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41. 发明申请

WO0132072A3 BIODEGRADABLE POLYMER/CERAMIC IMPLANT MATERIAL WITH BIMODAL DEGRADATION PROFILE 审中-公开
标题翻译：可生物降解的聚合物/陶瓷植入材料，具有二元降解型材
公开(公告)号：WO0132072A3
公开(公告)日：2001-09-20
申请号：PCT/US0041711
申请日：2000-10-30
申请人： OSTEOBIOLOGICS INC
发明人： NIEDERAUER GABRIELE G , LEATHERBURY NEIL C , SLIVKA MICHAEL A , KIESWETTER KRISTINE
IPC分类号： A61L27/44 , A61L27/46 , A61L27/58 , A61F2/02 , A61F2/28
CPC分类号： A61L27/58 , A61L27/446 , A61L27/46 , C08L67/04
摘要： A biodegradable therapeutic implant material having a bimodal degradation profile made from a biodegradable polymer having a biodegradable ceramic substantially uniformly distributed therein is provided. Preferably the material is nonporous (fully dense). Methods of using the materials of this invention for healing of defects in bone, cartilage, and other tissues are also provided. Methods of making such therapeutic implant materials are also provided including the steps of preparing the polymer in uncured form, mixing particles of a biodegradable ceramic into said polymer, and applying heat and pressure to the mixture to produce a substantially nonporous, cohesive implant material. Methods of making porous implants by dissolving out the biodegradable ceramic materials in vivo or in vitro are also provided as are the porous implant themselves.
摘要翻译：提供了具有由具有基本上均匀分布在其中的可生物降解的陶瓷的可生物降解的聚合物制成的双峰降解曲线的可生物降解的治疗性植入材料。优选地，该材料是无孔的（完全致密的）。还提供了使用本发明的材料治愈骨，软骨和其他组织中的缺陷的方法。还提供了制备这种治疗性植入材料的方法，包括以未固化形式制备聚合物的步骤，将可生物降解陶瓷的颗粒混合到所述聚合物中，并向混合物施加热量和压力以产生基本上无孔的粘结植入材料。多孔植入物本身也可以通过在体内或体外溶解可生物降解的陶瓷材料来制造多孔植入物的方法。

42. 发明专利

DE69732721T2 未知
公开(公告)号：DE69732721T2
公开(公告)日：2006-05-18
申请号：DE69732721
申请日：1997-12-03
申请人： OSTEOBIOLOGICS INC
发明人： LEATHERBURY C , KIESWETTER KRISTINE , SLIVKA A , NIEDERAUER GABRIELE
IPC分类号： A61L27/00 , A61L27/34 , A61F2/00 , A61F2/02 , A61L27/12 , A61L27/54 , A61L27/58 , C08L67/04
摘要： This invention provides biodegradable, biocompatible polymeric films having uniform selected thicknesses between about 60 micrometers and about 5 mm useful in the manufacture of therapeutic implants for insertion into a patient's body. The films may be shaped to cover implants made of other materials to improve their biocompatibility. The films may be coated with or incorporate bioactive agents. They may have differing properties, e.g., porosity, thickness, and degradation rate, in different areas.

43. 发明专利

CA2555586A1 IMPLANT SCAFFOLD COMBINED WITH AUTOLOGOUS OR ALLOGENIC TISSUE 未知
公开(公告)号：CA2555586A1
公开(公告)日：2005-09-22
申请号：CA2555586
申请日：2005-03-09
申请人： OSTEOBIOLOGICS INC
发明人： NIEDERAUER GABRIELE G , DINGER FRED B III
IPC分类号： A61L27/38 , A61F2/00 , A61F2/02 , A61F2/08 , A61F2/28 , A61F2/30 , A61L27/36 , A61L27/54
摘要： This invention provides implants comprising tissue having an intercellular matrix anchored to a biocompatible scaffold. The intercellular matrix of the tissue provides a natural medium to facilitate the healing and growth of damaged tissue in a patient. The present invention provides methods of treating damaged tissue in a patient by inserting such implants into the damaged tissue. The implants of the present invention include implants comprising allogenic and/or autologous tissue. The tissue may also be acellular.

44. 发明专利

AU2005221083A1 Implant scaffold combined with autologous or allogenic tissue 未知
公开(公告)号：AU2005221083A1
公开(公告)日：2005-09-22
申请号：AU2005221083
申请日：2005-03-09
申请人： OSTEOBIOLOGICS INC
发明人： NIEDERAUER GABRIELE G , DINGER FRED B III
IPC分类号： A61F2/02 , A61F2/00 , A61F2/08 , A61F2/28 , A61F2/30 , A61L27/36
摘要： This invention provides implants comprising tissue having an intercellular matrix anchored to a biocompatible scaffold. The intercellular matrix of the tissue provides a natural medium to facilitate the healing and growth of damaged tissue in a patient. The present invention provides methods of treating damaged tissue in a patient by inserting such implants into the damaged tissue. The implants of the present invention include implants comprising allogenic and/or autologous tissue. The tissue may also be acellular.

45. 发明专利

ES2238736T3 PELICULA POLIMERICA BIODEGRADABLE. 未知
公开(公告)号：ES2238736T3
公开(公告)日：2005-09-01
申请号：ES97952332
申请日：1997-12-03
申请人： OSTEOBIOLOGICS INC
发明人： LEATHERBURY NEIL C , KIESWETTER KRISTINE , SLIVKA MICHAEL A , NIEDERAUER GABRIELE
IPC分类号： A61L27/00 , A61F2/00 , A61F2/02 , A61L27/12 , A61L27/34 , A61L27/54 , A61L27/58 , C08L67/04
摘要： Un implante terapéutico que comprende al menos un recubrimiento parcial que es una película biodegradable, polimérica biocompatible que tiene un espesor seleccionado uniforme entre 60 micrómetros y 0.5 mm, capaz de degradarse in vivo en un período no superior a cuatro meses.

46. 发明专利

DE69625828T2 未知
公开(公告)号：DE69625828T2
公开(公告)日：2003-11-06
申请号：DE69625828
申请日：1996-10-07
申请人： OSTEOBIOLOGICS INC
发明人： WALTER ANN , LEATHERBURY C , NIEDERAUER O
IPC分类号： A61F2/02 , A61F2/28 , A61F2/30 , A61F2/38 , A61F2/44 , A61L27/18 , A61L27/50 , A61L27/56 , A61L27/58 , A61L31/06 , A61L31/14 , A61L27/00 , A61L31/00
摘要： This invention provides molded, biodegradable porous polymeric implant materials having a pore size distribution throughout the material which is substantially uniform. These materials can be molded into implants of any desired size and shape without loss of uniformity of pore size distribution. The implants are useful as biodegradable scaffolds for cell growth in healing of tissue defects. When manufactured to have an aspect ratio greater than about 3, the implants can be further hand-shaped to fit the defect into which they are placed and the desired shape for the regrown tissue.

47. 发明专利

AU3639301A Biodegradable polymer/ceramic implant material with bimodal degradation profile 未知
公开(公告)号：AU3639301A
公开(公告)日：2001-05-14
申请号：AU3639301
申请日：2000-10-30
申请人： OSTEOBIOLOGICS INC
发明人： NIEDERAUER GABRIELE G , LEATHERBURY NEIL C , SLIVKA MICHAEL A , KIESWETTER KRISTINE
IPC分类号： A61L27/44 , A61L27/46 , A61L27/58

48. 发明专利

AU7706398A Fiber-reinforced, porous, biodegradable implant device 未知
公开(公告)号：AU7706398A
公开(公告)日：1998-12-30
申请号：AU7706398
申请日：1998-05-29
申请人： OSTEOBIOLOGICS INC
发明人： SLIVKA MICHAEL A , NIEDERAUER GABRIELE G , KIESWETTER KRISTINE , LEATHERBURY NEIL C
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61F2/46 , A61L27/48 , A61L27/56 , B29C44/34 , B29C70/14
摘要： A fiber-reinforced, polymeric implant material useful for tissue engineering, and method of making same are provided. The fibers are preferably aligned predominantly parallel to each other, but may also be aligned in a single plane. The implant material comprises a polymeric matrix, preferably a biodegradable matrix, having fibers substantially uniformly distributed therein. In preferred embodiments, porous tissue scaffolds are provided which facilitate regeneration of load-bearing tissues such as articular cartilage and bone. Non-porous fiber-reinforced implant materials are also provided herein useful as permanent implants for load-bearing sites.

49. 发明专利

CA2274004A1 BIODEGRADABLE POLYMERIC FILM 未知
公开(公告)号：CA2274004A1
公开(公告)日：1998-06-11
申请号：CA2274004
申请日：1997-12-03
申请人： OSTEOBIOLOGICS INC
发明人： SLIVKA MICHAEL A , KIESWETTER KRISTINE , LEATHERBURY NEIL C , NIEDERAUER GABRIELE
IPC分类号： A61L27/00 , A61F2/00 , A61F2/02 , A61L27/12 , A61L27/34 , A61L27/54 , A61L27/58
摘要： This invention provides biodegradable, biocompatible polymeric films having uniform selected thicknesses between about 60 micrometers and about 5 mm useful in the manufacture of therapeutic implants for insertion into a patient's body. The films may be shaped to cover implants made of other materials to improve their biocompatibility. The films may be coated with or incorporate bioactive agents. They may have differing properties, e.g., porosity, thickness, and degradation rate, in different areas.

50. 发明专利

AU4084597A Handheld materials tester 未知
公开(公告)号：AU4084597A
公开(公告)日：1998-03-06
申请号：AU4084597
申请日：1997-08-22
申请人： OSTEOBIOLOGICS INC
发明人： NEIDERAUER MARK Q , WILKES ROBERT P , NIEDERAUER GEORGE M , CRISTANTE SABINE , CLINE STEVEN F , TYNMANN ROBERT A
IPC分类号： G01N3/48 , A61B5/103 , G01N3/40 , G01N3/42 , G01N33/483
摘要： A handheld materials testing device is provided for measuring compressive properties of a material, preferably articular cartilage in vivo. The device is computer-controlled and provides a readout indicative of the desired compressive property, which in the case of bodily tissue, may be indicative of the state of health of the tissue. The device does not require precise perpendicular alignment and is preferably capable of compensating for force applied by the user against the tissue.

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