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41. 发明授权

US09345878B2 System and method for compensating for shifting of neurostimulation leads in a patient 有权
标题翻译：用于补偿患者神经刺激导线移位的系统和方法
公开(公告)号：US09345878B2
公开(公告)日：2016-05-24
申请号：US12495442
申请日：2009-06-30
申请人： Andrew DiGiore , Kristen Jaax , Courtney Lane
发明人： Andrew DiGiore , Kristen Jaax , Courtney Lane
IPC分类号： A61N1/08
CPC分类号： A61N1/08 , A61N2001/083
摘要： A method for determining a change in position of a neurostimulation lead relative to a stimulation target tissue of a patient is provided. The method comprises implanting a first proximity sensor on a surface of the patient, implanting a second proximity sensor on the surface of the patient, measuring a change in a distance between the first and second proximity sensors, and inferring the change in position of the lead relative to the stimulation target tissue from the measured change in distance. The method further comprises inferring an increase in a distance between the lead and the stimulation target tissue when the distance between the first and second proximity sensors increases. The method also comprises conveying electrical stimulation energy to therapeutically stimulate the stimulation target tissue, and modulating a stimulation parameter in response to the measured change in distance.
摘要翻译：提供了一种用于确定神经刺激引线相对于患者的刺激目标组织的位置变化的方法。该方法包括在患者的表面上植入第一接近传感器，在患者的表面上植入第二接近传感器，测量第一和第二接近传感器之间的距离的变化，并推断引线的位置变化相对于刺激目标组织的距离测量的变化。该方法还包括当第一和第二接近传感器之间的距离增加时，推断引线和刺激目标组织之间的距离的增加。该方法还包括传送电刺激能量以治疗刺激刺激目标组织，以及响应于所测量的距离变化来调制刺激参数。

42. 发明授权

US08914112B2 Methods and systems of treating pancreatitis pain caused by sphincter of Oddi dysfunction 有权
标题翻译：治疗由Oddi功能障碍括约肌引起的胰腺炎疼痛的方法和系统
公开(公告)号：US08914112B2
公开(公告)日：2014-12-16
申请号：US12358002
申请日：2009-01-22
申请人： Todd K. Whitehurst , Rafael Carbunaru , Kristen N. Jaax , Andrew DiGiore , Brett Schleicher , Greg Baldwin , Roger Hastings
发明人： Todd K. Whitehurst , Rafael Carbunaru , Kristen N. Jaax , Andrew DiGiore , Brett Schleicher , Greg Baldwin , Roger Hastings
IPC分类号： A61N1/36 , A61N1/372
CPC分类号： A61N1/36007 , A61N1/36071 , A61N1/37205 , A61N1/37252
摘要： Methods and systems of treating a patient with pancreatitis pain include providing a stimulator, configuring one or more stimulation parameters to control sphincter of Oddi function, programming the stimulator with the one or more stimulation parameters, generating a stimulus configured to control sphincter of Oddi function with the stimulator in accordance with the one or more stimulation parameters, and applying the stimulus with the stimulator to one or more stimulation sites in accordance with the one or more stimulation parameters.
摘要翻译：用于治疗患有胰腺炎疼痛的患者的方法和系统包括提供刺激器，配置一个或多个刺激参数以控制Oddi功能的括约肌，用所述一个或多个刺激参数编程所述刺激器，产生被配置为控制Oddi功能的括约肌的刺激，所述刺激器根据所述一个或多个刺激参数，以及根据所述一个或多个刺激参数将刺激器刺激施加到一个或多个刺激部位。

43. 发明授权

US08731686B2 Burr hole plug having dual slidable clamping mechanisms 有权
标题翻译：钻孔塞具有双滑动夹紧机构
公开(公告)号：US08731686B2
公开(公告)日：2014-05-20
申请号：US12630761
申请日：2009-12-03
申请人： Courtney Lane , Jesse Geroy , James C. Makous , Todd Whitehurst , Matthew Flowers , John Michael Barker , Terry Ferrell , John Swoyer , Brett Schleicher , Jeff Gagnon , Andrew DiGiore , Ellis Garai , Kristen Jaax , Rafael Carbunaru
发明人： Courtney Lane , Jesse Geroy , James C. Makous , Todd Whitehurst , Matthew Flowers , John Michael Barker , Terry Ferrell , John Swoyer , Brett Schleicher , Jeff Gagnon , Andrew DiGiore , Ellis Garai , Kristen Jaax , Rafael Carbunaru
IPC分类号： A61N1/00
CPC分类号： A61B17/0057 , A61B90/10 , A61B2090/103 , A61N1/0534 , A61N1/0539
摘要： A burr hole plug comprises a plug base configured for being mounted around a burr hole. The plug base includes an aperture through which an elongated medical device exiting the burr hole may pass. The burr hole plug further comprises a retainer configured for being mounted within the aperture of the plug base. The retainer further includes first and second slidable clamping mechanisms configured for securing the medical devices therebetween within the aperture of the plug base. A method comprises introducing the medical device through the burr hole, mounting a plug base around the burr hole, such that the medical device extends through the plug base aperture, mounting the retainer within the aperture of the plug base, and sliding the first and second clamping mechanisms secure the medical device therebetween.
摘要翻译：毛刺孔塞包括构造成围绕钻孔安装的塞子基座。插头基座包括一个孔，通过该孔可以使离开钻孔的细长医疗装置通过。毛刺孔塞还包括保持器，其构造成用于安装在插头基座的孔内。保持器还包括第一和第二可滑动夹紧机构，其被构造用于将医疗装置固定在插头基座的孔内。一种方法包括：通过毛刺孔引导医疗装置，将插头基座安装在毛刺孔周围，使得医疗装置延伸穿过插头基座孔口，将保持器安装在插头基座的孔内，并将第一和第二夹紧机构将医疗装置固定在其间。

44. 发明授权

US08676322B2 Methods and systems of treating pancreatitis pain 有权
标题翻译：治疗胰腺炎疼痛的方法和系统
公开(公告)号：US08676322B2
公开(公告)日：2014-03-18
申请号：US12358073
申请日：2009-01-22
申请人： Todd K. Whitehurst , Kristen N. Jaax , Rafael Carbunaru , Greg Baldwin , Brett Schleicher , Andrew DiGiore , Roger Hastings
发明人： Todd K. Whitehurst , Kristen N. Jaax , Rafael Carbunaru , Greg Baldwin , Brett Schleicher , Andrew DiGiore , Roger Hastings
IPC分类号： A61N1/05
CPC分类号： A61N1/36007 , A61N1/0551 , A61N1/36071 , A61N1/37205 , A61N1/37252
摘要： Methods and systems of treating a patient with pancreatitis pain include providing a stimulator, configuring one or more stimulation parameters to treat pancreatitis pain, programming the stimulator with the one or more stimulation parameters, generating a stimulus configured to treat pancreatitis pain with the stimulator in accordance with the one or more stimulation parameters, and applying the stimulus with the stimulator to one or more stimulation sites in accordance with the one or more stimulation parameters.
摘要翻译：治疗患有胰腺炎疼痛的患者的方法和系统包括提供刺激器，配置一个或多个刺激参数以治疗胰腺炎疼痛，用所述一个或多个刺激参数编程所述刺激器，产生被配置为按照所述刺激器治疗胰腺炎疼痛的刺激与所述一个或多个刺激参数相关联，并且根据所述一个或多个刺激参数将刺激器刺激施加到一个或多个刺激位点。

45. 发明申请

US20130046361A1 MOLDABLE CHARGER WITH SHAPE-SENSING MEANS FOR AN IMPLANTABLE PULSE GENERATOR 有权
标题翻译：具有可变形脉冲发生器的形状感测装置的可模拟充电器
公开(公告)号：US20130046361A1
公开(公告)日：2013-02-21
申请号：US13569027
申请日：2012-08-07
申请人： Andrew DiGiore , Brett Schleicher , Greg Baldwin
发明人： Andrew DiGiore , Brett Schleicher , Greg Baldwin
IPC分类号： A61N1/36
CPC分类号： A61N1/3787
摘要： Electrical energy is transcutaneously transmitted from an external charger to an implanted medical device. The external charger includes a charging head that is selectively shapeable to conform to the surface of a patient to enhance charge efficiency and patient comfort. An alternating current charging coil is housed in the charging head and configured for transcutaneously transmitting electrical energy to the implanted medical device. The shape of the coil is changeable as the charging head is shaped, and at least one sensor determines changes in the shape of the charging coil and causes the charge of the coil to be adjusted based on the coil shape.
摘要翻译：电能从外部充电器经皮传输到植入式医疗装置。外部充电器包括充电头，该充电头可选择地成形以符合患者的表面以增强充电效率和患者舒适度。交流充电线圈被容纳在充电头中并且被配置为将电能经皮地传输到植入的医疗装置。线圈的形状可以随着充电头的形状而变化，并且至少一个传感器确定充电线圈的形状的变化，并且基于线圈形状来调节线圈的充电。

46. 发明授权

US08260434B2 Paddle lead configurations for electrical stimulation systems and methods of making and using 失效
标题翻译：用于电刺激系统的桨导线配置及其制作和使用方法
公开(公告)号：US08260434B2
公开(公告)日：2012-09-04
申请号：US12018397
申请日：2008-01-23
申请人： Andrew DiGiore , Greg Baldwin
发明人： Andrew DiGiore , Greg Baldwin
IPC分类号： A61N1/00 , A61B1/04
CPC分类号： A61N1/05 , A61N1/0553
摘要： A paddle lead includes a paddle body with a plurality of electrodes disposed on the paddle body. The plurality of electrodes includes a first electrode and a second electrode. The first electrode and the second electrode are disposed laterally around the circumference of the paddle body. At least one connecting wire is disposed on, or within, the paddle body to electrically couple the first electrode and the second electrode.
摘要翻译：桨引线包括具有设置在桨体上的多个电极的桨体。多个电极包括第一电极和第二电极。第一电极和第二电极围绕桨体的圆周横向设置。至少一个连接线设置在桨体上或其内部，以电耦合第一电极和第二电极。

47. 发明授权

US08260432B2 Moldable charger with shape-sensing means for an implantable pulse generator 有权
标题翻译：具有用于可植入脉冲发生器的形状感测装置的可成型充电器
公开(公告)号：US08260432B2
公开(公告)日：2012-09-04
申请号：US12495645
申请日：2009-06-30
申请人： Andrew DiGiore , Brett Schleicher , Greg Baldwin
发明人： Andrew DiGiore , Brett Schleicher , Greg Baldwin
IPC分类号： A61N1/00
CPC分类号： A61N1/3787
摘要： Electrical energy is transcutaneously transmitted from an external charger to an implanted medical device. The external charger includes a charging head that is selectively shapeable to conform to the surface of a patient to enhance charge efficiency and patient comfort. An alternating current charging coil is housed in the charging head and configured for transcutaneously transmitting electrical energy to the implanted medical device. The shape of the coil is changeable as the charging head is shaped, and at least one sensor determines changes in the shape of the charging coil and causes the charge of the coil to be adjusted based on the coil shape.
摘要翻译：电能从外部充电器经皮传输到植入式医疗装置。外部充电器包括充电头，该充电头可选择地成形以符合患者的表面以增强充电效率和患者舒适度。交流充电线圈被容纳在充电头中并且被配置为将电能经皮地传输到植入的医疗装置。线圈的形状可以随着充电头的形状而变化，并且至少一个传感器确定充电线圈的形状的变化，并且基于线圈形状来调节线圈的充电。

48. 发明授权

US08224460B2 Anchoring units for leads of implantable electric stimulation systems and methods of making and using 有权
标题翻译：可植入电刺激系统的引导锚定单元及其制作和使用方法
公开(公告)号：US08224460B2
公开(公告)日：2012-07-17
申请号：US13207876
申请日：2011-08-11
申请人： Brett Schleicher , Andrew DiGiore , Rafael Carbunaru , Courtney Lane , Kristen N. Jaax
发明人： Brett Schleicher , Andrew DiGiore , Rafael Carbunaru , Courtney Lane , Kristen N. Jaax
IPC分类号： A61N1/00
CPC分类号： A61N1/0558
摘要： A nerve stimulation lead has a distal end, a proximal end, and a longitudinal length. The nerve stimulation lead includes a plurality of electrodes disposed at the distal end, a plurality of terminals disposed at the proximal end, and a plurality of conductive wires electrically coupling the plurality of electrodes electrically to the plurality of terminals. The nerve stimulation lead also includes at least one anchoring unit disposed on the nerve stimulation lead. The at least one anchoring unit is configured and arranged for anchoring the nerve stimulation lead against a bony structure.
摘要翻译：神经刺激引线具有远端，近端和纵向长度。神经刺激引线包括设置在远端的多个电极，设置在近端的多个端子，以及将多个电极电连接到多个端子的多个导线。神经刺激引线还包括设置在神经刺激引线上的至少一个锚定单元。所述至少一个锚定单元被配置和布置成用于将神经刺激引线抵靠骨结构锚定。

49. 发明授权

US08019443B2 Anchoring units for leads of implantable electric stimulation systems and methods of making and using 有权
标题翻译：可植入电刺激系统的引导锚定单元及其制作和使用方法
公开(公告)号：US08019443B2
公开(公告)日：2011-09-13
申请号：US12413081
申请日：2009-03-27
申请人： Brett Schleicher , Andrew DiGiore , Rafael Carbunaru , Courtney Lane , Kristen N. Jaax
发明人： Brett Schleicher , Andrew DiGiore , Rafael Carbunaru , Courtney Lane , Kristen N. Jaax
IPC分类号： A61N1/00
CPC分类号： A61N1/0558
摘要： A nerve stimulation lead has a distal end, a proximal end, and a longitudinal length. The nerve stimulation lead includes a plurality of electrodes disposed at the distal end, a plurality of terminals disposed at the proximal end, and a plurality of conductive wires electrically coupling the plurality of electrodes electrically to the plurality of terminals. The nerve stimulation lead also includes at least one anchoring unit disposed on the nerve stimulation lead. The at least one anchoring unit is configured and arranged for anchoring the nerve stimulation lead against a bony structure.
摘要翻译：神经刺激引线具有远端，近端和纵向长度。神经刺激引线包括设置在远端的多个电极，设置在近端的多个端子，以及将多个电极电连接到多个端子的多个导线。神经刺激引线还包括设置在神经刺激引线上的至少一个锚定单元。所述至少一个锚定单元被配置和布置成用于将神经刺激引线抵靠骨结构锚定。

50. 发明申请

US20110160796A1 AUTOMATIC EVALUATION TECHNIQUE FOR DEEP BRAIN STIMULATION PROGRAMMING 有权
标题翻译：自动评估技术用于深层脑刺激编程
公开(公告)号：US20110160796A1
公开(公告)日：2011-06-30
申请号：US12976658
申请日：2010-12-22
申请人： Courtney Lane , Rafael Carbunaru , David K.L. Peterson , Andrew DiGiore
发明人： Courtney Lane , Rafael Carbunaru , David K.L. Peterson , Andrew DiGiore
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61N1/36139 , A61N1/0531 , A61N1/0534 , A61N1/36082 , A61N1/37282
摘要： Neurostimulation systems and methods for providing therapy to a patient suffering from a symptom of a disease that latently responds to electrical stimulation therapy are provided. First electrical stimulation energy is conveyed to or from a tissue region of the patient in accordance with a first set of stimulation parameters, thereby affecting the symptom. A predetermined period of time estimated for the symptom to resolve in response to electrical stimulation therapy is allowed to elapse. Second electrical stimulation energy is conveyed to or from the tissue region in accordance with a second set of stimulation parameters different from the first set of stimulation parameters.
摘要翻译：提供了神经刺激系统和用于向患有潜在的电刺激治疗反应的疾病症状的患者提供治疗的方法。根据第一组刺激参数将第一电刺激能量传送到患者的组织区域或从患者的组织区域传送，从而影响症状。对于电刺激治疗反应的症状的预定时间段被允许经过。根据与第一组刺激参数不同的第二组刺激参数将第二电刺激能量传送到组织区域或从组织区域传送。

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