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41. 发明授权

US07138432B1 Arylsulfonamido-substituted hydroxamic acid derivatives 失效
标题翻译：芳基磺酰氨基取代的异羟肟酸衍生物
公开(公告)号：US07138432B1
公开(公告)日：2006-11-21
申请号：US10048932
申请日：2000-08-07
申请人： Werner Breitenstein , Kenji Hayakawa , Genji Iwasaki , Takanori Kanazawa , Tatsuhiko Kasaoka , Shinichi Koizumi , Shinichiro Matsunaga , Motowo Nakajima , Junichi Sakaki
发明人： Werner Breitenstein , Kenji Hayakawa , Genji Iwasaki , Takanori Kanazawa , Tatsuhiko Kasaoka , Shinichi Koizumi , Shinichiro Matsunaga , Motowo Nakajima , Junichi Sakaki
IPC分类号： A61K31/18 , C07C303/00
CPC分类号： C07D207/32 , C07C311/29 , C07D213/42 , C07D215/12 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/06 , C07D249/08 , C07D257/04 , C07D295/125 , C07D295/13 , C07D295/135 , C07D307/52 , C07D333/20
摘要： α-Amino hydroxamic acid derivative of formula (I), in which R is C2–C7-alkyl, which is mono-, di- or trisubstituted by halogen, nitro, lower acyloxy, trifluoromethoxy, cyano, C3–C5-cycloalkyl or unsubstituted or substituted C3–C4-heteroaryl comprising one or two heteroatoms selected from the group consisting of O, S and N; or C3–C7-alkenyl or C3–C7-alkynyl, which in each case is unsubstituted or mono-, di- or trisubstituted by halogen, nitro, lower acyloxy, trifluoromethoxy, cyano, C3–C5-cycloalkyl or unsubstituted or substituted C3–C6-heteroaryl comprising one or two heteroatoms selected from the group consisting of O, S and N; and the other symbols are as defined in claim 1, are described. These compounds are MMP and in particular MMP2 inhibitors and can be used for treatment of MMP dependent diseases, in particular inflammation conditions, rheumatoid arthritis, osteoarthritis, tumors (tumor growth, metastasis, progression or invasi n) and pulmonary disorders (e.g. emphysema, COPD).
摘要翻译：式（I）的α-氨基异羟肟酸衍生物，其中R为C 2 -C 7 -C 7 - 烷基，其被卤素单，二或三取代，硝基，低级酰氧基，三氟甲氧基，氰基，C 3 -C 5 - 环烷基或未取代或取代的C 3 -C 4 - 包含一个或两个选自O，S和N的杂原子的杂芳基; 或C 3 -C 7 - 烯基或C 3 -C 7 - 炔基，其在每种情况下为未取代的或被卤素，硝基，低级酰氧基，三氟甲氧基，氰基，C 3 -C 5 - 环烷基或未取代或取代的C 1 - 3个-C 6 -C 6 - 杂芳基，其包含一个或两个选自O，S和N的杂原子; 并且其它符号如权利要求1中所定义。这些化合物是MMP，特别是MMP2抑制剂，可用于治疗MMP依赖性疾病，特别是炎症病症，类风湿性关节炎，骨关节炎，肿瘤（肿瘤生长，转移，进展或侵袭性）和肺部疾病（例如肺气肿，COPD ）。

42. 发明授权

US07112589B2 Cysteine protease inhibitors with 2-cyano-4-amino-pyrimidine structure and cathepsin k inhibitory activity for the treatment of inflammations and other diseases 失效
标题翻译：具有2-氰基-4-氨基 - 嘧啶结构的半胱氨酸蛋白酶抑制剂和用于治疗炎症等疾病的组织蛋白酶k抑制活性
公开(公告)号：US07112589B2
公开(公告)日：2006-09-26
申请号：US10487741
申请日：2002-08-29
申请人： Eva Altmann , Kenji Hayakawa , Genji Iwasaki
发明人： Eva Altmann , Kenji Hayakawa , Genji Iwasaki
IPC分类号： C07D239/42 , A61K31/506
CPC分类号： C07D239/42 , C07D401/12 , C07D403/12
摘要： The invention provides compounds of formula I or a pharmaceutically acceptable salt or ester thereof (I), wherein the symbols have meaning as defined, which are inhibitors of cathepsin K and find use pharmaceutically for treatment of diseases and medical conditions in which cathepsin K is implicated, e.g. various disorders including inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis and tumors
摘要翻译：本发明提供式I化合物或其药学上可接受的盐或酯（I），其中符号具有如上所定义的含义，其是组织蛋白酶K的抑制剂，并且可用于药物治疗用于组织蛋白酶K的疾病和医学病症，例如各种疾病，包括炎症，类风湿性关节炎，骨关节炎，骨质疏松症和肿瘤

43. 发明授权

US06857888B2 Socket for electrical parts 有权
标题翻译：电气部件插座
公开(公告)号：US06857888B2
公开(公告)日：2005-02-22
申请号：US10305128
申请日：2002-11-27
申请人： Kenji Hayakawa
发明人： Kenji Hayakawa
IPC分类号： H01R24/00 , H01R13/24 , H01R13/629 , H01R33/76 , H01R107/00 , H01R11/22
CPC分类号： H01R13/629 , H05K7/1084
摘要： A socket for an electrical part has a socket body to which an IC package as an electrical part is accommodated, the socket body being provided with a number of contact pins which are contacted to or separated from solder balls as terminals of the electrical part, a movable member arranged to be movable with respect to the socket body, and lever members mounted to both sides of the socket body to be rotatable. In this structure, when the lever members are rotated, the movable member is moved to displace the contact pins so as to be contacted to or separated from the solder balls of the electrical part, respectively. In such structure, each of the lever members are formed with pressing portion which acts to press a portion of the movable member in accordance with the rotation of the lever members and when the movable member is moved so as to approach a lowermost position thereof by the rotation of the lever member, the pressing portion and the pressed portion achieves surface-to-surface contact to each other.
摘要翻译：用于电气部件的插座具有容纳作为电气部件的IC封装的插座主体，所述插座主体设置有多个接触销，所述接触针与所述电气部件的端子接触或分离，作为所述电气部件的端子，可移动部件布置成相对于插座主体可移动，以及安装到插座主体的两侧以可转动的杆部件。在这种结构中，当杠杆构件旋转时，可移动构件被移动以移动接触销，以分别与电气部件的焊球接触或分离。在这种结构中，每个杠杆构件形成有按压部分，该按压部分根据杠杆构件的旋转而按压可动构件的一部分，并且当可移动构件移动到接近其最下位置时杠杆构件，按压部和被按压部的旋转实现了表面到表面的接触。

44. 发明授权

US06439910B2 Rotatable guide member for a socket for electrical parts 有权
标题翻译：用于电气部件的插座的可旋转引导构件
公开(公告)号：US06439910B2
公开(公告)日：2002-08-27
申请号：US09880853
申请日：2001-06-15
申请人： Kenji Hayakawa
发明人： Kenji Hayakawa
IPC分类号： H01R1122
CPC分类号： H05K7/10 , G01R1/0466 , G01R1/0483 , H01R13/193
摘要： In a socket for electrical parts, a number of contact pins contacting a number of terminals of an electrical part are arranged, in grid shape, to a socket body in which the electrical part is accommodated, and a guide member is provided for the socket body for guiding a peripheral edge portion of the electrical part to a predetermined position of the socket body. The guide member is formed with an accommodation space into which the electrical part is guided and accommodated and has first and second mount positions apart by substantially 180° from each other, and the position of the accommodation space with respect to arrangement region of the contact pins on the side of the socket body is made variable by changing the mounting position of the guide member.
摘要翻译：在用于电气部件的插座中，与电气部件的多个端子相接触的多个接触销以格子形状布置到容纳电气部件的插座主体中，并且为插座本体提供引导部件用于将电气部件的周边部分引导到插座主体的预定位置。引导构件形成有容纳空间，电气部件被引导和容纳在该容纳空间中，并且具有彼此大致180°分开的第一和第二安装位置，并且容纳空间相对于接触销的布置区域的位置通过改变导向件的安装位置，使插座主体的一侧可变。

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