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41. 发明申请

WO1993008172A1 PROCESS FOR PREPARING (S) (+)-4,4'-(1-METHYL-1,2-ETHANEDIYL)-BIS(2,6-PIPERAZINEDIONE) 审中-公开
标题翻译：（±）-4,4' - （1-甲基-1,2 - 乙二胺基） - 双（2,6-哌嗪基）
公开(公告)号：WO1993008172A1
公开(公告)日：1993-04-29
申请号：PCT/GB1992001942
申请日：1992-10-22
申请人： EUROCETUS BV , SICOR LIMITED , MACDONALD, Peter, Lindsay , STRADI, Riccardo , ROSSETTO, Pierluigi , HOLTHUIS, Josephus, Johannes, Maria
发明人： EUROCETUS BV , SICOR LIMITED
IPC分类号： C07D241/08
CPC分类号： C07D241/08
摘要： A process for the preparation of (S) (+)-4,4 -(1-methyl-1,2-ethanediyl)-bis-(2,6-piperazinedione) (ICRF-187) in which an intermediate 1,2-diaminopropane tetraacetic acid product is synthesized together with byproduct salt, characterized in that the tetraacetic acid intermediate product is subjected to ring formation in the form of a crude product having substantial amounts of salt thereby to produce the desired ICRF-187.
摘要翻译：（S）（+） - 4,4 - （1-甲基-1,2-乙二基） - 双（2,6-哌嗪二酮）（ICRF-187）的制备方法，其中中间体 1,2-二氨基丙烷四乙酸产物与副产物盐一起合成，其特征在于四乙酸中间产物以大量盐形式的粗产物形成环，从而产生所需的ICRF-187。

42. 发明申请

WO2012057972A2 CLAMP FOR SPRINKLER SUPPORT ASSEMBLY 审中-公开
标题翻译：用于喷头支架组件的夹钳
公开(公告)号：WO2012057972A2
公开(公告)日：2012-05-03
申请号：PCT/US2011/054733
申请日：2011-10-04
申请人： PNM, INC. , SILCOX, Paul S.F. , MACDONALD, Peter M. , MACDONALD III, Norman J.
发明人： SILCOX, Paul S.F. , MACDONALD, Peter M. , MACDONALD III, Norman J.
IPC分类号： A62C35/00 , B23P17/04 , F16B2/12
CPC分类号： A62C35/68 , E04B9/006 , F16B2/185 , F16B5/0225 , F16B5/121 , Y10T29/49826
摘要： A fire sprinkler support assembly includes a leg configured to extend transverse to each of a pair of adjacent parallel spaced beams. The leg includes levered clamp assemblies that are configured for connecting and supporting each end of the leg to a corresponding one of the beams. The levered clamp assemblies include a first plate and a second plate, each plate configured to straddle the beam. The levered clamp assemblies also include a lever assembly. The lever assembly includes a rod passing through corresponding rod openings in the first and second plates, and a lever pivotally connected to one end of the rod. The lever includes a cam surface disposed adjacent to the first plate. The lever assembly is configured to reduce spacing between the plates upon actuation of the lever, whereby the leg is secured to the beam.
摘要翻译：防火喷洒器支撑组件包括构造成横向于一对相邻的平行隔开的梁中的每一个延伸的支腿。腿包括杠杆式夹具组件，其被配置用于将腿的每个端部连接和支撑到相应的一个梁上。杠杆式夹紧组件包括第一板和第二板，每个板构造成跨在梁上。杠杆式夹具组件还包括杠杆组件。杠杆组件包括穿过第一和第二板中的相应的杆开口的杆和枢转地连接到杆的一端的杠杆。杠杆包括邻近第一板布置的凸轮表面。杠杆组件构造成在杠杆致动时减小板之间的间距，由此腿被固定到梁上。

43. 发明申请

WO2010016931A2 POLYMORPHS OF FLUTICASONE FUROATE AND PROCESS FOR PREPARATION THEREOF 审中-公开
标题翻译：氟磷酸酯的聚合物及其制备方法
公开(公告)号：WO2010016931A2
公开(公告)日：2010-02-11
申请号：PCT/US2009/004534
申请日：2009-08-06
申请人： PLUS CHEMICALS SA , TEVA PHARMACEUTICALS USA, INC. , MACDONALD, Peter, Lindsay , ROSSETTO, Pierluigi , KOVACSNE-MEZEI, Adrienne , GABRIEL, Roman , JEGOROV, Alexandr , FAUSTMANN, Jiri
发明人： MACDONALD, Peter, Lindsay , ROSSETTO, Pierluigi , KOVACSNE-MEZEI, Adrienne , GABRIEL, Roman , JEGOROV, Alexandr , FAUSTMANN, Jiri
IPC分类号： C07J31/00 , A61K31/58 , A61P5/44
CPC分类号： C07J31/006
摘要： Provided are polymorphs of fluticasone furoate and processes for preparation thereof.
摘要翻译：提供了糠酸氟替卡松的多晶型物及其制备方法。

44. 发明申请

WO2009111061A1 PROCESS FOR THE PREPARATION OF SORAFENIB AND SALTS THEREOF 审中-公开
标题翻译：制备SORAFENIB及其销售的方法
公开(公告)号：WO2009111061A1
公开(公告)日：2009-09-11
申请号：PCT/US2009/001448
申请日：2009-03-05
申请人： SICOR INC. , ROSSETTO, Pierluigi , MACDONALD, Peter, Lindsay , CANAVESI, Augusto
发明人： ROSSETTO, Pierluigi , MACDONALD, Peter, Lindsay , CANAVESI, Augusto
IPC分类号： C07D213/81 , C07D233/61
CPC分类号： C07D233/61 , C07D213/81
摘要： Methods for the synthesis of the N-carbamoyl imidazole Formulae (I), (II) and its 1 :1 adduct with imidazole are provided. Methods for the preparation of these crystalline intermediates in a high state of purity are also provided. These intermediates react cleanly under mild conditions to produce sorafenib in high yield and purity, without generating difficult-to-remove impurities.
摘要翻译：提供了合成N-氨基甲酰咪唑的方法式（I），（II）及其与咪唑的1:1加合物。还提供了制备高纯度的这些结晶中间体的方法。这些中间体在温和条件下干净地反应以高产率和纯度产生索拉非尼，而不产生难以除去的杂质。

45. 发明申请

WO2008057291B1 CRYSTALLINE AND AMORPHOUS IMATINIB BASE, IMATINIB MESYLATE- AND PROCESSES FOR PREPARATION THEREOF 审中-公开
标题翻译：晶体和非晶形象碱基，甲基丙烯酸甲酯和其制备方法
公开(公告)号：WO2008057291B1
公开(公告)日：2008-08-21
申请号：PCT/US2007022747
申请日：2007-10-26
申请人： SICOR INC , MACDONALD PETER LINDSAY , ROSSETTO PIERLUIGI , JEGOROV ALEXANDR , GIOLITO ANDREA , TENTORIO DARIO , CANAVESI AUGUSTO , GAVENDA ALES
发明人： MACDONALD PETER LINDSAY , ROSSETTO PIERLUIGI , JEGOROV ALEXANDR , GIOLITO ANDREA , TENTORIO DARIO , CANAVESI AUGUSTO , GAVENDA ALES
IPC分类号： C07D401/04 , A61K31/506 , A61P35/00
CPC分类号： C07D401/04 , C07D295/155
摘要： The present invention provides crystalline forms of imatinib base, imatinib base free of desmethyl imatinib, and imatinib mesylate free of desmethyl imatinib mesylate, processes of their preparation and pharmaceutical compositions of imatinib mesylate.
摘要翻译：本发明提供结晶形式的伊马替尼碱，不含脱甲基伊马替尼的伊马替尼碱和不含甲磺酸伊马替尼的甲磺酸伊马替尼，其制备方法和甲磺酸伊马替尼的药物组合物。

46. 发明申请

WO2007028167A3 DEVICES FOR TRANSCUTANEOUS DELIVERY OF VACCINES AND TRANSDERMAL DELIVERY OF DRUGS AND USES THEREOF 审中-公开
标题翻译：疫苗递送和药物转运的设备及其用途
公开(公告)号：WO2007028167A3
公开(公告)日：2007-12-06
申请号：PCT/US2006034620
申请日：2006-09-05
申请人： IOMAI CORP , GLENN GREGORY M , DOERKSEN KYLE J , ELLINGSWORTH LARRY R , EPPERSON DIANE E , FRERICHS DAVID , HAMER MERVYN L , HENNINGSGAARD AARON A , INOUYE MATTHEW D , JAMES ADRIAN B , KAPLAN JONATHAN I , LAI JOHN W , LISTER ROBERT I , LUBENSKY DAVID A , MACDONALD PETER S , MADSEN SALLY H , MASON BRIAN J , MCELHANEY CHRISTINE W , MOHRI LIONEL , PIGLIACAMPO ANTHONY C , ROMERO GINA L , STEEVES CHARLES F III , VILLAR CHRISTINA P , YU JIANMEI
发明人： GLENN GREGORY M , DOERKSEN KYLE J , ELLINGSWORTH LARRY R , EPPERSON DIANE E , FRERICHS DAVID , HAMER MERVYN L , HENNINGSGAARD AARON A , INOUYE MATTHEW D , JAMES ADRIAN B , KAPLAN JONATHAN I , LAI JOHN W , LISTER ROBERT I , LUBENSKY DAVID A , MACDONALD PETER S , MADSEN SALLY H , MASON BRIAN J , MCELHANEY CHRISTINE W , MOHRI LIONEL , PIGLIACAMPO ANTHONY C , ROMERO GINA L , STEEVES CHARLES F III , VILLAR CHRISTINA P , YU JIANMEI
IPC分类号： A61M35/00
CPC分类号： A61B17/20 , A61B17/205 , A61B2017/00115 , A61B2017/00761 , A61B2090/065 , A61M35/006 , A61M37/0015 , A61M2037/0023 , A61M2037/0061
摘要： The invention provides devices for the disruption of one or more layers of skin and methods of their use to administer therapeutic agents, e.g., antigens or drugs. The devices are designed to disrupt a defined area of skin. The defined area can approximate the area that a patch or other suitable vehicle for therapeutic agent, e.g., drug or vaccine, delivery is designed to contact. Exemplary devices employ a mask to define the area to be disrupted. Other devices disrupt a defined area by rotating in place. For devices that employ a mask that is secured to the skin, the invention provides methods of disrupting the stratum corneum by first securing the mask to the skin and then disrupting the skin. For rotating devices, the disrupting member is simply placed against the skin and actuated to effect disruption.
摘要翻译：本发明提供用于破坏一层或多层皮肤的装置及其用于施用治疗剂例如抗原或药物的方法。这些设备旨在破坏定义的皮肤区域。限定的面积可以近似用于治疗剂（例如药物或疫苗）递送被设计为接触的补片或其它合适的载体的区域。示例性设备使用掩模来限定待破坏的区域。其他设备通过旋转到位来破坏定义的区域。对于使用固定在皮肤上的面罩的装置，本发明提供了通过首先将面罩固定在皮肤上然后破坏皮肤来破坏角质层的方法。对于旋转装置，干扰构件被简单地放置在皮肤上并被致动以实现中断。

47. 发明申请

WO2007056181A2 IMPROVED PROCESS FOR THE PREPARATION OF CICLESONIDE 审中-公开
标题翻译：改进CICLESONIDE的制备方法
公开(公告)号：WO2007056181A2
公开(公告)日：2007-05-18
申请号：PCT/US2006/043025
申请日：2006-11-02
申请人： SICOR, INC. , PIERLUIGI, Rossetto , MACDONALD, Peter, Lindsay
发明人： PIERLUIGI, Rossetto , MACDONALD, Peter, Lindsay
CPC分类号： C07J71/0031 , C07J71/00
摘要： Provided is a process for increasing the 22R/22S epimeric ratio of ciclesonide.
摘要翻译：提供了增加环索奈德的22R / 22S差向异构体比例的方法。

48. 发明申请

WO2007022173A2 CRYSTALLINE FORMS FENOLDOPAM MESYLATE 审中-公开
标题翻译：结晶形式FENOLDOPAM MESYLATE
公开(公告)号：WO2007022173A2
公开(公告)日：2007-02-22
申请号：PCT/US2006/031815
申请日：2006-08-15
申请人： SICOR, INC. , MACDONALD, Peter, Lindsey , BIGATTI, Ettore , ROSSETTO, Pierluigi , ARONHIME, Judith , LEVI, Sigalit
发明人： MACDONALD, Peter, Lindsey , BIGATTI, Ettore , ROSSETTO, Pierluigi , ARONHIME, Judith , LEVI, Sigalit
IPC分类号： C07D233/16 , A61K31/50 , A61P9/12
CPC分类号： C07D223/16 , C07D233/16
摘要： The invention provides new crystalline forms of fenoldopam mesylate, i.e. fenoldopam mesylate Type I, fenoldopam mesylate Type III, fenoldopam mesylate Type V, and fenoldopam mesylate Type VI, methods of preparing the crystalline forms, and pharmaceutical compositions comprising the fenoldopam mesylate crystalline forms of the invention.
摘要翻译：本发明提供了甲磺酸非诺多泮的新结晶形式，即甲磺酸非诺多泮，I型非诺多泮，甲磺酸非诺多泮，甲磺酸非诺多泮V型和甲磺酸非诺多泮VI型，制备晶型的方法和药物组合物包含本发明的非诺多泮甲磺酸盐晶型。

49. 发明申请

WO2004109496A2 ELECTRONIC WHITEBOARD 审中-公开
标题翻译：电子白板
公开(公告)号：WO2004109496A2
公开(公告)日：2004-12-16
申请号：PCT/US2004/016975
申请日：2004-06-01
申请人： POLY VISION CORPORATION , HILDEBRANDT, Peter, W. , GILLESPIE, Scott, Paul , DEAKIN, Lynda, Alison , WILSON, Scott, E. , HUTCHINSON, Ian, G. , PRACHAR, Timothy, J. , WATSON, James, D. , DUNN, Michael, H. , WILLIAMS, Guy, L. , ADLER, Ari, T. , PATRON, Tony, P. , SENATORE, Stephen, J. , MACDONALD, Peter, S. , DESMOND, Matthew, A. , HICKS, Graham, MacDonald , GILMORE, David , WEGENER, Katrin , RAGAN, Jeanne, M. , ENDERS, Thomas, Franz , BOURN, Douglas, R. , MACINTOSH, Eric, Allan , ZEH, Mark, A.
发明人： HILDEBRANDT, Peter, W. , GILLESPIE, Scott, Paul , DEAKIN, Lynda, Alison , WILSON, Scott, E. , HUTCHINSON, Ian, G. , PRACHAR, Timothy, J. , WATSON, James, D. , DUNN, Michael, H. , WILLIAMS, Guy, L. , ADLER, Ari, T. , PATRON, Tony, P. , SENATORE, Stephen, J. , MACDONALD, Peter, S. , DESMOND, Matthew, A. , HICKS, Graham, MacDonald , GILMORE, David , WEGENER, Katrin , RAGAN, Jeanne, M. , ENDERS, Thomas, Franz , BOURN, Douglas, R. , MACINTOSH, Eric, Allan , ZEH, Mark, A.
IPC分类号： G06F3/033
CPC分类号： G06F21/84
摘要： A method and apparatus for use with a whiteboard and an archive memory, the whiteboard having a surface for displaying images, the method for grouping presented images together for storage in the archive memory and password protecting the image groups in separate session files where a password is subsequently required to access the session file images.
摘要翻译：一种与白板和存档存储器一起使用的方法和装置，该白板具有用于显示图像的表面，用于将呈现的图像分组在一起以存储在归档存储器中的方法和密码保护单独的会话文件中密码为随后需要访问会话文件映像。

50. 发明申请

WO9958200A8 FIRE-SUPPRESSION SPRINKLER SYSTEM AND METHOD FOR INSTALLATION AND RETROFIT 审中-公开
标题翻译：防火喷雾器系统及其安装和改造方法
公开(公告)号：WO9958200A8
公开(公告)日：2001-03-22
申请号：PCT/US9910222
申请日：1999-05-11
申请人： PNM INC , MACDONALD NORMAN J , MACDONALD PETER M
发明人： MACDONALD NORMAN J , MACDONALD PETER M
IPC分类号： A62C35/00 , A62C35/60 , A62C35/68
CPC分类号： A62C35/60 , A62C35/68
摘要： A fire suppression sprinkler system (10), and method for installing a sprinkler system (10) in new and existing buildings. The system includes a manifold (12) that supplies fire-suppression fluid to a set of wall-mounted sprinkler heads (14) via flexible sprinkler head conduits (16) through an unobstructed path (18). The installation and retrofit methods include determining the location of the sprinkler head (14), installing the manifold (12), making sure that there is an unobstructed path (18) between the manifold (12) and the sprinkler head location, running the conduit (16) through the path (18) by snaking it where necessary through the wall (50) to which the sprinkler head (14) is mounted, connecting the conduit (16) to the manifold (12) and sprinkler head (14), and then mounting the sprinkler head (14).
摘要翻译：一种消防喷淋系统（10），以及在新建和现有建筑物内安装喷淋系统（10）的方法。该系统包括歧管（12），其通过柔性喷洒头管道（16）通过无障碍路径（18）向一组壁挂式喷洒头（14）提供消防流体。安装和改造方法包括确定喷洒头（14）的位置，安装歧管（12），确保在歧管（12）和喷洒头位置之间存在无障碍路径（18），运行导管（16）通过路径（18）通过在必要时通过安装喷洒头（14）的壁（50）将其连接，将导管（16）连接到歧管（12）和喷洒头（14），然后安装喷头（14）。

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