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41. 发明授权

US10307188B2 Shape adaptable intramedullary fixation device 有权
公开(公告)号：US10307188B2
公开(公告)日：2019-06-04
申请号：US15285811
申请日：2016-10-05
申请人： The University of British Columbia , British Columbia Cancer Agency Branch
发明人： Edward Scott Harshman , Steven Charles Dimmer , Daniel Reed Baker , David Thomas Stinson , Robert N. Meek , Robin John Noel Coope , Lok Tin Lam
IPC分类号： A61B17/72 , A61B17/16 , A61B17/17 , A61B17/88 , A61B17/34
摘要： Implantable devices for fixation of curved bone such as the pelvic ring pubic symphysis and acetabulum, and methods for the use of the devices are disclosed. The implantable devices are convertible between a flexible state and a rigid state, and include an elongate structure having a proximal bone interface, a main body, and a distal bone interface. In a flexible state, the devices may be inserted along, and conform to a curved pathway, and in the rigid state, the devices may support the mechanical loads required to fixate a fracture.

42. 发明申请

US20180235925A1 BISPHENOL COMPOUNDS AND METHODS FOR THEIR USE 审中-公开
公开(公告)号：US20180235925A1
公开(公告)日：2018-08-23
申请号：US15821294
申请日：2017-11-22
申请人： British Columbia Cancer Agency Branch , The University of British Columbia
发明人： Raymond John Andersen , Javier Garcia Fernandez , Marianne Dorothy Sadar , Nasrin Mawji , Carmen Adriana Banuelos , Jun Wang
IPC分类号： A61K31/336 , C07C43/215 , C07D303/14 , C07C43/23 , A61K31/09 , C07C229/08 , A61K45/06
CPC分类号： A61K31/336 , A61K31/09 , A61K45/06 , C07C43/215 , C07C43/23 , C07C229/08 , C07C2601/14 , C07D303/14
摘要： Compounds having a structure of Formula I: wherein G, a, Q, L2, R1, R2, R3, R4, R5 and R6 are as defined herein are provided. Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.

43. 发明授权

US09804083B2 Optical standard for calibration of spectral measuring systems 有权
公开(公告)号：US09804083B2
公开(公告)日：2017-10-31
申请号：US14766439
申请日：2014-02-11
申请人： Verisante Technology, Inc. , British Columbia Cancer Agency Branch
发明人： Haishan Zeng , Hequn Wang , Thomas Andrew Braun
IPC分类号： G01J3/28 , G01N21/27 , G01N21/65 , G01N21/64 , A61B5/00
CPC分类号： G01N21/278 , A61B5/0075 , A61B2560/0233 , G01N21/645 , G01N21/65 , G01N2021/6482
摘要： Examples of an optical standard and a calibration apparatus for calibrating or characterizing a spectroscopy system using such optical standard are disclosed. The optical standard can comprises a mixture of acetaminophen and barium sulfate, wherein a mass of the acetaminophen in the mixture is being less than a mass of the BaSO4. Such optical standard can be used in a calibration device for calibrating or characterizing a spectroscopy system. The calibration device can comprise a substrate base with a top surface and a bottom surface. The top surface can include a section for receiving the optical standard sample. The receiving section can be adhesive. The calibration device can further comprise a film that can be attached to the top surface of the substrate base to cover at least the section of the substrate where the optical standard is being placed. The calibration device can be disposed after the calibration measurements are completed. The optical standard and the calibration apparatus using the optical standard can be used as a wavelength calibration standard to calibrate a Raman system, a reflectance reference standard for a reflectance spectral measurement or for a reliability check in a fluorescence spectral system.

44. 发明申请

US20170298033A1 BISPHENOL DERIVATIVES AND THEIR USE AS ANDROGEN RECEPTOR ACTIVITY MODULATORS 审中-公开
公开(公告)号：US20170298033A1
公开(公告)日：2017-10-19
申请号：US15489162
申请日：2017-04-17
申请人： THE UNIVERSITY OF BRITISH COLUMBIA , British Columbia Cancer Agency Branch
发明人： Raymond ANDERSEN , Marianne Dorothy SADAR , Kunzhong JIAN , Nasrin R. MAWJI , Jun WANG , Carmen Adriana BANUELOS , Yu-Chi YANG
IPC分类号： C07D295/088 , C07C317/28 , C07C317/22 , C07C317/18 , A61K45/06 , A61K31/09 , A61K31/5375 , A61K31/4164 , A61K31/145 , A61K31/10 , C07D233/60 , C07C43/23
CPC分类号： C07D295/088 , A61K31/09 , A61K31/10 , A61K31/145 , A61K31/4164 , A61K31/5375 , A61K45/06 , C07C43/23 , C07C69/28 , C07C233/18 , C07C311/04 , C07C311/51 , C07C317/18 , C07C317/22 , C07C317/28 , C07D233/60
摘要： Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, and X, are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.

45. 发明申请

US20170164953A1 DRILL ATTACHMENT FOR CANNULATED SURGICAL DRILLS 审中-公开
公开(公告)号：US20170164953A1
公开(公告)日：2017-06-15
申请号：US15441226
申请日：2017-02-23
申请人： BRITISH COLUMBIA CANCER AGENCY BRANCH
发明人： Lok Tin LAM , Scott Elton YOUNG , Derek THONG
IPC分类号： A61B17/16
CPC分类号： A61B17/1637 , A61B17/162 , A61B17/1624 , A61B17/1662 , A61B17/1697 , A61B17/844 , A61B17/8625 , A61B17/8685 , A61B2017/00393 , A61B2017/00473 , A61B2017/00477 , B23B45/005 , F16D41/22
摘要： A hammer drill attachment is provided for attachment to a bi-directional surgical drill. The attachment comprises a lengthwise adapter to engage a chuck of the surgical drill, a transmission mechanism, and a quick-release mechanism. The transmission mechanism comprises a pair of toothed plates, the teeth of a proximal plate configured to permit engagement with the teeth of a distal plate. When the proximal plate rotates in a first direction, the proximal plate transmits a rotational motion to the distal plate. When the proximal plate rotates in a second direction, the proximal plate transmits an axial percussive force to the distal plate. The quick-release mechanism comprises a socket to receive a collet, a socket seater, and a latching arm to move the socket seater with respect to the socket, thereby seating or unseating the collet in the socket.

46. 发明申请

US20170049460A1 CANNULATED HAMMER DRILL ATTACHMENT 审中-公开
标题翻译： CANNULATED HAMMER钻孔附件
公开(公告)号：US20170049460A1
公开(公告)日：2017-02-23
申请号：US15335218
申请日：2016-10-26
申请人： BRITISH COLUMBIA CANCER AGENCY BRANCH
发明人： Robin John Noel Coope
IPC分类号： A61B17/16 , A61B17/86 , B23B45/00 , A61B17/84
CPC分类号： A61B17/1637 , A61B17/162 , A61B17/1624 , A61B17/1662 , A61B17/1697 , A61B17/844 , A61B17/8625 , A61B17/8685 , A61B2017/00393 , A61B2017/00473 , A61B2017/00477 , B23B45/005 , F16D41/22
摘要： A hammer drill attachment is provided for attachment to a bi-directional surgical drill. The hammer drill attachment is configured to provide a rotating output in a first direction of rotation when the drill is operated in its first direction of rotation, and the hammer drill attachment is configured to provide a hammering output when the drill is operated in its second direction of rotation.
摘要翻译：提供锤钻附件用于附接到双向手术钻头。锤钻附件构造成当钻头沿其第一旋转方向操作时在第一旋转方向上提供旋转输出，并且锤钻附件构造成当钻头在其第二方向上操作时提供锤击输出的旋转。

47. 发明授权

US09532789B2 Cannulated hammer drill attachment 有权
标题翻译：插管锤钻附件
公开(公告)号：US09532789B2
公开(公告)日：2017-01-03
申请号：US14241998
申请日：2012-11-14
申请人： BRITISH COLUMBIA CANCER AGENCY BRANCH
发明人： Robin John Noel Coope
IPC分类号： A61B17/16 , A61B17/84 , A61B17/86 , B23B45/00
CPC分类号： A61B17/1637 , A61B17/162 , A61B17/1624 , A61B17/1662 , A61B17/1697 , A61B17/844 , A61B17/8625 , A61B17/8685 , A61B2017/00393 , A61B2017/00473 , A61B2017/00477 , B23B45/005 , F16D41/22
摘要： A hammer drill attachment is provided for attachment to a bi-directional surgical drill. The hammer drill attachment is configured to provide a rotating output in a first direction of rotation when the drill is operated in its first direction of rotation, and the hammer drill attachment is configured to provide a hammering output when the drill is operated in its second direction of rotation.
摘要翻译：提供锤钻附件用于附接到双向手术钻头。锤钻附件构造成当钻头沿其第一旋转方向操作时在第一旋转方向上提供旋转输出，并且锤钻附件构造成当钻头在其第二方向上操作时提供锤击输出的旋转。

48. 发明申请

US20150377769A1 OPTICAL STANDARD FOR CALIBRATION OF SPECTRAL MEASURING SYSTEMS 审中-公开
标题翻译：用于校准光谱测量系统的光学标准
公开(公告)号：US20150377769A1
公开(公告)日：2015-12-31
申请号：US14766439
申请日：2014-02-11
申请人： VERISANTE TECHNOLOGY, INC. , BRITISH COLUMBIA CANCER AGENCY BRANCH
发明人： Haishan Zeng , Hequn Wang , Thomas Andrew Braun
IPC分类号： G01N21/27 , G01N21/64 , G01N21/65
CPC分类号： G01N21/278 , A61B5/0075 , A61B2560/0233 , G01N21/645 , G01N21/65 , G01N2021/6482
摘要： Examples of an optical standard and a calibration apparatus for calibrating or characterizing a spectroscopy system using such optical standard are disclosed. The optical standard can comprises a mixture of acetaminophen and barium sulfate, wherein a mass of the acetaminophen in the mixture is being less than a mass of the BaSO4. Such optical standard can be used in a calibration device for calibrating or characterizing a spectroscopy system. The calibration device can comprise a substrate base with a top surface and a bottom surface. The top surface can include a section for receiving the optical standard sample. The receiving section can be adhesive. The calibration device can further comprise a film that can be attached to the top surface of the substrate base to cover at least the section of the substrate where the optical standard is being placed. The calibration device can be disposed after the calibration measurements are completed. The optical standard and the calibration apparatus using the optical standard can be used as a wavelength calibration standard to calibrate a Raman system, a reflectance reference standard for a reflectance spectral measurement or for a reliability check in a fluorescence spectral system.
摘要翻译：公开了用于校准或表征使用这种光学标准的光谱系统的光学标准和校准装置的示例。光学标准可以包括对乙酰氨基酚和硫酸钡的混合物，其中混合物中对乙酰氨基酚的质量小于BaSO 4的质量。这种光学标准可用于校准或表征光谱系统的校准装置中。校准装置可以包括具有顶表面和底表面的基底。顶表面可以包括用于接收光学标准样品的部分。接收部分可以是粘合剂。校准装置还可以包括可以附着到基板基底的顶表面的膜，以至少覆盖放置光学标准的基板的至少部分。校准装置可以在校准测量结束后进行设置。使用光学标准的光学标准和校准装置可用作校准拉曼系统的波长校准标准，用于反射光谱测量的反射参考标准或荧光光谱系统中的可靠性检查。

49. 发明申请

US20150366454A1 METHOD AND APPARATUS FOR OPTICAL MEASUREMENTS UNDER AMBIENT LIGHT CONDITIONS 审中-公开
标题翻译：在光环境条件下进行光学测量的方法和装置
公开(公告)号：US20150366454A1
公开(公告)日：2015-12-24
申请号：US14766445
申请日：2014-02-14
申请人： VERISANTE TECHNOLOGY, INC. , BRITISH COLUMBIA CANCER AGENCY BRANCH
发明人： Haishan ZENG , Jianhua ZHAO , Michael SHORT , Thomas Andrew BRAUN
IPC分类号： A61B5/00 , G01J3/44 , F21K99/00 , G01J3/10
CPC分类号： A61B5/0071 , A61B5/0075 , A61B5/742 , A61B2560/0247 , F21K9/60 , G01J3/10 , G01J3/44 , G01J2003/104
摘要： Examples of a spectroscopy system with a specially design ambient illumination system are disclosed. The ambient illumination system comprises one or more light emitting diodes (LEDs) that provide illumination light in the wavelength of 400-785 nm. The ambient illumination system can further comprise a filter to block light above 785 nm. The filter can be placed directly in front of LED emitters. The LEDs can be white LEDs or RGB LEDs. The spectroscopy system can further comprise a control system that can receive a signal from the spectral probe when the spectral measurements commence and can instantaneously send a signal to automatically switch off the ambient illumination system and to receive a signal from the spectral probe when the spectral measurements are terminated and automatically switch on the ambient illumination system. Examples of methods of operating the spectroscopy system and the ambient illumination system are disclosed.
摘要翻译：公开了具有特别设计的环境照明系统的光谱系统的实例。环境照明系统包括提供400-785nm波长的照明光的一个或多个发光二极管（LED）。环境照明系统还可以包括用于阻挡高于785nm的光的滤光器。滤波器可以直接放在LED发射器的前面。 LED可以是白色LED或RGB LED。光谱系统还可以包括一个控制系统，当光谱测量开始时可以从光谱探测器接收信号，并且可以瞬时发送一个信号以自动切断环境照明系统，并在光谱测量时接收来自光谱探测器的信号被终止并自动打开环境照明系统。公开了操作光谱系统和环境照明系统的方法的实例。

50. 发明申请

US20150297245A1 A DRILL ATTACHMENT FOR CANNULATED SURGICAL DRILLS 有权
标题翻译：用于手术治疗的钻孔装置
公开(公告)号：US20150297245A1
公开(公告)日：2015-10-22
申请号：US14440839
申请日：2013-11-14
申请人： BRITISH COLUMBIA CANCER AGENCY BRANCH
发明人： Lok Tin Lam , Scott Elton Young , Derek Thong
IPC分类号： A61B17/16 , B23B45/00
CPC分类号： A61B17/1637 , A61B17/162 , A61B17/1624 , A61B17/1662 , A61B17/1697 , A61B17/844 , A61B17/8625 , A61B17/8685 , A61B2017/00393 , A61B2017/00473 , A61B2017/00477 , B23B45/005 , F16D41/22
摘要： A hammer drill attachment is provided for attachment to a bi-directional surgical drill. The attachment comprises a lengthwise adapter to engage a chuck of the surgical drill, a transmission mechanism, and a quick-release mechanism. The transmission mechanism comprises a pair of toothed plates, the teeth of a proximal plate configured to permit engagement with the teeth of a distal plate. When the proximal plate rotates in a first direction, the proximal plate transmits a rotational motion to the distal plate. When the proximal plate rotates in a second direction, the proximal plate transmits an axial percussive force to the distal plate. The quick-release mechanism comprises a socket to receive a collet, a socket seater, and a latching arm to move the socket seater with respect to the socket, thereby seating or unseating the collet in the socket.
摘要翻译：提供锤钻附件用于附接到双向手术钻头。附件包括纵向适配器，以接合外科钻头的卡盘，传动机构和快速释放机构。传动机构包括一对齿形板，近侧板的齿构造成允许与远侧板的齿接合。当近侧板沿第一方向旋转时，近侧板向远侧板传递旋转运动。当近侧板沿第二方向旋转时，近侧板向远侧板传递轴向冲击力。快速释放机构包括用于容纳夹头的插座，插座座和锁定臂，以相对于插座移动插座座，从而将夹头安放或插入插座中。

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