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41. 发明授权

US11187625B2 Reciprocating microtome drive system 有权
公开(公告)号：US11187625B2
公开(公告)日：2021-11-30
申请号：US15895978
申请日：2018-02-13
申请人： Sakura Finetek U.S.A., Inc.
发明人： Hwai-Jyh Michael Yang , Xuan S. Bui
IPC分类号： G01N1/06 , G05B15/02
摘要： An apparatus having a sample sectioning device including a cutting mechanism that is operable to cut sections from a sample and a sample holder that is operable to hold the sample. The apparatus further includes a drive system coupled with the sample holder to drive movement of the sample holder and a reciprocating member coupled to the drive system to drive vertical movement of the drive system. The reciprocating member to move in a reciprocating manner within an angle of rotation of less than 180 degrees. A surface orientation sensor may further be provided that is operable to sense an orientation of a surface of the sample held by the sample holder.

42. 发明授权

US11112337B2 Microtome with generator 有权
公开(公告)号：US11112337B2
公开(公告)日：2021-09-07
申请号：US15811474
申请日：2017-11-13
申请人： Sakura Finetek U.S.A., Inc.
发明人： Xuan S. Bui , Alyicia Marie Rios , Erico Von Bueren
IPC分类号： G01N1/06 , H05B45/10 , B26D7/01 , B26D7/27 , G01N21/25 , G01N1/31
摘要： A sample sectioning device including a cutting mechanism that is operable to cut sections from a sample, a sample holder operable to move relative to the cutting mechanism, the sample holder having a first side and a second side, the first side faces the cutting mechanism and is dimensioned to receive a sample, a light source coupled to the sample holder, wherein the light source is operable to emit a light from the first side of the sample holder and through a sample positioned on the first side, and a generator operable to generate an electrical energy for providing power to the light source.

43. 外观设计

USD923478S1 Bottle 有权
公开(公告)号：USD923478S1
公开(公告)日：2021-06-29
申请号：US29691389
申请日：2019-05-15
申请人： SAKURA FINETEK U.S.A., INC.
设计人： Joseph T. Sestak

44. 发明申请

US20190105021A1 TISSUE CASSETTE READER 审中-公开
公开(公告)号：US20190105021A1
公开(公告)日：2019-04-11
申请号：US16154634
申请日：2018-10-08
申请人： Sakura Finetek U.S.A., Inc.
发明人： Erico VON BUEREN , Joshua GREENLEE
IPC分类号： A61B10/00 , A61B90/96 , G01N1/31
摘要： An apparatus and system including an apparatus to identify an identifier on a tissue cassette in an assembly of a plurality of tissue cassettes including a light source operable to illuminate a plurality of tissue cassettes; a sensor operable to automatically capture an identifier on an individual tissue cassette or an image of the plurality of tissue cassettes in the assembly; and where the sensor is operable to capture reflected light from the light source of an image of the plurality of tissue cassettes, a converter to convert image data into an electronic signal. The system may include a processor operable to compare an identifier with a tissue processing protocol. A method including sensing identifiers on tissue cassettes each containing a tissue sample in an assembly comprising a plurality of tissue cassettes; and determining or verifying a tissue processing protocol of a tissue sample based on the sensed identifier.

45. 发明授权

US09347857B2 Microtome with surface orientation sensor to sense orientation of surface of sample 有权
标题翻译：切片机具有表面定向传感器，用于检测样品表面的取向
公开(公告)号：US09347857B2
公开(公告)日：2016-05-24
申请号：US14502915
申请日：2014-09-30
申请人： Sakura Finetek U.S.A., Inc.
发明人： Hwai-Jyh Michael Yang , Xuan S. Bui
IPC分类号： B26D5/00 , G01N1/00 , G01N1/06
CPC分类号： G01N1/06 , Y10S83/9155 , Y10T83/04 , Y10T83/141 , Y10T83/525 , Y10T83/536 , Y10T83/538 , Y10T83/6572
摘要： A sample sectioning device includes a cutting mechanism, a sample holder, a drive system, and a surface orientation sensor. The sample holder is operable to hold a sample. The cutting mechanism is operable to cut sections from the sample. The drive system is coupled with the sample holder. The drive system is operable to drive movement between the sample held by the sample holder and the cutting mechanism. The surface orientation sensor is operable to sense an orientation of a surface of the sample held by the sample holder.
摘要翻译：样品切片装置包括切割机构，样品保持器，驱动系统和表面取向传感器。样品架可操作以容纳样品。切割机构可操作以从样品切割切片。驱动系统与样品架连接。驱动系统可操作地驱动由样品架保持的样品与切割机构之间的运动。表面取向传感器可操作以感测由样品保持器保持的样品的表面的取向。

46. 发明授权

US08796038B2 Method for orienting tissue samples on a microtome sectionable biopsy support 有权
标题翻译：在切片机切片活检支架上定向组织样本的方法
公开(公告)号：US08796038B2
公开(公告)日：2014-08-05
申请号：US13678846
申请日：2012-11-16
申请人： Biopath Automation, L.L.C. , Sakura Finetek U.S.A., Inc.
发明人： Warren P. Williamson, IV , Stephen P. Whitlatch , Carlos A. Saez
IPC分类号： G01N1/06 , G01N1/31 , G01N1/36 , G01N33/483
CPC分类号： B01L9/52 , G01N1/06 , G01N1/312 , G01N1/36 , G01N33/4833 , Y10T436/25
摘要： Tissue orientation devices include a perforated tissue support with at least one perforated channel for receiving a tissue sample, and a plurality of tabs configured to extend along and into the channel to retain the tissue sample during processing and embedding. Tissue orientation devices include elongated legs coupled together for holding one or more biopsy tissue samples therebetween. Associated methods include using the cassettes and orientation devices to hold and orient tissue samples for processing, embedding and microtome sectioning.
摘要翻译：组织取向装置包括具有至少一个用于接收组织样本的穿孔通道的穿孔组织支撑件，以及多个突出部，其被构造成沿着和延伸通道以在加工和嵌入期间保持组织样本。组织取向装置包括连接在一起的细长腿以在其间保持一个或多个活检组织样本。相关方法包括使用盒和取向装置来保持和定向组织样品进行加工，嵌入和切片机切片。

47. 发明申请

US20130078670A1 MICROTOME SECTIONABLE BIOPSY SUPPORT FOR ORIENTING TISSUE SAMPLES 有权
标题翻译：用于面向组织样品的MICROTOME部分生物支持
公开(公告)号：US20130078670A1
公开(公告)日：2013-03-28
申请号：US13678846
申请日：2012-11-16
申请人： BIOPATH AUTOMATION, L.L.C. , SAKURA FINETEK U.S.A., INC.
发明人： Warren P. Williamson, IV , Stephen P. Whitlatch , Carlos A. Saez
IPC分类号： G01N33/483
CPC分类号： B01L9/52 , G01N1/06 , G01N1/312 , G01N1/36 , G01N33/4833 , Y10T436/25
摘要： Tissue orientation devices include a perforated tissue support with at least one perforated channel for receiving a tissue sample, and a plurality of tabs configured to extend along and into the channel to retain the tissue sample during processing and embedding. Tissue orientation devices include elongated legs coupled together for holding one or more biopsy tissue samples therebetween. Associated methods include using the cassettes and orientation devices to hold and orient tissue samples for processing, embedding and microtome sectioning.
摘要翻译：组织取向装置包括具有至少一个用于接收组织样本的穿孔通道的穿孔组织支撑件，以及多个突出部，其被构造成沿着和延伸通道以在加工和嵌入期间保持组织样本。组织取向装置包括连接在一起的细长腿以在其间保持一个或多个活检组织样本。相关方法包括使用盒和取向装置来保持和定向组织样品进行加工，嵌入和切片机切片。

48. 发明授权

US08329120B2 Microtome sectionable biopsy support for orienting tissue samples 有权
标题翻译：用于定向组织样本的切片机可切片活检支架
公开(公告)号：US08329120B2
公开(公告)日：2012-12-11
申请号：US12692208
申请日：2010-01-22
申请人： Warren P. Williamson, IV , Stephen P. Whitlatch , Carlos A. Saez
发明人： Warren P. Williamson, IV , Stephen P. Whitlatch , Carlos A. Saez
IPC分类号： A61B10/00
CPC分类号： B01L9/52 , G01N1/06 , G01N1/312 , G01N1/36 , G01N33/4833 , Y10T436/25
摘要： Tissue orientation devices include a perforated tissue support with at least one perforated channel for receiving a tissue sample, and a plurality of tabs configured to extend along and into the channel to retain the tissue sample during processing and embedding. Tissue orientation devices include elongated legs coupled together for holding one or more biopsy tissue samples therebetween. Associated methods include using the cassettes and orientation devices to hold and orient tissue samples for processing, embedding and microtome sectioning.
摘要翻译：组织取向装置包括具有至少一个用于接收组织样本的穿孔通道的穿孔组织支撑件，以及多个突出部，其被构造成沿着和延伸通道以在加工和嵌入期间保持组织样本。组织取向装置包括连接在一起的细长腿以在其间保持一个或多个活检组织样本。相关方法包括使用盒和取向装置来保持和定向组织样品进行加工，嵌入和切片机切片。

49. 发明申请

US20120044342A1 DIGITAL MICROSCOPE 审中-公开
标题翻译：数字显微镜
公开(公告)号：US20120044342A1
公开(公告)日：2012-02-23
申请号：US13212955
申请日：2011-08-18
申请人： PAUL HING , CHRISTIAN ROMER , SVEN HENSLER
发明人： PAUL HING , CHRISTIAN ROMER , SVEN HENSLER
IPC分类号： H04N7/18
CPC分类号： G02B21/367 , G02B21/361 , G02B21/365
摘要： A method including sensing an image without magnification of a portion of a tissue sample on a substrate with a sensor; displaying the sensed image on a display at a sensor to display pixel ratio greater than one to one; and performing at least one of the following: refreshing the sensed image at a predetermined rate, storing the sensed image, modifying the sensor to display pixel ratio, and sensing a magnified view of an area of the portion of the tissue sample. An apparatus comprising a digital microscope comprising: at least one image sensor; a stage configured to support at least one microscope slide; a first optic configured to project an image with a magnification of one or less; a second optic disposed between the at least one sensor and the stage, the second optic configured to project an image with a magnification greater than one; and a light source; and a computer coupled to the digital microscope and operable to direct an image capture by the at least one image sensor of a portion of a microslide on the stage projected through the first optic or the second optic
摘要翻译：一种方法，包括用传感器在基底上感测图像而不放大组织样本的一部分; 在传感器的显示器上显示感测图像以显示大于1比1的像素比; 并且执行以下中的至少一个：以预定速率刷新感测到的图像，存储感测图像，修改传感器以显示像素比，以及感测组织样本的该部分区域的放大视图。一种包括数字显微镜的装置，包括：至少一个图像传感器; 配置成支撑至少一个显微镜载玻片的台架; 第一光学器件，被配置为投影具有一个或更小的放大率的图像; 设置在所述至少一个传感器和所述台之间的第二光学器件，所述第二光学器件被配置为以大于1的倍率投影图像; 和光源; 以及耦合到所述数字显微镜并且可操作以将所述至少一个图像传感器的图像捕获引导到通过所述第一光学器件或所述第二光学器件投影的所述平台上的微滑块的一部分的图像的计算机

50. 发明申请

US20110054679A1 INTEGRATED TISSUE PROCESSING AND EMBEDDING SYSTEMS, AND METHODS THEREOF 有权
标题翻译：综合组织加工和嵌入系统及其方法
公开(公告)号：US20110054679A1
公开(公告)日：2011-03-03
申请号：US12549313
申请日：2009-08-27
申请人： GILLES LEFEBVRE , ROBERT E. EVANS
发明人： GILLES LEFEBVRE , ROBERT E. EVANS
IPC分类号： G06F19/00
CPC分类号： B25J11/00 , B08B3/022 , B08B7/00 , B08B7/04 , G01N1/36 , G05B15/02 , Y10S901/02
摘要： Apparatus and methods for integrating tissue processors and embedding systems. An apparatus, of one aspect, includes a robot. The robot has a work envelope that encompasses a location having a tissue holder and an input of an embedding system. The tissue holder has at least one processed tissue. The robot is configured to transfer the tissue holder from the location to the input of the embedding system. A method, of one aspect, may include moving a robot to a location having a tissue holder. The tissue holder may have at least one processed tissue. The robot may engage with the tissue holder at the location. The robot may move the tissue holder from the location to an input to an embedding system. The robot may disengage from the tissue holder at the input to the embedding system. Other methods, apparatus, and systems are also disclosed.
摘要翻译：用于整合组织处理器和嵌入系统的装置和方法。一方面，一种装置包括机器人。机器人具有包括具有组织保持器和嵌入系统的输入的位置的工作信封。组织保持器具有至少一个处理过的组织。机器人被配置为将组织保持器从位置传送到嵌入系统的输入。一个方面的方法可以包括将机器人移动到具有纸巾支架的位置。组织保持器可以具有至少一个处理过的组织。机器人可以在位置处与组织保持器接合。机器人可以将组织保持器从位置移动到输入到嵌入系统。机器人可以在嵌入系统的输入处从组织保持器脱离。还公开了其它方法，装置和系统。

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