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41. 发明申请

WO2006048450A2 NOVEL PEPTIDES FOR USE IN THE TREATMENT OF OBESITY 审中-公开
标题翻译：用于治疗肥胖症的新型药物
公开(公告)号：WO2006048450A2
公开(公告)日：2006-05-11
申请号：PCT/EP2005/055760
申请日：2005-11-04
申请人： NOVO NORDISK A/S , SENSFUSS, Ulrich , CHRISTENSEN, Leif , CONDE FRIEBOES, Kilian Waldemar , PETTERSSON, Ingrid
发明人： SENSFUSS, Ulrich , CHRISTENSEN, Leif , CONDE FRIEBOES, Kilian Waldemar , PETTERSSON, Ingrid
IPC分类号： C07K14/68 , A61K38/34 , C07K7/50 , C07K7/64 , A61K38/12 , A61K47/48
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08
摘要： The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of obesity as well as a variety of diseases or conditions associated with obesity.
摘要翻译：本发明涉及有效调节一种或多种黑皮质素受体类型的新型肽化合物，治疗中化合物的用途，包括向有需要的患者施用化合物的治疗方法，以及使用药物制造中的化合物。本发明的化合物在治疗肥胖以及与肥胖相关的各种疾病或病症方面特别有意义。

42. 发明申请

WO2003047355A1 APPARATUS AND METHOD FOR STUNNING OF SLAUGHTER ANIMALS 审中-公开
标题翻译：用于刺激动物动物的装置和方法
公开(公告)号：WO2003047355A1
公开(公告)日：2003-06-12
申请号：PCT/DK2002/000795
申请日：2002-11-28
申请人： SLAGTERIERNES FORSKNINGSINSTITUT , CHRISTENSEN, Leif
发明人： CHRISTENSEN, Leif
IPC分类号： A22B1/00
CPC分类号： A22B7/00
摘要： An apparatus for stunning of slaughter animals has a driving corridor (1) with a driving gate system, which comprises a driving gate (10), conveyance devices (10a) for mechanical conveyance of the driving gate in the corridor, and control means (11) to control the gate (10) in relation to the walls (12) of the driving corridor. A stunning box (2) is placed in continuation of the driving corridor (1) and it has fixation devices (13) for an animal in the box. The driving gate system is designed to convey the driving gate (10) into the stunning box (2). The fixation of the animal in the box is considerably easier to carry out for the operator than by traditional apparatuses, because the animal is driven all the way forward to a position where it can be fixed. The gate prevents the animal from walking backwards in the box away from the hoops, irrespective of its size.
摘要翻译：一种用于捣毁屠宰动物的装置具有驱动走廊（1），其具有驱动门系统，该驱动走廊包括驱动门（10），用于机械传送走廊中的驱动门的输送装置（10a）和控制装置）以相对于驾驶走廊的墙壁（12）控制门（10）。一个令人惊叹的盒子（2）被放置在驱动走廊（1）的继续位置，并且它具有盒子中的动物的固定装置（13）。驱动门系统被设计成将驱动门（10）传送到惊险箱（2）中。因为动物一直向前驱动到可以固定的位置，因此动物在箱子中的固定比传统装置更容易进行操作。门防止动物在箱子的后方向后移动，不管其大小如何。

43. 发明申请

WO1996002558A1 LINKED PEPTIDE NUCLEIC ACIDS 审中-公开
标题翻译：连接的肽核酸
公开(公告)号：WO1996002558A1
公开(公告)日：1996-02-01
申请号：PCT/US1995009084
申请日：1995-07-13
申请人： ISIS PHARMACEUTICALS, INC. , PERSEPTIVE BIOSYSTEMS , BUCHARDT, Dorte +lf , EGHOLM, Michael , NIELSEN, Peter , DUEHOLM, Kim, L. , CHRISTENSEN, Leif , COULL, James, M. , KIELY, John , GRIFFITH, Michael
发明人： ISIS PHARMACEUTICALS, INC. , PERSEPTIVE BIOSYSTEMS , BUCHARDT, Dorte +lf , BUCHARDT, Ole +di
IPC分类号： C07H21/00
CPC分类号： C07H21/00 , A61K38/00 , C07K5/06026 , C07K7/06 , C07K7/08 , C07K14/003 , C12N15/10 , C12N15/113 , C12N15/1132 , C12N15/1135 , C12N2310/13 , C12N2310/15 , C12N2310/3181 , C12N2310/3513 , C12Q1/68 , C12Q1/6813 , C12Q1/6869 , C12Q2525/107 , C12Q2537/119 , C12Q2535/107
摘要： Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to a peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be oriented either parallel or antiparallel to each other.
摘要翻译：新型肽核酸和新型连接肽核酸，与核酸形成三链结构。肽核酸包括配体，例如通过合适的接头连接到肽主链上的天然存在的核碱基。包括C-嘧啶和异嘧啶的其它核碱基可以用作Hoogsteen链中的配体以增加结合亲和力。两个肽核酸链与接头连接在一起以形成双肽核酸。双重化合物中肽核酸的单个链可以彼此平行或反平行取向。

44. 发明申请

WO2013087118A1 PORTABLE ELECTRONIC DEVICE FOR WEARING AT THE EAR AND A METHOD OF OPERATING A PORTABLE ELECTRONIC DEVICE 审中-公开
标题翻译：用于佩戴耳塞的便携式电子设备和操作便携式电子设备的方法
公开(公告)号：WO2013087118A1
公开(公告)日：2013-06-20
申请号：PCT/EP2011/073030
申请日：2011-12-16
申请人： WIDEX A/S , KROGSGAARD, Klaus , LUND-OLESEN, Torsten , KALLESOEE, Christian , HALES, Jan, Harry , CHRISTENSEN, Leif, Hoejslet , KIDMOSE, Preben
发明人： KROGSGAARD, Klaus , LUND-OLESEN, Torsten , KALLESOEE, Christian , HALES, Jan, Harry , CHRISTENSEN, Leif, Hoejslet , KIDMOSE, Preben
IPC分类号： H04R25/02 , H04R1/10 , H02M3/157
CPC分类号： H04R25/00 , H01M8/1011 , H01M8/1013 , H01M2250/30 , H04R1/1025 , H04R25/02 , H04R2225/31 , H04R2225/33 , H04R2225/67 , H04R2460/03 , Y02B90/18 , Y02E60/522 , Y02E60/523
摘要： A portable electronic device (100) comprises a fuel cell (101) and a boost converter (102), wherein said boost converter (102) is adapted for boosting the fuel cell voltage a level suitable to power the portable electronic device (100) and wherein said boost converter (102) is powered by said fuel cell (101). The invention also provides a method of operating a portable electronic device.
摘要翻译：便携式电子设备（100）包括燃料电池（101）和升压转换器（102），其中所述升压转换器（102）适于将燃料电池电压升高到适于为便携式电子设备（100）供电的电平，以及其中所述升压转换器（102）由所述燃料电池（101）供电。本发明还提供一种操作便携式电子设备的方法。

45. 发明申请

WO2009010398A1 STABILIZED PROLACTIN RECEPTOR ANTAGONISTS 审中-公开
标题翻译：稳定的促胰岛素受体拮抗剂
公开(公告)号：WO2009010398A1
公开(公告)日：2009-01-22
申请号：PCT/EP2008/058591
申请日：2008-07-03
申请人： NOVO NORDISK A/S , OLSEN, Ole, Hvilsted , RAND, Kasper , ANDERSEN, Mette, Dahl , TARABYKINA, Svetlana , CHRISTENSEN, Leif
发明人： OLSEN, Ole, Hvilsted , RAND, Kasper , ANDERSEN, Mette, Dahl , TARABYKINA, Svetlana , CHRISTENSEN, Leif
IPC分类号： A61K38/22 , C07K14/575
CPC分类号： C07K14/4703 , A61K38/00
摘要： The invention relates to novel prolactin receptor antagonist compounds, to methods of preparing said compounds, to pharmaceutical compositions comprising these compounds and to the use of the compounds for the treatment of diseases related to proliferative disorders.
摘要翻译：本发明涉及新颖的催乳素受体拮抗剂化合物，制备所述化合物的方法，包含这些化合物的药物组合物以及该化合物用于治疗与增殖性疾病相关的疾病的用途。

46. 发明申请

WO2008040758A1 PEPTIDES WITH HIGH AFFINITY FOR THE PROLACTIN RECEPTOR 审中-公开
标题翻译：具有高亲和力的前列腺素受体的肽
公开(公告)号：WO2008040758A1
公开(公告)日：2008-04-10
申请号：PCT/EP2007/060501
申请日：2007-10-03
申请人： NOVO NORDISK A/S , NØRSKOV-LAURITSEN, Leif , CHRISTENSEN, Leif
发明人： NØRSKOV-LAURITSEN, Leif , CHRISTENSEN, Leif
IPC分类号： C07K14/575 , C12N15/12 , C07K16/26 , A61K38/22
CPC分类号： C07K14/57554
摘要： The present invention is concerned with peptides binding to the prolactin receptor, wherein said peptides have an improved binding via binding site 1 (BS1) to the prolactin receptor. In one embodiment, said improved binding is achieved by mutation of positions 61, 71 and 73.
摘要翻译：本发明涉及与催乳素受体结合的肽，其中所述肽具有通过结合位点1（BS1）与催乳素受体的改善的结合。在一个实施方案中，所述改进的结合通过位置61,71和73的突变实现。

47. 发明申请

WO2004099246A3 PEPTIDES FOR USE IN TREATING OBESITY 审中-公开
标题翻译：用于治疗肥胖的药物
公开(公告)号：WO2004099246A3
公开(公告)日：2005-05-19
申请号：PCT/DK2004000308
申请日：2004-05-05
申请人： NOVO NORDISK AS , SENSFUSS ULRICH , CONDE FRIEBOES KILIAN WALDEMAR , CHRISTENSEN LEIF , PETTERSON INGRID VIVIKA , HANSEN THOMAS KRUSE , ANKERSEN MICHAEL , MADSEN KJELD
发明人： SENSFUSS ULRICH , CONDE FRIEBOES KILIAN WALDEMAR , CHRISTENSEN LEIF , PETTERSON INGRID VIVIKA , HANSEN THOMAS KRUSE , ANKERSEN MICHAEL , MADSEN KJELD
IPC分类号： A61K38/00 , C07K14/68 , A61K38/08 , C07K7/04 , C07K7/06
CPC分类号： C07K7/02 , A61K38/00 , C07K7/56 , C07K14/68
摘要： Novel cyclic and linear peptides of the formula R -x-x -x -x -x -x -x -x -X -X -X -X -R are useful in the treatment of obesity are provided.
摘要翻译：式R 1-x x 1 -x 2 -x 3 -x 4 -x 5 -x 6-x 7的新型环状和线性肽 8> -X 9〜-X 10 -R 11 -R 2可用于治疗肥胖症。

48. 发明申请

WO2004099246A2 PEPTIDES FOR USE IN TREATING OBESITY 审中-公开
标题翻译：用于治疗肥胖的药物
公开(公告)号：WO2004099246A2
公开(公告)日：2004-11-18
申请号：PCT/DK2004/000308
申请日：2004-05-05
申请人： NOVO NORDISK A/S , SENSFUSS, Ulrich , CONDE FRIEBOES, Kilian, Waldemar , CHRISTENSEN, Leif , PETTERSON, Ingrid, Vivika , HANSEN, Thomas, Kruse , ANKERSEN, Michael , MADSEN, Kjeld
发明人： SENSFUSS, Ulrich , CONDE FRIEBOES, Kilian, Waldemar , CHRISTENSEN, Leif , PETTERSON, Ingrid, Vivika , HANSEN, Thomas, Kruse , ANKERSEN, Michael , MADSEN, Kjeld
IPC分类号： C07K14/68
CPC分类号： C07K7/02 , A61K38/00 , C07K7/56 , C07K14/68
摘要： Novel cyclic and linear peptides of the formula R 1 -x-x 1 -x 2 -x 3 -x 4 -x 5 -x 6 -x 7 -X 8 -X 9 -X 10 -X 11 -R 2 are useful in the treatment of obesity are provided.
摘要翻译：式R 1-x x 1 -x 2 -x 3 -x 4 -x 5 -x 6-x 7的新型环状和线性肽 8> -X 9〜-X 10 -R 11 -R 2可用于治疗肥胖症。

49. 发明申请

WO2003079799A1 ARRANGEMENT AND METHOD FOR DIVISION OF ANIMALS INTO GROUPS AND TRANSFER OF GROUPS OF ANIMALS TO A STUNNING APPARATUS 审中-公开
标题翻译：将动物分类到动物组织和将动物群转移到动物装置的装置和方法
公开(公告)号：WO2003079799A1
公开(公告)日：2003-10-02
申请号：PCT/DK2003/000203
申请日：2003-03-26
申请人： SLAGTERIERNES FORSKNINGSINSTITUT , CHRISTENSEN, Leif
发明人： CHRISTENSEN, Leif
IPC分类号： A22B1/00
CPC分类号： A22B1/00
摘要： An arrangement for division of animals into groups and transfer of groups of animals to a stunning apparatus (3) comprises an oblong corridor section (10) in which animals can be driven from an entrance end to an exit end. It has a division gate (12) in the corridor section between the entrance end and the exit end, which gate is placed in such a way that the corridor area (1Ob) between the division gate and the exit end has room for a number of animals corresponding to the group size. In continuation of the corridor section (10) a transfer section (16) is placed at the exit end of the section, which transfer section has room for a number of animals corresponding to the group size and has a connection with the entrance to the stunning apparatus. The transfer section between the corridor section and the stunning apparatus provides the advantage that the division process becomes less dependent on the subsequent process where a group of animals are driven into the stunning apparatus and stunned, which increases the capacity of the system.
摘要翻译：用于将动物分成组并将动物群转移到惊人装置（3）的安排包括长方形走廊部分（10），动物可以从入口端驱动到出口端。它在入口端和出口端之间的走廊部分具有一个分隔门（12），该门被设置成使得分隔门与出口端之间的走廊区域（10b）具有多个动物对应组的大小。在走廊部分（10）的继续中，转移部分（16）放置在该部分的出口端处，该转运部分具有与组大小对应的多个动物的空间，并且具有与惊人的入口的连接仪器。走廊部分和令人惊叹的装置之间的转运部分具有以下优点，即分割过程变得较少依赖于一组动物被驱动到惊险装置中并使其震惊的随后过程，这增加了系统的容量。

50. 发明专利

NO803634A 未知
公开(公告)号：NO803634A
公开(公告)日：1980-12-02
申请号：NO803634
申请日：1980-12-02
申请人： CHRISTENSEN LEIF , LYHNE NIELS EJLER
发明人： CHRISTENSEN LEIF
IPC分类号： A01K13/00 , A01M1/20 , A01M1/24 , B05B7/24 , A01M
CPC分类号： A01M13/003 , A01K13/003 , A01M1/245 , A01M2200/011 , A01M2200/012 , B05B7/2405 , B05B7/2424 , B05B7/2486

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