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41. 发明申请

US20070066957A1 Methods and apparatus for inducing controlled renal neuromodulation 有权
标题翻译：诱导受控肾神经调节的方法和装置
公开(公告)号：US20070066957A1
公开(公告)日：2007-03-22
申请号：US11252462
申请日：2005-10-18
申请人： Denise Demarais , Nicolas Zadno
发明人： Denise Demarais , Nicolas Zadno
IPC分类号： A61M31/00
CPC分类号： A61N1/327 , A61N1/0514 , A61N1/08 , A61N1/36007
摘要： Methods and apparatus are provided for inducing, monitoring and controlling renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. In some embodiments, tissue impedance, conductance or conductivity may be monitored to determine the effects of pulsed electric field therapy, e.g., to determine an extent of electroporation and its degree of irreversibility. Pulsed electric field electroporation of tissue causes a decrease in tissue impedance and an increase in tissue conductivity. If induced electroporation is reversible, upon cessation of the pulsed electric field, tissue impedance and conductivity should approximate baseline levels; however, if electroporation is irreversible, impedance and conductivity changes should persist. Thus, monitoring of impedance or conductivity may be utilized to determine the onset of electroporation and to determine the type or extent of electroporation. Furthermore, monitoring data may be used in one or more manual or automatic feedback loops to control the electroporation.
摘要翻译：提供了使用脉冲电场诱导，监测和控制肾神经调节以实现电穿孔或电融合的方法和装置。在一些实施例中，可以监测组织阻抗，电导或电导率以确定脉冲电场治疗的效果，例如确定电穿孔的程度及其不可逆程度。组织的脉冲电场电穿孔导致组织阻抗的减少和组织传导性的增加。如果诱导电穿孔是可逆的，则在脉冲电场停止时，组织阻抗和电导率应近似基线水平; 然而，如果电穿孔是不可逆的，阻抗和电导率的变化应该持续。因此，可以使用阻抗或电导率的监测来确定电穿孔的发作并确定电穿孔的类型或程度。此外，监测数据可用于一个或多个手动或自动反馈回路中以控制电穿孔。

42. 发明申请

US20160000498A1 BALLOON CATHETER APPARATUSES FOR RENAL DENERVATION 有权
标题翻译：用于肾功能衰竭的气囊导管装置
公开(公告)号：US20160000498A1
公开(公告)日：2016-01-07
申请号：US14676649
申请日：2015-04-01
申请人： Denise Zarins , Hanson Gifford, III , Mark Deem , Nicolas Zadno , Benjamin J. Clark , Andrew Wu , Kenneth J. Michlitsch
发明人： Denise Zarins , Hanson Gifford, III , Mark Deem , Nicolas Zadno , Benjamin J. Clark , Andrew Wu , Kenneth J. Michlitsch
IPC分类号： A61B18/14 , A61B18/12
CPC分类号： A61B18/1492 , A61B18/1206 , A61B18/18 , A61B2018/00023 , A61B2018/00077 , A61B2018/0016 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00648 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61B2018/1435 , A61B2018/1465 , A61N1/0551 , A61N1/32 , A61N1/327 , A61N1/36007 , A61N7/022
摘要： Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first position. The apparatus also may deliver energy at one or more additional lengthwise and angular positions within the body lumen to create less-than-full circumferential treatment zone(s) at the one or more additional positions that are offset lengthwise and angularly from the first treatment zone. Superimposition of the first treatment zone and the one or more additional treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion. Various embodiments of methods and apparatus for achieving such non-continuous circumferential treatment are provided.
摘要翻译：提供了用于不间断地周围处理体腔的方法和装置。装置可以定位在患者的体腔内，并且可以在第一纵向和角位置处递送能量，以在第一位置处产生小于整个圆周的处理区域。该装置还可以在体腔内的一个或多个附加的纵向和角度位置处递送能量，以在一个或多个附加位置处创建小于整个圆周处理区域，该一个或多个附加位置从第一处理区域纵向和角度偏移。第一处理区和一个或多个另外的处理区的叠置限定非连续的圆周处理区而不形成连续的周向损伤。提供了用于实现这种非连续圆周处理的方法和装置的各种实施例。

43. 发明授权

US09023037B2 Balloon catheter apparatus for renal neuromodulation 有权
标题翻译：气球导管装置用于肾神经调节
公开(公告)号：US09023037B2
公开(公告)日：2015-05-05
申请号：US13868426
申请日：2013-04-23
申请人： Denise Zarins , Hanson Gifford, III , Mark Deem , Nicolas Zadno , Benjamin J. Clark , Andrew Wu , Kenneth J. Michlitsch
发明人： Denise Zarins , Hanson Gifford, III , Mark Deem , Nicolas Zadno , Benjamin J. Clark , Andrew Wu , Kenneth J. Michlitsch
IPC分类号： A61B18/12 , A61B18/18 , A61N1/32 , A61N1/36 , A61B18/14 , A61N1/05 , A61N7/02 , A61B18/00
CPC分类号： A61B18/1492 , A61B18/1206 , A61B18/18 , A61B2018/00023 , A61B2018/00077 , A61B2018/0016 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00648 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61B2018/1435 , A61B2018/1465 , A61N1/0551 , A61N1/32 , A61N1/327 , A61N1/36007 , A61N7/022
摘要： Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first position. The apparatus also may deliver energy at one or more additional lengthwise and angular positions within the body lumen to create less-than-full circumferential treatment zone(s) at the one or more additional positions that are offset lengthwise and angularly from the first treatment zone. Superimposition of the first treatment zone and the one or more additional treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion. Various embodiments of methods and apparatus for achieving such non-continuous circumferential treatment are provided.
摘要翻译：提供了用于不间断地周围处理体腔的方法和装置。装置可以定位在患者的体腔内，并且可以在第一纵向和角位置处递送能量，以在第一位置处产生小于整个圆周的处理区域。该装置还可以在体腔内的一个或多个附加的纵向和角度位置处递送能量，以在一个或多个附加位置处创建小于整个圆周处理区域，该一个或多个附加位置从第一处理区域纵向和角度偏移。第一处理区和一个或多个另外的处理区的叠置限定非连续的圆周处理区而不形成连续的周向损伤。提供了用于实现这种非连续圆周处理的方法和装置的各种实施例。

44. 发明申请

US20130042505A1 HEEL PROTECTOR 有权
标题翻译：护理人员
公开(公告)号：US20130042505A1
公开(公告)日：2013-02-21
申请号：US13210219
申请日：2011-08-15
申请人： Grace Hwang , Nicolas Zadno
发明人： Grace Hwang , Nicolas Zadno
IPC分类号： A43B13/26
CPC分类号： A43C13/00 , A43B21/265 , A43B21/437 , A43B21/52 , A43C15/04
摘要： A shielding cup is provided for use with a self-fusing member or collapsible heat-concentrating accessory. The shielding cup is attached to a shoe heel as a temporary fix for a worn heel tip. The cup can be attached to the heel by a self-fusing member that binds to itself. The cup can also be attached by using a heat source and collapsible heat-concentrating accessory to concentrate heat on the heat-shrink version of the shielding cup.
摘要翻译：提供了一个屏蔽杯，用于与自熔合部件或可折叠的热集中附件一起使用。屏蔽杯被连接到鞋跟上，作为磨损的脚跟尖端的临时固定。杯子可以通过与自身结合的自熔合构件附着到脚跟上。也可以通过使用热源和可折叠的热集中附件来连接杯子，以将热量集中在屏蔽杯的热收缩型上。

45. 发明授权

US08347891B2 Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen 有权
标题翻译：用于进行体腔不连续周边处理的方法和装置
公开(公告)号：US08347891B2
公开(公告)日：2013-01-08
申请号：US11599890
申请日：2006-11-14
申请人： Denise Demarais , Hanson Gifford, III , Mark Deem , Nicolas Zadno , Benjamin J. Clark , Andrew Wu , Kenneth J. Michlitsch
发明人： Denise Demarais , Hanson Gifford, III , Mark Deem , Nicolas Zadno , Benjamin J. Clark , Andrew Wu , Kenneth J. Michlitsch
IPC分类号： A61B18/12
CPC分类号： A61B18/1492 , A61B18/1206 , A61B18/18 , A61B2018/00023 , A61B2018/00077 , A61B2018/0016 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00648 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61B2018/1435 , A61B2018/1465 , A61N1/0551 , A61N1/32 , A61N1/327 , A61N1/36007 , A61N7/022
摘要： Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first position. The apparatus also may deliver energy at one or more additional lengthwise and angular positions within the body lumen to create less-than-full circumferential treatment zone(s) at the one or more additional positions that are offset lengthwise and angularly from the first treatment zone. Superimposition of the first treatment zone and the one or more additional treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion. Various embodiments of methods and apparatus for achieving such non-continuous circumferential treatment are provided.
摘要翻译：提供了用于不间断地周围处理体腔的方法和装置。装置可以定位在患者的体腔内，并且可以在第一纵向和角位置处递送能量，以在第一位置处产生小于整个圆周的处理区域。该装置还可以在体腔内的一个或多个附加的纵向和角度位置处递送能量，以在一个或多个附加位置处创建小于整个圆周处理区域，该一个或多个附加位置从第一处理区域纵向和角度偏移。第一处理区和一个或多个另外的处理区的叠置限定非连续的圆周处理区而不形成连续的周向损伤。提供了用于实现这种非连续圆周处理的方法和装置的各种实施例。

46. 发明授权

US08131371B2 Methods and apparatus for monopolar renal neuromodulation 有权
标题翻译：单极肾神经调节的方法和装置
公开(公告)号：US08131371B2
公开(公告)日：2012-03-06
申请号：US11403329
申请日：2006-04-13
申请人： Denise Demarals , Hanson Gifford, III , Mark Deem , Howard R. Levin , Mark Gelfand , Nicolas Zadno
发明人： Denise Demarals , Hanson Gifford, III , Mark Deem , Howard R. Levin , Mark Gelfand , Nicolas Zadno
IPC分类号： A61N1/00 , A61N1/30
CPC分类号： A61N1/36007 , A61N1/0551 , A61N1/32 , A61N1/327
摘要： Methods and apparatus are provided for monopolar neuromodulation, e.g., via a pulsed electric field. Such monopolar neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, monopolar neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such monopolar neuromodulation is performed bilaterally.
摘要翻译：提供了用于单极神经调节的方法和装置，例如通过脉冲电场。这种单极神经调节可能会导致不可逆的电穿孔或电融合，坏死和/或诱导凋亡，基因表达的改变，动作电位减弱或阻断，细胞因子上调的变化和靶神经纤维中的其他条件。在一些实施方案中，单极神经调节被应用于有助于肾功能的神经纤维。在一些实施方案中，这种单极神经调节是双侧进行的。

47. 发明申请

US20100222854A1 APPARATUSES FOR INHIBITING RENAL NERVE ACTIVITY VIA AN INTRA-TO-EXTRAVASCULAR APPROACH 审中-公开
标题翻译：用于通过内向外方法抑制肾脏神经活动的装置
公开(公告)号：US20100222854A1
公开(公告)日：2010-09-02
申请号：US12777995
申请日：2010-05-11
申请人： Denise Demarais , Nicolas Zadno , Benjamin J. Clark , Erik Thai , Howard R. Levin , Mark Gelfand
发明人： Denise Demarais , Nicolas Zadno , Benjamin J. Clark , Erik Thai , Howard R. Levin , Mark Gelfand
IPC分类号： A61F7/12 , A61F7/00 , A61M5/32
CPC分类号： A61N7/022 , A61B18/02 , A61B18/04 , A61B18/12 , A61B18/1492 , A61B2018/0022 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61F7/007 , A61F7/12 , A61F7/123 , A61F2007/126 , A61M5/44 , A61M2210/1082 , A61N1/28 , A61N1/36007 , A61N1/403 , A61N5/00 , A61N5/025 , A61N5/045 , A61N5/0603 , A61N7/00 , A61N7/02 , A61N2007/003 , A61N2007/0078
摘要： Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.
摘要翻译：提供了用于热诱导的肾神经调节的方法和装置。热诱导的肾神经调节可以通过直接和/或通过间接施加热能来加热或冷却有助于肾功能的神经纤维或者供给或灌注神经纤维的血管结构来实现。在一些实施例中，神经纤维，非目标组织或热能递送元件的参数可以经由一个或多个传感器来监测，以控制热诱导的神经调节。在一些实施方案中，可以提供保护元件以减少在非靶组织中诱导的热损伤程度。

48. 发明授权

US07756583B2 Methods and apparatus for intravascularly-induced neuromodulation 有权
标题翻译：血管内诱导神经调节的方法和装置
公开(公告)号：US07756583B2
公开(公告)日：2010-07-13
申请号：US11266993
申请日：2005-11-04
申请人： Denise Demarais , Nicolas Zadno , Benjamin J. Clark , Erik Thai
发明人： Denise Demarais , Nicolas Zadno , Benjamin J. Clark , Erik Thai
IPC分类号： A61N1/00 , A61N1/30
CPC分类号： A61B18/1492 , A61B17/12136 , A61B2018/00083 , A61B2018/00285 , A61B2018/00434 , A61B2018/00613 , A61M25/0108 , A61M25/10 , A61N1/327 , A61N1/36007 , A61N1/36121 , A61N1/36182 , A61N1/37205 , A61N1/40
摘要： Methods and apparatus are provided for intravascularly-induced neuromodulation using a pulsed electric field, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation, etc., in target neural fibers. In some embodiments, the intravascular PEF system comprises a catheter having a pair of bipolar electrodes for delivering the PEF, with a first electrode positioned on a first side of an impedance-altering element and a second electrode positioned on an opposing side of the impedance-altering element. A length of the electrodes, as well as a separation distance between the first and second electrodes, may be specified such that, with the impedance-altering element deployed in a manner that locally increases impedance within a patient's vessel, e.g., with the impedance-altering element deployed into contact with the vessel wall at a treatment site within the patient's vasculature, a magnitude of applied voltage delivered across the bipolar electrodes necessary to achieve desired neuromodulation is reduced relative to an intravascular PEF system having similarly spaced electrodes but no (or an undeployed) impedance-altering element. In a preferred embodiment, the impedance-altering element comprises an inflatable balloon configured to locally increase impedance within a patient's vasculature. The methods and apparatus of the present invention may be used to modulate a neural fiber that contributes to renal function.
摘要翻译：提供了使用脉冲电场进行血管内诱导的神经调节的方法和装置，例如，在靶神经纤维中实现不可逆的电穿孔或电融合，坏死和/或诱导细胞凋亡，基因表达的改变，细胞因子上调的变化等。在一些实施例中，血管内PEF系统包括导管，其具有用于传送PEF的一对双极电极，第一电极位于阻抗改变元件的第一侧上，第二电极位于阻抗变换元件的相对侧上，改变元素可以规定电极的长度以及第一和第二电极之间的间隔距离，使得以阻抗变化元件部署的方式，其局部地增加患者血管内的阻抗，例如阻抗 - 改变元件被部署成与病人血管系统中的治疗部位处的血管壁接触，相对于具有类似间隔开的电极而没有（或一个或多个）的血管内PEF系统，减少了实现所需神经调节所需双极电极的施加电压的大小未部署）阻抗变化元件。在优选实施例中，阻抗改变元件包括构造成在患者的脉管系统内局部增加阻抗的可充气球囊。本发明的方法和装置可用于调节有助于肾功能的神经纤维。

49. 发明申请

US20090221939A1 METHODS AND APPARATUS FOR THERMALLY-INDUCED RENAL NEUROMODULATION 有权
标题翻译：用于热诱导的肾脏神经调节的方法和装置
公开(公告)号：US20090221939A1
公开(公告)日：2009-09-03
申请号：US11504117
申请日：2006-08-14
申请人： Denise Demarais , Nicolas Zadno , Benjamin J. Clark , Erik Thai , Howard R. Levin , Mark Gelfand
发明人： Denise Demarais , Nicolas Zadno , Benjamin J. Clark , Erik Thai , Howard R. Levin , Mark Gelfand
IPC分类号： A61F7/00 , A61N7/02
CPC分类号： A61N7/022 , A61B18/02 , A61B18/04 , A61B18/12 , A61B18/1492 , A61B2018/0022 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61F7/007 , A61F7/12 , A61F7/123 , A61F2007/126 , A61M5/44 , A61M2210/1082 , A61N1/28 , A61N1/36007 , A61N1/403 , A61N5/00 , A61N5/025 , A61N5/045 , A61N5/0603 , A61N7/00 , A61N7/02 , A61N2007/003 , A61N2007/0078
摘要： Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.
摘要翻译：提供了用于热诱导的肾神经调节的方法和装置。热诱导的肾神经调节可以通过直接和/或通过间接施加热能来加热或冷却有助于肾功能的神经纤维或者供给或灌注神经纤维的血管结构来实现。在一些实施例中，神经纤维，非目标组织或热能递送元件的参数可以经由一个或多个传感器来监测，以控制热诱导的神经调节。在一些实施方案中，可以提供保护元件以减少在非靶组织中诱导的热损伤程度。

50. 发明申请

US20060142801A1 Methods and apparatus for intravascularly-induced neuromodulation 有权
标题翻译：血管内诱导神经调节的方法和装置
公开(公告)号：US20060142801A1
公开(公告)日：2006-06-29
申请号：US11266993
申请日：2005-11-04
申请人： Denise Demarais , Nicolas Zadno , Benjamin Clark , Erik Thai
发明人： Denise Demarais , Nicolas Zadno , Benjamin Clark , Erik Thai
IPC分类号： A61N1/00
CPC分类号： A61B18/1492 , A61B17/12136 , A61B2018/00083 , A61B2018/00285 , A61B2018/00434 , A61B2018/00613 , A61M25/0108 , A61M25/10 , A61N1/327 , A61N1/36007 , A61N1/36121 , A61N1/36182 , A61N1/37205 , A61N1/40
摘要： Methods and apparatus are provided for intravascularly-induced neuromodulation using a pulsed electric field, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation, etc., in target neural fibers. In some embodiments, the intravascular PEF system comprises a catheter having a pair of bipolar electrodes for delivering the PEF, with a first electrode positioned on a first side of an impedance-altering element and a second electrode positioned on an opposing side of the impedance-altering element. A length of the electrodes, as well as a separation distance between the first and second electrodes, may be specified such that, with the impedance-altering element deployed in a manner that locally increases impedance within a patient's vessel, e.g., with the impedance-altering element deployed into contact with the vessel wall at a treatment site within the patient's vasculature, a magnitude of applied voltage delivered across the bipolar electrodes necessary to achieve desired neuromodulation is reduced relative to an intravascular PEF system having similarly spaced electrodes but no (or an undeployed) impedance-altering element. In a preferred embodiment, the impedance-altering element comprises an inflatable balloon configured to locally increase impedance within a patient's vasculature. The methods and apparatus of the present invention may be used to modulate a neural fiber that contributes to renal function.
摘要翻译：提供了使用脉冲电场进行血管内诱导的神经调节的方法和装置，例如，在靶神经纤维中实现不可逆的电穿孔或电融合，坏死和/或诱导细胞凋亡，基因表达的改变，细胞因子上调的变化等。在一些实施例中，血管内PEF系统包括导管，其具有用于传送PEF的一对双极电极，第一电极位于阻抗改变元件的第一侧上，第二电极位于阻抗变换元件的相对侧上，改变元素可以规定电极的长度以及第一和第二电极之间的间隔距离，使得以阻抗变化元件部署的方式，其局部地增加患者血管内的阻抗，例如阻抗 - 改变元件被部署成与病人血管系统中的治疗部位处的血管壁接触，相对于具有类似间隔开的电极而没有（或一个或多个）的血管内PEF系统，减少了实现所需神经调节所需双极电极的施加电压的大小未部署）阻抗变化元件。在优选实施例中，阻抗改变元件包括构造成在患者的脉管系统内局部增加阻抗的可充气球囊。本发明的方法和装置可用于调节有助于肾功能的神经纤维。

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