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41. 发明申请

US20090192149A1 Imidazo Compounds 审中-公开
标题翻译：咪唑化合物
公开(公告)号：US20090192149A1
公开(公告)日：2009-07-30
申请号：US12226212
申请日：2007-04-12
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Stjepan Jelakovic , Stefan Stutz
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Stjepan Jelakovic , Stefan Stutz
IPC分类号： A61K31/5383 , C07D498/04 , A61P35/00
CPC分类号： C07D513/04 , C07D498/04
摘要： The application relates to novel heterocyclic compounds of the general formula (I) and salts, preferably pharmaceutically acceptable salts, thereof, in which R, R1, R2, Q, m and n have the meanings explained in detail in the description and * designates an asymmetric carbon atom, a process for their preparation and the use of these compounds as medicaments, in particular as aromatase inhibitors.
摘要翻译：本申请涉及通式（I）的新型杂环化合物和其盐，优选其药学上可接受的盐，其中R，R 1，R 2，Q，m和n具有在说明书中详细说明的含义，*表示不对称碳原子，其制备方法和这些化合物作为药物的用途，特别是芳香酶抑制剂。

42. 发明申请

US20090088576A1 Process for the Stereoselective Preparation of Alcohols From Alpha, Beta-Insaturated Compounds 审中-公开
标题翻译：用于α，β-不饱和化合物的醇的立体选择性制备方法
公开(公告)号：US20090088576A1
公开(公告)日：2009-04-02
申请号：US12223338
申请日：2007-01-29
申请人： Peter Herold , Stefan Stutz , Robert Mah , Aleksandar Stojanovic , Isabelle Lyothier , Dirk Behnke , Felix Spindler , Erhard Bappert
发明人： Peter Herold , Stefan Stutz , Robert Mah , Aleksandar Stojanovic , Isabelle Lyothier , Dirk Behnke , Felix Spindler , Erhard Bappert
IPC分类号： C07D231/56
CPC分类号： C07D471/04 , C07D231/56
摘要： A process for the synthesis of an alcohol of formula (I), using as intermediate a compound of formula (V).
摘要翻译：用于合成式（I）的醇的方法，使用式（V）化合物作为中间体。

43. 发明申请

US20090088426A1 Substituted 4-Phenyl Piperidines for Use as Renin Inhibitors 失效
标题翻译：用作肾素抑制剂的取代的4-苯基哌啶子
公开(公告)号：US20090088426A1
公开(公告)日：2009-04-02
申请号：US12224440
申请日：2007-10-03
申请人： Peter Herold , Robert Mah , Stefan Stutz , Vincenzo Tschinke , Aleksandar Stojanovic , Dirk Behnke , Nathalie Jotterand , Stjepan Jelakovic
发明人： Peter Herold , Robert Mah , Stefan Stutz , Vincenzo Tschinke , Aleksandar Stojanovic , Dirk Behnke , Nathalie Jotterand , Stjepan Jelakovic
IPC分类号： A61K31/538 , C07D265/36 , A61P9/00 , A61P13/12
CPC分类号： C07D413/12
摘要： Compounds of the general formula (I) and the salts thereof, preferably the pharmaceutically acceptable salts thereof; in which R1 is straight-chain C1-8-alkanoyloxy, straight-chain C1-8-alkoxy, straight-chain C1-8-alkoxy-straight-chain-C1-8-alkoxy, straight-chain C1-8-alkoxycarbonylamino, straight-chain C0-8-alkylcarbonylamino, optionally N-mono- or N,N-di-C1-8-alkylated amino or hydroxy or straight-chain omega-hydroxy-C1-8-alkyl.
摘要翻译：通式（I）的化合物及其盐，优选其药学上可接受的盐; 其中R 1为直链C 1-8 - 烷酰氧基，直链C 1-8 - 烷氧基，直链C 1-8 - 烷氧基 - 直链-C 1-8 - 烷氧基，直链C 1-8烷氧基羰基氨基，直链C0-8-烷基羰基氨基，任选N-单或N，N-二-C 1-8 - 烷基化氨基或羟基或直链ω-羟基-C 1-8 - 烷基。

44. 发明申请

US20090048241A1 Condensed Imidazole Derivatives as Aromatase Inhibitors 失效
标题翻译：浓缩咪唑衍生物作为芳香酶抑制剂
公开(公告)号：US20090048241A1
公开(公告)日：2009-02-19
申请号：US12226209
申请日：2007-04-12
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Stefan Stutz
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Stefan Stutz
IPC分类号： C07D498/04 , A61K31/5365
CPC分类号： C07D513/04
摘要： The application relates to novel heterocyclic compounds of the general formula (I) and salts, preferably pharmaceutically acceptable salts, thereof, in which R, R1, R2, R3, Q, m and n have the meanings explained in detail in the description, and * designates an asymmetric carbon atom, a process for their preparation and the use of these compounds as medicaments, in particular as aromatase inhibitors.
摘要翻译：本申请涉及通式（I）的新型杂环化合物及其盐，优选药学上可接受的盐，其中R，R 1，R 2，R 3，Q，m和n具有在说明书中详细说明的含义， *表示不对称碳原子，其制备方法和这些化合物作为药物的用途，特别是芳香酶抑制剂。

45. 发明申请

US20090012068A1 Condensed Imidazole Derivatives as Aldosterone Synthase Inhibitors 有权
标题翻译：浓缩咪唑衍生物作为醛固酮合酶抑制剂
公开(公告)号：US20090012068A1
公开(公告)日：2009-01-08
申请号：US12223789
申请日：2007-04-12
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Chirstiane Marti , Stefan Stutz , Bibia Bennacer
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Chirstiane Marti , Stefan Stutz , Bibia Bennacer
IPC分类号： A61K31/542 , C07D498/04 , A61K31/5383 , A61P5/00 , C07D513/04
CPC分类号： C07D513/04
摘要： The application relates to novel heterocyclic compounds of the general formula (I) and salts, preferably pharmaceutically acceptable salts, thereof, in which R, R1, R2, R3, Q, m and n have the meanings explained in detail in the description, a process for their preparation and the use of these compounds as medicaments, in particular as aldosterone synthase inhibitors.
摘要翻译：本申请涉及通式（I）的新型杂环化合物和其盐，优选其药学上可接受的盐，其中R，R 1，R 2，R 3，Q，m和n具有在说明书中详细说明的含义，其制备方法和这些化合物作为药物的用途，特别是作为醛固酮合酶抑制剂。

46. 发明申请

US20090012055A1 Organic compounds 失效
标题翻译：有机化合物
公开(公告)号：US20090012055A1
公开(公告)日：2009-01-08
申请号：US12068443
申请日：2008-02-06
申请人： Peter Herold , Robert Mah , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Nathalie Jotterand
发明人： Peter Herold , Robert Mah , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Nathalie Jotterand
IPC分类号： A61K31/397 , C07D211/40 , A61K31/445 , C07D265/36 , A61K31/538 , C07D413/02 , A61K31/454 , A61K31/4525 , A61K31/5415 , A61P13/12 , A61P9/00 , C07D279/16 , C07D401/02 , C07D215/00 , A61K31/4709 , A61K31/5377 , C07D239/24 , A61K31/506
CPC分类号： C07D211/42 , C07D401/12 , C07D413/12
摘要： Novel substituted piperidines of the general formulae (I) and (II) with the substituent definitions as explained in detail in the description are described. The compounds are suitable in particular as renin inhibitors and are highly potent.
摘要翻译：描述通式（I）和（II）的新颖取代的哌啶与具有如在说明书中详细说明的取代基定义。该化合物特别适合作为肾素抑制剂，并且是非常有效的。

47. 发明申请

US20080076784A1 Bicyclic, Nitrogen-Containing Heterocycles and Aromatase Inhibitors 审中-公开
标题翻译：双环，含氮杂环和芳香酶抑制剂
公开(公告)号：US20080076784A1
公开(公告)日：2008-03-27
申请号：US11597585
申请日：2005-05-27
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Christoph Schumacher , Michael Quirmbach
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Christoph Schumacher , Michael Quirmbach
IPC分类号： A61K31/435 , A61K31/437 , A61K31/517 , A61P43/00 , C07D221/04 , C07D239/70 , C07D471/04
CPC分类号： C07D221/04 , C07D217/02 , C07D239/74 , C07D471/04
摘要： The application relates to novel heterocyclic compounds of the general formula (I) (I*) in which R, R1, R2, X, Y, Z and n have the meanings defined in the description, to a process for their preparation and to the use of these compounds as medicaments, in particular as aromatase inhibitors.
摘要翻译：本申请涉及通式（I）（I *）的新型杂环化合物，其中R 1，R 2，R 2，X，Y，Z和n具有描述中定义的含义，其制备方法和这些化合物作为药物的用途，特别是芳香酶抑制剂。

48. 发明申请

US20070066582A1 Diaminoalcohols as therapeutic compounds 审中-公开
标题翻译：二氨基醇作为治疗化合物
公开(公告)号：US20070066582A1
公开(公告)日：2007-03-22
申请号：US11522316
申请日：2006-09-18
申请人： Peter Herold , Robert Mah , Stefan Stutz , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Dirk Behnke , Nathalie Jotterand , Michael Quirmbach , Christoph Schumacher
发明人： Peter Herold , Robert Mah , Stefan Stutz , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Dirk Behnke , Nathalie Jotterand , Michael Quirmbach , Christoph Schumacher
IPC分类号： A61K31/55 , A61K31/54 , A61K31/5375 , A61K31/538 , A61K31/496 , A61K31/497 , A61K31/495 , A61K31/50 , A61K31/505
CPC分类号： A61K31/404 , Y02A50/411
摘要： Use of compounds of the general formula (I) wherein R1, R2, R3, R4, R5, R6 and X have the definitions elucidated in more detail in the description, as beta-secretase, cathepsin D, plasmepsin II and/or HIV protease inhibitors.
摘要翻译：通式（I）的化合物其中R 1，R 2，R 3，R 4，R 4， R 5，R 6和X的定义在说明书中更详细地描述为β-分泌酶，组织蛋白酶D，浆细胞素II和/或HIV蛋白酶抑制剂。

49. 发明申请

US20070010511A1 Organic compounds 失效
标题翻译：有机化合物
公开(公告)号：US20070010511A1
公开(公告)日：2007-01-11
申请号：US10574108
申请日：2004-09-30
申请人： Peter Herold , Robert Mah , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Nathalie Jotterand
发明人： Peter Herold , Robert Mah , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Nathalie Jotterand
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/46 , C07D453/02
CPC分类号： C07D211/42 , C07D401/12 , C07D413/12
摘要： Novel substituted piperidines of the general formulae (I) and (II) with the substituent definitions as explained in detail in the description are described. The compounds are suitable in particular as renin inhibitors and are highly potent.
摘要翻译：描述通式（I）和（II）的新颖取代的哌啶与具有如在说明书中详细说明的取代基定义。该化合物特别适合作为肾素抑制剂，并且是非常有效的。

50. 发明授权

US06261346B1 Method for protecting metal surfaces against corrosion in liquid or gaseous media 失效
标题翻译：保护金属表面免受液体或气体介质腐蚀的方法
公开(公告)号：US06261346B1
公开(公告)日：2001-07-17
申请号：US09319144
申请日：1999-07-29
申请人： Wolfgang Breuer , Robert Schuetz , Guenther Uphues , Claus-Peter Herold , Rafael Pi
发明人： Wolfgang Breuer , Robert Schuetz , Guenther Uphues , Claus-Peter Herold , Rafael Pi
IPC分类号： C23F1114
CPC分类号： C23F11/141 , C09K8/54 , C23F11/142 , C23F11/145
摘要： A process useful for protecting metal surfaces against corrosion in is presented involving: (a) forming a corrosion inhibitor having a compound corresponding to formula (I): where R1, R2 and R3 independently of one another represent an alkyl or hydroxyalkyl group containing 1 to 4 carbon atoms, an aryl or alkylaryl group or a group corresponding to formula (II): A− is an anion, n is the number 2 or 3, p is a number of 1 to 3 and R5 is an alkyl or alkenyl group containing 7 to 23 carbon atoms and 0, 1, 2 or 3 double bonds, and R4 is a group corresponding to formula (II) or (III): where R1, R2 and R3 are as defined above and Z is a group —(CH2)m— or a group corresponding to formula (IV): m is an integer of 1 to 6, X is a group NH or an oxygen atom and D is a dimer fatty acid residue containing on average 36 to 54 carbon atoms; (b) combining the corrosion inhibitor with liquid aqueous, liquid non-aqueous or gaseous media; and (c) contacting the corrosion inhibitor with metal. The corrosion inhibitor used in the is biodegradable and shows low aquatic toxicity.
摘要翻译：提出了一种用于保护金属表面免受腐蚀的方法，涉及：（a）形成具有对应于式（I）的化合物的腐蚀抑制剂：其中R 1，R 2和R 3彼此独立地表示含有1至 4个碳原子，芳基或烷基芳基或对应于式（II）的基团：A-是阴离子，n是数2或3，p是1至3的数，R 5是含有 7至23个碳原子和0,1,2或3个双键，R4是与式（II）或（III）相应的基团：其中R1，R2和R3如上定义，Z是基团 - （CH2 ）m-或对应于式（IV）的基团：m是1至6的整数，X是NH或氧原子，D是含有平均36至54个碳原子的二聚脂肪酸残基; （b）将腐蚀抑制剂与液体水性，液体非水性或气态介质结合; 和（c）使腐蚀抑制剂与金属接触。所用的腐蚀抑制剂是可生物降解的，水生毒性低。

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