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41. 发明申请

WO2018157152A1 SUNSCREEN 审中-公开
公开(公告)号：WO2018157152A1
公开(公告)日：2018-08-30
申请号：PCT/US2018/020007
申请日：2018-02-27
申请人： CONTINUUM GROUP LLC
发明人： LYLE, John , FUNG, Victor
IPC分类号： A61K8/99 , A61Q17/04 , A61Q19/08
摘要： As people age, the microbiome of human skin changes through processes of selection due both to external and intrinsic factors. While human lifespan is finite determined by the inevitable decay of human cellular and genomic structures, the lifespan and aging of the microbiome is more ecological in nature, driven by selective pressures both connected and unconnected to human's own aging. Through the manipulation of the microbiome, using corollaries of processes used in ecosystem restoration, this invention includes ways, compositions and formulations to restore the microbiome of the skin allowing the skin to be in a more youthful and/or native state and prevent or reverse some of the undesirable appearances of aging. The invention described herein restores a putative ancestral microbiome function and thus protects the skin from damage caused by the UV rays present in sunshine.

42. 发明申请

WO2018014030A1 MULTI-COMPARTMENT CAPSULE 审中-公开
标题翻译：多分区胶囊
公开(公告)号：WO2018014030A1
公开(公告)日：2018-01-18
申请号：PCT/US2017/042430
申请日：2017-07-17
申请人： MULTIPLY LABS INC.
发明人： PARIETTI, Federico , MELOCCHI, Alice , ZEMA, Lucia , GAZZANIGA, Andrea
IPC分类号： A61K9/48 , A61K9/52 , A61K9/14 , A61K45/06
摘要： A method of making a capsule comprising a plurality of compartments, the method comprising: initiating extrusion of a filament solution through a filament extruder; laying the filament solution to form a base of the capsule; forming a first compartment in the plurality of compartments, wherein the forming creates a first barrier wall having a first predetermined release time; forming a second compartment in the plurality of compartments, wherein the forming creates a second barrier wall having a second predetermined release time; filling the first compartment with a first material; filling the second compartment with a second material; and sealing the plurality of compartments thereby forming the capsule with a first sealed compartment and a second sealed compartment.
摘要翻译：一种制造包含多个隔室的胶囊的方法，所述方法包括：开始通过长丝挤出机挤出长丝溶液; 铺设细丝溶液以形成胶囊的基部; 在所述多个隔室中形成第一隔室，其中所述形成形成具有第一预定释放时间的第一隔壁; 在所述多个隔室中形成第二隔室，其中所述形成形成具有第二预定释放时间的第二隔壁; 用第一材料填充第一隔室; 用第二种材料填充第二隔室; 并密封多个隔室，从而形成具有第一密封隔室和第二密封隔室的胶囊。

43. 发明申请

WO2017096397A1 NOVEL ANTIBODIES FOR THE TREATMENT OF CANCERS 审中-公开
标题翻译：用于治疗癌症的新型抗体
公开(公告)号：WO2017096397A1
公开(公告)日：2017-06-08
申请号：PCT/US2016/065002
申请日：2016-12-05
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , WADEHRA, Madhuri , BRAUN, Jonathan
发明人： WADEHRA, Madhuri , BRAUN, Jonathan
IPC分类号： A61P35/00 , C07K16/28 , C07K16/30 , A61K39/395 , G01N33/574 , G01N33/577 , G01N33/53
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K2039/505 , C07K16/28 , C07K2317/40 , C07K2317/565 , C07K2317/73 , C07K2317/92 , C07K2317/94 , G01N33/574 , G01N33/577
摘要： Provided herein are novel anti-EMP2 antibodies useful for the treatment and diagnosis of cancers that express or overexpress EMP2. In one aspect, provided herein is an isolated antibody that binds to Epithelial Membrane Protein 2 (EMP2), that includes heavy chain variable region and a light chain variable region. The heavy chain variable region includes three heavy chain complementary determining regions (HCDRs) and the light chain variable region includes three light chain variable regions (LCDRs). In some embodiments, the sequence of HCDR1 is SEQ ID NO: 11, the sequence of HCDR2 is SEQ ID NO: 12, the sequence of HCDR3 is SEQ ID NO: 13, the sequence of LCDR1 is SEQ ID NO:14, the sequence of LCDR2 is SEQ ID NO: 15, and the sequence of LCDR3 is SEQ ID NO: 16.
摘要翻译：本文提供了用于治疗和诊断表达或过表达EMP2的癌症的新型抗EMP2抗体。在一个方面，本文提供了结合上皮膜蛋白2（EMP2）的分离的抗体，其包含重链可变区和轻链可变区。重链可变区包含三个重链互补决定区（HCDR），轻链可变区包含三个轻链可变区（LCDR）。在一些实施方案中，HCDR1的序列是SEQ ID NO：11，HCDR2的序列是SEQ ID NO：12，HCDR3的序列是SEQ ID NO：13，LCDR1的序列是SEQ ID NO：14，序列 LCDR2的序列是SEQ ID NO：15，并且LCDR3的序列是SEQ ID NO：16。

44. 发明申请

WO2016164921A1 PET IMAGING TRACER FOR IMAGING PROSTATE CANCER 审中-公开
标题翻译： PET成像追踪器用于成像前列腺癌
公开(公告)号：WO2016164921A1
公开(公告)日：2016-10-13
申请号：PCT/US2016/026980
申请日：2016-04-11
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , WILSON, David
发明人： WILSON, David , FLAVELL, Robert, R.
IPC分类号： A61K31/70 , A61K31/7008 , C07H5/06 , C07H15/12
CPC分类号： A61K31/7008 , A61B6/037 , A61K31/70 , A61K51/0402 , A61K51/0491 , C07B59/005 , C07H15/203 , G01T1/2914
摘要： In various embodiments, the invention provides a radiotracer comprising a positron emitting atom bound to a deoxy sugar moiety. The radiotracer is reversible bound to a caging moiety that prevents or retards tissue uptake of the radiotracer while the caging moiety is in place. An exemplary caging moiety is acid labile and is cleaved upon uptake of the radiotracer by tissue with an acidic pH.
摘要翻译：在各种实施方案中，本发明提供了包含与脱氧糖部分结合的正电子发射原子的放射性示踪剂。放射性示踪剂是可逆的结合到笼状部分，其在封闭部分就位的情况下防止或延缓放射性示踪剂的组织摄取。示例性的笼状部分是酸不稳定的，并且在用酸性pH吸收放射性示踪剂的组织时被切割。

45. 发明申请

WO2015077548A1 POLYMERS FUNCTIONALIZED WITH BRØNSTED ACID GROUPS 审中-公开
标题翻译：功能齐全的聚合物聚合物
公开(公告)号：WO2015077548A1
公开(公告)日：2015-05-28
申请号：PCT/US2014/066791
申请日：2014-11-21
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： VAN HUMBECK, Jeffrey , LONG, Jeffrey, R. , MCDONALD, Thomas, M.
IPC分类号： B01J20/26
CPC分类号： B01D53/02 , B01D2253/202 , B01D2257/406 , B01J20/226 , B01J20/261 , B01J20/264 , B01J20/3425 , B01J20/3483 , B01J20/3491 , C08G61/10 , C08G77/00 , C08G2261/1426 , C08G2261/143 , C08G2261/1452 , C08G2261/312 , C08G2261/72 , C08G2261/80
摘要： Porous aromatic framework polymers functionalized with Brønsted acid moieites are prepared by polymerization of a three-dimensional organic aryl or heteroaryl monomer and its copolymerization with a second aryl or heteroaryl monomer functionalized with one or more Brønsted acid moiety. The polymers are characterized by a stable three-dimensional structure, which, in exemplary embodiments, includes interpenetrating subunits within one or more domain of the bulk polymer structure. The polymers are of use in methods of adsorbing ammonia and amines and in devices and systems configured for this purpose.
摘要翻译：通过三维有机芳基或杂芳基单体的聚合和与与一个或多个布朗斯台德酸部分官能化的第二芳基或杂芳基单体的共聚制备用布朗斯台德酸雾状物官能化的多孔芳族骨架聚合物。聚合物的特征在于稳定的三维结构，其在示例性实施方案中包括在本体聚合物结构的一个或多个结构域内的互穿亚基。聚合物可用于吸附氨和胺的方法以及为此配置的装置和系统。

46. 发明申请

WO2014165861A1 METAL-CATALYZED COUPLING OF ARYL AND VINYL HALIDES WITH ALPHA, ALPHA-DIFLUOROCARBONYL COMPOUNDS 审中-公开
标题翻译：与ALPHA，ALPHA-DIFLOCOBONYL化合物的芳基和乙烯基金属的金属催化偶联
公开(公告)号：WO2014165861A1
公开(公告)日：2014-10-09
申请号：PCT/US2014/033227
申请日：2014-04-07
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： HARTWIG, John, F. , GE, Shaozhong , CHAŁADAJ, Wojciech
IPC分类号： C07C45/86 , C07C49/80 , B01J23/44
CPC分类号： C07C45/68 , B01J23/44 , B01J31/2404 , B01J2531/824 , C07B39/00 , C07C17/361 , C07C41/18 , C07C45/004 , C07C45/86 , C07C49/80 , C07C67/297 , C07C67/343 , C07C67/42 , C07C69/612 , C07C69/76 , C07C201/12 , C07C205/45 , C07C221/00 , C07C225/22 , C07C231/12 , C07C269/06 , C07C319/20 , C07C323/22 , C07D213/50 , C07D213/56 , C07D215/12 , C07D215/14 , C07D217/18 , C07D295/104 , C07D317/16 , C07D317/26 , C07D317/54 , C07D333/24 , C07F7/0818 , C07F7/083 , C07F15/006 , C07C49/84
摘要： The coupling of aryl, heteroaryl, and vinyl halides with α,α-difluoroketones or silyl ethers or siylenol ethers of α,α-difluoroketones and α,α-difluoroamides and esters are described. Further derivatization of the coupling products (such as ketone cleavage and Baeyer-Villiger oxidation) is also described.
摘要翻译：描述了芳基，杂芳基和卤乙烯与α，α-二氟代酮和α，α-二氟酰胺和酯的α，α-二氟代酮或甲硅烷基醚或二甲苯醚的偶联。还描述了偶联产物（如酮裂解和Baeyer-Villiger氧化）的进一步衍生。

47. 发明申请

WO2014153425A1 METHODS AND SYSTEM FOR LIQUEFACTION, HYDROLYSIS AND FERMENTATION OF AGRICULTURAL FEEDSTOCKS 审中-公开
标题翻译：农业饲料的液化，水解和发酵方法与系统
公开(公告)号：WO2014153425A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/031262
申请日：2014-03-19
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ENERGY BEET DESIGNS, LLC
发明人： ZHANG, Ruihong , ZICARI, Steven, M. , DIENER, John, E. , TISCHER, James, R. , MANTERNACH, Jeffrey, H. , PUCHEU, William, C. , MOORE, Jimmy, L. , WINCKLER, Joseph, W.
IPC分类号： C12P7/06 , C12P7/08
CPC分类号： C12P7/14 , C10L1/02 , C12P7/06 , C12P7/10 , C12P2201/00 , Y02E50/16 , Y02E50/17
摘要： Treatment of agricultural biomass without separation of the biomass to extract fermentable feedstock, instead using a hydrolytic process upstream of the fermentation process, provides an efficient and cost-effective process for forming ethanol from agricultural biomass.
摘要翻译：处理农业生物质而不分离生物质以提取可发酵原料，而是使用发酵过程上游的水解过程，为从农业生物质中形成乙醇提供了有效和成本有效的方法。

48. 发明申请

WO2013173844A1 HETEROARYLCYANINE DYES 审中-公开
标题翻译：异氟烷染料
公开(公告)号：WO2013173844A1
公开(公告)日：2013-11-21
申请号：PCT/US2013/041907
申请日：2013-05-20
申请人： PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
发明人： YUE, Stephen , SHEN, Gene , SUN, Wei-chuan
IPC分类号： C07D495/04 , C09B23/00 , C09B57/00
CPC分类号： G01N21/6486 , C07D487/04 , C07D495/04 , C09B23/0066 , C09B23/06 , C09B23/08 , C09B23/083 , C09B57/00
摘要： The present invention provides heteroaryl functionalized cyanine dyes including a reactive functional moiety, or which are conjugated to a carrier molecule.
摘要翻译：本发明提供了包括反应性官能部分或与载体分子缀合的杂芳基官能化花青染料。

49. 发明申请

WO2013148400A1 METHODS AND COMPOSITION FOR SEQUENCING MODIFIED NUCLEIC ACIDS 审中-公开
标题翻译：用于测序改良的核酸的方法和组合物
公开(公告)号：WO2013148400A1
公开(公告)日：2013-10-03
申请号：PCT/US2013/032816
申请日：2013-03-18
申请人： PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
发明人： KORLACH, Jonas , TURNER, Stephen , CLARK, Tyson, A.
IPC分类号： C12Q1/68 , G01N33/48
CPC分类号： C12Q1/6869 , C12Q1/6827 , C12Q2535/122 , C12Q2537/164 , C12Q2521/514
摘要： Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, a basic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.
摘要翻译：提供了方法，组合物和系统用于表征修饰的核酸。在某些优选实施方案中，提供单分子测序方法用于鉴定核酸序列内的修饰的核苷酸。通过本文提供的方法可检测的修饰物包括化学修饰的碱基，酶修饰的碱基，碱基位点，非天然碱基，二级结构和与模板核酸结合的试剂。

50. 发明申请

WO2013116383A1 NON-ANTICOAGULANT SULFATED OR SULFONATED SYNTHETIC POLYMERS 审中-公开
标题翻译：非抗坏血酸硫化或磺化合成聚合物
公开(公告)号：WO2013116383A1
公开(公告)日：2013-08-08
申请号：PCT/US2013/023919
申请日：2013-01-30
申请人： BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE S.A. , DOCKAL, Michael , SCHEIFLINGER, Fritz , KNAPPE, Sabine , TILL, Susanne , HAI, Ton , SANDERS, Paul
发明人： DOCKAL, Michael , SCHEIFLINGER, Fritz , KNAPPE, Sabine , TILL, Susanne , HAI, Ton , SANDERS, Paul
IPC分类号： A61K31/795 , A61P7/04
CPC分类号： A61K31/795 , A61K31/37 , A61K31/7024 , A61K31/727 , A61K38/37 , A61K38/4846 , A61K2300/00
摘要： The present invention provides pharmaceutical formulations including a non-anticoagulant, non-saccharide polymer that with at least one sulfate or sulfonate moiety. The pharmaceutical formulations of the invention are of use to improve blood clotting in a subject. Also provided are useful analytical methods utilizing these polymers to query the dynamics of blood clotting in vitro.
摘要翻译：本发明提供药物制剂，其包含与至少一种硫酸盐或磺酸盐部分的非抗凝血剂，非糖类聚合物。本发明的药物制剂可用于改善受试者的血液凝固。还提供了使用这些聚合物来查询体外血液凝固动力学的有用的分析方法。

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