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41. 发明申请

US20060163088A1 Amperometric sensor with counter electrode isolated from fill solution 审中-公开
标题翻译：电流传感器与反电极隔离填充液
公开(公告)号：US20060163088A1
公开(公告)日：2006-07-27
申请号：US11340834
申请日：2006-01-26
申请人： Joshua Xu , Chang-Dong Feng
发明人： Joshua Xu , Chang-Dong Feng
IPC分类号： G01F1/64 , G01N27/26
CPC分类号： G01N27/404
摘要： An amperometric sensor includes a sensor body having a distal end and an interior containing an electrolytic fill solution. A porous membrane is disposed proximate the distal end to allow diffusion of molecules or ions of interest. A working electrode is disposed within the sensor body proximate the membrane. A counter electrode is disposed to conduct current between the counter electrode and the working electrode. The counter electrode is physically isolated from the electrolytic fill solution. A method of measuring a concentration of the molecules or ions of interest is also provided.
摘要翻译：电流传感器包括具有远端的传感器本体和包含电解填充溶液的内部。多孔膜靠近远端设置以允许感兴趣的分子或离子的扩散。工作电极设置在靠近膜的传感器体内。设置对电极以在对电极和工作电极之间传导电流。对电极与电解填充液物理隔离。还提供了测量感兴趣的分子或离子的浓度的方法。

42. 发明授权

US06949523B2 Aglycon dammarane sapogenins, their use as anti-cancer agents, and a process for producing same 有权
标题翻译： Aglycon dammarane sapogenins，它们作为抗癌剂的用途及其制备方法
公开(公告)号：US06949523B2
公开(公告)日：2005-09-27
申请号：US09910887
申请日：2001-07-24
申请人： Dong Huang , Dong Feng Qi
发明人： Dong Huang , Dong Feng Qi
IPC分类号： C07J17/00 , A61K31/715 , A61K31/58 , A61K35/78
CPC分类号： C07J17/005
摘要： This invention relates to a group of novel sapogenins, their use in anti-cancer applications, and to a process for their production. More particularly, this invention pertains to a novel group of dammarane sapogenins, PAM-120, PBM-110 and PBM-100 (the dammarance sapogenine structure is specifically clean of any sugar moieties (glycons) at any position and hydroxyl at C-20) and PAN-20 and PAN-30 (the dammarance sapogenin structure has sugar moieties but is free of hydroxyl at C-20), obtained by chemical cleavage of dammarane saponins. The invention also includes a novel application of the said sapogenins for anti-cancer treatment by using them separately or together, and/or jointly with other drugs, as well as to the process of producing these novel sapogenins. Said novel dammarane sapogenins show surprising anti-cancer effect when applied, particularly against multi-drug resistant cancers.
摘要翻译：本发明涉及一组新的皂甙元，它们在抗癌应用中的用途，以及它们的制备方法。更具体地说，本发明涉及一组新的一组抗坏血酸皂苷元PAM-120，PBM-110和PBM-100（在任何位置上任何糖部分（糖）和C-20处的羟基）和PAN-20和PAN-30（该抑制皂苷元结构具有糖部分，但在C-20时不含羟基），通过化学裂解dammarane皂甙获得。本发明还包括通过分别或一起使用它们，和/或与其它药物联合使用所述皂苷元进行抗癌治疗的新应用，以及生产这些新型皂甙元的方法。所述新型的dammarane sapogenins在使用时显示出惊人的抗癌作用，特别是针对多重耐药性癌症。

43. 发明授权

US06888014B2 Dammarane sapogenins, their use as anti-cancer agents, and a process for producing same 有权
标题翻译：丹参皂苷元，它们作为抗癌剂的用途及其制备方法
公开(公告)号：US06888014B2
公开(公告)日：2005-05-03
申请号：US09982018
申请日：2001-10-19
申请人： Dong Huang , Dong Feng Qi
发明人： Dong Huang , Dong Feng Qi
IPC分类号： A61K9/00 , A61K31/575 , A61K31/704 , A61K36/25 , A61P35/00 , C07J9/00 , C07J17/00 , A61K31/56 , C07J53/00
CPC分类号： C07J17/005
摘要： This invention relates to a group of novel sapogenins, their use in anti-cancer applications, and to a process for their production. More particularly, this invention pertains to a novel group of dammarane sapogenins, PAM-120, PBM-110 and PBM-100 (the dammarance sapogenine structure is specifically clean of any sugar moieties (glycons) at any position and hydroxyl at C-20) and PAN-20 and PAN-30 (the dammarance sapogenin structure has sugar moieties but is free of hydroxyl at C-20), obtained by chemical cleavage of dammarane saponins. The invention also includes a novel application of the said sapogenins for anti-cancer treatment by using them separately or together, and/or jointly with other drugs, as well as to the process of producing these novel sapogenins. Said novel dammarane sapogenins show surprising anti-cancer effect when applied, particularly against multi-drug resistant cancers.
摘要翻译：本发明涉及一组新的皂甙元，它们在抗癌应用中的用途，以及它们的制备方法。更具体地说，本发明涉及一组新的一组抗坏血酸皂苷元PAM-120，PBM-110和PBM-100（在任何位置上任何糖部分（糖）和C-20处的羟基）和PAN-20和PAN-30（该抑制皂苷元结构具有糖部分，但在C-20时不含羟基），通过化学裂解dammarane皂甙获得。本发明还包括通过分别或一起使用它们，和/或与其它药物联合使用所述皂苷元进行抗癌治疗的新应用，以及生产这些新型皂甙元的方法。所述新型的dammarane sapogenins在使用时显示出惊人的抗癌作用，特别是针对多重耐药性癌症。

44. 发明申请

US20050041919A1 Optical fiber coupling having liquid crystal adaptive coupler 有权
标题翻译：具有液晶自适应耦合器的光纤耦合器
公开(公告)号：US20050041919A1
公开(公告)日：2005-02-24
申请号：US10948855
申请日：2004-09-23
申请人： Dong-Feng Gu , Donald Taber , Bruce Winker
发明人： Dong-Feng Gu , Donald Taber , Bruce Winker
IPC分类号： G02B6/32 , G02B6/35 , G02F1/139 , G02F1/29 , G02B6/26
CPC分类号： G02F1/292 , G02B6/32 , G02B6/351 , G02B6/3556 , G02F1/1392
摘要： An apparatus for optically coupling a light source with a light-receiving end face of an optical waveguide comprises a lens for focusing a light beam emitted from the light source at a focal point on the light-receiving end face of the optical waveguide. An adaptive coupler, positioned in the optical path, is responsive to a beam steering control signal for steering and aligning the focal point relative to the light-receiving end face of the optical waveguide. In one form, the adaptive coupler comprises a pair of transparent substrates having confronting, parallel inner faces, the inner face of one of the pair of substrates carrying a beam intercepting, optically transparent, constant potential electrode and the inner face of the other of the pair of substrates carrying an electrically resistive, beam intercepting, optically transparent film. A pair of spaced apart electrodes in electrical contact with the film apply a linear voltage gradient along the film. An electro-optical phase shifting medium is disposed between the confronting inner faces of the substrates. The application of selected voltages to the electrodes creates a linear voltage gradient along the aforementioned film on the inner face of the one substrate resulting in a linearly varying electric field between that film and the constant potential electrode creating a corresponding linear variation in the refractive index of the liquid crystal medium and a linear wavefront tilt in the intercepting optical beam.
摘要翻译：用于将光源与光波导的光接收端面光学耦合的装置包括用于将从光源发射的光束聚焦在光波导的光接收端面上的焦点处的透镜。定位在光路中的自适应耦合器响应于光束转向控制信号，用于相对于光波导的光接收端面转向和对准焦点。在一种形式中，自适应耦合器包括一对具有相对的平行内表面的透明基板，一对基板中的一个基板的内表面承载光束拦截，光学透明的恒定电位电极，另一个的内表面一对基板承载电阻，光束截取的光学透明膜。与膜电接触的一对间隔开的电极沿膜施加线性电压梯度。电光移相介质设置在基板的相对的内表面之间。将选择的电压施加到电极在一个衬底的内表面上沿着上述膜产生线性电压梯度，导致该膜和恒电位电极之间线性变化的电场产生相应的线性变化液晶介质和截取光束中的线性波前倾斜。

45. 发明授权

US06602401B1 Amperometric sensor for low level dissolved oxygen with self-depleting sensor design 有权
公开(公告)号：US06602401B1
公开(公告)日：2003-08-05
申请号：US09707740
申请日：2000-11-01
申请人： Chang-Dong Feng
发明人： Chang-Dong Feng
IPC分类号： G01N27404
CPC分类号： G01N27/404
摘要： A dissolved oxygen sensor having a cathode and anode immersed in an electrolyte is designed to provide a low background current in the sensor when a potential is applied to the cathode. The background current is maintained at a desired level by selecting the area and length of a channel or path of diffusion of residual oxygen in the electrolyte to the cathode. The area (A) of the diffusion channel in relation to its length (L) is selected to be at or below a selected ratio, A/L.

46. 发明授权

US06265750B1 Electrochemical gas sensor and method of making the same 有权
标题翻译：电化学气体传感器及其制作方法
公开(公告)号：US06265750B1
公开(公告)日：2001-07-24
申请号：US09353907
申请日：1999-07-15
申请人： Chang-Dong Feng , Edmond Y. Chu
发明人： Chang-Dong Feng , Edmond Y. Chu
IPC分类号： H01L2714
CPC分类号： G01N27/404
摘要： An electrochemical gas sensor including a substrate defining an opening therethrough, a sensing electrode connected to a first surface of the substrate and adjacent a first end of the opening, a diffusion barrier connected to the sensing electrode, a counter electrode adjacent a second end of the opening, and an electrolyte located in the opening between the sensing electrode and the counter electrode.
摘要翻译： 1.一种电化学气体传感器，包括限定穿过其中的开口的基板，连接到所述基板的第一表面并且邻近所述开口的第一端的感测电极，连接到所述感测电极的扩散阻挡层，邻近所述第二端的对电极开口和位于感测电极和对电极之间的开口中的电解质。

47. 发明授权

US09029130B2 Unitary plastic conductivity sensor 有权
标题翻译：单一塑料电导率传感器
公开(公告)号：US09029130B2
公开(公告)日：2015-05-12
申请号：US13325265
申请日：2011-12-14
申请人： Chang-Dong Feng , Barry W. Benton
发明人： Chang-Dong Feng , Barry W. Benton
IPC分类号： C12M1/34 , C12M3/00 , C12M1/00 , C12M1/36 , C12M1/38 , C12N9/00 , C12N11/00 , G01N27/07 , G01N27/30
CPC分类号： G01N27/07 , G01N27/30
摘要： A contacting-type conductivity sensor includes an electrically-insulative plastic body and a plurality of electrodes. The plurality of conductive electrodes is disposed in the plastic body. Each electrode is constructed of plastic and fused with the electrically-insulative plastic body. A method of manufacturing the conductivity sensor is provided along with a single-use bioreactor employing the sensor.
摘要翻译：接触型电导率传感器包括电绝缘塑料体和多个电极。多个导电电极设置在塑料体中。每个电极由塑料构成，并与电绝缘塑料体熔合。与使用该传感器的一次性生物反应器一起提供制造电导率传感器的方法。

48. 发明申请

US20120178153A1 pH SENSOR INTEGRATION TO SINGLE USE BIOREACTOR/MIXER 有权
标题翻译： pH传感器集成到单个使用的生物反应器/混合器
公开(公告)号：US20120178153A1
公开(公告)日：2012-07-12
申请号：US13325254
申请日：2011-12-14
申请人： Chang-Dong Feng , Barry W. Benton , Dave Anderson , Fong S. Yang , Wayne B. Wood
发明人： Chang-Dong Feng , Barry W. Benton , Dave Anderson , Fong S. Yang , Wayne B. Wood
IPC分类号： C12M1/00
CPC分类号： C12M23/14 , C12M41/26 , C12M41/32 , C12M41/34
摘要： A pH sensing bioreaction system is provided. The system includes a bioreaction container having a plastic wall and a pH sensor attached to the plastic wall. The pH sensor includes a sensor body having a flange that is sealingly attached to the plastic wall. The sensor body has a reference electrolyte therein and a first sensing element disposed in the reference electrolyte. The first sensing element is configured to contact both the reference electrolyte and a sample solution inside the bioreaction container. A second sensing element is positionable into an interior of the bioreaction container. The pH sensor has a plurality of configurations that include a booted configuration in which at least one sensing element is isolated from the interior of the bioreaction container, and a service configuration in which the at least one sensing element is fluidically coupled to the interior of the bioreaction container.
摘要翻译：提供pH感应生物反应系统。该系统包括具有塑料壁和附着在塑料壁上的pH传感器的生物反应容器。 pH传感器包括具有密封地附接到塑料壁的凸缘的传感器本体。传感器主体中具有参考电解质，并且设置在参考电解质中的第一感测元件。第一感测元件被配置为接触生物反应容器内的参考电解质和样品溶液。第二感测元件可定位到生物反应容器的内部。 pH传感器具有多个构造，其包括引导构造，其中至少一个感测元件与生物反应容器的内部隔离，并且其中至少一个感测元件流体地联接到生物反应容器的内部的服务构造生物反应容器。

49. 发明授权

US08072599B2 Real-time, hybrid amplitude-time division polarimetric imaging camera 有权
标题翻译：实时混合振幅时分极化成像相机
公开(公告)号：US08072599B2
公开(公告)日：2011-12-06
申请号：US12404108
申请日：2009-03-13
申请人： Tallis Y. Chang , Jian Ma , Bing Wen , Dong-Feng Gu , Sung J. Choi , Bruce K. Winker
发明人： Tallis Y. Chang , Jian Ma , Bing Wen , Dong-Feng Gu , Sung J. Choi , Bruce K. Winker
IPC分类号： G01J4/00
CPC分类号： G01J4/04 , G03B15/00
摘要： This disclosure relates to a real-time, hybrid amplitude-time division polarimetric imaging camera used to derive and calculate Stokes parameters of input light.
摘要翻译：本公开涉及用于导出和计算输入光的斯托克斯参数的实时混合振幅 - 时间分割偏振成像相机。

50. 发明授权

US07837847B2 High purity water pH sensor with shielded flowing liquid junction 有权
标题翻译：高纯度水pH传感器，带有屏蔽流动液体接头
公开(公告)号：US07837847B2
公开(公告)日：2010-11-23
申请号：US11904620
申请日：2007-09-27
申请人： Chang-Dong Feng , Beth M. Covey , Wayne B. Wood
发明人： Chang-Dong Feng , Beth M. Covey , Wayne B. Wood
IPC分类号： G01N27/30 , G01N27/401 , G01N27/403 , G01N27/36
CPC分类号： G01N27/36 , G01N27/401
摘要： A pH sensor is provided. The pH sensor includes a body, a glass electrode, a reference electrode and a solution ground. The glass electrode is disposed on the body to contact a liquid sample. The reference electrode has a reference fill solution disposed within the body. The solution ground electrode is operably coupled to the body and has a portion of the solution ground electrode that is disposed within a harbor such that a portion of the solution ground electrode is configured to contact the liquid sample. The body has a passageway that extends from the reference fill solution to an aperture proximate the liquid sample.
摘要翻译：提供pH传感器。 pH传感器包括主体，玻璃电极，参比电极和溶液接地。玻璃电极设置在身体上以接触液体样品。参考电极具有设置在体内的参考填充溶液。溶液接地电极可操作地耦合到主体并且具有设置在港口内的溶液接地电极的一部分，使得溶液接地电极的一部分被配置为接触液体样品。主体具有从参考填充溶液延伸到靠近液体样品的孔的通道。

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