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    • 46. 发明授权
    • Soluble epidermal growth factor receptor isoforms
    • 可溶性表皮生长因子受体亚型
    • US08017752B1
    • 2011-09-13
    • US12731387
    • 2010-03-25
    • Nita J. MaihleJill Reiter
    • Nita J. MaihleJill Reiter
    • C12P19/34C07K14/71
    • G01N33/57449G01N33/6872G01N2333/485
    • The present invention relates to the discovery of soluble isoforms of an Epidermal Growth Factor Receptor, or sErbB1 variants, the provision of the sequences of nucleic acids encoding these isoforms, purified recombinant proteins, novel antibodies specific for these isoforms, and the use of immunoassay and other protein assay techniques to measure the concentration of these protein isoforms in a patient biological sample in the femtomolar range. The present invention also provides methods for determining the presence of an ovarian carcinoma in the patient by assaying the concentration of soluble ErbB1 variants in a biological sample from a patient.
    • 本发明涉及表皮生长因子受体或sErbB1变体的可溶性同种型的发现,编码这些同种型的核酸序列的提供,纯化的重组蛋白,对这些同种型特异的新抗体,以及使用免疫测定和 其他蛋白质测定技术来测量这些蛋白质同种型在患者生物样品中的浓度。 本发明还提供了通过测定来自患者的生物样品中可溶性ErbB1变体的浓度来确定患者中卵巢癌存在的方法。
    • 50. 发明授权
    • Screwless magnetic eyewear
    • 无螺纹磁性眼镜
    • US07794080B2
    • 2010-09-14
    • US11610245
    • 2006-12-13
    • Dennis Zelazowski
    • Dennis Zelazowski
    • G02C5/22
    • G02C5/2209G02C2200/02G02C2200/08Y10T16/526
    • The invention provides a magnetic connector for use between members to magnetically connect members such as members between eyewear. Magnetic connector has first and second magnets positioned in or on first and second eyewear members, respectively. Magnets are positioned substantially parallel to each other in a plane and rotate about an axis. A magnetic field of attraction is created between magnets when magnets are in sufficient proximity to each other thereby substantially connecting members. When magnets disengage or fall out of alignment due to force or pressure against members, magnets disengage and allow members to break away without damage.
    • 本发明提供了一种磁性连接器,用于在构件之间磁性地连接诸如眼镜之间的构件的构件。 磁性连接器分别具有位于第一和第二眼镜构件中或第一眼镜构件上的第一和第二磁体。 磁体在平面中基本上彼此平行地定位并且围绕轴线旋转。 当磁体彼此足够接近,从而基本上连接构件时,在磁体之间产生吸引磁场。 当磁体由于对构件的力或压力而脱离或脱离对准时,磁体脱离并允许构件脱离而不损坏。