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    • 41. 发明授权
    • Amido spiropiperidines promote the release of growth hormone
    • 酰胺丙哌啶促进生长激素的释放
    • US06420376B1
    • 2002-07-16
    • US09614193
    • 2000-07-10
    • James R. TataArthur A. Patchett
    • James R. TataArthur A. Patchett
    • C07D40106
    • C07D401/06C07D211/34C07D401/12C07D401/14C07D405/14
    • The present invention is directed to certain spiropiperidines of the general structural formula: wherein R1, R2, R3, R3a, R3b, R4 and R5 are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.
    • 本发明涉及一般结构式的某些螺哌啶:其中R1,R2,R3,R3a,R3b,R4和R5如本文所定义。 这些化合物促进人和动物中生长激素的释放。 这种性质可以用于促进食用动物的生长,使食用肉制品的生产更有效,并且在人类中,用于治疗以生长激素分泌不足为特征的生理或医学病症,例如生长激素缺乏的身材矮小 儿童,并且治疗通过生长激素的合成代谢作用改善的医疗状况。 还公开了含有这些化合物作为其活性成分的生长激素释放组合物。
    • 44. 发明授权
    • Piperidines promote release of growth hormone
    • 皮质激素促进生长激素的释放
    • US5877182A
    • 1999-03-02
    • US926212
    • 1997-09-09
    • Ravi NargundArthur A. PatchettJames Tata
    • Ravi NargundArthur A. PatchettJames Tata
    • C07D401/06C07D471/10A61K31/445C07D221/20
    • A61K31/663C07D401/06C07D471/10
    • The present invention is directed to certain piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein B is selected from: ##STR2## and R.sup.1, R.sup.1a, R.sup.2a, R.sup.3a, R.sup.3b, R.sup.4, R.sup.4a, R.sup.4b, R.sup.5, D,E, X, Y, n, x and y are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.
    • 本发明涉及以下通式结构式的某些哌啶,吡咯烷和六氢-1H-吖庚因:其中B选自:其中R 1,R 1a,R 2a,R 3a,R 3b,R 4,R 4a, R4b,R5,D,E,X,Y,n,x和y如本文所定义。 这些化合物促进人和动物中生长激素的释放。 这种性质可以用于促进食用动物的生长,使食用肉制品的生产更有效,并且在人类中,用于治疗以生长激素分泌不足为特征的生理或医学病症,例如生长激素缺乏的身材矮小 儿童,并且治疗通过生长激素的合成代谢作用改善的医疗状况。 还公开了含有这些化合物作为其活性成分的生长激素释放组合物。
    • 45. 发明授权
    • Bridged piperidines promote release of growth hormone
    • 桥连的哌啶促进生长激素的释放
    • US5731317A
    • 1998-03-24
    • US401849
    • 1995-03-10
    • Zhijian LuArthur A. PatchettJames R. Tata
    • Zhijian LuArthur A. PatchettJames R. Tata
    • C07D451/02A61K31/445A61K31/46
    • C07D451/00C07D451/02
    • The present invention is directed to certain novel compounds identified as bridged piperidines of the general structural formula: ##STR1## wherein R.sup.1, R.sup.1a, R.sup.2a, R.sup.3, R.sup.3a,R.sup.4, R.sup.5, A, X, and Y are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.
    • 本发明涉及确定为通式结构式的桥连哌啶的某些新化合物:其中R1,R1a,R2a,R3,R3a,R4,R5,A,X和Y如本文所定义。 这些化合物促进人和动物中生长激素的释放。 这种性质可以用于促进食用动物的生长,使食用肉制品的生产更有效,并且在人类中,用于治疗以生长激素分泌不足为特征的生理或医学病症,例如生长激素缺乏的身材矮小 儿童,并且治疗通过生长激素的合成代谢作用改善的医疗状况。 还公开了含有这些化合物作为其活性成分的生长激素释放组合物。