07C213/00 , C07D401/04 , C07C215/42
摘要： The invention relates to novel piperidino-dihydrothienopyrimidine sulfoxides of formula I, wherein Ring A is a 6-membered aromatic ring which may optionally comprise one or two nitrogen atoms and wherein R is Cl and wherein R may be located either in the para-, meta- or ortho-position of Ring A, wherein S* is a sulphur atom that represents a chiral center, and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.

47. 发明申请

US20120035143A1 DRUG COMBINATIONS CONTAINING PDE4 INHIBITORS AND NSAIDS 有权
标题翻译：含有PDE4抑制剂和NSAIDS的药物组合
公开(公告)号：US20120035143A1
公开(公告)日：2012-02-09
申请号：US13201270
申请日：2010-02-18
申请人： Peter Nickolaus , Rolf Goeggel , Daniel Peter
发明人： Peter Nickolaus , Rolf Goeggel , Daniel Peter
IPC分类号： A61K31/60 , A61K31/5415 , A61P29/00 , A61K31/519
CPC分类号： A61K31/196 , A61K31/44 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： The present invention relates to new drug combinations which contain in addition to one or more PDE4-inhibitors at least one NSAID (=non-steroidal anti-inflammatory drug) (2), processes for preparing them and their use in treating in particular respiratory complaints such as for example COPD, chronic sinusitis and asthma.The invention particularly relates to those drug combinations which contain, in addition to one or more, preferably one PDE4 inhibitor of general formula 1 wherein X is SO or SO2, but preferably SO, and wherein R1, R2, R3 and R4 have the meanings given in claim 1, at least one NSAID (2), the preparation thereof and the use thereof for the treatment of respiratory complaints.
摘要翻译：本发明涉及除一种或多种PDE4抑制剂外还包含至少一种NSAID（=非甾体抗炎药物）（2）的新药物组合，其制备方法及其在治疗特别是呼吸道疾病中的用途例如COPD，慢性鼻窦炎和哮喘。本发明特别涉及除了一种或多种，优选一种通式1的PDE4抑制剂之外，其中X是SO或SO 2，但优选为SO，并且其中R1，R2，R3和R4具有给定的含义的那些药物组合在权利要求1中，至少一种NSAID（2），其制备及其用于治疗呼吸道疾病的用途。

48. 发明申请

US20060116371A1 Substituted pteridines for the treatment of inflammatory diseases 有权
公开(公告)号：US20060116371A1
公开(公告)日：2006-06-01
申请号：US11282161
申请日：2005-11-18
申请人： Domnic Martyres , Horst Dollinger , Birgit Jung , Peter Nickolaus
发明人： Domnic Martyres , Horst Dollinger , Birgit Jung , Peter Nickolaus
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/525 , C07D475/02
CPC分类号： C07D475/08 , C07D475/06
摘要： The invention relates to new pteridines which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.

49. 发明申请

US20050165010A1 Use of substituted pteridines for the treatment of respiratory diseases 审中-公开
标题翻译：使用取代的蝶啶治疗呼吸系统疾病
公开(公告)号：US20050165010A1
公开(公告)日：2005-07-28
申请号：US11034281
申请日：2005-01-12
申请人： Peter Nickolaus , Christopher Meade , Domnic Martyres , Juergen Mack , Birgit Jung , Horst Dollinger , Georg Dahmann
发明人： Peter Nickolaus , Christopher Meade , Domnic Martyres , Juergen Mack , Birgit Jung , Horst Dollinger , Georg Dahmann
IPC分类号： A61K31/519 , A61K31/525 , A61K31/5377 , A61K31/541
CPC分类号： A61K31/525 , A61K31/519 , A61K31/5377 , A61K31/541
摘要： The invention relates to the use of pteridines for the treatment of inflammatory and obstructive respiratory complaints, preferably asthma or COPD, as well as pharmaceutical compositions containing these compounds.
摘要翻译：本发明涉及使用蝶啶用于治疗炎性和阻塞性呼吸道感染，优选哮喘或COPD，以及含有这些化合物的药物组合物。

50. 发明授权

US09115142B2 Heterocycle-substituted piperazino-dihydrothienopyrimidines 有权
标题翻译：杂环取代的哌嗪子基 - 二氢噻吩并嘧啶
公开(公告)号：US09115142B2
公开(公告)日：2015-08-25
申请号：US14134367
申请日：2013-12-19
申请人： Pascale Pouzet , Ralf Anderskewitz , Horst Dollinger , Dennis Fiegen , Thomas Fox , Rolf Goeggel , Christoph Hoenke , Domnic Martyres , Peter Nickolaus , Klaus Klinder
发明人： Pascale Pouzet , Ralf Anderskewitz , Horst Dollinger , Dennis Fiegen , Thomas Fox , Rolf Goeggel , Christoph Hoenke , Domnic Martyres , Peter Nickolaus , Klaus Klinder
IPC分类号： C07D495/04 , A61K31/519 , C07D519/00
CPC分类号： C07D495/04 , A61K31/519 , A61K2300/00
摘要： Dihydrothienopyrimidinesulphoxides of formula 1 wherein X is SO or SO2, R1 is H or C1-6-alkyl, R2 is H or an organic group as disclosed herein, and R3 is an optionally substituted, mono- or bicyclic, unsaturated, partially saturated or saturated heterocycle or an optionally substituted, mono- or bicyclic heteroaryl, and the pharmacologically acceptable salts thereof, as well as pharmaceutical compositions which contain these compounds. These dihydrothienopyrimidinesulphoxides are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system, or cancers.
摘要翻译：式1的二氢噻吩并嘧啶亚砜，其中X是SO或SO 2，R 1是H或C 1-6 - 烷基，R 2是H或如本文所公开的有机基团，并且R 3是任选取代的单或双环不饱和的，部分饱和的或饱和的杂环或任选取代的单环或双环杂芳基及其药理学上可接受的盐，以及含有这些化合物的药物组合物。这些二氢噻吩并嘧啶亚砜适用于治疗呼吸道或胃肠道疾病，关节，皮肤或眼睛的炎性疾病，外周或中枢神经系统疾病或癌症。

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