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41. 发明公开

EP2098264A1 Aktives Retina-Implantat mit einer Vielzahl von Bildelementen 有权
公开(公告)号：EP2098264A1
公开(公告)日：2009-09-09
申请号：EP09161695.3
申请日：2004-06-03
申请人： Retina Implant AG
发明人： Graf, Heinz-Gerhard , Dollberg, Alexander , Höfflinger, Bernd , Nisch, Wilfried , Hämmerle, Hugo , Stett, Alfred , Stelzle, Martin , Zrenner, Eberhart
IPC分类号： A61N1/36
CPC分类号： A61N1/36046
摘要： Ein aktives Retina-Implantat (10) enthält eine Vielzahl von Bildelementen (18), die einfallendes Licht in elektrische Stimulationssignale für über Stimulationselektroden zu kontaktierende Zellen der Retina umwandeln. Jedes Bildelement (18) ist mit zumindest eine Bildzelle (19) versehen, die einfallendes Licht in elektrische Signale umwandelt, wobei ferner zumindest ein Verstärker vorgesehen ist, dessen Eingang mit der Bildzelle (19) und dessen Ausgang mit zumindest einer Stimulationselektrode (22) verbunden ist, an die er ein Stimulationssignal liefert. Ferner ist eine Energieversorgung (14) vorgesehen, die extern eingekoppelte Fremdenergie als Versorgungsspannung (V cc1 , V cc2 ) für die Bildzellen (19) und die Verstärker bereitstellt. Hierbei wird das Stimulationssignal in Form von analogen Spannungspulsen bestimmter Pulslänge und Pulsabstände geliefert, deren Amplitude von der Intensität des einfallenden Lichtes abhängt ( Fig. 1 ).
摘要翻译：活性视网膜植入物（10）包括多个图像元素（18）。每个像素具有将入射光转换为电信号的至少一个图像单元（19），至少一个具有连接到图像单元的入口的放大器和连接到接收刺激信号的至少一个刺激电极（22）的出口，以及产生外部耦合的能量作为图像单元和放大器的电源电压（V ccl，V cc2）的能量供应（14）。图像单元具有对数特性曲线，根据该对数特性曲线，限定强度的入射光被转换成具有确定幅度的电信号。还包括独立权利要求：（1）替代活性视网膜植入物; 和（2）使用图像单元作为活性视网膜植入物的像素。

42. 发明公开

EP2066401A2 IMPLANTIERBARE VORRICHTUNG 有权
标题翻译：可植入装置
公开(公告)号：EP2066401A2
公开(公告)日：2009-06-10
申请号：EP07802327.2
申请日：2007-09-15
申请人： Retina Implant AG
发明人： ROTHERMEL, Albrecht
IPC分类号： A61N1/36 , A61N1/378 , A61N1/05
CPC分类号： A61N1/36046 , A61N1/36036
摘要： The invention relates to an implantable device (10), designed to emit electrical stimulation signals to the surrounding tissue by means of at least one stimulation electrode (17). Said device (10) has an input stage, which is connected via a cable to a supply unit (12), said unit supplying the input stage with at least one substantially square-wave electrical alternating current, which is almost devoid of d.c. voltage, when averaged over time, in relation to an external mass (29) that can be connected to the tissue (64).

43. 发明授权

EP2010116B1 Compound subretinal prostheses with extra-ocular parts 失效
标题翻译：复合视网膜下假体与眼外部分
公开(公告)号：EP2010116B1
公开(公告)日：2012-01-11
申请号：EP07724321.0
申请日：2007-04-18
申请人： Retina Implant AG
发明人： BARTZ-SCHMIDT, Karl, Ulrich , GRISANTI, Salvatore , SZURMAN, Peter , GEKELER, Florian
IPC分类号： A61F9/08
CPC分类号： A61F9/08 , A61F9/00727
摘要： In a method for introducing a retinal implant to a position within a subretinal region of an eye, the following Steps are performed: a) preparing a fornix-based scleral flap at a distance from the limbus; b) detaching the retina by subretinal injection of balanced salt Solution, from the vitreous cavity and creating a localized bubble in the area of the scleral flap; c) performing in the upper hemisphere of the eye a peripheral retinotomy and detaching a part of the retina; d) advancing the implant into the subretinal Space and placing an inner portion of said implant on the retinal pigment epithelium onto the desired position; and e) closing the sclera flap.

44. 发明授权

EP1014902B1 VORRICHTUNG FÜR EINEN ZUGANG IN DEN SUBRETINALRAUM EINES AUGES 有权
标题翻译：设备中，用于眼的视网膜连接
公开(公告)号：EP1014902B1
公开(公告)日：2009-11-25
申请号：EP98950052.5
申请日：1998-09-18
申请人： Retina Implant AG
发明人： GABEL, Veit-Peter , KOBUCH, Karin , ZRENNER, Eberhart
IPC分类号： A61F9/007 , A61F9/00
CPC分类号： A61F9/00727 , A61B2017/320044 , A61B2090/062 , A61F9/0017 , A61F9/007 , A61F2250/0067

45. 发明公开

EP2012873A1 ACTIVE SUB-RETINA IMPLANT 审中-公开
标题翻译： AKTIVES SUBRETINALES植物
公开(公告)号：EP2012873A1
公开(公告)日：2009-01-14
申请号：EP07724506.6
申请日：2007-04-24
申请人： Retina Implant AG
发明人： ZRENNER, Eberhart , WROBEL, Walter-G , GEKELER, Florian , HARSCHER, Alex , WILKE, Robert
IPC分类号： A61N1/36 , A61F2/14 , A61F9/08
CPC分类号： A61N1/36 , A61F2/147 , A61F9/08 , A61N1/0543 , A61N1/36046
摘要： The implant (10) has a set of stimulation electrodes (22), which deliver electrical stimulation signals to cells of a retina in an eye of a patient, to be contacted. Imaging units (18) convert incident light into the stimulation signals, where the electrodes are divided into two groups that are controlled temporally and successively for delivery of the signals. A repetition frequency of each group of electrodes lies between 0.2 Hertz and 6 Hertz.
摘要翻译：植入物（10）具有一组刺激电极（22），其将电刺激信号传递到待接触的患者的眼睛中的视网膜的细胞。成像单元（18）将入射光转换成刺激信号，其中电极被分成两组，时间上和连续地被控制以传递信号。每组电极的重复频率在0.2赫兹和6赫兹之间。

46. 发明授权

EP2943250B1 VORRICHTUNG ZUR KONTAKTIERUNG UND/ODER ELEKTROSTIMULATION VON BIOLOGISCHEM GEWEBE 有权
标题翻译： VORRICHTUNG ZUR KONTAKTIERUNG UND / ODER ELEKTROSTIMULATION VON BIOLOGISCHEM GEWEBE
公开(公告)号：EP2943250B1
公开(公告)日：2017-09-27
申请号：EP13811835.1
申请日：2013-12-10
申请人： Retina Implant AG
发明人： KOKELMANN, Martin
IPC分类号： A61N1/375 , A61N1/05 , A61N1/08 , A61N1/36
CPC分类号： A61N1/0543 , A61N1/08 , A61N1/36125 , A61N1/3758

47. 发明授权

EP2408514B1 ACTIVE RETINAL IMPLANT 有权
标题翻译： ACTIVE视网膜植入物
公开(公告)号：EP2408514B1
公开(公告)日：2017-01-25
申请号：EP10706528.6
申请日：2010-02-24
申请人： Retina Implant AG
发明人： WROBEL, Walter-G , ZRENNER, Eberhart , ROTHERMEL, Albrecht
IPC分类号： A61N1/05 , A61N1/06 , A61F9/008 , A61F9/007 , A61N5/06
CPC分类号： A61N5/0601 , A61F9/0079 , A61F2009/00863 , A61N1/0543 , A61N5/0622 , A61N2005/0648 , A61N2005/0652 , A61N2005/0653 , A61N2005/0659 , A61N2005/0662

48. 发明公开

EP2408514A2 ACTIVE RETINAL IMPLANT 有权
标题翻译： AKTIVES NETZHAUTIMPLANTAT
公开(公告)号：EP2408514A2
公开(公告)日：2012-01-25
申请号：EP10706528.6
申请日：2010-02-24
申请人： Retina Implant AG
发明人： WROBEL, Walter-G , ZRENNER, Eberhart , ROTHERMEL, Albrecht
IPC分类号： A61N1/05
CPC分类号： A61N5/0601 , A61F9/0079 , A61F2009/00863 , A61N1/0543 , A61N5/0622 , A61N2005/0648 , A61N2005/0652 , A61N2005/0653 , A61N2005/0659 , A61N2005/0662
摘要： The invention relates to an active retinal implant (10) to be implanted into an eye, with an array (16) of stimulation elements (17) that emit stimulation signals to cells of the retina, wherein the stimulation elements (17) are designed as radiation-emitting elements.
摘要翻译：本发明涉及要植入眼睛的活性视网膜植入物（10），其具有将刺激信号发射到视网膜的细胞的刺激元件（17）的阵列（16），其中刺激元件（17）被设计为辐射发射元件。

49. 发明授权

EP1635905B1 AKTIVES RETINA-IMPLANTAT MIT EINER VIELZAHL VON BILDELEMENTEN 有权
标题翻译：带有图形元素的多种活性视网膜植入物
公开(公告)号：EP1635905B1
公开(公告)日：2011-11-30
申请号：EP04739550.4
申请日：2004-06-03
申请人： Retina Implant AG
发明人： GRAF, Heinz, Gerhard , DOLLBERG, Alexander , HÖFFLINGEN, Bernd , NISCH, Wilfried , HÄMMERLE, Hugo , STETT, Alfred , STELZLE, Martin , ZRENNER, Eberhart
IPC分类号： A61N1/36
CPC分类号： A61N1/36046
摘要： The invention relates to an active retina implant (10) containing a plurality of picture elements (18) that convert incident light into electrical stimulation signals for cells of the retina to be contacted by means of simulation electrodes. Each picture element (18) is provided with at least one picture cell (19) that converts incident light into electrical signals. The inlet of an amplifier is connected to the picture cell (19) and the outlet of said amplifier is connected to at least one stimulation electrode (22) to which it delivers a stimulation signal. An energy supply (14) provides externally coupled energy as the supply voltage (Vccl, Vcc2) for the picture cells (19) and the amplifier. In one form of embodiment, the picture cell (19) has a logarithmic characteristic curve according to which incident light of a defined intensity is converted into electrical signals of a defined amplitude. In another form of embodiment, the stimulation signal is supplied in the form of analog voltage pulses of defined lengths and distances, the amplitude of said pulses depending on the intensity of the incident light.

50. 发明授权

EP1178763B1 RETINA-IMPLANTAT UND VERFAHREN ZUR HERSTELLUNG EINES SOLCHEN 有权
标题翻译：视网膜植入物和方法生产同样
公开(公告)号：EP1178763B1
公开(公告)日：2008-12-10
申请号：EP00929480.2
申请日：2000-05-03
申请人： Retina Implant AG
发明人： NISCH, Wilfried , STETT, Alfred , SCHUBERT, Markus , GRAF, Michael , GRAF, Heinz, Gerhard , HÄMMERLE, Hugo , ZRENNER, Eberhart , STELZLE, Martin , SACHS, H.
IPC分类号： A61F2/14
CPC分类号： A61N1/0543 , A61F2/14 , A61F9/08 , A61N1/3787
摘要： The invention relates to a retina implant (30) and a method for producing the same. The inventive retina implant comprises a chip (36) for subretinal implantation and has a receiver coil (37). Said receiver coil is provided for inductively inducing electromagnetic energy and is coupled to a converter device (35) for converting an alternating voltage induced in the receiver coil (37) into a direct voltage that is appropriate for supplying current to the chip (36). The receiver coil (37) is configured and dimensioned to be placed and positioned on the eyeball (10) outside of the sclera (12). The converter device (35) is preferably constructed as a separate unit which can be positioned on the sclera (12) outside of the eyeball (10).

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